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1.
Article in Chinese | WPRIM | ID: wpr-798635

ABSTRACT

Objective@#To analyze the results of occupational physical examination for major occupational hazard exposed laborer in 2018 in Guangzhou, to provide scientific basis for occupational health supervise.@*Methods@#In January 2019, descriptive epidemiological methods were used as the data sources of the Occupational Disease and Occupational Health Information Surveillance System and the report data of Guangzhou Occupational Health Inspection Agency, collecting 2733 employers from 28 Occupational Health Inspection Organizations in 11 administrative regions of Guangzhou from January to December 2018, as well as the occupational health examination data of 97688 workers exposed to the occupational-disease-risk factors, to analyze the inspection of suspected occupational diseases and contraindications during the period of work of the workers who were monitored for the occupational hazard factors (silicon dust, welding fume, benzene, lead, Ethylene Dichloride, N-hexane, high temperature and hand-transmitted vibration) .@*Results@#Total 128 cases of suspected occupational disease were detected, including 3 suspected silicosis, 8 suspected welder's pneumoconiosis, 17 suspected other pneumoconiosis, 10 suspected benzene poisoning, 1 suspected lead poisoning and 89 suspected noise deafness. There were 2061 cases of occupational contraindication, among which 550 cases were contraindication of high temperature, 261 cases were benzene and 1089 cases were noise.@*Conclusion@#The Occupational Health Inspection Institution of this city should continuously monitor the occupational health status of the harmful workers during their work, do a good job of prevention, and strengthen the labor protection.

2.
Article in Chinese | WPRIM | ID: wpr-817664

ABSTRACT

@#With the rapid development of surgery and the expansion of indications for surgical treatment ,the number of non-obstetric operations during pregnancy and infant operations has been increasing. Most of these operations need to be performed under general anesthesia,and the developing brain of fetus and infants are inevitably exposed to general anesthetics. Therefore,in recent years,the neurotoxicity effects of general anesthetics on the developing brain have become the focus and controversy in the medical sciences. Especially in 2016,US Food and Drug Administration(FDA)added black box for warning of general anesthetics commonly used in clinic,which caused confusion among doctors,patients and staffs in the related fields. Therefore,we will elaborate the preclinical and clinical studies of neurotoxicity of general anesthetics in combination with the characteristics of developing brain.

3.
Article in Chinese | WPRIM | ID: wpr-804930

ABSTRACT

Objective@#To learn about the cardiovascular health effects of workers expose to benzene-toluene-xylene and noise in painting workshop of automobile manufacturing enterprises, and to provide intervention measures and strategies for the health of workers.@*Methods@#The effects of noise exposure, benzene-toluene-xylene exposure and combined exposure on workers' blood pressure and electrocardiogram were analyzed through epidemiological investigation, workplace monitoring and occupational health examination in several automobile enterprises which had carried out occupational hazard factors monitoring and occupational health examination in our hospital from April to October 2017.@*Results@#There were differences in age, sex, working years, smoking, drinking and physical exercise among workers in different exposure groups (P<0.05) . The systolic blood pressure level of workers in benzene-toluene-xylene exposure group and combined exposure group was significantly different comparing with control group (P< 0.05) , After the factors of age and working years were adjusted. The abnormity rate of electrocardiogram in workers were not statistically significant in all groups (P>0.05) .@*Conclusion@#The benzene-toluene-xylene exposure and noise combined with benzene-toluene-xylene exposure in painting workshop of automobile manufacturing enterprises has positive influence on the systolic blood pressure of workers. Regular physical examination and health intervention measures should be strengthened to improve health.

4.
China Occupational Medicine ; (6): 173-177, 2018.
Article in Chinese | WPRIM | ID: wpr-881680

ABSTRACT

OBJECTIVE: To analyze the relationship between the cumulative noise exposure( CNE) and prevalence of hypertension in automotive manufacturing workers. METHODS: A total of 1 535 noise-exposed male workers with length of service ≥ 1. 0 year from automobile manufacturing industries in Guangzhou City was chosen as study subjects by convenience sampling method. The noise intensity in the workplace was measured, the CNE calculated, and the occupational health examination conducted. RESULTS: The prevalence of hypertension of the study subjects was 8. 1%( 125/1 535). The prevalence of hypertension showed an upward trend with the increase of CNE( P < 0. 01). The multivariate logistic regression analysis showed that the prevalence risk of hypertension increased with the increase of CNE after adjusting for confounding factors such as body mass index,smoking and wearing personal protective equipment in automobile manufacturing workers( P < 0. 01). CONCLUSION: There is a dose-effect relationship between prevalence of hypertension and CNE in automobile manufacturing workers who exposed to noise.

5.
Article in Chinese | WPRIM | ID: wpr-698589

ABSTRACT

BACKGROUND: Currently, whether the use of sodium hypochlorite (NaOCl) influences the bond strength of fiber posts is still uncertain. OBJECTIVE: To evaluate the influence of NaOCl on the bond strength of fiber posts by Meta-analysis. METHODS: Randomized controlled trials about the impact of NaOCl irrigation to the bond strength of fiber posts were retrieved from PubMed, EMbase, Web Of Science, OVID, CBM, ClinicalKey, CNKI, CqVip and WanFang databases, and other databases through manual retrieval as well. The deadline of the collection was December 31, 2016, with no limit of regions and languages. A Meta-analysis was performed with the bond strength of fiber posts as an indicator. RESULTS: A total of 11 randomized controlled trials were included. In the experimental group (NaOCl group), the root canal was rinsed with NaOCl, and dried followed by fiber post bonding using the total-etching system, the self-etching system and the self-adhesive system. In the control group, the root canal was washed with pure water or normal saline.Meta-analysis showed that weighted mean difference(WMD)(NaOCl group/control group)=-0.90,95% confidence interval(CI)(-1.50,-0.31),Z=2.97,P=0.003.Subgroup analysis showed that WMD(total-etching:NaOCl group/control group)=-2.38,95% CI(-4.86,0.10),Z=1.88,P=0.06;WMD(self-etching:NaOCl group/control group)=-1.22,95% CI(-2.17,-0.28),Z=2.55, P=0.01;WMD(self-adhesive:NaOCl group/control group)=-1.97,95% CI(-2.30,-1.64),Z=11.73,P<0.000 01.As the limited number of enrolled samples in the total-etching group and self-etching group results in a higher heterogeneity, further investigations are warranted. The present data suggests that irrigating the surface of root canals with NaOCl alone has negative impact on the bond strength of fiber posts using the self-adhesive system.

6.
International Eye Science ; (12): 1346-1348, 2018.
Article in Chinese | WPRIM | ID: wpr-695446

ABSTRACT

·AIM: To observe the efficacy and safety of a new posterior chamber intraocular lens ( ICMO V4c ) implantation in patients with high myopia and low astigmatism and to provide reference for the clinical diagnosis and treatment of these patients. ·METHODS: The study was to analyze the clinical data of patients with high myopia who underwent ICMO V4c implantation with low degree of astigmatism in our hospital from January 2015 to December 2016. The patients were followed up for 1, 3 and 6mo after operation. The items we analyzed including preoperative and postoperative uncorrected visual acuity ( UCVA) and best corrected visual acuity ( BCVA), diopter, spherical and cylinder equivalent, and manifest refraction spherical equivalent ( MRSE ), intraocular pressure ( IOP ), endothelial cell counting, anterior chamber depth (ACD), arch height and postoperative complications. ·RESULTS: Postoperative UCVA and BCVA improved compared with preoperative, and the difference between preoperative and postoperative was statistically significant (P<0. 05). All spherical and cylinder equivalent, and MRSE were reduced after surgery ( t = 38. 510, 20. 100, 34. 300; P<0. 01). The mean intraocular pressure increased at 1 and 3mo after operation ( t= 3. 998, 2. 837, all P<0. 05), but it returned to normal at 6mo ( t=0. 383, P>0. 05). The corneal endothelium counts in the patients at 3mo and 6mo after surgery were lower than those before surgery (t= 2. 119, 2. 411; all P<0. 05). The depth of anterior chamber was reduced to a certain extent within 6mo after operation, and recovered after surgery at 6mo after surgery, but it was still lower than the preoperative level (t=5. 850, 5. 260, 2. 556; all P<0. 05). The overall level of ocular arch after operation was stable and no significant fluctuations were observed. The incidence of postoperative complications in the surgical eye was low and significantly improved after active treatment. ·CONCLUSION: The new posterior chamber intraocular lens implantation in the treatment of high myopia with low astigmatism reaches satisfaction with less complications, is a good supplement to corneal refractive surgery.

7.
Article in Chinese | WPRIM | ID: wpr-806486

ABSTRACT

Objective@#To analyze the results of occupational physical examination for silica dust, benzene and noise-exposed laborer in 2016 in Guangzhou, to provide basis for occupational health supervise.@*Methods@#The data were derived from "occupational disease and health information surveillance system" and the summary data reported by all the occupational physical examination agencies, and analyzed by descriptive epidemiology method.@*Results@#77506 data from 21 agencies of 12 district were collected, and 63 suspected occupational disease were detected, which including 1 silicosis, 8 benzene poisoning, 54 noise deafness.@*Conclusion@#Noise exposure was distributed widely, noise deafness had to be focused on, occupational chronic benzene poisoning and silicosis should be monitored continuously. Small, foreign economy and manufacturing industry should be supervised firstly.

8.
China Occupational Medicine ; (6): 176-187, 2017.
Article in Chinese | WPRIM | ID: wpr-881594

ABSTRACT

OBJECTIVE: To explore the relationship between noise-induced hearing loss, hypertension and abnormal electrocardiogram(ECG) in noise-exposed workers. METHODS: A judgment sampling method was adopted to select 555 male workers with hearing loss as study group and 555 male workers with normal hearing as control group in the similar environment in an automobile manufacturing enterprise in Guangzhou. Pure tone audiometry,blood pressure measurement and ECG examination were performed in both groups to analyze the relationship between hearing loss and hypertension and abnormal ECG. RESULTS: The prevalence rate of hypertension and abnormal ECG was higher in the hearing loss group than the control group(P < 0. 05). The multiple logistic regression analysis showed that after adjusting confounding factors such as age,seniority,body mass index,drinking et al,the risk of hypertension in hearing loss group was higher than the control group(P < 0. 05) and the odds ratio(OR) was 2. 255 [95% confidence interval(CI) : 1. 093-4. 655 ],while adjusting the confounding factor of drinking,the risk of ECG abnormalities in hearing loss group was higher than the control group(P < 0. 05) and the OR was 1. 408(95% CI: 1. 027-1. 930). CONCLUSION: Workers exposed to noise with hearing loss increase the risk of hypertension and abnormal ECG.

9.
National Journal of Andrology ; (12): 728-733, 2017.
Article in Chinese | WPRIM | ID: wpr-812887

ABSTRACT

Objective@#To explore the effects of Xialiqi Capsules(XLQ) on the expressions of the proliferating cell nuclear antigen (PCNA) and caspase-3 in the prostate tissue of the BPH rat model.@*METHODS@#Fifty male SD ratswereequally randomized into groups A (sham operation control), B (BPH model control), C (high-dose XLQ), D (low-dose XLQ), and E (finasteridecontrol) andthe BPH modelswere established by subcutaneous injection of testosterone propionate at 0.5 mg per kilogram of the body weight per day for 30 days after castration. After modeling, the animals in groups A and B were treated intragastricallywith normal saline, while those in C, D, and E with XLQ at 1.20 and 0.61 g per kilogram of the body weight per day or finasterideat 0.8 mg per kilogram of the body weight per day, respectively, all for 30 days. Then,the bilateral prostates were harvestedfrom the rats for calculation of the prostatic index (prostate wet weight/ body weight) and determination of the expressions of PCNA and caspase-3 in the prostate tissue by immunohistochemistry and immunofluorescence staining, respectively.@*RESULTS@#The prostate wet weight and prostate index were significantly increased in group B as compared with group A, ([1326±60] vs[471±17] g, P<0.01; [2.89±0.18] vs [1.06±0.06] mg/g, P<0.01), but decreased in groups C ([914±36] g;[2.02±0.08] mg/g), D ([1 099±46]g;[2.39±0.11] mg/g), and E ([817±53] g;[1.83±0.10] mg/g)in comparison with B (P<0.01), with statistically significant differences among groups C, D, and E(P<0.01) and most significantly in E.The PCNA level in the prostate tissue wasremarkably higher in group B than in A, but lower in groups C, D and E than in B. The expression of caspase-3 was down-regulatedin group B as compared with A, but up-regulated in groups C, D and E in comparison with B, most significantly in E.@*CONCLUSIONS@#Xialiqi Capsules can effectively reduce the prostate wet weight and prostatic index of in rats with BPH by inhibiting the level of PCNA and promoting the expression of caspase-3.


Subject(s)
Animals , Capsules , Caspase 3 , Metabolism , Drugs, Chinese Herbal , Pharmacology , Finasteride , Pharmacology , Male , Orchiectomy , Organ Size , Proliferating Cell Nuclear Antigen , Metabolism , Prostate , Metabolism , Pathology , Prostatic Hyperplasia , Drug Therapy , Metabolism , Pathology , Random Allocation , Rats , Rats, Sprague-Dawley , Urological Agents , Pharmacology
10.
Chinese Journal of Rheumatology ; (12): 439-443, 2017.
Article in Chinese | WPRIM | ID: wpr-617983

ABSTRACT

Objective To study the expression of plasma oxidized low-density lipoprotein (oxLDL) in children with acute phase Kawasaki disease (KD), and investigate its value for early prediction of coronary artery lesions in KD. Methods Totally 80 children with KD were collected. Children were divided into four groups by the results of echocardiogram of coronary artery in different periods: CAL1 group (children with coronary artery lesions (CAL+) both in acute and sub-acute phase, 8 cases), CAL2 group (children with CAL+in acute phase but recovery normal (CAL-) in sub-acute phase, 10 cases), NCAL1 group (children with CAL-in acute phase but occur CAL+ in sub-acute phase, 10 cases) and NCAL2 group (children with CAL- both in acute and sub-acute phase, 52 cases). The serum samples (before the use of intravenous immunoglobulin) were collected in acute phase. Twenty healthy controls and twenty fever controls were enrolled into the study, and their serum samples were collected. OxLDL was measured by enzyme linked immunosorbent assay (ELISA). They were compared using ANOVA, pairwise comparison LSD-t test. And ROC curve analysis was used to determine the threshold. Results Compared with the control groups,plasma oxLDL levels were higher in children with KD, both CA+and CAL-[(15.0±3.3) mU/L, (12.3±3.5) mU/L vs (9.2±2.2) mU/L, (8.0±2.3) mU/L, F=20.435, P<0.05]. Plasma oxLDL levels were increased more significantly in children with CAL+ than children with CAL- in KD [(15.0 ±3.3) mU/L vs (12.3 ±3.5) mU/L, t=2.28, P=0.002]. There was significant difference in the concentration of oxLDL between the groups of Kawasaki disease (F=5.068, P=0.003). Plasma oxLDL levels were significantly higher in the NCAL1 group than those in the NCAL2 group [(14.5 ±3.8) mU/L vs (11.9±3.3) mU/L, t=2.29, P=0.02], but there were no statistically significant difference between the NCAL1 group and CAL1 or CAL2 group [(14.5±3.8) mU/L vs (15.9±3.9) mU/L, (14.5±3.8) mU/L vs (14.2±2.7) mU/L, t=0.73, 0.20;P=0.41, 0.84]. ROCs analysis indicated that oxLDL≥13.83 mU/L, could be the threshold for the prediction of coronary artery lesions with the sensitivity of 0.607 and a specificity of 0.75. Conclusion OxLDL plays an important role in coronary artery lesions in KD. The coronary endothelial dysfunction is earlier than coronary dilatation, and oxLDL is expected to become a reliable early predictor of coronary artery lesions in KD.

11.
Journal of Medical Research ; (12): 139-141,156, 2017.
Article in Chinese | WPRIM | ID: wpr-611463

ABSTRACT

Objective To investigate the changes of serum 8-hydroxy-2'-deoxyguanosine(8-OHDG) in Kawasaki disease (KD) children and to explore the importance of 8-OHDG in predicting the severity of coronary artery lesions in Kawasaki Disease.Methods The serum 8-OHDG was measured in KD patients group (n =60),fever patients group (n =12) and health control group (n =12) by ELISA method.Among the KD patients,30 KD patients were in acute stage (10 cases had coronary artery lesions,20 coronary were normal) and 30 patients were in recovery stage.The serum 8-OHDG and brain natriuretic peptide (BNP) were also compared between patients with coronary artery lesions (CALs) and patients with no coronary artery lesions NCALs).ROC curve analysis was used to test the 8-OHDG and BNP predictive values in KD with coronary artery lesions.Results The serum level of 8-OHDG was higher in acute KD patients than recovery KD patients,fever patients and healthy children (P < 0.05) The serum 8-OHDG was higer in CALs patients than the NCALs patients (P < 0.05).The serum BNP was higer in CALs patients than the NCALs patients (P < 0.01).Analysis of the ROC curve showed that serum 8-OHDG had a positive predictive value of 64.3% and a negative predictive value of 93.8%for distinguishing KD with CALs from KD NCALs when cutoff value was 57.02pg/ml.The area under the curve was 0.820.The serum BNP had a a positive predictive value of 47.6% and a negative predictive value of 100% for distinguishing KD with CALs from KD NCALs when cutoff value was 815pg/ml.The area under the curve was 0.745.Conclusion The serum 8-OHDG may have better predictive value than BNP in diagnose KD children with coronary artery lesions.

12.
China Occupational Medicine ; (6): 301-304, 2016.
Article in Chinese | WPRIM | ID: wpr-876947

ABSTRACT

OBJECTIVE: To investigate the sentinel surveillance status of occupational hazards in Guangzhou manufacturing enterprises. METHODS: The stratified random sampling method was used to extract manufacturing enterprises with serious occupational hazard as sentinel enterprises in Guangzhou,2012-2014. The dynamic changes of samples were analyzed based on the sampling monitoring of occupational hazards. RESULTS: From 2012 to 2014,a total of 8 639 occupational hazard sample sites from 577 sentinel enterprises included in 11 kinds of industries were tested and the total over-standard rate was 7. 41%( 640 /8 639). The over-standard rate in these 3 years showed an increasing tendency each year( P <0. 01). The over-standard rates in different kinds of occupational hazard factors from high to low were physical factors,dust factor,inorganic chemistry factors and organic chemistry factors( P < 0. 01). The over-standard rates of occupational hazard factors in different industries from high to low were ship building,construction material,glass gem,wooden furniture,machinery manufacturing,other industries,storage battery,printing and packaging,the chemical,leather bags and shoes and electronic equipment manufacturing industry( P < 0. 01). The over-standard rates of occupational hazard factors in different scales from high to low were medium-sized,large-sized,small-sized and micro-sized enterprises( P <0. 01). CONCLUSION: Guangzhou City should carry on sentinel surveillance work on occupational hazards on factors of physical,dust and inorganic chemistry in key industries such as ship building,construction materials,glass gem,wood furniture and machinery manufacturing,especially in the large and medium-sized enterprises.

13.
Article in English | WPRIM | ID: wpr-277959

ABSTRACT

Objective To investigate the diagnosis and surgical treatment strategies of intravenous leiomyomatosis(IVL)extending through inferior vena cava into the right cardiac cavities. Methods Thirty patients of IVL extending through inferior vena cava into the right cardiac cavities were treated in Peking Union Medical College Hospital from November 2002 to January 2015.The following variables were studied: age,cardiopulmonary bypass time,deep hypothermic circulatory arrest time,origins of IVL,blood loss,duration of post-operative hospital stay,hospitalization expenses,edema of lower extremity,blood transfusion,postoperative complication,residual IVL,and re-grow or recurrence. Results Thirteen of 30 patients reported double lower limb edema. The cardiopulmonary bypass was applied in 27 cases,and the average duration of cardiopulmonary bypass was(106.9±53.7)min. Then,21 patients were treated with the deep hypothermic circulatory arrest,and the mean time was(28.2±11.6) min. The tumors originated from the genital veins in 9 cases,the iliac vein in 13 cases,and both veins in 8 cases. The average intra-operative blood loss volume was (2060.5±2012.3)ml,and 21 patients received blood transfusion. The average hospitalization time was(18.9±8.3)days and the average hospitalization expenses was (80 840.4±28 264.2)RMB yuan. While 14 patients had postoperative complications,there was no serious postoperative complication or death.All patients have shown a favorable outcome.Conclusions Tumor embolus extending through inferior vena cava into the right cardiac cavities should be suspected in patients with multiple hysteromyoma. Successful therapy for IVL with right cardiac cavities extension is dependent on reasonable surgical treatment strategies. Surgical removal of the ovaries is vital to avoid IVL re-grow or recurrence.


Subject(s)
Cardiopulmonary Bypass , Circulatory Arrest, Deep Hypothermia Induced , Female , Heart Neoplasms , General Surgery , Humans , Leiomyomatosis , General Surgery , Length of Stay , Neoplasm Recurrence, Local , Ovary , Postoperative Complications , Vascular Neoplasms , General Surgery , Veins , Pathology , Vena Cava, Inferior , Pathology
14.
Article in Chinese | WPRIM | ID: wpr-350533

ABSTRACT

<p><b>OBJECTIVE</b>To provide data for the occupational health supervision by analyzing the occupational health status in manufacturing industry in Guangzhou, China.</p><p><b>METHODS</b>The occupational health investigation was performed in 280 enterprises randomly selected from 8 industries based on industry stratification. According to the occupational health standards, 198 out of the 280 enterprises were supervised and monitored. Sample testing was performed in 3~5 workplaces where workers were exposed to the highest concentration/intensity of occupational hazard for the longest time. Comparative analyses of the overproof rates of hazard were performed among enterprises, workplaces, and testing items from different industries.</p><p><b>RESULTS</b>The concentrations of occupational hazard in 42.93% (85/198) of enterprises and 22.96% (200/871) of workplaces were above the limit concentration. The most severe hazards were the noises in shipbuilding and wooden furniture industries and the welding fumes in shipbuilding industry. Less than 30% of enterprises were able to provide occupational health examination and periodic test reports of occupational hazard in workplaces. The rate of the workers with abnormal occupational health examination results and the need for reexamination reached 6.63% (832/12 549), and they were mostly from shipbuilding, wooden furniture, and chemical industries.</p><p><b>CONCLUSION</b>The occupational health supervision should be strengthened in enterprises, and hazard from noises and dusts should be selectively controlled or reduced. The publication of relevant data and information of occupational health in enterprises should be promoted to enhance social supervision.</p>


Subject(s)
Chemical Industry , China , Dust , Humans , Interior Design and Furnishings , Manufacturing Industry , Noise, Occupational , Occupational Exposure , Occupational Health , Welding , Workplace
15.
Article in Chinese | WPRIM | ID: wpr-350528

ABSTRACT

<p><b>OBJECTIVE</b>To perform a sampling survey of occupational hazard in typical industrial enterprises in Guangzhou, China, by means of sentinel surveillance, to understand the classification, distribution, and concentration/intensity of occupational hazard as well as the characteristics and development of occupational health management in Guangzhou, and to provide a scientific basis for occupational health supervision.</p><p><b>METHODS</b>Fifteen enterprises in information technology (IT), shipbuilding, chemical, leather and footwear, and auto repair industries were enrolled as subjects. Dynamic surveillance for occupational hazard and occupational health management was performed in workplaces of those enterprises.</p><p><b>RESULTS</b>The overall overproof rate of occupational hazard in the 15 sentinel enterprises from 2012 to 2014 was 6.16% (45/731). There was no significant difference in the overproof rate between the three years (P > 0.05). During the three years, enterprises in shipbuilding industry had significant higher overproof rates than those in other industries (P < 0.05). According to the results of occupational health management questionnaire, the overall coincidence rate of survey items was 57.88% (393/679); enterprises in IT industry had significant lower coincidence rates than those in other industries in 2012 and 2014 (47.62%, 29.63%; P < 0.05), while enterprises in leather and footwear industry had significant lower coincidence rates than those in other industries in 2013 (40.63%; P < 0.05).</p><p><b>CONCLUSION</b>The enterprises in shipbuilding industry are the key to the prevention and control of occupational hazard in Guangzhou. To strengthen surveillance for occupational health in workplaces in Guangzhou, it is important to enhance occupation health supervision among small and micro enterprises and develop continuous sentinel surveillance for occupational hazard in key industries.</p>


Subject(s)
China , Humans , Industry , Occupational Health , Sentinel Surveillance , Surveys and Questionnaires , Workplace
16.
Chinese Journal of Cancer ; (12): 205-216, 2015.
Article in English | WPRIM | ID: wpr-349601

ABSTRACT

<p><b>INTRODUCTION</b>Most hepatocellular carcinomas (HCC) develop in a background of underlying liver disease including chronic hepatitis B. However, the effect of antiviral therapy on the long-term outcome of patients with hepatitis B virus (HBV)-related HCC treated with chemoembolization is unclear. This study aimed to evaluate the survival benefits of anti-HBV therapy after chemoembolization for patients with HBV-related HCC.</p><p><b>METHODS</b>A total of 224 HCC patients who successfully underwent chemoembolization were identified, and their survival and other relevant clinical data were reviewed. Kaplan-Meier and Cox regression analyses were performed to validate possible effects of antiviral treatment on overall survival (OS).</p><p><b>RESULTS</b>The median survival time (MST) was 15.9 (95% confidence interval [CI], 9.5-27.7) months in the antiviral group and 9.6 (95% CI, 7.8-13.7) months in the non-antiviral group (log-rank test, P = 0.044). Cox multivariate analysis revealed that antiviral treatment was a prognostic factor for OS (P = 0.008). Additionally, a further analysis was based on the stratification of the TNM tumor stages. In the subgroup of early stages, MST was significantly longer in the antiviral-treatment group than in the non-antiviral group (61.8 months [95% CI, 34.8 months to beyond the follow-up period] versus 26.2 [95% CI, 14.5-37.7] months, P = 0.012). Multivariate analysis identified antiviral treatment as a prognostic factor for OS in the early-stage subgroup (P = 0.006). However, in the subgroup of advanced stages, MST of the antiviral-treated group was comparable to that of the non-antiviral group (8.4 [95% CI, 5.2-13.5] months versus 7.4 [95% CI, 5.9-9.3] months, P = 0.219). Multivariate analysis did not indicate that antiviral treatment was a significant prognostic factor in this subgroup.</p><p><b>CONCLUSION</b>Antiviral treatment is associated with prolonged OS time after chemoembolization for HCC, especially in patients with early-stage tumors.</p>


Subject(s)
Antiviral Agents , Carcinoma, Hepatocellular , Chemoembolization, Therapeutic , Drug Therapy, Combination , Hepatitis B virus , Hepatitis B, Chronic , Humans , Liver Neoplasms , Mortality , Neoplasm Staging , Prognosis , Retrospective Studies
17.
Article in Chinese | WPRIM | ID: wpr-312092

ABSTRACT

<p><b>OBJECTIVE</b>To investigate noise hazard and its influence on hearing loss in workers in the automotive component manufacturing industry.</p><p><b>METHODS</b>Noise level in the workplace of automotive component manufacturing enterprises was measured and hearing examination was performed for workers to analyze the features and exposure levels of noise in each process, as well as the influence on hearing loss in workers.</p><p><b>RESULTS</b>In the manufacturing processes for different products in this industry, the manufacturing processes of automobile hub and suspension and steering systems had the highest degrees of noise hazard, with over-standard rates of 79.8% and 57.1%, respectively. In the different technical processes for automotive component manufacturing, punching and casting had the highest degrees of noise hazard, with over-standard rates of 65.0% and 50%, respectively. The workers engaged in the automotive air conditioning system had the highest rate of abnormal hearing ability (up to 3.1%).</p><p><b>CONCLUSION</b>In the automotive component manufacturing industry, noise hazard exceeds the standard seriously. Although the rate of abnormal hearing is lower than the average value of the automobile manufacturing industry in China, this rate tends to increase gradually. Enough emphasis should be placed on the noise hazard in this industry.</p>


Subject(s)
Automobiles , China , Hearing Loss, Noise-Induced , Epidemiology , Hearing Tests , Humans , Manufacturing Industry , Noise, Occupational , Occupational Exposure , Occupations , Workplace
18.
Article in Chinese | WPRIM | ID: wpr-257618

ABSTRACT

<p><b>OBJECTIVE</b>To investigate whether endoscopic saphenous vein harvesting (EVH )reduces leg wound morbidity and improves rehabilitation of lower extremity as compared to open vein harvesting (OVH) in patients with coronary artery disease.</p><p><b>METHODS</b>The clinical data of 333 patients who underwent isolated coronary artery bypass graft surgery (CABG) between January 2007 and December 2011 were retrospectively analyzed.These patients were divided into EVH group (n=210) and OVH group (n=123). Parameters including age,sex,with/without diabetes mellitus,leg wound complications rate,postoperative hospital stay,hospitalization expense,and vein graft patency were analyzed.</p><p><b>RESULTS</b>The age,sex,with/without diabetes mellitus were not significantly different between two groups (P>0.05). However,the incidences of leg wound complications, poor wound healing, wound infections, wound pain,wound numbness, and edema of lower extremity were significantly lower in the EVH group than the OVH group (P<0.05). The ecchymoma and deep vein thrombosis incidences were not significantly different between these two groups (P>0.05). The postoperative hospital stay showed no significant difference (P>0.05), while the hospitalization expense was significantly higher in the EVH group than in the OVH group (P<0.05). There was no statistical difference of vein graft patency (P>0.05).</p><p><b>CONCLUSION</b>The EVH system is a safe and effective alternative to OVH because it can markedly reduce postoperative leg wound morbidity and the EVH vein graft has good patency.</p>


Subject(s)
Coronary Artery Bypass , Coronary Artery Disease , Endoscopy , Humans , Length of Stay , Lower Extremity , Retrospective Studies , Saphenous Vein , Tissue and Organ Harvesting , Vascular Surgical Procedures
19.
Article in Chinese | WPRIM | ID: wpr-269512

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of parent training combined with methylphenidate treatment on family relationships in children with attention deficit/hyperactivity disorder (ADHD).</p><p><b>METHODS</b>Fifty-nine parents of children with ADHD under methylphenidate treatment participated in a modified 5-week training program. The intervention effect was evaluated using the Conners Parent Symptom Questionnaire, ADHD Rating Scale-IV Home Version (ADHD-RS-IV Home Version), Caregiver Strain Questionnaire, Parent-Child Relationship Self-rating Scale and Piers-Harris Children's Self-Concept Scale. Parents also completed the training satisfaction survey before and after the intervention.</p><p><b>RESULTS</b>After the 5-week parent training, compared with the baseline values, total scores of Conners Parent Symptom Questionnaire and scores of conduct problems and anxiety significantly decreased, and scores of attention deficit, hyperactivity, impulsivity and oppositional defiant behaviors of ADHD-RS-IV Home Version, and Caregiver Strain Questionnaire total scores were all significantly decreased (P<0.05), while total scores of the Parent-Child Relationship Self-Rating Scale and Piers-Harris Children's Self-Concept Scale were significantly increased (P<0.05).</p><p><b>CONCLUSIONS</b>Modified 5-week parent training program may improve parent-child relationship and reduce parenting stress in ADHD families.</p>


Subject(s)
Adolescent , Attention Deficit Disorder with Hyperactivity , Drug Therapy , Psychology , Central Nervous System Stimulants , Therapeutic Uses , Child , Female , Humans , Male , Methylphenidate , Therapeutic Uses , Parent-Child Relations , Parents , Education , Psychology , Self Concept
20.
National Journal of Andrology ; (12): 304-308, 2014.
Article in Chinese | WPRIM | ID: wpr-309717

ABSTRACT

<p><b>OBJECTIVE</b>To study the influence of lipopolysaccharide (LPS)-induced inflammation on the testicular histology and reproductive endocrine function in male rats and investigate the possible mechanism of inflammation affecting male fertility.</p><p><b>METHODS</b>Thirty-six male SD rats were randomly divided into a control group (A) and three LPS intervention groups (B, C, and D) to receive saline and LPS (5 mg/kg i. p, once), respectively. The animals in groups B, C, and D were killed by anesthesia at 12, 24, and 72 hours after treatment. Histopathological changes in the left testis of the rats were observed by HE staining and the levels of the reproductive hormones T, FSH, and LH in the serum were determined by ELISA.</p><p><b>RESULTS</b>Compared with group B, group A showed clear structure of seminiferous tubules, orderly arrangement of spermatogenic cells, a slightly decreased number of sperm in some seminiferous tubular lumens, and shed spermatogenic cells in the rat testis tissue; group C exhibited thinner seminiferous epithelia, disordered structure of seminiferous tubules, irregular arrangement of spermatogenic cells, decreased number of mature sperm and obvious shedding of spermatogenic cells in seminiferous tubular lumens; group D manifested similar findings to those of group C, with even more shed spermatogenic cells that blocked the tubular lumens. The levels of serum T, LH, and FSH were (0.490 +/- 0.028) ng/ml, (6.290 +/- 0.515) ng/L, and (1.837 +/- 0.127) IU/L in group A, (0.460 +/- 0.024) ng/ml, (5.881 +/- 0.124) ng/L, and (1.707 +/- 0.098) IU/L in group B, (0.417 +/- 0.021) ng/ml, (5.123 +/- 0.271) ng/L, and (1.620 +/- 0.115) IU/L in group C, and (0.378 +/- 0.021) ng/ml, (4.504 +/- 0.279) ng/L and (1.562 +/- 0.216) IU/L in group D, all decreased in group B as compared with A (P > 0.05). The decreases of T and LH were extremely significant (P < 0.01) and that of FSH was significant in groups C and D (P < 0.05) in comparison with A.</p><p><b>CONCLUSION</b>LPS-induced inflammation affects the testicular tissue and reproductive endocrine function of male rats, resulting in decreased levels of serum T, LH, and FSH.</p>


Subject(s)
Animals , Endocrine System , Physiology , Fertility , Physiology , Follicle Stimulating Hormone , Blood , Humans , Lipopolysaccharides , Toxicity , Luteinizing Hormone , Blood , Male , Random Allocation , Rats , Reproduction , Seminiferous Tubules , Pathology , Spermatocytes , Testis , Pathology , Testosterone , Blood
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