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Chinese Journal of Contemporary Pediatrics ; (12): 583-588, 2020.
Article in Chinese | WPRIM | ID: wpr-828702


OBJECTIVE@#To study the effect of bronchopulmonary dysplasia (BPD) on neurobehavioral development within one year after birth in preterm infants.@*METHODS@#A retrospective analysis was performed for the preterm infants with a gestational age of 0.05). Based on the Gesell Developmental Scale, compared with the non-BPD group, the BPD group had significantly lower global developmental quotient (DQ) and DQs of fine motor, adaptive behavior, and personal-social behavior at the corrected gestational ages of 3, 6, and 12 months (P0.05). The mental development index at the corrected gestational age of 3 months was significantly higher than that at the corrected gestational ages of 6 and 12 months in both groups (P<0.001).@*CONCLUSIONS@#Preterm infants with BPD have delayed neurodevelopment within one year after birth compared with those without BPD, which should be taken seriously in clinical practice.

Humans , Infant , Infant, Newborn , Bronchopulmonary Dysplasia , Gestational Age , Infant, Premature , Neonatal Screening , Retrospective Studies
Chinese Journal of Contemporary Pediatrics ; (12): 1202-1205, 2014.
Article in Chinese | WPRIM | ID: wpr-289502


<p><b>OBJECTIVE</b>To compare the risk factors between preterm and small-for-gestational-age (SGA) births.</p><p><b>METHODS</b>A total of 1 270 newborns who had no obstetric risk factors or maternal diseases were enrolled in this study. Their mothers' stature, body weight, passive smoking, and history of abnormal pregnancy were investigated using the self-designed questionnaire. The infants were divided into four groups: preterm, appropriate-for-gestational-age (AGA), SGA, and term infants. Multivariate logistic regression analysis was performed to compare the risk factors between preterm and SGA births.</p><p><b>RESULTS</b>A weight gain less than 9 kg during pregnancy increased the risks of preterm (OR=1.63, 95% CI: 1.12-2.07) and SGA (OR=1.92, 95% CI: 1.56-2.58). The histories of abortion (OR=1.46, 95% CI: 1.09-1.93) and preterm birth (OR=2.63, 95% CI: 1.81-3.92) were independent risk factors for preterm births, while low pre-pregnancy body mass index (<18.5) (OR=2.16, 95% CI: 1.53-3.16), short stature (<1.55 m) (OR=2.46, 95% CI: 1.78-3.48), and passive smoking (OR=2.24, 95% CI: 1.65-2.98) were independent risk factors for SGA births.</p><p><b>CONCLUSIONS</b>Due to different risk factors between preterm and SGA births, specific preventive measures should be taken pertinently to reduce the incidence of the two bad pregnancy outcomes.</p>

Humans , Infant, Newborn , Body Mass Index , Infant, Small for Gestational Age , Logistic Models , Premature Birth , Risk Factors , Tobacco Smoke Pollution
Chinese Journal of Medical Genetics ; (6): 266-269, 2012.
Article in Chinese | WPRIM | ID: wpr-295497


<p><b>OBJECTIVE</b>To analyze de novo copy number variations (CNVs) in a Chinese family affected with autism spectrum disorders (ASD).</p><p><b>METHODS</b>Affymetrix Cytogenetics Whole Genome 2.7M Array assay was performed to identify potential CNVs in four members from the family.</p><p><b>RESULTS</b>A total of 89 de novo CNV regions were identified in the autistic siblings. The CNV regions in total have exceeded 1/1000 of the lengths of chromosomes 5, 11 and 14. In addition, de novo CNV regions were also identified at 3p26.1, 4q22.2, and 5p15.2, which encompassed 10 genes associated with nerve development including GRM7, GRID2 and CTNND2.</p><p><b>CONCLUSION</b>A number of nerve development associated genes were at the de novo CNV sites, which may provide new clues for genetic research of ASD. High-resolution array-comparative genomic hybridization is an effective method for detecting submicroscopic chromosomal imbalances.</p>

Child, Preschool , Female , Humans , Male , Child Development Disorders, Pervasive , Genetics , Comparative Genomic Hybridization , Methods , DNA Copy Number Variations