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1.
Chinese Journal of Nephrology ; (12): 81-90, 2022.
Article in Chinese | WPRIM | ID: wpr-933845

ABSTRACT

Objective:To access the clinical efficacy and safety of hydroxychloroquine (HCQ) in treatment of IgA nephropathy (IgAN).Methods:The data of IgAN patients who were diagnosed by renal biopsy in the First Affiliated Hospital, College of Medicine, Zhejiang University from May 2016 to August 2020 and had been treated with HCQ for more than 6 months without other immunosuppressants were retrospectively analyzed. The efficacy and side effects were compared between groups according to the baseline urine protein/creatinine ratio (UPCR) or whether combined with renin-angiotensin-aldosterone system inhibitor (RAASi).Results:A total of 121 patients were enrolled, including 45 males (37.19%). At baseline, the median UPCR was 0.69(0.45, 1.00) g/g; the median estimated glomerular filtration rate (eGFR) was 93.46(73.14, 115.67) ml·min -1·(1.73 m 2) -1; the median serum creatinine was 80.00(61.00, 98.00) μmol/L, and the serum albumin was (44.39±3.36) g/L. After HCQ treatment, UPCR and red blood cells were significantly decreased compared with baseline (all P<0.05). Triglyceride, total cholesterol and low-density lipoprotein cholesterol were also significantly decreased during the follow-up period. Serum creatinine, eGFR, serum albumin and serum uric acid remained stable. After 6 months of follow-up, the total remission rate was 56.88%, including 15.60% of partial remission and 41.28% of complete remission; at the end of follow-up, the median follow-up time was 280.00(214.00, 411.00) days and the total remission rate was 56.20%, including 9.92% of partial remission and 46.28% of complete remission. Group analysis showed that the remission rate was 60.53% ( n=76) and 48.48% ( n=33) at 6 months (Mann-Whitney U test, Z=-2.331, P=0.020) and 57.65% ( n=85) and 52.78% ( n=36) at the end of follow-up (Mann-Whitney U test, Z=-1.673, P=0.094) between patients with baseline UPCR<1 g/g and patients with baseline UPCR≥1 g/g; and the remission rate was 66.67% ( n=30) and 53.16% ( n=79) at 6 months (Mann-Whitney U test, Z=1.062, P=0.288) and 61.29% ( n=31) and 54.44% ( n=90) at the end of follow-up (Mann-Whitney U test, Z=0.930, P=0.352) between patients with single HCQ and patients with HCQ+RAASi. For side effects, the eGFR of 2 patients decreased by more than 30% compared with baseline, 1 patient relapsed and 1 patient developed blurred vision. Conclusions:HCQ is safe and effective for the treatment of IgAN.

2.
Article in Chinese | WPRIM | ID: wpr-885360

ABSTRACT

Objective:To analyze Traditional Chinese Medicine(TCM) prescriptions in COVID-19 patients in Shanghai area.Methods:Two hundred and forty patients were enrolled in the study, including 19 mild cases, 199 moderate cases, 16 severe case and 6 critical cases. The COVID-19 formula in Shanghai area was extracted and input in TCM Inheritance platform. Data association method such as software association rules,improved mutual information method,complex system entropy clustering,unsupervised entropy hierarchical clustering were used to analyze the frequency,herb flavor and meridian, combination rule and core combination of different types of Chinese herbs in the treatment of COVID-19 in Shanghai area.Results:According to the frequency analysis of 240 prescriptions of Chinese medicine,194 herbs were found. The COVID-19 formula herbs were all "cold", the frequency of use in mild, moderate, severe and critical cases was [46.02%(104/226), 46.31%(1 230/2 656), 37.06%(146/394), 39.24%(31/79)]. The flavor was mainly "bitter" and the frequency of use in 4 types of disease were [36.53%(122/332), 37.33%(1 445/3 857), 35.96%(205/564), 33.62%(39/113)]. Scutellaria was the most frequently used TCM of "bitter and cold". The drugs used were mainly lung,stomach and spleen meridians. By comparing the formulas between mild and moderate cases,herb combinations with the highest frequency were all "scutellaria glycyrrhiza" and "tangerine glycyrrhiza". The formulas for 19 mild cases were collected,and 197 drug combinations were counted, and 125 Chinese medicine association rules,including 13 Chinese herbs. The formulas were extracted in 199 moderate cases of COVID-19, a total of 92 drug combinations and 38 Chinese medicine association rules were collected,including 19 Chinese herbs. In 16 severe cases, a total of 62 drug combination models and 46 Chinese medicine association rules were collected,including 17 Chinese herbs. For the 6 critical cases,80 Chinese medicine prescriptions were combined,and 10 Chinese medicine association rules, including 12 Chinese herbs.Conclusions:The herbal prescriptions of COVID-19 in Shanghai are characterized by clearing away heat and resolving dampness. By analyzing prescription rules with complex system entropy clustering, association compatibility ideas of different types of traditional Chinese medicine are found to be different among four types of COVID-19 cases. Analyzing the connection rules in formulas, by using the theory of TCM and pharmacology of traditional Chinese medical formula in different COVID-19 patients may be helpful for general practitioners.

3.
Journal of Clinical Hepatology ; (12): 1643-1645, 2020.
Article in Chinese | WPRIM | ID: wpr-822910

ABSTRACT

Chronic inflammation of the liver is a risk factor that promotes the progression of hepatocellular carcinoma, and in the presence of viral infection, enhanced Fc receptor signal will further aggravate inflammatory response and participate in the process of canceration. Polymeric immunoglobulin receptor (pIgR) not only plays a critical role in first-line anti-infection immunity, but also promotes the metastasis and growth of early-stage hepatocellular carcinoma. Identifying pIgR as a predictive index for metastatic potential in patients with early-stage liver cancer can help to promote the stratification and treatment decisions for such patients, which has a positive significance in improving patient prognosis. Targeted inhibition of the pIgR/Yes signal cascade as a potential treatment option may provide more treatment options for controlling tumor size to allow resection or transplantation.

4.
Article in Chinese | WPRIM | ID: wpr-805259

ABSTRACT

Objective@#To analyze the association between 24 h urinary sodium excretion and microalbuminuria (MAU) among Chinese people aged from 18 to 69 years old.@*Methods@#2 400 subjects aged from 18 to 69 years old were selected form Gaomi and Fushan sites of Shandong Province and Xinyi and Ganyu sites of Jiangsu Province in 2013 by using multi-stage stratified cluster random sampling method. Questionnaire survey, physical measurement and 24 h urine collection were conducted. 2 262 subjects were finally included in the analysis. According to the quartile of 24 h urinary sodium, all subjects were divided into Q1-Q4 groups and the levels of urinary microalbumin and MAU among different groups were compared. The relationship between urinary sodium and MAU was analyzed by multivariate logistic regression analysis.@*Results@#The age of subjects was (42.1±13.5) years old, including 1 124 males (49.7%). The 24 h urine volume, urinary sodium, urine albumin M (P25, P75) and MAU detection rate were (1 411±495) ml, (166.4±71.6) mmol/d, 12.5 (9.6, 17.4) mg/d and 9.0% (203 cases), respectively. With the increase of urinary sodium level, the level of urinary albumin increased (Ptrend<0.001), and the prevalence of MAU also showed an upward trend (Ptrend<0.001). Multivariate logistic regression analysis showed that after adjusting for age, gender, smoking, alcohol consumption, BMI, hypertension and diabetes, the risk of MAU in Q4 group increased by 174% compared with Q1 group, and OR (95%CI) value was 2.74 (1.80-4.16).@*Conclusion@#24 h urinary sodium is associated with the prevalence of MAU and salt reduction can help reduce MAU.

5.
Chinese Journal of Nephrology ; (12): 30-35, 2019.
Article in Chinese | WPRIM | ID: wpr-734922

ABSTRACT

Objective To investigate the association between microalbuminuria and cardiovascular risk factors in a general Chinese population.Methods A multi-stage cluster randomized sampling method was used to select 2400 residents (18-69 years old) in four counties in Shandong and Jiangsu provinces in October 2013 to March 2014.24-hour MAU were measured for each subject.The prevalence of MAU in different groups was analyzed.The relationship between the aggregation of risk factors and MAU was analyzed.Logistic regression analysis was used to evaluate the association between MAU and cardiovascular risk factors.Results A total of 2265 subjects were included in the analysis.The prevalence of MAU was 8.96% (203/2265,95% CI:7.82-10.21).The prevalence of MAU in obesity,hypertension,diabetes,hypertriglyceridemia,and low HDL-C group were 14.65% (63/430),12.53% (104/830),20.22% (36/178),15.57% (64/411),11.99% (53/442) respectively,which were significantly higher than the corresponding healthy population (all P < 0.01).Multivariate logistic regression analysis showed that obesity,hypertension,diabetes,and hypertriglyceridemia were risk factors for MAU.The OR(95% CI) values were 1.491(1.016-2.265),1.660(1.190-2.314),2.291 (1.494-3.515) and 1.734(1.205-2.495) respectively.With the increase in the number of influencing factors,urinary albumin levels and the prevalence of MAU all showed an upward trend.Conclusion MAU was associated with cardiovascular risk factors such as obesity,hypertension,diabetes,and hypertriglyceridemia.

6.
Article in Chinese | WPRIM | ID: wpr-710844

ABSTRACT

Objective To survey the utilization of basic public health service among hypertensive and diabetic patients in communities.Methods A survey on the utilization of basic public health service was conducted between October 2014 and November 2014,1 511 patients with hypertension and 1 508 patients with type 2 diabetes aged ≥35 years were randomly selected for the survey from 18 communities in 2 cities and 4 townships of Shandong and Jiangsu provinces in China.Results The survey showed that 87.0% (1 314/1 511) of hypertensive patients and 88.5% (1 334/1 508) of diabetic patients visited community hcalth services within the year,and the blood pressure/blood glucose elevation were found in community health services in 68.5% (1 035/1 511) of the hypertensive patients and 53.3% (804/1 508) of the diabetic patients,respectively.The proportion of participants in community health education was higher in rural areas than that in urban areas [hypertension 73.2% (556/760) vs.60.3% (453/751),x2 =48.48,P < 0.01;diabetes 77.8% (591/760) vs.62.6% (468/748),x2 =43.73,P < 0.01].The proportion of outpatients who were followed up for more than 4 times was higher in rural areas than that in urban areas [hypertension 61.3% (466/760) vs.48.4% (363/751),x2 =79.31,P < 0.01;diabetes 58.8% (447/760) vs.50.5% (378/748),x2 =17.78,P <0.01].The self-test rate of blood pressure and blood glucose in the urban was higher than that in rural areas [hypertension 41.8% (314/751) vs.17.8% (135/760),x2=104.59,P<0.01;diabetes41.7% (312/748) vs.11.3% (86/760),x2=179.28,P < 0.01].The proportion of patients with hypertension who did not take medication was higher in rural areas than in that in urban areas [36.7% (279/760) vs.24.0% (180/751),x2 =70.88,P < 0.01],and the proportion of patients with diabetes who did not take medication was not statistically significant between rural and urban areas [20.8% (156/760) vs.19.8% (148/748),x2 =1.95,P > 0.05].The control rates of hypertension and diabetes were 39.8% (602/1 511) and 39.6% (597/ 1 508),respectively.82.5% (1 247/1 511) hypertensive patients and 75.6% (1 140/1 508) diabetic patients selected community clinics for treatment and disease management,and satisfaction rate with primary health care in community clinics were 82.1% (1 077/1 312) and 82.5% (1 101/1 334) respectively.Conclusions High percentage of community clinic choice and visit was found,and most of the patients got the recommendation about health life style.But difference existed between the practice of self-monitoring of blood pressure and fasting blood glucose and control of blood pressure and blood glucose and plan of chronic disease prevention and control.

7.
The Journal of Practical Medicine ; (24): 1504-1507,1528, 2018.
Article in Chinese | WPRIM | ID: wpr-697809

ABSTRACT

Objective To explore the correlation of EGFR and Ki-67 expressions in lung adenocarcino-ma with MSCT features and general clinical characteristics. Methods According to the differences in EGFR 19/21 gene mutation in the tumor tissues ,120 patients with lung adenocarcinoma were divided into positive group or wild type group. And Ki-67 expression in the tumor tissues was also detected. The test results were analyzed ,and the clinical data and theMSCT imaging features were examined by using the SPSS 19.0. Results The expression of EGFR differed statistically with lymphatic metastasis ,organ metastasis ,pleural indentation ,andnodule types (P < 0.05),but had no statistical significance with age ,sex ,degree of differentiation ,tumor size ,tumor-lung boundary ,burr ,lobulated sign ,vacuole sign and pleural effusion.The high expression of Ki-67 had statistical sig-nificance with lymphatic metastasis and tumor size(P < 0.05)while had no statistical significance with other in-dicators.Ki-67 expression was significantly positively correlated with EGFR(P < 0.05). Conclusions Tumor size ,pleural indentation ,lymphatic metastasis ,organ metastasis and nodular types of lung adenocarcinoma have guiding significance in judging EGFR mutation , proliferation activity ,prognosis and therapy.

8.
Article in Chinese | WPRIM | ID: wpr-686606

ABSTRACT

Objective To explore the MRI characterisitics of primary dilated cardiomyopathy and isolated left ventricular non-compaction.Methods The patients who were diagnosed as primary dilated cardiomyopathy (n=18) and isolated left ventricular non-compaction (n=10) were enrolled,and the MRI was performed.The thickness of non-compaction myocardium (NC),compaction myocardium (C) in end-diastole,the feature of movement of myocardium,the number of non-compaction segment,the fraction shortening of non-compaction and the distribution were compared.Results Totally 823 segments were analyzed in primary dilated cardiomyopathy,in which 124 segments were non-compaction myocardium;397 segments were analyzed in isolated left ventricular non-compaction,in which 115 segments were non-compaction myocardium.The NC,NC/C,NC/(NC+C),and the fraction shortening of the isolated left ventricular non-compaction patients were higher than those of primary dilated cardiomyopathy patients (all P<0.05).The features of distribution showed that the apical segment was mostly involved,and the basal segment was less involved or hardly involved.The anterior and lateral segments were more involved in the free wall,the septal was less involved.Conclusion The MRI characteristics of primary dilated cardiomyopathy and isolated left ventricular non-compaction are different,especially in the distribution,non compacted segments,NC and NC/C,which is important for diagnosis and differential diagnosis of the two diseases.

9.
Article in Chinese | WPRIM | ID: wpr-493052

ABSTRACT

Objective To explore the profiles of physical activity domains among professionals with different occupational activity patterns.Methods A cluster random sampling method was used to recruit employed adults aged 30-60 years in Beijing as well as Zhejiang province.The information on the physical activity domains was collected with a revised Global Physical Activity Questionnaire (GPAQ).Results Of 3 326 professionals,about 30.79%,50.75% and 18.46% adults had Class Ⅰ (mostly sedentary reading or writing during work time) ,Class Ⅱ (mostly working with arms or legs with little effort) ,and Class Ⅲ (working with effort)occupational activity patterns,respectively.The median volume of leisure time activity and bicycling were all 0 Met-min/week,and no significant difference of domestic activity volume was detected among all the three classes of professionals.Of all the non-occupational activity volume among three classes of adults,domestic activity accounted for the most proportion (58.87%) performed by adults of Class Ⅱ,traffic activity accounted for the most proportion (34.2%) by those of Class Ⅲ,and leisure time activity accounted for the most proportion (12.7%) by those of Class Ⅰ.Most time was spent in sedentary behaviors by those of Class Ⅰ after hours.Conclusions Besides the generally low level of moderate activity,the diversity of the domains of physical activity among this population was evident.It is necessary to develop appropriate technology to improve physical activity for professionals with different occupational activity patterns.

10.
Chinese Journal of Epidemiology ; (12): 790-793, 2015.
Article in Chinese | WPRIM | ID: wpr-302078

ABSTRACT

<p><b>OBJECTIVE</b>To examine the association between 24 h urinary sodium to potassium ratio and metabolic syndrome (MS) in Chinese adults.</p><p><b>METHODS</b>A population-based cross-sectional study was conducted among Chinese adults aged 18-69 years in Shandong province in 2011. Data on 24 h urinary excretion of sodium and potassium and components of MS were examined. Participants were divided into four groups according to the quartile of 24 h urinary sodium to potassium ratio.</p><p><b>RESULTS</b>Of the 1 906 Chinese adults eligible for final data analysis, 471 (24.7%) were with MS. After completion of multivariate logistic regression analysis, when compared to the participants with 24 h urinary sodium to potassium ratio < 4.3, the OR (95% CI) of participants with 24 h urinary sodium to potassium ratio during 4.3-5.6, 5.7-8.1, and ≥ 8.1 were 1.27 (0.93-1.71), 1.06 (0.78-1.46), and 1.45 (1.06-1.97), respectively (P values for linear trend < 0.05). As for the components of MS, the odds of central obesity and elevated blood pressure but not the odds of elevated triglycerides, low high density lipoprotein cholesterol and elevated fasting glucose, had significantly increases with successive 24 h urinary sodium to potassium ratio quartiles (P values for linear trends < 0.05).</p><p><b>CONCLUSION</b>The 24 h urinary sodium to potassium ratio appeared significantly associated with the odds of MS.</p>


Subject(s)
Adolescent , Adult , Aged , Asians , Blood Glucose , Cholesterol, HDL , Blood , Cross-Sectional Studies , Humans , Hypertension , Metabolic Syndrome , Urine , Middle Aged , Obesity, Abdominal , Potassium , Urine , Sodium , Urine , Triglycerides , Blood , Young Adult
11.
China Pharmacist ; (12): 1935-1937, 2015.
Article in Chinese | WPRIM | ID: wpr-670117

ABSTRACT

Objective:To observe the effect of simvastatin at different doses on the inflammatory factors and renal function in se-nile patients with diabetic kidney disease ( DKD) . Methods:Totally 160 cases of DKD patients were randomly divided into the control group, low dose group, conventional dose group and high dose group. All the patients were given the foundation treatment, and the low dose group, conventional dose group and high dose group was respectively given simvastatin 10, 20,40 mg·d-1 . The changes of in-flammatory cytokines (CRP, ICAM-1 and IL-1β) and renal index (BUN, Cr, UAER, 24hUpro and Uβ2-MG) among the groups were observed and compared before and after the 4-week treatment. Results:CRP in the high dose group after the treatment was significantly decreased when compared with that before the treatment and that in the control group after the treatment, and the difference was statisti-cally significant (P0.05). BUN in the four groups after the treatment had no obvious change when compared with that before the treatment, and there was no significant difference among the groups (P>0. 05). Cr and UAER in the four groups after the treatment were significantly decreased (P0. 05). Conclusion:Simvastatin can improve diabetic nephropathy conditions in two aspects of inflammation factors and renal in-dex, and simvastatin at high dose shows more advantages.

12.
Article in Chinese | WPRIM | ID: wpr-477369

ABSTRACT

Objective To evaluate the relationship between long non-coding RNAs (LncRNA) in tumor tissues and clinico-pathological features of hepatocllular carcinoma (HCC).Methods Using hepatocellular carcinoma gene database GSE36376,we conducted a study on eight LncRNAs which are associated with liver diseases and analyzed the correlation between these LncRNAs and HCC clinico-pathological characteristics.We also evaluated the potential effect of LncRNAs on HCC development.Results H19 was overexpressed in non-tumorous tissues of HCC (P < 0.05),while MEG3,HOXA13,KCNQ1OT1 were all upregulated in tumorous tissues (all P < 0.05).HULC level in HCC tumorous tissues was negatively correlated with AJCC staging,BCLC staging and tumor size (all P < 0.05).UCA1 was positively correlated with BCLC staging (r =0.135,P < 0.05).Univariate analysis and multivariate logistic analyses showed that UCA1 was a risk factor of intrahepatic metastasis of HCC (OR =6.054,95% CI =1.429 ~ 25.642,P < 0.05); in contrast,HULC overexpression in tumorous tissues played a positive role in HCC tumor size (OR=0.805,95%CI=0.678 ~0.956,P<0.05).Conclusion HULC in tumorous tissues suppressed HCC proliferation,while UCA1 was a risk factor of HCC aggressiveness.

13.
Article in Chinese | WPRIM | ID: wpr-476917

ABSTRACT

Objective To observe the protective effect of Xiaohuangdecotion against liver damage inα-naphthylisothiocyanate (ANIT)- induced cholestasis in rats and probe the potential mechanisms.Methods Male Wistar rats (40) were randomly divided into a normal group, a model group, aXiaohuangdecotion treatment group, and a UDCA control group (10 for each). Except for rats in the normal group, ANIT solution (6 ml/kg) was administered in other rats by gavages for cholestasis model. After ANIT treated 48 h, rats inXiaohuangdecotion group and UDCA group were treated withXiaohuangdecotion (1.73 g/kg) and UDCA (10 mg/kg) respectively for 1 week. And, rats in the normal group and the model group were given an equal volume of saline. At the end of the experiment, liver function rats were examined. Liver histology was examined by HE staining, and CD68 factor was tested by immunohistochemistry and Western blot.Results Compared with the model group, the content of ALT (164.6 ± 53.4 U/Lvs. 208.4 ± 28.5 U/L), AST (247.6 ± 76.1 U/Lvs. 341.8 ± 32.8 U/L), ALP (601.0 ± 101.1 U/Lvs. 720.6 ± 123.3 U/L), TBiL (96.5 ± 18.1μmol/Lvs. 149.6 ± 30.2μmol/L), DBiL (73.7 ± 16.6μmol/Lvs. 140.3 ± 28.6μmol/L) and TBA (93.4 ± 13.0μmol/Lvs. 146.5 ± 38.9μmol/L) were significantly reduced in the treatment group (P<0.01 orP<0.05). Compared with the model group, CD68 level (7.08 ± 0.19 vs. 17.42 ± 0.48)were significantly reduced by intervention ofXiaohuangdecotion (P<0.01).ConclusionsXiaohuangdecotion could improve liver functions and reduce CD68 expression, leading to a good hepatoprotective and jaundice-relieving effects.

14.
Chinese Journal of Epidemiology ; (12): 242-245, 2014.
Article in Chinese | WPRIM | ID: wpr-321620

ABSTRACT

Objective To describe the prevalence of leisure-time physical exercise and sedentary behavior among Chinese elderly.Methods A face-to-face questionnaire survey was carried out in Disease Surveillance Points System (DSPs) and Nonger county in Xinjiang autonomous region to collect information on non-communicable diseases related risk factors.Information on frequency and duration of leisure-time moderate-intensity and vigorous-intensity physical activity was collected by Global Physical Activity Questionnaire (GPAQ).Multi-stage stratified random sampling method was used to select individuals aged 18 and over to be interviewed.A total of 15 193 individuals aged 60 and over were included in the analysis.Sample was weighted to represent the population of Chinese elderly.Wc analyzed the percentages of those who did not engage in leisure-time moderate-intensity and vigorous-intensity physical activity,those who engaging in leisure-time moderate-intensity at least 30 minutes per day and at least three days per week or equivalent (regular exercise) and those who engaged in leisure-time moderate-intensity at least 30 minutes per day and at least five days per week or equivalent (active exercise).Sedentary time and time spending on watching television were also analyzed.Results Percentage of those who did not engage in leisure-time physical activity was 85.4% (95% CI:83.5%-87.3%) among Chinese elderly.Chinese elderly exhibited low prevalence of leisure-time activity with 12.0% (95%CI:10.0%-13.1%) for regular exercise and with 9.9% (95%CI:8.5%-11.3 %) for active exercise.Elderly living in urban areas engaged more regular exercise (23.8%,95%CI:20.7%-26.9%) or active exercise (20.5%,95%CI:17.9%-23.1%) than those living in rural areas (P<0.05).Elderly with higher education or higher household income exhibited higher prevalence of leisure-time physical activity when compared to those with lower education or lower income (P<0.05).Furthermore,Chinese elderly spent 4.2 hours (95%CI:4.1-4.4 hours) per day in sedentary behaviors and 105.1 minutes (95%CI:100.6-109.6 minutes) per day in watching television (P<0.05).Those living in urban areas,with higher education or higher household income would spend more time in sedentary behaviors or watching television,compared to those living in rural areas,with lower education or lower income (P<0.05).Conclusion Low prevalence in leisure-time physical exercise appeared in the Chinese elderly,especially in those living in the rural areas.

15.
Article in Chinese | WPRIM | ID: wpr-298923

ABSTRACT

<p><b>OBJECTIVE</b>To explore the knowledge, attitude and behavior of salt reduction among Chinese adults aged over 18 years old in 2010.</p><p><b>METHODS</b>A total of 96 916 adults aged over 18 were recruited from 162 surveillance points in 2010, applying multi-stage stratified cluster random sampling method.Information about subjects salt reduction related knowledge, attitude and behavior were collected by face-to-face interview. After performing complex weighted analysis, the awareness, willingness and behavior rates were compared by different genders, age groups, urban, rural and different regions.</p><p><b>RESULTS</b>The unweighted salt reduction rate of the awareness, willingness and behavior among Chinese adults were 63.0%, 84.5% and 44.5%. After being weighted, the awareness rate was 62.9%, the awareness rate difference was not significant between males (62.4%) and females (63.4%) (χ(2) = 1.66, P > 0.05), but the urban areas (77.1%) were significantly higher than the rural areas (56.3%) (χ(2) = 85.11, P < 0.01) . The difference among different ages was significant (χ(2) = 228.68, P < 0.01) with descending order in 18-44, 45-59 and ≥ 60 years old (67.8%, 59.8%, 50.1%, respectively). The difference among different regions was not significant (χ(2) = 9.82, P < 0.01) in eastern, central and western China (68.2%, 61.3%, 57.1%, respectively). After being weighted, the willingness rate was 83.8%, the willingness rate in females (85.8%) was significantly higher than that in males (81.9%) (χ(2) = 61.92, P < 0.01) , and the urban areas (87.1%) were significantly higher than the rural areas (82.3%) (χ(2) = 15.49, P < 0.01) . The difference among different ages was significant (χ(2) = 74.50, P < 0.01) with descending order in 18-44, 45-59 and ≥ 60 years old (85.3%, 83.1%, 79.6%, respectively). The difference was not significant (χ(2) = 0.58, P > 0.05) among eastern, central and western China (84.3%, 84.0%, 82.9%, respectively). After being weighted, the behavior rate of salt reduction was 42.2%, the behavior rate in females (45.6%) was significantly higher than that in males (38.8%) (χ(2) = 107.74, P < 0.01), and urban areas (56.5%) were significantly higher than the rural areas (35.6%) (χ(2) = 74.38, P < 0.01) . The difference was not significant (χ(2) = 4.19, P > 0.05) among 18-44, 45-59 and ≥ 60 years old(41.5%, 43.6%, 42.2%, respectively). The behavior rate of salt reduction difference in eastern China(47.8%) was significantly higher than that in central (38.9%) and western (38.0%) (χ(2) = 7.22, P < 0.05).</p><p><b>CONCLUSIONS</b>The rate of willingness to reduce salt is higher, but the awareness rate and the behavior rate of salt reduction are not high, especially among the population who are from rural area, or who are from central and western China.</p>


Subject(s)
Adult , Asians , China , Diet, Sodium-Restricted , Female , Health Knowledge, Attitudes, Practice , Humans , Male , Rural Population , Urban Population
16.
Article in Chinese | WPRIM | ID: wpr-302582

ABSTRACT

<p><b>OBJECTIVE</b>To describe the prevalence and relationship between screen time and sub-health status among middle school students in weekdays and weekends.</p><p><b>METHODS</b>With multistage stratified random cluster sampling, 14 400 students from junior and senior middle schools in 288 classes of 30 schools in 4 cities( Shenyang, Chongqing, Xinxiang, Guangzhou) were investigated in October, 2011. A total of 13 817 valid questionnaires were retained for analysis. Survey content includes general demographic information, screen time, sub-health state. Logistic regression model was used to analyze the relationship between screen time and sub-health status.</p><p><b>RESULTS</b>The screen time among middle school students > 2 h/d on weekdays and weekends were 15.1% (2 085/13 817) and 58.5% (8 077/13 817) , respectively. Among them, the boys' screen time > 2 h/d on weekdays and weekends were 17.9% (1 187/6 644) and 61.3% (4 070/6 644), which were higher than girls (12.5% (898/7 173), 55.9% (4 007/7 173) )(χ² values were 76.95 and 41.35, respectively. P < 0.01). The prevalence of physical sub-health status, psychological sub-health status and sub-health status were 24.8% (3 431/13 817), 21.7% (2 997/13 817) and 22.1% (3 051/13 817), respectively. Among them, the girls' prevalence of physical sub-health status, psychological sub-health status and sub-health status were 26.0% (1 863/7 173), 22.9% (1642/7 173) and 23.1% (1 658/7 173) ), respectively, which were higher than boys' (23.6% (1 568/6 644), 20.4% (1 355/6 644) and 21.0% (1 393/6 644)) (χ² values were 10.39, 12.66 and 9.25, respectively. P < 0.05). The senior students' prevalence of physical sub-health status, psychological sub-health status and sub-health status were 31.6% (2 176/6 884) , 28.3% (1 946/6 884) and 28.9% (1 990/6 884), respectively, which were higher than junior students' (18.1% (1 255/6 933), 15.2% (1 051/6 933) and 15.3% (1 061/6 933)) (χ² values were 337.65, 349.46 and 371.54, respectively, P < 0.05). After adjusting on demographic characteristics, compared with screen time ≤ 2 h/d on weekday, screen time > 2 h/d on weekday was significantly associated with physical sub-health status, psychological sub-health status and sub-health status (OR (95% CI): 1.39 (1.25-1.55), 1.62 (1.45-1.81) and 1.59 (1.43-1.78)). And compared with screen time ≤ 2 h/d on weekend, screen time > 2 h/d on weekend was also significantly associated with physical sub-health status, psychological sub-health status and sub-health status (OR(95% CI):1.49 (1.37-1.61), 1.81 (1.66-1.98), and 1.71 (1.57-1.87)).</p><p><b>CONCLUSION</b>The rate of the screen time > 2 h/d and the detection ratio of sub-health among the middle school students in Shenyang, Chongqing, Xinxiang, Guangzhou in 2011 were high. Screen time >2 h/d on weekdays or weekends was a risk factor for sub-health status.</p>


Subject(s)
Adolescent , China , Epidemiology , Cities , Data Collection , Female , Health Status , Humans , Logistic Models , Male , Microcomputers , Prevalence , Risk Factors , Schools , Sex Factors , Students , Surveys and Questionnaires , Television , Urban Population
17.
Journal of Clinical Hepatology ; (12): 954-957, 2014.
Article in Chinese | WPRIM | ID: wpr-498949

ABSTRACT

Phosphatidylinositol 3-kinase,Akt,and the mammalian target of rapamycin (PI3K/Akt/mTOR)signaling pathway is shown to play a key role in the tumorigenesis,proliferation,metastasis,apoptosis,and angiogenesis of hepatocellular carcinoma (HCC)by regulating gene expression.The components and functions of PI3K/Akt/mTOR signaling pathway are briefly described,and the research advances in the action mechanism of PI3K/Akt/mTOR signaling pathway in the progression of HCC and related inhibitors are reviewed.It is disclosed that blocking the PI3K/Akt/mTOR signaling pathway may become a new therapy for HCC.

18.
Article in Chinese | WPRIM | ID: wpr-444487

ABSTRACT

Objective This study aimed to analyze the clinical features of novel H7N9 avian influenza virus infection in human and its prognosis after integrative treatment.Methods Eighteen H7N9 infected patients were admitted to Shanghai Public Health Clinical Center from 5 April 2013 to 19 April 2013,and were divided into mild group (8 cases) and severe group (10 cases) based on their baseline disease conditions.Patients in mild group were administered modified Yinqiao powder and Shengjiang powder,while patients in severe group were administered modified Qinwen Baidu Decoction or Xuanbai Chengqi Decoction,in addition to antiviral,anti infection,glucocorticoids and human immunoglobulin treatment in both groups.Baseline characteristics and outcomes of these patients were analyzed,and factors associated with prognosis were also evaluated.Measurement data were compared by t test or rank sum test,categorical variables were compared by chi square test or Fisher exact test.Factors associated with prognosis were evaluated by Logistic regression analysis.Results Compared to mild group,patients in severe group suffered from a significantly elevated C reactive protein [(102.61± 30.80) mg/L vs (38.44± 22.31) mg/L; t=4.717,P<0.01],and significantly lowered CD3+,CD4+,CD8+ and CD45+T cell levels (all P<0.05).Compared to regimens with glucocorticoids and human immunoglobulin,traditional Chinese medicine (TCM) contained therapy achieved a higher recovery rate in H7N9 infected patients,but with no statistical significance (P>0.05).Univariate Logistic regression analysis showed that myoglobin might be a risk factor associated with prognosis of H7N9 infection (P =0.029),and rnultivariable analysis showed that high levels of myoglobin might be negatively related to the prognosis of H7N9-infected patients,But with no statistical significance (P=0.053).Conclusions Severe H7N9-infected patients suffer from active inflammation and lowered T cell mediated immune response.Integrative therapy is effective for novel H7N9 avian influenza virus infection,and helps to improve the outcomes of infected patients.

19.
Article in Chinese | WPRIM | ID: wpr-599788

ABSTRACT

Objective To investigate the clinical application of acupuncture combined with general anesthe -sia in gynecologic laparoscopic surgery .Methods 60 ASA( the American society of anesthesiologists )Ⅰ-Ⅱpatients undergoing elective gynecologic laparoscopic surgery were randomly divided into the acupuncture group and control group.Patients in the acupuncture group were chosen Hegu (LI 4),Neiguan(PC 6) on both sides.After acupuncture, the two acupoints,electroacupuncture stimulated 20-30min,then administered general anesthesia ,electroacupuncture until surgery finished ,the control group received general anesthesia only .The drug dosages of the two groups was regu-lated,maintained anesthesia depth bispectral index ( BIS) between 40 and 60.The changes of the blood pressure ( BP) ,heart rate and BIS of the two groups at the same time points were observed;the propofol and remifentanil dos-age after the surgery ,the awaken time and extubation time ,OAA/S score and pain score after wake ,the happening of restlessness,chills,nausea and vomiting ,the usage of narcotic analgesics postoperation ,and the intraoperative aware-ness were recorded .The effect of acupuncture combined with general anesthesia was evaluated .Results Anesthetic dosage propofol of the acupuncture group [(7.44 ±1.30)μg· kg-1· h-1] was less than [(8.66 ±1.24)μg· kg-1· h-1] of the control group (t=3.720,P=0.001),remifentanil dosage was also less than the control group [acupunc-ture group (10.59 ±2.58)μg· kg-1· h-1,control group (11.93 ±2.27)μg· kg-1· h-1,t=2.168,P=0.034]. Compared with the basic value ,the BP values were higher at the time of intraoperation ,waking,extubation and 10 min after extubation (all P<0.05),the acupuncture group had more stable BP .Compared with the acupuncture group , heart rates in the control group were faster at extubation and 10min after extubation .Recovery time and extubation time of the acupuncture group were (9.05 ±2.36)min and (1.61 ±2.40)min,which were shorter than (12.50 ± 3.20)min and (15.90 ±3.37)min of the control group (P<0.05).Pain score(VAS) in the acupuncture group was lower than that of the control group .Consciousness score was higher in the acupuncture group ,the incidence rates of restlessness,chills were less.Conclusion The use of acupuncture combined with general anesthesia in gynecologic laparoscopic surgery can reduce the dosage of general anesthetics ,shorten the awaken time and extubation time ,increase the OAA/S score of the patients ,relieve pain ,and the recovery quality is higher .

20.
Article in Chinese | WPRIM | ID: wpr-436087

ABSTRACT

Objective To investigate the relationship between various stages of chronic hepatitis B virus (HBV) infection and lipid metabolism and its influencing factors.Methods Seventy-two cases of chronic hepatitis B (CHB),40 cases of liver cirrhosis and 17 cases of hepatocellular carcinoma (HCC) were enrolled.One-way ANOVA analyses were used to compare age,gender,liver function,lipid metabolism,and HBV DNA levels of each group.Pearson correlation analysis was used to study the correlation between HBV DNA and lipid metabolism.Binary Logistic regression analyses were performed to explore the risk factors of cirrhosis and HCC in patients with CHB.Results Differences of age,alanine aminotransferase (ALT),albumin (Alb),triglyceride (TG),and cholesterol(CHO) among the three groups (CHB group,cirrhosis group and HCC group) were statistically significant (all P<0.05).TG levels in cirrhosis and HCC groups were (-0.061± 0.234)lg mmol/L and (-0.061±0.253) lg mmol/L,respectively,which were both significantly lower than that of the CHB group (0.116±0.182) lg mmol/L (F=11.466,P=0.000).CHO level in cirrhosis group was (0.460±0.333) lg mmol/L,which was lower than that in CHB group (0.586±0.101) lg mmol/L (F=4.892,P=0.009).The HBV DNA levels inversely correlated with TG and CHO levels in CHB group (r=-0.266,P=0.024; r=-0.309,P=0.008,respectively).The HBV DNA levels of cirrhosis and HCC patients positively correlated with ALT levels (r=0.355,P =0.007).Old age (OR=1.096,95%CI:1.025-1.172),low Alb (OR=0.000,95%CI:0.000-0.000),and low levels of ALT (OR=0.128,95%CI:0.026-0.641) were risk factors for development of cirrhosis and HCC in CHB patients (all P<0.05).Conclusions With the progression of liver injuries,TG and CHO levels are reduced.Further studies of correlation between risk factors for the development of cirrhosis and HCC and lipid metabolism in CHB patients are needed.

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