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1.
Article in English | WPRIM | ID: wpr-918627

ABSTRACT

BACKGROUND/OBJECTIVES@#There has been an increased interest in determining calcium magnesium, sodium, and potassium's distinct effects on hypertension over the past decade, yet they simultaneously regulate blood pressure. We aimed at examining the association of dietary calcium, magnesium, sodium, and potassium independently and jointly with hypertension using National Health and Nutrition Examination Survey data from 2007 to 2014.MATERIALS/METHODS: The associations were examined on a large cross-sectional study involving 16684 US adults aged>20 years, using multivariate analyses with logistical models. @*RESULTS@#Sodium and calcium quartiles assessed alone were not associated with hypertension. Potassium was negatively associated with hypertension in the highest quartile, 0.64 (95% confidence interval [CI], 0.48–0.87). When jointly assessed using the high and low cut-off points, low sodium and corresponding high calcium, magnesium, and potassium intake somewhat reduced the odds of hypertension 0.39 (95% CI, 0.20–0.76). The sodiumto-potassium ratio was positively associated with hypertension in the highest quartile1.50 (95% CI, 1.11–2.02). When potassium was adjusted for sodium intake and sodium-topotassium ratio assessed among women, increased odds of hypertension were reported in the highest quartile as 2.02 (95% CI, 1.18–3.34) and 1.69 (95% CI, 1.12–2.57), respectively. The association of combined minerals on hypertension using dietary goals established that men meeting the reference intakes for calcium and exceeding for magnesium had reduced odds of hypertension 0.51 (95% CI, 0.30–0.89). Women exceeding the recommendations for both calcium and magnesium had the lower reduced odds of 0.30 (95% CI, 0.10–0.69). @*CONCLUSIONS@#Our results suggest that the studied minerals' association on hypertension is stronger when jointly assessed, mostly after gender stratification. As compared to men, women increased their risk of hypertension even with a low sodium intake. Women would also reasonably reduce their risk of developing hypertension by increasing calcium and magnesium intake. In comparison, men would somewhat be protected from developing hypertension with calcium intake meeting the dietary goals and magnesium exceeding the nutritional goals.

2.
Article in Chinese | WPRIM | ID: wpr-911742

ABSTRACT

The clinical date of 5 adult patients with severe tetanus admitted in the ICU of Jiangsu Provincial Subei People′s Hospital between October 2019 and January 2021 were analyzed retrospectively. There were 2 males and 3 females, aged 19-65 years. Patients had a history of trauma 5 to 30 days before the onset of the disease, and were admitted 1 to 11 days after the onset of the disease. The main manifestations were neck pain with limited movement, difficulty in opening the mouth, paroxysomal convulsions of the neck and both upper limbs, generalized paroxysomal convulsions or abdominal muscle tension, and abdominal pain. At the time of admission, the wounds of 2 patients had healed. After admission, all patients were treated with local debridement, metronidazole combined with penicillin/cephalosporin for anti-infection, and human tetanus immunoglobulin (HTIG) 3 000 U was injected into the gluteus and deltoid muscles to neutralize the free toxin in the body. Midazolam combined with magnesium sulfate was intravenously infused to control and relieve skeletal muscle spasm.Among them, 3 patients received tracheotomy and ventilation due to respiratory failure. One patient underwent bedside continuous renal replacement therapy (CRRT) for severe skeletal muscle spasm resulting in rhabdomyolysis syndrome and acute kidney injury. All five patients with severe tetanus were cured and discharged.

3.
Chinese Critical Care Medicine ; (12): 938-943, 2021.
Article in Chinese | WPRIM | ID: wpr-909431

ABSTRACT

Objective:To investigate the risk factors and prognosis of early septic shock-related thrombocytopenia.Methods:Retrospective analysis of clinical data of patients with septic shock admitted to the department of intensive care unit (ICU) of Northern Jiangsu People's Hospital from June 2016 to November 2020 was conducted. According to the lowest platelet count (PLT) in the early stage of septic shock (within 24 hours of using vasoactive drugs), the patients were divided into mild thrombocytopenia group [PLT (50-100)×10 9/L], severe thrombocytopenia group (PLT < 50×10 9/L) and normal platelet group (PLT > 100×10 9/L). The differences in general information, laboratory indicators, mechanical ventilation time, length of ICU stay, in-hospital stay, and 28-day mortality among the three groups were analyzed. Multivariate Logistic regression was used to analyze the influencing factors of thrombocytopenia, and the 28-day Kaplan-Meier survival curve of patients with different PLT levels was drawn. Results:A total of 486 patients with septic shock were enrolled, including 123 patients with mild thrombocytopenia, 75 patients with severe thrombocytopenia and 288 patients with normal platelets. Patients with diabetes ( χ2 = 30.460, P < 0.001), abdominal infection ( χ2 = 15.024, P = 0.001), urinary tract infection ( χ2 = 36.633, P < 0.001), bloodstream infection ( χ2 = 7.755, P = 0.022), Gram negative (G -) bacilli infection ( χ2 = 19.569, P < 0.001), hyperlactic acidemia ( H = 23.404, P < 0.001), elevated procalcitonin (PCT, H = 43.368, P < 0.001), high acute physiology and chronic health evaluation Ⅱ (APACHEⅡ, F = 11.122, P < 0.001) and high sequential organ failure assessment (SOFA, F = 84.328, P < 0.001) were more likely to have thrombocytopenia within 24 hours of septic shock. Multivariate Logistic regression analysis of early septic shock-related thrombocytopenia showed that, diabetes [odds ratio ( OR) = 0.19, 95% confidence interval (95% CI) was 0.08-0.42, P < 0.001], urinary tract infection ( OR = 0.33, 95% CI was 0.13-0.83, P = 0.018), G - bacilli infection ( OR = 0.20, 95% CI was 0.07-0.58, P = 0.003), hyperlactic acidemia ( OR = 1.25, 95% CI was 1.07-1.46, P = 0.005) and high APACHEⅡ score ( OR = 0.85, 95% CI was 0.78-0.92, P < 0.001) were independent risk factors for platelets < 50×10 9/L. Abdominal infection was an independent risk factor for PLT (50-100)×10 9/L ( OR = 0.56, 95% CI was 0.34-0.95, P = 0.03). High SOFA score was an independent risk factor for PLT ≤ 100×10 9/L [PLT < 50×10 9/L: OR = 2.03, 95% CI was 1.65-2.52, P < 0.001; PLT (50-100)×10 9/L: OR = 1.31, 95% CI was 1.16-1.48, P < 0.001]. There were no significant differences in mechanical ventilation time, length of ICU stay, and in-hospital stay among the three groups ( H values were 0.142, 2.134, and 3.990, respectively, all P > 0.05). The 28-day mortality of septic shock patients increased with the severity of thrombocytopenia ( χ2 = 40.406, P < 0.001), and the 28-day mortality of severe thrombocytopenia group and mild thrombocytopenia group was significantly higher than those of the normal platelet group [66.7% (50/75), 43.1% (53/123) vs. 27.8% (80/288), both P < 0.05]. Kaplan-Meier survival curve analysis showed that the 28-day survival rate gradually decreased with the decrease of PLT, and the 28-day survival rate was higher in the normal platelet group (Log-Rank test: χ2 = 80.667, P < 0.001). Conclusions:Diabetes, abdominal infection, urinary tract infection, G - bacilli infection, hyperlactic acidemia, high APACHEⅡ score, and high SOFA score are independent risk factors for early septic shock-related thrombocytopenia. Early thrombocytopenia in patients with septic shock indicates a high risk of 28-day death.

4.
Chinese Journal of Endemiology ; (12): 854-856, 2021.
Article in Chinese | WPRIM | ID: wpr-909111

ABSTRACT

Objective:To understand the assessment results of external quality control of iodine deficiency disorders laboratories of centers for disease control and prevention at the three levels of province, city and county, so as to promote the improvement of testing ability of laboratories at all the three levels in Fujian Province.Methods:In 2019, iodine deficiency disorders laboratories of one provincial and nine municipal centers for disease control and prevention in Fujian Province participated in the external quality control blind sample examination of urinary iodine, salt iodine and water iodine; iodine deficiency disorders laboratories of 84 county-level centers for disease control and prevention participated in the blind sample examination of external quality control of urinary iodine and salt iodine. The external quality control assessment results were collected and analyzed by descriptive statistics.Results:The qualified rates of urinary iodine, salt iodine and water iodine in provincial and municipal iodine deficiency disorders laboratories all reached 100.0% (10/10); the qualified rate of urinary iodine in county-level iodine deficiency disorders laboratories was 96.4% (81/84), and the qualified rate of salt iodine was 100.0% (84/84).Conclusion:The overall detection capacity of provincial, municipal and county-level iodine deficiency disorders laboratories in Fujian Province remains at a high level, and the urinary iodine detection capacity of some county-level iodine deficiency disorders laboratories still needs to be improved.

5.
Article in Chinese | WPRIM | ID: wpr-907721

ABSTRACT

Objective:The present study aimed to explore the clinical value of neutrophil to lymphocyte and platelet ratio (NLPR) for acute kidney injury (AKI) in elderly patients with sepsis.Methods:This was a retrospective analysis of 360 elderly patients with sepsis or septic shock who were admitted to Intensive Care Unit (ICU) of Zhongnan Hospital of Wuhan University. They were divided into AKI and non-AKI groups based on the KDIGO-AKI criteria. The independent risk factors of AKI were identified via logistic regression analysis, and the calculation of the receiver-operating characteristic (ROC) curves were used to evaluate the diagnostic capability of NLPR for AKI and the short-term outcome of sepsis patients.Results:Total of 195 (54.2%) patients were attributed to the AKI group, while 165 (45.8%) patients were allocated to the non-AKI group. The median of NLPR was significantly higher in the AKI group compared with the non-AKI group ( Z=8.640, P<0.001). Compared with the non-AKI group, the in-hospital death and the length of ICU stay increased (all P<0.05). Patients with AKI required more vasoactive drugs, mechanical ventilation, and renal replacement therapy (all P<0.05). After adjusting the demographic and clinical variables, multivariate logistic regression analysis showed that NLPR was an independent risk factor of AKI ( OR=1.016, 95% CI 1.002-1.030, P=0.027). The ROC curves showed the excellent clinical value of NLPR and which was significantly higher than the neutrophil to lymphocyte ratio (NLR) and serum creatinine. In addition, the present study revealed that the NLPR was also positively correlated with the stage of AKI ( r=0.525, P<0.001). Conclusions:The NLPR is derived from a complete blood cell count, as a new comprehensive inflammatory parameter that is simple and easily available, it is an independent risk factor for AKI in elderly sepsis patients, and should be paid attention in the clinical practice.

6.
Article in English | WPRIM | ID: wpr-880322

ABSTRACT

BACKGROUND@#Previous studies have suggested that screen time (ST) has a negative effect on children's emotional and behavioral health, but there are few longitudinal studies that have been conducted with infants and toddlers. This study sought to examine the effect of ST in early childhood on emotional and behavioral problems in children aged 4 years, based on a birth cohort study in China.@*METHODS@#A total of 2492 children aged 4 years were enrolled in this study. The parents and guardians of each child completed a questionnaire that included items eliciting information on children's birth information, socio-demographic information at baseline, and ST at each follow-up. Emotional and behavioral problems were assessed using the Strengths and Difficulties Questionnaire (SDQ) at 4 years of age. Multivariate logistic analysis was used to explore the effects of ST on emotional and behavioral problems.@*RESULTS@#The percentages of children with ST > 0 h/day at age 0.5 years, ST > 2 h/day at age 2.5 years, and ST > 2 h/day at age 4 years were 45.7, 55.5, and 34.5% respectively. The prevalence of emotional and behavioral problems was 10.8%. ST at 6 months was a risk factor for emotional symptoms and hyperactivity at the age of 4 years. ST at age 2.5 years was a risk factor for hyperactivity at the age of 4 years. However, ST at age 4 years was a risk factor for total difficulties, conduct problems, peer problems, hyperactivity, and prosocial behavior.@*CONCLUSIONS@#Higher ST exposure at early childhood is associated with later emotional and behavioral problems. In particular, sustained high ST exposure is a risk factor for behavioral problems. These findings suggested the importance of controlling ST to prevent the occurrence of emotional and behavioral problems in the early years.


Subject(s)
Altruism , Child, Preschool , China/epidemiology , Cohort Studies , Emotions , Female , Humans , Male , Prevalence , Problem Behavior/psychology , Psychomotor Agitation/psychology , Screen Time
7.
Article in Chinese | WPRIM | ID: wpr-886087

ABSTRACT

Objective To investigate the indoor air quality in urban and rural areas in Xi'an, to analyze the relationship between indoor pollutants and living habits, and to study the impact of pollutants on health, so as to provide reference for improving indoor environment. Methods Through random cluster sampling, 29 families from rural areas and 53 families from urban areas were selected from Xi'an. Data was collected by questionnaire survey and on-site environmental sampling. Non-parametric test and Chi-square test were used for statistical analysis. Results Overall, the values of CO, NO2, toluene and xylene in Xi'an were far lower than the national standards. The medians of CO2, PM2.5, PM10, and formaldehyde were 0.1%, 44.5 μg/m3, 51.5 μg/m3, and 34.5 μg/m3, respectively. The differences in the values of CO, NO2, formaldehyde, toluene and xylene in urban and rural areas were statistically significant (P2 were higher in families with humidifiers and potted plants (P2 were higher in families with pets (P10, CO, and NO2 were significantly correlated with children's sleep duration and colds (P<0.05). Conclusion The indoor air pollution in urban areas is higher than that in rural areas in Xi'an. It is suggested that residents should be cautious about the use of humidifiers, planting potted plants, and keeping pets, to reduce indoor air pollution and improve their health.

8.
Chinese Journal of Endemiology ; (12): 337-341, 2021.
Article in Chinese | WPRIM | ID: wpr-883721

ABSTRACT

Objective:The iodine excretion of adult individuals was calculated by two creatinine correction methods of urinary iodine, and the significance and value of the methods to measure individual iodine nutrition levels were assessed to provide a reference basis for further epidemiological investigation and study of iodine deficiency disorders.Methods:Healthy adults aged 18 - 59 years from Fujian Province were recruited and their 24 h urine, fasting urine, and morning spot urine (8:00 - 12:30) were collected and the corresponding urinary iodine and creatinine concentrations were measured. The estimated 24 h urinary iodine excretion was calculated using two different creatinine correction and creatinine estimation formulas were compared with the measured 24 h urinary iodine excretion.Results:There were no significant differences in measured 24 h urinary iodine excretion value, estimated 24 h urinary iodine excretion value 1 of fasting urine and morning spot urine, and estimated 24 h urinary iodine excretion 2 of fasting urine and morning spot urine between genders (μg/d: 195.5 vs 190.9, 190.0 vs 181.7, 160.2 vs 144.2, 174.8 vs 179.2, 148.3 vs 131.5); there were no significant differences in measured 24 h urinary iodine excretion and fasting urinary estimated 24 h urinary iodine excretion 1, estimated 24 h urinary iodine excretion 2 ( P > 0.05), and there were significant differences in measured 24 h urinary iodine excretion and morning spot urinary estimated 24 h urinary iodine excretion 1, estimated 24 h urinary iodine excretion 2 ( P < 0.01). And there were significant linear correlations between measured 24 h urinary iodine excretion and estimated 24 h urinary iodine excretion 1 of fasting urine and morning spot urine, estimated 24 h urinary iodine excretion 2 of fasting urine and morning spot urine ( r = 0.772, 0.266, 0.828, 0.391, P < 0.01). Conclusions:It is feasible to estimate 24 h urinary iodine excretion in adults with creatinine-corrected fasting urinary iodine concentration. Creatinine-corrected fasting urinary iodine concentration can be used as an individual iodine nutrition level evaluation index, but whether it is applicable to children and pregnant women remains to be further studied.

9.
Article in Chinese | WPRIM | ID: wpr-883553

ABSTRACT

Objective:To systematically review the teaching effects of flipped classroom (FC) in undergraduate medical education in China.Methods:Such databases as CNKI, VIP Data, and WanFang, were electronically searched for literature of randomized controlled trials (RCTs) on FC versus lecture-based learning (LBL) applied in medical education in China up to March, 2018. The included literature were evaluated for the quality, and RevMan5.3 software was used for Meta-analysis.Results:A total of 26 RCTs were included in the study, including 4 249 students, of whom the FC group had 2 135 cases, while LBL group had 2 114 cases. The students in FC group got significantly higher scores than those of the students in LBL group in the theoretical scores (WMD = 7.81, 95%CI = 5.18 -10.43, P < 0.05), skills tests (WMD = 4.69, 95%CI = 0.65 -8.73, P < 0.05). Conclusion:The FC can significantly improve the teaching results in undergraduate medical education.

10.
Article in English | WPRIM | ID: wpr-922201

ABSTRACT

BACKGROUND@#The 2019 novel coronavirus disease (COVID-19) emerges in China, which spreads rapidly and becomes a public health emergency of international concern. Chinese government has promptly taken quarantine measures to block the transmission of the COVID-19, which may cause deleterious consequences on everyone's behaviors and psychological health. Few studies have examined the associations between behavioral and mental health in different endemic areas. This study aimed to describe screen time (ST), physical activity (PA), and depressive symptoms, as well as their associations among Chinese college students according to different epidemic areas.@*METHODS@#The study design is cross-sectional using online survey, from 4 to 12 February 2020, 14,789 college students accomplished this online study, participants who did not complete the questionnaire were excluded, and finally this study included 11,787 college students from China.@*RESULTS@#The average age of participants was 20.51 ± 1.88 years. 57.1% of the college students were male. In total, 25.9% of college students reported depression symptoms. ST > 4 h/day was positively correlated with depressive symptoms (β = 0.48, 95%CI 0.37-0.59). COVID-19ST > 1 h/day was positively correlated with depressive symptoms (β = 0.54, 95%CI 0.43-0.65), compared with COVID-19ST ≤ 0.5 h/day. Compared with PA ≥ 3 day/week, PA < 3 day/week was positively associated with depression symptoms (β = 0.01, 95%CI 0.008-0.012). Compared with low ST and high PA, there was an interaction association between high ST and low PA on depression (β = 0.31, 95%CI 0.26-0.36). Compared with low COVID-19ST and high PA, there was an interaction association between high COVID-19ST and low PA on depression (β = 0.37, 95%CI 0.32-0.43). There were also current residence areas differences.@*CONCLUSIONS@#Our findings identified that high ST or low PA was positively associated with depressive symptoms independently, and there was also an interactive effect between ST and PA on depressive symptoms.


Subject(s)
Adult , COVID-19/psychology , China/epidemiology , Cross-Sectional Studies , Depression/etiology , Exercise , Female , Humans , Male , Mental Health/statistics & numerical data , Screen Time , Students/psychology , Time Factors , Universities , Young Adult
11.
Chinese Journal of Nephrology ; (12): 123-130, 2020.
Article in Chinese | WPRIM | ID: wpr-799544

ABSTRACT

Objective@#To explore the clinical and cytogenetic characteristics and risk factors of multiple myeloma (MM) patients with renal impairment (RI).@*Methods@#A total of 113 newly diagnosed patients with MM in the department of nephrology and hematology in Zhongnan Hospital of Wuhan University from January 2013 to December 2017 were enrolled. The patients were divided into RI group and non-renal impairment (NRI) group according to whether serum creatinine (Scr) at the time of diagnosis was higher than 177 μmol/L. The clinical and laboratory data of two groups were compared. The risk factors of RI in MM patients were analyzed by binary logistic regression, and then the receiver operating characteristic curve (ROC) was drawn to evaluate the predictive value of these risk factors.@*Results@#The incidence of RI in 113 MM patients was 34.5%. Compared with NRI group, levels of white blood cells, serum uric acid, blood urea nitrogen, neutrophil-to-lymphocyte ratio (NLR), cystatin C, β2-microglobulin (β2-MG), blood phosphorus, urine light chain, bone-marrow plasma cell percentage, International Staging System (ISS) stage III percentage, light chain type percentage, positive urinary Bence-Jones protein percentage and positive urinary protein percentage were higher in RI group, while levels of estimated glomerular filtration rate (eGFR), serum bicarbonate concentration and globulin were lower in RI group (all P<0.05). There were no significant differences in other clinical variables between the two groups (all P>0.05). Fluorescence in situ hybridization (FISH) was applied to 42 MM patients to detect the following five genetic abnormalities: IgH rearrangement, 1q21 amplification, RB1 deletion, D13S319 deletion and P53 deletion. Among them, 29 (69.0%) patients were abnormal. The incidence of RB1 deletion in RI group was higher than NRI group (P<0.05), and there were no significant differences in the incidences of other genetic abnormalities (all P>0.05). Further logistic regression analysis showed that increase of NLR (OR=1.589, 95%CI 1.115-2.266, P=0.010), bone-marrow plasma cell percentage (OR=1.053, 95%CI 1.008-1.101, P=0.021) and β2-MG (OR=22.166, 95%CI 2.146-228.927, P=0.009), light chain type (OR=15.399, 95%CI 1.002-236.880, P=0.049), and hyperuricemia (OR=11.707, 95%CI 1.580-86.717, P=0.016) were the independent risk factors for RI in MM patients. The comparison of area under the ROC (AUC) among these risk factors showed the AUC of β2-MG was larger than that of NLR or uric acid (both P<0.05), while there were no significant differences in the rest of pairwise comparison (all P>0.05). The AUC of β2-MG predicting RI was the largest (AUC=0.907, 95%CI 0.853-0.962, P<0.001).@*Conclusions@#MM patients have high morbidity of RI, and there are more RI patients with RB1 deletion in RI patients. Light chain type, hyperuricemia, high level of NLR, high bone-marrow plasma cell percentage and increased β2-MG are the independent risk factors for RI in MM patients. Among them, β2-MG is the best predictor for RI, and NLR plays an important role in predicting RI as a convenient and effective inflammatory marker.

12.
Chinese Journal of Endemiology ; (12): 146-149, 2020.
Article in Chinese | WPRIM | ID: wpr-866072

ABSTRACT

Objective:To analyze the disease burden of iodine deficiency disorders (IDD) and its changes in China in 1990 and 2016.Methods:Based on the data of Global Burden of Disease Study 2016 (GBD 2016), a descriptive statistical method was used to compare and analyze the changes of deaths number, mortality, disability adjusted life year [DALY, including years of life lost (YLL) and years lived with disability (YLD)], DALY rate and other disease burden indicators caused by IDD in China in 1990 and 2016.Results:The GBD 2016 data showed that the deaths number from IDD in China decreased from 259.31 in 1990 to 116.41 in 2016, the mortality decreased from 0.022 827/100 000 in 1990 to 0.008 515/100 000 in 2016; and the mortality in different age groups had decreased, the children mortality in the < 5 years old group had decreased from 0.088 639/100 000 to 0.009 875/100 000. The DALY and YLD due to IDD in China increased from 406.13 thousand person-years and 391.68 thousand person-years in 1990 to 455.05 thousand person-years and 451.95 thousand person-years in 2016, while YLL decreased from 14.45 thousand person-years to 3.10 thousand person-years; the DALY rate, YLL rate, and YLD rate decreased from 35.75 person-years per 100 000, 1.27 person-years per 100 000 and 34.48 person-years per 100 000 in 1990 to 33.29 person-years per 100 000, 0.23 person-years per 100 000 and 33.06 person-years per 100 000 in 2016. The main component of DALY for IDD was YLD, and the proportion increased from 96.44% in 1990 to 99.32% in 2016.Conclusions:The mortality of IDD in China has decreased, and IDD in the younger age group has been effectively controlled; however, the disease burden, especially the burden caused by disability has increased, and the disability of the population due to IDD should be given special attention.

13.
Article in Chinese | WPRIM | ID: wpr-864184

ABSTRACT

Hemophagocytic syndrome (HPS) is a serious rapid-developing disease with high mortality, which is more commonly seen in children.The etiology and clinical manifestation of HPS are heterogenous.For the past few years, the understanding of HPS is greatly improved with advances in diagnosis and treatment.However, there are still a lot of refractory cases.This article describes the etiology, pathogenesis, diagnosis, treatment of HPS, in order to enhance understanding of this disease.

14.
China Pharmacy ; (12): 3051-3054, 2020.
Article in Chinese | WPRIM | ID: wpr-843088

ABSTRACT

OBJECTIVE:To optimize the ant i-infective treatment plan for the super-premature infants and provide reference for the clinical treatment of the super-premature infants and the whole pharmaceutical care. METHODS :A super-premature infant with gestational age of 25+5 weeks and weight of 400 g was delivered in the second department of neonatology in Hunan Maternal and Child Health Hospital. This child suffered from complex complications. Clinical pharmacists ,relevant medical staff and hospital infection department personnel formed a multidisciplinary treatment team. According to Neonatal Sepsis Treatment Scheme , Antimicrobial Treatment Guide ,Premature Medicine ,combining with the analysis of infection indicators ,biochemical indicators , vital signs and other indicators ,a individualized anti-infective diagnosis and treatment plan was developed for the child. After entering the NICU ,this child was given Piperacillin sodium and sulbactam sodium for injection (100 mg/kg,ivgtt,q12 h)for anti-infective treatment ;considering the possibility of sepsis ,clinical pharmacists suggested that Piperacillin sodium and sulbactam sodium for injection should be stopped and Meropenem for injection (40 mg/kg,ivgtt,q12 h)should be used instead. After 7 day of meropenem treatment ,clinical pharmacists suggested adding antifungal Fluconazole injection (5.0 mg/kg,ivgtt,qod). After 11 days of meropenem treatment ,in order to avoid the aggravation of infection ,according to the drug sensitivity results (sensitive to Ticarcillin sodium and clavulanate potassium for injection ),clinical pharmacists suggested adding Ticarcillin sodium and clavulanate potassium for injection (75 mg/kg,ivgtt,q8 h)for combined anti-infective treatment ,and hospital infection treatment was carried out at the same time. After the infection index was stable ,all antibiotics were stopped. When E. coli infection occurred later,clinical pharmacists suggested that Piperacillin tazobactam sodium for injection (75 mg/kg,ivgtt,q8 h)should be used. After the infection aggravated ,Piperacillin tazobactam sodium for injection was stopped and Imipenem cilastatin sodium forinjection(20 mg/kg,ivgtt,q8 h)was used instead. The child received ladder treatment after the decline of infection index ,and Ceftazidime for injection (50 mg/kg,ivgtt,q12 h)was used. RESULTS :The doctors adopted the above suggestions. After treatment ,the prognosis of the child was good ,the vital signs were stable ,and the body weight reached 3 000 g at discharge. CONCLUSIONS :For preterm infants as special group ,before using antibiotics ,clinical pharmacists should focus on the vital signs ,infection indicators and laboratory test results of the child ,so as to help doctors improve the treatment plan and ensure the effectiveness and safety of their medication.

15.
Article in Chinese | WPRIM | ID: wpr-811706

ABSTRACT

We used the epidemic data of COVID-19 published on the official website of the municipal health commission in Anhui province. We mapped the spatiotemporal changes of confirmed cases, fitted the epidemic situation by the population growth curve at different stages and took statistical description and analysis of the epidemic situation in Anhui province. It was found that the cumulative incidence of COVID-19 was 156/100 000 by February 18, 2020 and the trend of COVID-19 epidemic declined after February 7, changing from J curve to S curve. The actual number of new cases began to decrease from February 2 to February 4 due to the time of case report and actual onset delayed by 3 to 5 days.

16.
Article in Chinese | WPRIM | ID: wpr-787689

ABSTRACT

This article briefly introduces the strategic framework of genetic technology of Chinese government and Chinese Academy of Sciences, and the remarkable progress of genetic technology under this guidance. Using bibliometric and patent analysis methods, we reveal the current status of genetic technology research and development in China. China has made great achievements, both in terms of quantity and quality of academic publications, and quantity of patent applications. However, there are still something need to be improved, such as international cooperation and combination the efforts of enterprises, universities and research institutes. In the future, China will improve top-level planning and government guidance and supervision. In addition, it is also crucial to encourage investment from enterprise and communities, and to broadcast the science and technology to the whole society. Moreover, actions have to be taken to reduce the risks of bio-safety and bio-security. The innovation and breakthrough of genetic technology is a key to sustainable development in the bio-industry and bio-economy in China.

17.
Chinese Journal of Nephrology ; (12): 123-130, 2020.
Article in Chinese | WPRIM | ID: wpr-870945

ABSTRACT

Objective:To explore the clinical and cytogenetic characteristics and risk factors of multiple myeloma (MM) patients with renal impairment (RI).Methods:A total of 113 newly diagnosed patients with MM in the department of nephrology and hematology in Zhongnan Hospital of Wuhan University from January 2013 to December 2017 were enrolled. The patients were divided into RI group and non-renal impairment (NRI) group according to whether serum creatinine (Scr) at the time of diagnosis was higher than 177 μmol/L. The clinical and laboratory data of two groups were compared. The risk factors of RI in MM patients were analyzed by binary logistic regression, and then the receiver operating characteristic curve (ROC) was drawn to evaluate the predictive value of these risk factors.Results:The incidence of RI in 113 MM patients was 34.5%. Compared with NRI group, levels of white blood cells, serum uric acid, blood urea nitrogen, neutrophil-to-lymphocyte ratio (NLR), cystatin C, β 2-microglobulin (β 2-MG), blood phosphorus, urine light chain, bone-marrow plasma cell percentage, International Staging System (ISS) stage III percentage, light chain type percentage, positive urinary Bence-Jones protein percentage and positive urinary protein percentage were higher in RI group, while levels of estimated glomerular filtration rate (eGFR), serum bicarbonate concentration and globulin were lower in RI group (all P<0.05). There were no significant differences in other clinical variables between the two groups (all P>0.05). Fluorescence in situ hybridization (FISH) was applied to 42 MM patients to detect the following five genetic abnormalities: IgH rearrangement, 1q21 amplification, RB1 deletion, D13S319 deletion and P53 deletion. Among them, 29 (69.0%) patients were abnormal. The incidence of RB1 deletion in RI group was higher than NRI group ( P<0.05), and there were no significant differences in the incidences of other genetic abnormalities (all P>0.05). Further logistic regression analysis showed that increase of NLR ( OR=1.589, 95% CI 1.115-2.266, P=0.010), bone-marrow plasma cell percentage ( OR=1.053, 95% CI 1.008-1.101, P=0.021) and β 2-MG ( OR=22.166, 95% CI 2.146-228.927, P=0.009), light chain type ( OR=15.399, 95% CI 1.002-236.880, P=0.049), and hyperuricemia ( OR=11.707, 95% CI 1.580-86.717, P=0.016) were the independent risk factors for RI in MM patients. The comparison of area under the ROC ( AUC) among these risk factors showed the AUC of β 2-MG was larger than that of NLR or uric acid (both P<0.05), while there were no significant differences in the rest of pairwise comparison (all P>0.05). The AUC of β 2-MG predicting RI was the largest ( AUC=0.907, 95% CI 0.853-0.962, P<0.001). Conclusions:MM patients have high morbidity of RI, and there are more RI patients with RB1 deletion in RI patients. Light chain type, hyperuricemia, high level of NLR, high bone-marrow plasma cell percentage and increased β 2-MG are the independent risk factors for RI in MM patients. Among them, β 2-MG is the best predictor for RI, and NLR plays an important role in predicting RI as a convenient and effective inflammatory marker.

18.
Article in Chinese | WPRIM | ID: wpr-870178

ABSTRACT

To analyze the predictive value of serum intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP) on all-cause and cardiovascular mortality in maintaining hemodialysis (MHD) patients. A total of 224 MHD patients were prospectively investigated and followed up for 2 years. Serum iPTH levels were not associated with all-cause death and cardiovascular death ( HR=1.001, 95% CI 1.000-1.004, P=0.048) . The level of serum ALP was associated with cardiovascular death ( HR=1.002, 95% CI 1.000-1.004, P=0.033) . ALP≥106 IU/L was an independent risk factor for cardiovascular death in MHD patients ( P<0.05) . The joint variable was correlated with mortality in MHD patients ( HR=1.002, 95% CI 1.000~1.004, P=0.033) , that equal or over 37.28 was an independent risk factor for mortality ( P<0.05).

19.
China Pharmacy ; (12): 1314-1319, 2020.
Article in Chinese | WPRIM | ID: wpr-821795

ABSTRACT

OBJECTIVE:To simultaneo usly determine the contents of atractylenolide Ⅱ ,β-eudesmol,atractyloxin and atractylone in Atractylodes chinensis ,and to evaluate the quality of A. chinensis with different growth years combined with color difference principle. METHODS :HPLC method was adopted. The determination performed on Agilent Eclipse XDB-C 18 column with mobile phase consisted of acetonitrile- 0.2% phosphoric acid (gradient elution )at the flow rate of 1.0 mL/min;the detection wavelengths were set as 208 nm(atractylenolide Ⅱ,β-eudesmol),340 nm(atractyloxin)and 220 nm(atractylone);the sample size was 15 μ L. Using atractyloxin as reference,QAMS was adopted to establish relative correction factors (RCFs) of atractylenolideⅡ,β-eudesmol and atractylone ;the content of each component in A. chinensis with different growth years were calculated. The contents of above 4 components were determined by external standard method and then compared with the results of QAMS. The color difference values of A. chinensis powder were measured based on color difference principle. The correlation analysis of above 4 components content with color was carried out by Pearson correlation analysis. RESULTS :The separation degree of atractylenolide Ⅱ,β-eudesmol,atractyloxin and atractylone in A. chinensis was higher than 1.5. The linear range were 1.01-10.10,3.30-33.00,4.40-44.00,5.34-53.40 μg/mL,respectively. RSDs of precision ,reproducibility and stability tests were all lower than 2%,while the average recovery rates were 101.34%-104.67%(RSD<1.5%,n=6). Using atractyloxin as reference , RCFs of atractylenolide Ⅱ,β-eudesmol and atractylone were 3.896 7,5.928 2,9.727 9,with RSD of 0.35%,2.89%,0.36% (n=6),respectively. Relative deviation of 3 components (except for atractyloxin ) in 24 batches of A. chinensis ranged 0.03%-1.45% between QAMS and external standard method ,which indicated that the results of two methods were consistent ,and the content of each component increased with the increase of growth years. Atractylenolide Ⅱ,β-eudesmol,atractyloxin and atractylone in A. chinensis had significant negative correlation with its color shade (L*),total color difference (E*ab)(P<0.01), and significant positive correlation with color red-green direction (a*), color yellow-blue direction (b*)(P<0.01). CONCLUSIONS:The established HPLC-QAMS method can be used for the determination of atractylenolide Ⅱ,β-eudesmol, atractyloxin and atractylone in A. chinensis . The longer the growth period is ,the higher each component content is. The color of A. chinensis is closely related to the content of each component ,and the content of effective components is higher in A. chinensis with dark yellowish brown color.

20.
Article in Chinese | WPRIM | ID: wpr-821203

ABSTRACT

Objective To analyze nutritional status among students participating in "nutrition improvement program" for the compulsory education students in Xi'an, and to provide a reference basis for student nutrition improvement. Methods Eleven districts and counties were selected. About 10% primary and junior high schools were selected from the nutrition improvement program. A total of 31,941 primary and junior high school students were selected. Height and weight were measured according to the standard methods. Results Malnutrition rate of 6~15 years old boys was 10.58% (stunting rate 2.40%, wasting rate 8.18%). Overweight and obesity rate was 14.23% and 11.22%, respectively. Malnutrition rate of 6~15 years old girls was 8.56% (stunting rate 2.17%, and wasting rate 6.40%). Overweight and obesity rate was 10.43% and 7.56%, respectively. The nutritional status of students in different gender, school period, feeding pattern and school location was analyzed. The malnutrition rate was higher in boys than in girls (10.58% vs 8.56%) (P<0.05). The combined obesity-overweight rate was higher in boys than girls (25.45% vs 17.99%) (P<0.05). The combined obesity-overweight rate was higher in 6~12 aged students than in 13-15 aged (22.82% vs 16.06%) (P<0.05). The combined obesity-overweight rate was higher (26.10%) (P<0.05) in the schools located in urban areas. The rate of malnutrition among students in the school-based cafeteria was higher (10.93%) (P<0.05), while the rate of overweight and obesity was higher in the students with meals supplied by the food suppling enterprise (25.18%) (P<0.05). Conclusions The malnutrition and overweight and obesity both existed in students who benefitted from the nutrition improvement program. Attention should be paid to the malnutrition of boys and county schools, the overweight and obesity of boys, 6-12 years old students, and urban students. It is suggested that while implementing the nutrition improvement plan, the nutrition health education in students should be strengthened to avoid an increase of overweight and obesity rate.

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