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1.
International Eye Science ; (12): 403-410, 2024.
Article in Chinese | WPRIM | ID: wpr-1011391

ABSTRACT

Diseases of ocular fundus are the leading causes of severe vision impairment or even blindness in patients worldwide, and the medical treatments are seriously limited by the difficulty of therapeutic drugs entering the fundus due to the various physiological barriers. Nano-drug delivery systems, with their nanoscale size and large surface area, can be loaded with therapeutic drugs of different physicochemical properties and modified with various surface active substances, which can not only improve the solubility and penetration of the drugs, but also protect biologic drugs from degradation and improve the biological safety and bioavailability, as well as deliver therapeutic drugs to specific ocular targets. All of these make the therapeutic potential enormous. Currently, more and more studies have been carried out to take advantage of nanomaterials for the treatment of different fundus diseases, including neurodegenerative diseases, fundus neovascularization, endophthalmitis and fundus tumors. This review analyzes the challenges and barriers faced by different routes of drug administration in the treatment of fundus diseases, the physicochemical properties of common nano-drug delivery systems that have been studied in related fields, and further summarizes the progress, advantages, limitations, and future directions of the application of various nano-drug delivery systems for the treatment of ocular fundus diseases in recent years.

2.
Cancer Research and Clinic ; (6): 592-595, 2023.
Article in Chinese | WPRIM | ID: wpr-996280

ABSTRACT

Objective:To analyze the screening results of urban cancer early diagnosis and early treatment project in Taiyuan City in 2020.Methods:Based on the method of cluster sampling, taking the urban community of Taiyuan City, Shanxi Province as the research site, all permanent residents aged 45-74 years (with local household registration and living in the local area for over 3 years) from January 2020 to December 2020 were selected. The cancer patients with confirmed diagnosis and those with severe medical and surgery diseases receiving treatment were excluded. The basic data and risk factors of the population were collected through questionnaires and the screening results were obtained from clinical screening in the project hospitals, and then the high risk rate of cancer, the detection rate of positive lesions, and the detection rate of suspected cases were calculated.Results:A total of 5 878 people participated in the screening of cancer early diagnosis and early treatment project. Among them, a total of 3 003 people (51.09%) were evaluated as a high-risk group of cancer. The sequence from low to high of positive detection rates of different cancers was listed as follow: liver cancer (3.87%, 21/542), upper gastrointestinal cancer (13.88%, 78/562), colorectal cancer (15.78%, 71/450), breast cancer (25.79%, 122/473), and lung cancer (54.92%, 536/976). Among them, the detection rate of positive lesions of lung cancer and liver cancer in males was higher than that in females, while the detection rate of positive lesions of the remaining cancer types in males was lower than that in females. The detection rates of suspected cases of various cancer types from low to high were listed as follow: liver cancer (0, 0/542), upper gastrointestinal cancer (0.55%, 3/562), lung cancer (0.71%, 7/976), breast cancer (2.75%, 13/473) and colorectal cancer (3.11%, 14/450). Among them, the detection rate of suspected cases of lung cancer in males was higher than that in females, and the detection rate of suspected cases of upper gastrointestinal cancer and colorectal cancer in males was lower than that in females.Conclusions:In the process of carrying out the project of early diagnosis and early treatment of cancer in Taiyuan in 2020, the public participation enthusiasm and compliance are good, but the detection rate of positive lesions and suspected cases are at a high level. The prevention and control of cancer cannot be ignored. Further publicity and education should be done, and more reasonable screening methods should be explored, so as to better improve the effect of cancer screening.

3.
Cancer Research and Clinic ; (6): 132-136, 2022.
Article in Chinese | WPRIM | ID: wpr-934644

ABSTRACT

Objective:To realize the understanding level of cancer awareness of residents in Shanxi Province, and to provide a scientific basis for cancer prevention and treatment.Methods:In April 2020, 1 897 local residents in Shanxi Province were recruited to fill in the core knowledge questionnaire of cancer prevention and treatment. The basic demographic information and the core knowledge of cancer prevention and control were collected, and the influencing factors for the understanding of the core knowledge of cancer prevention and treatment were analyzed by using multivariate logistic regression model.Results:In the survey on the awareness rate of core knowledge of cancer prevention and control among residents in Shanxi Province, 37 940 items were answered, among which 29 396 items were known, and the awareness rate of the population was 77.48% (29 396/37 940). The single-factor results showed that there were statistically significant differences in awareness rates of core knowledge of cancer prevention and treatment among the population with different gender, household registration, ethnic groups, education degree, occupation and different frequency of the health examination were statistically significant (all P < 0.05); there were no statistically significant differences in awareness rates of core knowledge among the population with different age, and smokers or non-smokers (all P >0.05).Multivariate logistic regression analysis showed that education degree of junior middle school or above ( OR = 3.412-16.767, 95% CI 1.755-32.476) and receiving physical examination once a year ( OR = 2.291, 95% CI 1.154-4.549) were the favorable factors for knowing the core knowledge of cancer prevention and treatment. Household location in rural area ( OR = 0.522, 95% CI 0.378-0.722) and non-Han nationality ( OR = 0.369, 95% CI 0.151-0.904) were the unfavorable factors for knowing the core knowledge of cancer prevention and treatment. Conclusions:The awareness of core knowledge of cancer prevention and treatment among residents in Shanxi Province is good, so it is necessary to continue to strengthen the publicity of cancer prevention and control and improve the awareness of cancer prevention and control in the future.

4.
Chinese Journal of General Surgery ; (12): 361-365, 2022.
Article in Chinese | WPRIM | ID: wpr-933647

ABSTRACT

Objective:To compare the clinical efficacy of laparoscopic integral pelvic floor/ligament repair (IPFLR) combined with a procedure for prolapse and hemorrhoids (PPH) and that laparoscopic IPFLR alone in the treatment of internal rectal prolapse (IRP) in women.Methods:Patients were divided into groups A in which 63 patients undergoing laparoscopic IPFLR alone, and group B of 67 patients reciving laparoscopic IPFLR combined with PPH. The degree of internal rectal prolapse (DIRP), Wexner constipation scale (WCS) score, Wexner incontinence scale (WIS) score, and Gastrointestinal Quality of Life Index (GIQLI) score were compared between these two groups and in each group those before surgery and 6 months, 2 years, and 5 years after surgery.Results:The number of bowel movements , DIRP, WCS score, WIS score, and GIQLI score before surgery were not significantly different between the two groups (all P>0.05). The DIRP, WCS score, WIS score, and GIQLI score in each group 6 months, 2 years, and 5 years after surgery in both two groups were significantly better than those before surgery (all P<0.001). The DIRP, WCS score, WIS score, and GIQLI score in group B were significantly better than those in group A at 6 months, 2 years, and 5 years after surgery (all P<0.05) except DIRP at 2 years after surgery (all P<0.05). There was a significant difference in the recurrence rate of IRP between the two groups when evaluated at 5 years after surgery ( P=0.001). Conclusions:Integral theory-guided laparoscopic IPFLR combined with PPH has a higher cure rate and a better clinical efficacy than laparoscopic IPFLR alone.

5.
Cancer Research and Clinic ; (6): 687-690, 2022.
Article in Chinese | WPRIM | ID: wpr-958917

ABSTRACT

Objective:To investigate the incidence and mortality of lung cancer in the cancer registration areas of Shanxi Province in 2017.Methods:The cancer registration data reported by 12 tumor registration areas of Shanxi in 2017 were sorted out and stratified by urban and rural areas and gender. The number of incidence and death ,the crude incidence and mortality, the cumulative rate (0-74 years), age-specific incidence and mortality, Chinese population standardized rate and world population standardized rate were calculated. The incidence and mortality were standardized by the 2000 China census standard population composition and Segi's world standard population composition.Results:In 2017, there were 2 275 new cases and 1 736 deaths of lung cancer in the tumor registration area of Shanxi Province. The crude incidence rate of lung cancer was 46.72/100 000 (male 63.99/100 000, female 28.80/100 000, urban area 58.05/100 000, rural area 39.09/100 000), Chinese population standardized rate was 31.67/100 000, the world population standardized rate was 32.10/100 000, and the cumulative rate (0-74 years) was 3.87/100 000. The crude mortality rate was 35.65/100,000 (male 49.84/100,000, female 20.93/100,000, urban area 44.53/100,000, rural area 29.67/100 000), Chinese population standardized rate was 23.82/100 000, the world population standardized rate was 24.14/100 000, and the cumulative rate (0-74 years) was 2.69/100,000. Overall, the age-specific incidence and mortality of lung cancer in 2017 were at a low level in 0-44 years age group, and increased rapidly after 45 years age group, and reached a peak in 85 years age group. The incidence and mortality of lung cancer in males were higher than that in females. Although there were some differences in the incidence and mortality of patients with different ago range in urban and rural areas, the overall trend was similar.Conclusions:Lung cancer is the most common malignant tumor threatening the health of residents in Shanxi Province. Male, urban areas and middle-aged and elderly population are the focus of cancer prevention and control in Shanxi Province. Lung cancer prevention and control should be targeted carried out according to the differences between urban and rural areas and gender.

6.
Cancer Research and Clinic ; (6): 925-929, 2022.
Article in Chinese | WPRIM | ID: wpr-996171

ABSTRACT

Objective:To investigate the risk of lung cancer and screening results of residents in 3 cities of Shanxi Province from 2014 to 2018.Methods:Cluster random sampling method was used to select permanent residents from 3 cities (Taiyuan, Jincheng and Yangquan) in Shanxi Province from January 2014 to December 2018 for lung cancer risk assessment. People at high risk of lung cancer were screened by low-dose spiral CT. The screening results were analyzed and the influencing factors of lung cancer occurrence were analyzed by unconditional logistic regression.Results:184 539 people were included in the survey, and 36 790 people (19.94%) were at high risk of lung cancer. The detection rate of high-risk of lung cancer in men was higher than that in women [29.76% (25 690/184 539) vs. 11.30% (1 100/184 539), χ2 = 10.44, P = 0.001]. A total of 12 660 people (34.41%) at high risk of lung cancer participated in clinical screening, and 3 038 people (24.00%) were positive in clinical screening for lung cancer. There were no statistical differences in the positive rate of clinical screening among people at high risk of lung cancer with different gender, nationality, education, marital status, occupation, history of harmful substance exposure, coal burning, clean heating, indoor oil fumes, and history of pulmonary tuberculosis (all P > 0.05). There were statistical differences in the positive rate of clinical screening among people at high risk of lung cancer with different age, smoking, drinking, drinking tea, physical exercise, exposure time of second-hand smoke, living environment air pollution, history of emphysema, history of pneumoconiosis, family history of lung cancer, mental depression, and history of trauma (all P < 0.05). Logistic regression analysis showed that age ≥ 50 years old, smoking, exposure to second-hand smoke for 1-14 years, living environment air pollution, history of emphysema, family history of lung cancer, and mental depression were the risk factors for positive clinical screening in people at high risk of lung cancer (all P < 0.05), and physical exercise was the protective factor for positive clinical screening in people at high risk of lung cancer ( P < 0.05). Conclusions:The screening rate of people at high risk of lung cancer in 3 cities of Shanxi Province needs to be improved. The detection rate of intrapulmonary nodules in people at high risk of lung cancer is mainly affected by age, smoking, exposure time of second-hand smoke, family history of lung cancer, history of emphysema and other factors.

7.
China Pharmacy ; (12): 1351-1356, 2021.
Article in Chinese | WPRIM | ID: wpr-877257

ABSTRACT

OBJECTIVE:To ev aluate the economics of pembrolizumab versus first-line chemotherapy in the treatment of advanced non-small cell lung cancer with high programmed cell death protein ligand 1(PD-L1)expression from the perspective of Chinese healthcare system. METHODS :Published KEYNOTE- 042 clinical trial data and relevant literature data were used to establish a Markov model to evaluate the economics of pembrolizumab versus first-line chemotherapy with a 20-years horizon and a 3-week cycle length ,discounting costs and utilities using a discount rate of 5%. One-way sensitivity analysis and probabilistic sensitivity analysis were used to evaluate the stability of the model results. RESULTS :The base-case results showed that pembrolizumab yield additional 1.62 QALYs more than first-line chemotherapy ,with an incremental cost of 54 648 yuan;the incremental cost-utility ratio was 33 686 yuan/QALY,which was lower than the willingness-to-pay threshold (WTP)in China. The results of one-way sensitivity analysis showed that the price of nivolumab ,the price of pembrolizumab and the proportion of patients who received second-line immunotherapy in first-line chemotherapy group had the greatest impact on the results. The results of probabilistic sensitivity analysis showed that the probability of pembrolizumab to be cost-effective gradually increased within the WTP of 0-140 000/QALY. When WTP was 70 892 yuan/QALY(one time of the per capita GDP of China in 2019),the probability of pembrolizumab to be cost-effective was 95%. When WTP beyond 100 000 yuan/QALY,the probability of pembrolizumab to be cost-effective was 100%. CONCLUSIONS :Pembrolizumab has economic advantages than first-line chemotherapy in the first-line treatment of non-small cell lung cancer with high PD-L 1 expression in China.

8.
Cancer Research and Clinic ; (6): 186-191, 2020.
Article in Chinese | WPRIM | ID: wpr-872477

ABSTRACT

Objective:To explore the cancer incidence and mortality in registration areas of Shanxi Province in 2014.Methods:The data of 12 cancer registration areas of Shanxi Province in 2014 were taken to analyze the characteristics of cancer incidence and mortality for patients with different age and gender in different areas. And then the results were compared with the malignant cancer incidence and mortality in the nationwide.Results:There were 11 703 new cases, including 6 559 males and 5 144 females in registration areas of Shanxi Province in 2014, and the incidence rate was 221.21/10 5, while the age-standardized incidence rate of Chinese population and world population was 163.91/10 5 and 163.25/10 5, respectively. The cancer incidence rate in urban areas was 247.02/10 5 and the age-standardized incidence rate of Chinese population was 171.35/10 5. In rural areas, the cancer incidence rate was 205.98/10 5 and the age-standardized incidence rate of Chinese population was 159.03/10 5. The common cancer sites were stomach, lung, esophagus, liver and colorectum for males. And breast, cervix, lung, esophagus, stomach were the common cancer sites for females. There were 7 283 malignant death cases, including 4 548 males and 2 735 females. The crude cancer mortality rate was 137.66/10 5, and the age-standardized mortality rate of Chinese population was 99.67/10 5 and world population was 100.11/10 5. The crude cancer mortality rate in urban areas was 141.03/10 5 and the age-standardized incidence rate of Chinese population was 92.84/10 5. In rural areas, the crude cancer mortality rate was 135.68/10 5 and the age-standardized mortality rate of Chinese population was 103.69/10 5. Male common malignant tumor deaths included lung cancer, gastric cancer, liver cancer, esophageal cancer and colorectal cancer, while lung, stomach, liver, esophagus and cervix were the common cancer death sites for females. Conclusions:The incidence and mortality of malignant tumors in registration areas in Shanxi Province are mainly lung cancer, upper gastrointestinal cancer and cervix uteri cancer. The incidence rates of stomach cancer and cervical cancer are high.

9.
Chinese Journal of Preventive Medicine ; (12): 524-529, 2018.
Article in Chinese | WPRIM | ID: wpr-806589

ABSTRACT

Objective@#To explore the relationship between smoking and hyperuricemia in Chinese residents.@*Methods@#Based on data from the China Health and Nutrition Survey (CHNS), residents with blood samples provided in the 2009 round (including information of socio-demographic factors, lifestyle behaviors, medical history, and laboratory examinations etc.) were selected as the participants in the current analysis. Unconditional logistic regression models were utilized to compute the ORs and corresponding 95%CIs for assessing the relationship between smoking and hyperuricemia.@*Results@#Among the 8 785 subjects, 1 435 had hyperuricemia with a prevalence rate of 16.3%, consisting of 886 men and 549 women with prevalence rates of 21.6% (886/4 110) and 11.7% (549/4 675) , respectively. Compared with never smokers, the adjusted OR (95%CI) for hyperuricemia was 0.83 (0.70-0.98) among current smokers, 0.77 (0.63-0.94) among current smokers with 20-39 years of smoking, and 0.79 (0.65-0.97) among current smokers with 11-20 cigarettes per day. When stratified by gender and compared with non-smoker, the adjusted OR (95%CI) for hyperuricemia among current smokers compared with never smokers was 0.83 (0.70-0.98) among men, while no significant association was found in female current smokers (OR=0.73, 95%CI: 0.42-1.26, P=0.260).@*Conclusion@#In Chinese residents, there is an inverse association between smoking and hyperuricemia prevalence, and this association may be related to duration and intensity of smoking among current smokers. The findings need to be validated in large prospective cohort studies.

10.
China Pharmacist ; (12): 1064-1066, 2018.
Article in Chinese | WPRIM | ID: wpr-705665

ABSTRACT

Objective: To analyze the correlation between HD-MTX blood concentration and acute drug-induced liver and kidney injury in the patients with osteosarcoma, and investigate the significance of HD-MTX concentration in the monitoring of liver and kidney toxicity. Methods: A total of 56 osteosarcoma patients treated with HD-MTX were selected, and after HD-MTX treatment, the blood concentration of MTX was detected by an HPLC-UV method in 48 h and 72 h after the administration. The liver and kidney function were measured at the same time. The correlation between the different concentrations of MTX and the change of liver and kidney func-tion was analyzed. Results: All the patients were monitored MTX blood concentration at different time points. After the 48-hour HD-MTX treatment, 4 patients (7. 14% ) were with acute drug-induced liver injury and 13 patients (23. 21% ) showed drug-induced kid-ney injury. The average C48hof liver injury was (2.90 ±0.78) μmol·L-1, and the average C48hof kidney injury was (1.65 ±1.12) μmol·L-1. After the 72-hour HD-MTX treatment, 7 patients ( 12. 50% ) were with drug-induced liver injury and 16 patients (28.57%) showed drug-induced kidney injury. The average C72hof liver injury was (0.30 ±0.17) μmol·L-1, while the average C48hof kidney injury was (0. 29 ± 0. 29) μmol·L-1. The function indices of liver ( ALT, ALP and TBIL) and kidney ( SCr) were significantly higher than those in the normal group (P<0. 05), and the blood concentration of MTX was partly significantly correlated with those indicators. Conclusion: There is a certain correlation between MTX induced injury and the blood drug concentration at par-ticular points, and C48hmay be more valuable to predict drug-induced liver and kidney injury.

11.
Cancer Research and Clinic ; (6): 690-693, 2018.
Article in Chinese | WPRIM | ID: wpr-712886

ABSTRACT

Objective To understand the incidence and mortality of malignancies as well as tumor burden of Shouyang County, Shanxi Province in 2012. Methods According to the review methods and the standards from the National Cancer Registry, the data of the incidence and mortality of malignant tumors in Shouyang County in 2012 were collected, collated and statistically analyzed. Results There were 389 new malignancies cases of Shouyang County in 2012, including 210 males and 179 females. The incidence rate was 187.61/100000 (190.00/100000 in males and 184.88/100000 in females). There were 263 death cases , including 164 males and 99 females. The mortality rate was 126.84/100000 (148.38/100000 in males and 102.25/100000 in females). The top 10 incidence of malignancies of the whole county was followed by lung cancer, cervical cancer, gastric cancer, liver cancer, colorectal anal cancer, esophageal cancer, breast cancer, bladder cancer, gallbladder cancer and uterus cancer, accounting for 86.12 % of the overall malignant cancers. The top 10 death malignancies of the whole county was followed by lung cancer, liver cancer, gastric cancer, esophageal cancer, Hodgkin disease, leukemia, colorectal cancer, bone cancer, brain tumor and pancreatic cancer, accounting for 87.45 % of the overall malignant cancers. Conclusion Lung cancer ranks first in the incidence and mortality of malignant tumors of Shouyang County, Shanxi Province, and the prevention and control of major tumors should be strengthened.

12.
China Pharmacist ; (12): 513-515, 2017.
Article in Chinese | WPRIM | ID: wpr-510077

ABSTRACT

Objective:To analyze the correlation between cyclosporin A blood concentration and drug-induced liver and kidney in-jury in the patients with aplastic anemia, investigate the significance of cyclosporin A concentration in the monitoring of liver and kidney toxicity, and provide theoretical basis for clinical individualized drug use. Methods:A total of 149 patients with aplastic anemia trea-ted with cyclosporin A as the main therapeutic drug were selected, and after 3-day treatment, the blood concentration of cyclosporin A was detected by an HPLC-UV method 10 minutes before the administration and 2 hours after the administration. The liver and kidney function were measured at the same time. The correlation between the different concentration of cyclosporine A and the change of liver and kidney function was analyzed. Results:All the patients were monitored cyclosporine A blood concentration with 1236 samples, and 34 patients (22. 82%) were with drug-induced liver injury and 51 patients (34. 23%) showed drug-induced kidney toxicity. The average C0 of liver injury patients was (297. 92 ± 74. 14) μg·L-1 , and C2 was (944. 47 ± 148. 47) μg·L-1 , while the average C0 of kidney injury patients was (311. 41 ± 52. 80)μg·L-1, and C2 was (926. 25 ± 136. 02) μg·L-1. The function indices of liver (ALT, AST, TBIL) and kidney (SC, BUN, UA) were significantly higher than those in the normal group (P<0. 05), and the blood concentration of cyclosporin A was significantly correlated with the liver,and kidney function. Conclusion:There is a certain correla-tion between cyclosporine A -induced toxicity and its blood concentration and C2 may be a more valuable predictor for drug -induced liver injury.

13.
Journal of International Oncology ; (12): 629-632, 2017.
Article in Chinese | WPRIM | ID: wpr-659118

ABSTRACT

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma with a high degree of heterogeneity.Studies have shown that microRNAs (miRNAs) are involved in many biological processes and are closely related to lymphoid hematopoietic system and play an important role in various stages of B-cell differentiation and malignant transformation.miRNAs are increasingly concerned as a potential biomarker,which are closely related to the classification of DLBCL.miRNAs are of great values for the diagnosis of the disease and help to determine the prognosis of different patients,which may become new therapeutic targets.

14.
Journal of International Oncology ; (12): 629-632, 2017.
Article in Chinese | WPRIM | ID: wpr-657253

ABSTRACT

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma with a high degree of heterogeneity.Studies have shown that microRNAs (miRNAs) are involved in many biological processes and are closely related to lymphoid hematopoietic system and play an important role in various stages of B-cell differentiation and malignant transformation.miRNAs are increasingly concerned as a potential biomarker,which are closely related to the classification of DLBCL.miRNAs are of great values for the diagnosis of the disease and help to determine the prognosis of different patients,which may become new therapeutic targets.

15.
Cancer Research and Clinic ; (6): 471-475, 2016.
Article in Chinese | WPRIM | ID: wpr-495472

ABSTRACT

Objective To explore the cancer incidence in registration areas in Shanxi Province. Methods Data of 8 cancer registration areas in 2011 were taken into account and cancer incidence in different areas with different ages was compared with that in other domestic areas. Results 8 395 new cases in Shanxi all cancer sites were reported in 2011, including 4 810 male and 3 585 female. The incidence of malignant cancer of Shanxi was 207.53/100 000, and the standardized incidence of Chinese population and world population were 125.20/100 000 and 165.72/100 000, respectively. In urban areas, the incidence of Shanxi and the standardized incidence of Chinese population were 202.49/100 000 and 112.81/100 000, respectively. In rural areas, incidence rate of Shanxi was 211.96/100 000 and the standardized incidence of Chinese population was 138.43/100 000. In Shanxi Province, the major malignant cancer sites for males involved stomach, lung, esophagus, liver and colorectum, and cancer sites for females were more on cervix, lung, breast, stomach and esophagus. Conclusions Upper gastrointestinal cancer and uterine cervix cancer are the major cancers in Shanxi registration areas. The incidence of stomach cancer and uterine cervix cancer in Shanxi Province are much higher than national average.

16.
China Pharmacist ; (12): 1685-1688,1728, 2015.
Article in Chinese | WPRIM | ID: wpr-671165

ABSTRACT

Objective:To establish an HPLC method for the determination of paclitaxel and docetaxel in plasma to provide refer-ence for the individualized treatment regimen and the evaluation of curative effect and adverse reactions. Methods:Paclitaxel and do-cetaxel were used as the internal standard for each other. The samples were precipitated by acetonitrile and separated on a DikMA Dia-monsil C18 column with a mixture of acetonitrile-water (55: 45) as the mobile phase. The flow rate was 1. 2 ml·min-1 . The column temperature was set at 25℃. Paclitaxel and docetaxel were detected by UV-detection (λ= 227 nm). Results: A linearity was ob-tained within the range of 0. 078-10. 0 mg·L-1 for paclitaxel and docetaxel. The limit of quantitation was 0. 039 mg·L-1 . The aver-age recovery of paclitaxel and docetaxel was 99. 85% and 100. 35%, respectively. The inter- and intra-day RSD were both less than 5% and the RSD for freeze-thaw stability was below 10%. The plasma concentration of paclitaxel in clinical samples was within the range of 0. 18-6. 16 mg·L-1 and obvious individual difference was shown. Conclusion:Therapeutic drug monitoring is very important due to the obvious differences in plasma concentration of paclitaxel and docetaxel. The established method is sensitive, accurate, con-venient and rapid in r the therapeutic drug monitoring, and is useful for the adverse drug reactions monitoring and pharmacokinetic study.

17.
Cancer Research and Clinic ; (6): 108-110, 2012.
Article in Chinese | WPRIM | ID: wpr-428482

ABSTRACT

ObjectiveTo explore the mental health status of patients with breast cancer and social support on their influence. Methods260 cases of patient with breast cancer were investigated by using the questionnaire of demographic characteristics and symptom check list 90(SCL-90)and social support rating scale(SSRS). ResultsBreast cancer patients ' mental health condition was worse than normal healthy people and their mood changes were obviously observed. Breast cancer patients achieved good social support.However, the urban patients with breast cancer got better social support than the rural patients and the difference were statistically significant(t =7.91, P =0.000). SCL-90 total score and its factors such as forced symptoms, sensitive interpersonal relationship, depression, anxiety, hostile, terror, paranoid,psychoticism,were negatively related with the social support (r =-0.278,-0.259,-0.165,-0.294,-0.215,-0.177,-0.175,-0.167,-0.219,all P < 0.05).ConclusionThe social support influences breast cancer patients'mental health,therefore,the patients with breast cancer should be given a better social support in order to improve the psychological health level and improve recovery.

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