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Chinese Journal of Hepatology ; (12): 381-385, 2012.
Article in Chinese | WPRIM | ID: wpr-261997


<p><b>OBJECTIVE</b>To investigate the association between concentration levels of fasting serum glucose and liver cirrhosis.</p><p><b>METHODS</b>A nested case-control study was carried out based on the sample cohort from the Nutrition Intervention Trials previously conducted in one country in Henan province. Using an automatic biochemical analysis system and enzyme-linked immunoassay, baseline serum samples from 310 liver cirrhosis patients and 620 healthy controls were tested for fasting glucose concentration, hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), and hepatitis C virus antibody (anti-HCV). Baseline demographic information was collected by questionnaire. The serum glucose values were divided into quintiles and applied to a logistic regression model to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).</p><p><b>RESULTS</b>The mean fasting blood glucose level was significantly higher in cases (4.5+/-1.8 mmol/L) than in controls (4.2+/-2.1 mmol/L) (t=-2.414, P=0.016). The individuals in the highest quintile had a significantly higher risk of disease than those in the lowest quintile [OR=1.672 (1.080, 2.588)]. Moreover, increase in glucose level was accompanied by increased risk, and the relation showed statistically significant linearity (P=0.002). The statistical significance of risk remained after adjustment for potential confounders, including sex, age, HBsAg, anti-HBc, and residence running water status [OR=1.96 (1.216, 3.157), P=0.001].</p><p><b>CONCLUSION</b>Elevated serum fasting glucose concentration was an independent risk factor of cirrhosis.</p>

Adult , Blood Glucose , Metabolism , Case-Control Studies , China , Epidemiology , Female , Humans , Liver Cirrhosis , Blood , Epidemiology , Male , Middle Aged , Prospective Studies , Risk Factors
Article in Chinese | WPRIM | ID: wpr-298715


<p><b>OBJECTIVE</b>To investigate the prevalence of human papillomavirus (HPV) and the HPV genotype distribution in invasive squamous cell carcinoma of the uterine cervix in the Mongolian women in Inner Mongolia autonomy region.</p><p><b>METHODS</b>The prevalence data of HPV in our department were retrospectively reviewed. INNO-LiPA genotyping technique was used to detect HPV genotypes in the reserved carcinoma tissue specimens.</p><p><b>RESULTS</b>Totally 63 tissue specimens were collected and detected. The prevalence of HPV was 93.7%. The positive rates of HPV among different clinical staging and different pathological grading were not significantly different (P >0.05). The prevalence of HPV16 was not significantly different among different age groups (P>0.05). HPV16 (69.8%), HPV18 (4.8%), HPV31 (4.8%), HPV39 (4.8%), and HPV52 (3.2%) were the 5 dominating HPV genotypes in all cases.</p><p><b>CONCLUSIONS</b>HPV infection is closely correlated with invasive squamous cell carcinoma of the uterine cervix in Mongolia women. HPV16 is the most important genotype in invasive squamous cell carcinoma of the uterine cervix, followed by HPV18, 31, and 39. HPV infection dose not affect the progression and differentiation of invasive squamous cell carcinoma of the uterine cervix.</p>

Adult , Aged , Asian Continental Ancestry Group , Carcinoma, Squamous Cell , Virology , Female , Genotype , Humans , In Vitro Techniques , Middle Aged , Papillomaviridae , Classification , Genetics , Papillomavirus Infections , Genetics , Virology , Polymerase Chain Reaction , Uterine Cervical Neoplasms , Virology
Article in Chinese | WPRIM | ID: wpr-290190


<p><b>OBJECTIVE</b>To investigate the prevalence of Human papillomaviruses (HPVs) among village women in Henan and to determine its relevant risk factors.</p><p><b>METHODS</b>A population based cross-sectional study on cervical cancer was conducted among village women in Xinmi, Henan. Women aged 20 - 54 who had sexual intercourse experiences were enrolled in this study. Self-sampling and direct-sampling were used in collecting women's vaginal discharge. 13 high-risk HPVs were tested with HC2 for all of the specimens. Then women with abnormal results did colposcopy and biopsy. The biopsy results were regarded as the golden standard.</p><p><b>RESULTS</b>There were 881 women enrolled in this paper and 881 self-sampling and 880 direct-sampling specimens were collected. The HPVs prevalence rates for the self-sampling and direct-sampling were 13.05% and 12.27%, respectively. Age-specific prevalence rates were 10.57% (20-), 9.60% (25-), 12.00% (30-), 9.52% (35-), 17.60% (40-), 13.74% (45-) and 12.80% (50 - 54). HPV prevalence rates were increased with progression of cervical disease (chi(2) = 200.69, P = 0.00). And HPV prevalence rates were higher in women with more advanced education background (chi(2) = 11.05, P = 0.01). HPV infection rate in women whose husbands have more than one sexual partner was 18.02% and whose husbands have only one sexual partner was 10.88% (chi(2) = 6.37, P = 0.01).</p><p><b>CONCLUSION</b>The infection rate of high-risk HPVs in this area is high. The relationship of HPV infection with age has not been observed in this study, but the the sexual activity is the major risk factor for cervical cancer.</p>

Adult , China , Epidemiology , Cross-Sectional Studies , Female , Humans , Middle Aged , Papillomaviridae , Papillomavirus Infections , Epidemiology , Risk Factors , Rural Population , Smegma , Virology , Surveys and Questionnaires , Uterine Cervical Neoplasms , Epidemiology , Virology
National Journal of Andrology ; (12): 936-938, 2006.
Article in Chinese | WPRIM | ID: wpr-289104


Cryptorchidism is a clinically common congenital deformity of the genital organ, the etiological factors of which are still not clarified up to now. Undescended testis is frequently accompanied with the anomalies of the spermatic cord, gubernaculum testis, processus vaginalis, and epididymis. Because these anatomical anomalies act as terminal factors or the ending in the links of the cause of cryptorchidism, it is of important directive significance for the clinical treatment of the problem to seek evidence of anatomical anomalies at orchiopexy to demonstrate the etiological factors of cryptorchidism.

Cryptorchidism , Epididymis , Congenital Abnormalities , Genitalia, Male , Congenital Abnormalities , Humans , Male , Spermatic Cord , Congenital Abnormalities , Testis , Congenital Abnormalities