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1.
Article in Chinese | WPRIM | ID: wpr-940655

ABSTRACT

ObjectiveTo explore the underlying mechanism of Gegen Qinliantang (GGQL) in the treatment of ulcerative colitis (UC) in rats and discuss the effects of modification of GGQL on its efficacy. MethodThe UC model was induced in rats by free access to 5% dextran sulfate sodium in saline solution. Male SD rats were randomly divided into a normal group, a model group, a positive control group (sulfasalazine enteric-coated tablets, 350 mg·kg-1), a GGQL group (17 g·kg-1), a Glycyrrhizae Radix et Rhizoma (GR)-absent GGQL group (17 g·kg-1), a Puerariae Lobatae Radix (PLR)-absent GGQL group (17 g·kg-1), a GR-PLR group (17 g·kg-1), and a Scutellariae Radix (SR)-Coptidis Rhizoma (CR) group (17 g·kg-1). The in vitro antioxidant activities of GGQL and its combinations were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and fluorescence recovery after photobleaching (FRAP) methods. The degree of colonic tissue injury in each group was evaluated based on the weight changes of rats, the length of the colon, the colon sections, and hematoxylin-eosin (HE)-stained histopathologic sections. The serum levels of myeloperoxidase (MPO), lipid peroxide (LPO), malondialdehyde (MDA), total superoxide dismutase (T-SOD), catalase (CAT), and reduced glutathione (GSH) were measured by colorimetry. The mRNA and protein expression of nuclear factor-erythroid 2 related factor (Nrf2), quinone oxidoreductase 1 (NQO1), and heme oxygenase-1 (HO-1) in colon tissues was detected by real-time fluorescence-based quantitative polymerase chain reaction (Real-time PCR) and Western blot, respectively. ResultCompared with the normal group, the model group showed colonic mucosal necrosis, inflammatory infiltration, increased serum levels of MPO, LPO, and MDA (P<0.01), blunted activities of T-SOD, CAT, and GSH (P<0.01), decreasing trend of mRNA expression of Nrf2, NQO1, and HO-1, reduced expression of Nrf2 protein (P<0.01), and decreasing trend of expression of NQO1 and HO-1 proteins. Compared with the model group, the GGQL and its combination groups showed improved pathological injury and morphological structure of colon tissues in UC rats, reduced serum levels of MPO, LPO, and MDA (P<0.05), potentiated T-SOD activity (the PLR-absent GGQL group), CAT activity (the GR-absent GGQL group and the SR-CR group), and GSH activity (P<0.01), and increased mRNA and protein expression of Nrf2, NQO1, and HO-1 in colon tissues. The difference in the GGQL group was significant (P<0.05). ConclusionGGQL has a restorative effect on the pathological injury of UC rats, and its mechanism may be related to the activation of the Nrf2 signaling pathway and inhibition of oxidative stress response. The absence of PLR or only presence of SR and CR has a great impact on the treatment of UC. The results can provide references for the clinical rational medication of Chinese medicine and the research on the mechanism of compound combinations.

2.
Chinese Journal of Microsurgery ; (6): 227-229, 2021.
Article in Chinese | WPRIM | ID: wpr-885779

ABSTRACT

The peroneal artery chimeric bone flap combined with chimeric flap of lateral femoral circumflex artery was applied in the repair of a case defects of both ulna and radius arteries combined with large extensive ring-like soft tissue defects of forearm in November, 2018, causing no blood supply to the hand. In the one-stage surgical procedure, anastomosis of the ulnar and radial arteries with the pedicle of the 2 flaps by Flow-through anastomosis were performed and the blood supply of the forearm and hand was restored. Six months after the surgery, the rotation functions of forearm, wrist joint and fingers were recovered. The patient was able to carry out daily activities and some of precision tasks.

3.
Article in Chinese | WPRIM | ID: wpr-875674

ABSTRACT

Objective To investigate the role of vestibular organs on stress analgesia induced by rotation in mice. Methods Female mice were randomly divided into morphine group and rotation group. After 15 minutes of intraperitoneal injection of naloxone or normal saline, the hot plate latency of mice in each group was observed following morphine injection or rotation (250 r/min, 15 s on with 5 s off). After subcutaneous injecting morphine for 7 consecutive days, tolerance was formed and the hot plate latency in morphine-tolerant mice after rotation was observed. P-aminophenylarsonic acid was injected into the inner ear to damage the vestibular organs of the mice and the hot plate latency was observed in chemically labyrinthectomy mice. Results Compared with the normal saline group, the hot plate latency of mice in the naloxone group did not change significantly after rotation (P>0.05), and the hot plate latency decreased significantly after subcutaneous injection of morphine (P<0.05). The morphine-tolerant mice had no significant change in the hot plate latency after rotation compared with the normal saline group (P>0.05). After injection of p-aminophenylarsonic acid into the inner ear, the recovery time of the righting reflex in mice was significantly increased, and the swimming ability was significantly reduced (P<0.05), and the hot plate latency of mice with chemical labyrinthectomy was significantly shortened after rotation (P<0.05). Conclusion Chemical labyrinthectomy completely blocked the rotation-induced stress analgesia in mice. Vestibular organs play an important role in rotation-induced stress analgesia, and this stress analgesia may be mediated by a non-opioid system.

4.
Chinese Journal of Radiology ; (12): 119-123, 2020.
Article in Chinese | WPRIM | ID: wpr-799428

ABSTRACT

Objective@#To explore the accurate display method of the local structure of small CT nodules in lung.@*Methods@#Close the automatic radiation dose adjustment technique. Keep the thickness of the phantom was 2 mm, the interval between the phantom layers was 2 mm, the pitch was 1, and the reconstructed convoluted nucleus was B80s. Group A controlled the scanning matrix FOV to be 500 mm×500 mm, 400 mm×400 mm, 300 mm×300 mm, 200 mm×200 mm and 100 mm×100 mm, while group B controlled the scanning matrix FOV to be 500 mm×500 mm. Use these parameters to scan the catphan 500 phantom, a routine chest CT conditioned scanning quality control model. The original data raw data were used to reconstruct the FOV to be 400 mm×400 mm, 300 mm×300 mm, 200 mm×200 mm and 100 mm×100 mm under the scanning FOV to be 500 mm×500 mm. All other conditions are consistent. Observe the high contrast resolution module of Catphan 500 phantom, and compare the line logarithms of two groups of images under different scanning FOV or different reconstruction FOV. Thirty-five patients with small pulmonary nodules from February 2018 to March 2018 of the Second Affiliated Hospital of Zhejiang University Medical College were retrospectively collected. The raw data were used to reconstruct the images. The FOV was 320 mm×320 mm in the conventional reconstruction group and 100 mm×100 mm in the local magnification reconstruction group. The subjective score data of the two groups were compared by using rank-sum test.@*Results@#When catphan 500 phantom was used, the number of lines in group A and group B increased gradually with the decreasing of FOV. The subjective score of local magnification reconstruction group (4.77±0.35) was higher than that of conventional reconstruction group (3.86±0.50) and the difference was statistically significant (Z=-5.763, P<0.05).@*Conclusion@#Local magnification and reconstruction of high-resolution CT images can achieve the same image quality as local magnification, local magnification and reconstruction of image quality is significantly better than simple image magnification.

5.
Article in Chinese | WPRIM | ID: wpr-868472

ABSTRACT

Objective:To optimize the scheme and process of chest CT scanning and control the dose level to the examined individuals by establishing the diagnostic reference level (DRL) and warning dose value from chest CT examinations in our hospital.Methods:The medical records for 205 511 examined individuals, who had undergone chest CT scans in the Second Affiliated Hospital of Zhejiang University Medical College from January 1, 2018 to December 31, 2019, were reviewed consecutively. For the two-year examination periods, these examined individuals were divided into two groups, one for 2018 totalling 90 507 and another for 2019 with a total of 115 004. The mean value of doses from chest CT scans in 2018 was set as the DRL for the hospital, with the 75th and 25th percentiles as the upper and lower limits of diagnostic reference range (DRR) and the 97.5th percentiles as the warning dose values. The doses above the upper limit of DRR were considered to be relatively-high whearas the ones exceeding the warning dose value to be over-high. Based on the analysis of the over high dose in 2018, the scanning scheme and inspection process of the chest CT scans were improved in 2019. The number of examinations were estimated for the 2018 period for chest plain CT scans, chest enhancement CT scans, lung cancer screening low-dose CT scans, and relatively-high and over-high dose CT scans, as well as the single scanning doses to the examined in the two groups. The number of examinations resulting in high dose to the examined due to different reasons before and after the improvement were studied. The various parameters on the examined in the two groups were compared statistically.Results:After the improvement, the average dose from chest plain CT scans decreased by 8.67 %, with the statistically significant difference as compared with before improvement ( t=55.71, P<0.05). The average dose from low-dose chest CT scans fell by 20.13% with statistically significant difference ( t=81.99, P<0.05). The fraction of the examinations with slightly-high doses arising from chest plain CT scans and low dose chest CT scans dropped by 3.66% and 17.15%, respectively. The fraction of the examinations with slightly-high dose from chest enhanced CT increased by 1.7%. The fraction of the examinations with over-high dose from chest plain CT scans, enhanced CT scans and low-dose CT scans decreased by 0.55%, 1.06% and 1.74%, respectively. After improvement, the optimized fraction of the examinations with over-high dose, dropped by 4.72%, 31.49% and 19.18% respectively. Conclusions:The establishment of the DRL and the warming dose value of for chest CT examinations in our hospital is helpful to find out the cause of high dose scanning, promote the optimization of dose, reduce the average dose to the examinedes, and avoid using excessive dose during scanning.

6.
Chinese Journal of Radiology ; (12): 119-123, 2020.
Article in Chinese | WPRIM | ID: wpr-868266

ABSTRACT

Objective:To explore the accurate display method of the local structure of small CT nodules in lung.Methods:Close the automatic radiation dose adjustment technique. Keep the thickness of the phantom was 2 mm, the interval between the phantom layers was 2 mm, the pitch was 1, and the reconstructed convoluted nucleus was B80s. Group A controlled the scanning matrix FOV to be 500 mm×500 mm, 400 mm×400 mm, 300 mm×300 mm, 200 mm×200 mm and 100 mm×100 mm, while group B controlled the scanning matrix FOV to be 500 mm×500 mm. Use these parameters to scan the catphan 500 phantom, a routine chest CT conditioned scanning quality control model. The original data raw data were used to reconstruct the FOV to be 400 mm×400 mm, 300 mm×300 mm, 200 mm×200 mm and 100 mm×100 mm under the scanning FOV to be 500 mm×500 mm. All other conditions are consistent. Observe the high contrast resolution module of Catphan 500 phantom, and compare the line logarithms of two groups of images under different scanning FOV or different reconstruction FOV. Thirty-five patients with small pulmonary nodules from February 2018 to March 2018 of the Second Affiliated Hospital of Zhejiang University Medical College were retrospectively collected. The raw data were used to reconstruct the images. The FOV was 320 mm×320 mm in the conventional reconstruction group and 100 mm×100 mm in the local magnification reconstruction group. The subjective score data of the two groups were compared by using rank-sum test.Results:When catphan 500 phantom was used, the number of lines in group A and group B increased gradually with the decreasing of FOV. The subjective score of local magnification reconstruction group (4.77±0.35) was higher than that of conventional reconstruction group (3.86±0.50) and the difference was statistically significant ( Z=-5.763, P<0.05). Conclusion:Local magnification and reconstruction of high-resolution CT images can achieve the same image quality as local magnification, local magnification and reconstruction of image quality is significantly better than simple image magnification.

7.
Journal of Clinical Hepatology ; (12): 887-890, 2019.
Article in Chinese | WPRIM | ID: wpr-778799

ABSTRACT

Liver cirrhosis is a progressive chronic liver disease due to one or more causes, with diffuse fibrosis in liver tissue, pseudolobules, and regenerative nodules as major histological features. Once liver cirrhosis enters the decompensated stage, the liver and several other organs are injured, which can hardly be recovered or reversed. This article introduces the process of Toll-like receptors in recognizing the changes in intestinal flora and the influence of this process on the development and progression of liver cirrhosis, as well as the protective effect of bile acid against liver cirrhosis by regulating intestinal flora. This article also reviews the advances in delaying liver cirrhosis after the treatment of intestinal dysbacteriosis and points out that the treatment of intestinal dysbacteriosis may become the major direction of liver cirrhosis treatment in future.

8.
Article in Chinese | WPRIM | ID: wpr-694207

ABSTRACT

Objective To discuss the clinical effect of prophylactic abdominal aorta balloon occlusion with Fogarty catheter before cesarean section in treating delivery woman with pernicious placenta previa.Methods The clinical data of 12 delivery women with pernicious placenta previa,who received prophylactic abdominal aorta balloon occlusion with Fogarty catheter before cesarean section,were retrospectively analyzed.The curative effect was evaluated.Results The average intraoperative blood loss in the 12 patients was (1256±318) ml.The uterus was successfully retained in 9 patients.Hysterectomy had to be carried out in 3 patients because of refractory hemorrhage;one of them had to receive total hysterectomy together with bladder repair as the placenta had penetrated into the bladder wall.After delivery no complications,such as infection,delayed hemorrhage,lower limb thrombosis,etc.,occurred.All 12 neonates were born smoothly.Conclusion Prophylactic abdominal aorta balloon occlusion with Fogarty catheter before cesarean section can effectively reduce intraoperative blood loss and help save the uterus.Therefore,it is a safe and effective therapeutic means for delivery woman with pernicious placenta previa before the performance of cesarean section.

9.
Article in Chinese | WPRIM | ID: wpr-693642

ABSTRACT

Objective To verify a method of calculation and prediction by screening the antibacterial components of classical Chinese medicinal herbs (TCM) for anti tuberculosis, and preliminarily evaluate the anti tuberculosis effect of the selected components. Methods The components database of Stemona, Bletilla striata and Chuanbei was established. Dock method was used to predict the anti tuberculosis components from the database, and then mycobacterium smegmatis, MIC and inhibition zone methods were used to evaluate the anti-tuberculosis effect of these predicted components. Results Three ingredients were selected. In vitro experiments also showed that the selected ingredients had the effect of anti-mycobacterium smegmatis by MIC and inhibition zone . Conclusions The virtual screening method could decrease consumption and increase the efficiency of finding anti-tuberculosis ingredients of TCM.

10.
Chinese Journal of Pediatrics ; (12): 915-922, 2018.
Article in Chinese | WPRIM | ID: wpr-810293

ABSTRACT

Objective@#To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD).@*Methods@#By retrieving the laboratory information system in 18 children′s hospitals from 2012 to 2017, the children with IPD were enrolled. Streptococcus pneumoniae (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc.). The clinical characteristics, serotype, drug resistance, treatment and prognosis were reviewed and analyzed. According to the telephone follow up results, the patients were divided into death group and recovered group. The index as an independent risk factor of mortality was demonstrated by multivariate logistic regression analysis.@*Results@#There were 1 138 children with IPD, including 684 male and 454 female. The proportion of male to female was 1.5∶1. The age ranged from one day to 16 years. The median age was 1 year 3 month. The majority was under 5 years of age (89.3%, n= 1 016), especially under 2 years of age (61.9%, n=704). In all cases, 88.2% (n=1 004) were community acquired infection. The infections included meningitis (n=446, 39.2%), pneumonia with bacteremia (n=339, 29.8%), and bacteremia without focus (n=232, 20.4%). Underlying diseases were found in 242 cases (21.3%). Co-infections were determined in 62 cases (5.4%) with mycoplasma, 27 cases (2.4%) with adenovirus and 34 cases with influenza virus (3.0%). The penicillin insensitivity (PNSP) rates in meningitis and non-meningitis isolates were 69.5% (276/397) and 35.9% (221/615), respectively. There were 81 strains serotyped, in which 93.8% (76/81) were covered by 13-valent protein-polysaccharide conjugate vaccine (PCV13). In the 965 patients who were followed up by phone call, 156 cases (16.2%) were confirmed dead. The independent risk factors for the death were under 2 years of age (OR=2.143, 95%CI 1.284-3.577, P=0.004), meningitis (OR=3.066, 95%CI 1.852-5.074, P<0.01), underlying disease (OR=4.801, 95%CI 2.953-7.804, P<0.01), septic shock(OR=3.542, 95%CI 1.829-6.859, P<0.01), disseminated intravascular coagulation (DIC) (OR=4.150, 95%CI 1.468-11.733, P=0.007), multiple organ failure (OR=12.693, 95%CI 6.623-24.325, P<0.01) and complications of central nervous system (OR=1.975, 95%CI 1.144-3.410, P=0.015).@*Conclusions@#Most children with IPD were under 5 years of age, having underlying diseases and acquired the infection in community. The independent risk factors for death were under two years old, meningitis, underlying diseases and multiple organ failure. The problem of drug resistance was severe. The universal immunization of PCV13 would be effective to prevent IPD in Chinese children.

11.
Article in Chinese | WPRIM | ID: wpr-515116

ABSTRACT

AIM To prepare D-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-modified artesunate liposomes and to investigate the in vitro anti-tumor activity.METHODS The liposomes prepared by thin-film dispersion method were characterized by transmission electron microscopy and particle size analyzer,and the encapsulation efficiency was determined by ultrafiltration centrifugation.The liposomes' cytotoxicity to human hepatoma HepG2 cells was evaluated by MTT method.RESULTS The average particle size,PDI,Zeta potential,encapsulation efficiency,drug loading of the liposomes were 126.7 nm,0.182,-10.1 mV,78.8% and 18.38%,respectively.The liposomes displayed a significant inhibition on HepG2 cells with the IC50 value of 0.034 μmol/mL.CONCLUSION Compared with non-TPGS-modified artesunate liposomes,the TPGS-modified artesunate liposomes prepared by this method afford smaller vesicle size,better stability and higher encapsulation efficiency with stronger in vitro anti-tumor activity.

12.
Article in Chinese | WPRIM | ID: wpr-663163

ABSTRACT

Objective To analyze the sites of CT scan and radiation dose to children, and to compare the dose difference between children and others aged above 14 years with the dose-monitoring software in a single scan. Methods A total of 125147 cases undergoing CT scans were selected from Jan 1 to Dec 31, 2016, including 542 in children group and 124605 in patients group aged above 14 years. Based on the self-designed CT dose of real-time detection and management software, the scan sites and the composition of the scanning dose were recorded and compared between children and patients aged above 14 years in a single scan. Results Head (39. 67%) and extremities (36. 90%) were the primary CT scan sites in children. Abdominal (20. 77%) and limbs (48. 87%) constituted the main part of effective dose to children. In children group, the average single DLP gradually increased with age ( Z =21. 42, P <0. 05). The mean DLP was (567. 38 ± 433. 03) mGy·cm and average effective dose (5. 58 ± 5. 45) mSv in children group, significantly lower than that in patients aged above[14 years (737. 75 ± 172. 40) mGy· cm and (11. 07 ± 2. 59) mSv, Z= -3. 74,-4. 12, P<0. 05]. DLPs in patients aged above 14 years were higher than or equal to those in children group, with a few exceptions of neck and limbs with higher values(Z= -2. 04、 -3. 97, P<0. 05). Effective doses in children were higher than or equal to those in the group aged above 14 years(Z= -3. 03, -3. 11, -4. 12,P<0. 05), with an exception of chest with higher value. Conclusions Although the parameters of CT scan and dose control were optimized to some extent in children, radiation protection on children still needs to be paid attention for due to the radiosensitivity of children. CT scanning on children should be more careful.

13.
Chinese Journal of Radiology ; (12): 794-799, 2017.
Article in Chinese | WPRIM | ID: wpr-662208

ABSTRACT

Objective To study the impacts of different tube voltage and different noise index(NI) guided automatic tube current modulation on the image quality and radiation dose in cerebrovascular imaging and determine the optimal scanning condition. Methods PH3 angiographic CT head phantom was used for head CTA examination. Scanning protocols: all the scanning objectives were divided into three groups according to the different tube voltages of 80, 100 and 120 kV. Each group applied certain tube current(300,400 mA)and automatic tube current modulation technique with NI from 3 to 10 to perform head CTA. There were 30 scanning proposals with different parameter combinations of tube voltage and tube current. The radiation dose [ CT dose index volume (CTDIvol), dose length product (DLP) and effective dose (ED)], objective indicators of images(CT value of the blood vessels and its noise, CT value of brain tissue and its noise, signal-to-noise ratio , contrast-to-noise ratio) and the subjective scores of the five cerebrovascular segments were recorded. Differences of CT value of the blood vessels and its noise, CT value of brain tissue and its noise, signal-to-noise ratio and contrast-to-noise ratio between different tube voltages and tube currents were analyzed by One-Way ANOVA. Results When the tube voltage was certain, the CTDIvol, DLP and ED were all dropped while NI was increased from 3 to 10. Compared with group(120 kV, 300 mA), CTDIvol of group with 100 kV, 300 mA decreased 35.32%(12.22/34.59), CTDIvol of group(100 kV, NI=6) decreased 46.72%(16.16/34.59). Compared with group(100 kV, 300 mA), CTDIvol of group (100 kV, NI=6) decreased 17.61%(3.94/22.37). When the tube voltage was certain and the tube current and NI were not certain, there is no statistical difference (P>0.05) between CT values of blood vessel and brain, while blood vessel noise, noise of brain, SNR and CNR showed statistical difference (P<0.05). When tube current and NI were certain while tube voltage was varied, all objective indicators discussed above all exhibited statistical difference (P<0.05). SNR and CNR of group(100 kV, NI=6) were higher than group(120 kV, 300 mA) with 6.31%(2.69/42.66)and 7.18%(2.64/36.78), respectively. The tube voltage, NI and tube current had no effect on the subjective scores of first and second grade vessel but greater impact on the fourth and fifth grade vessel. Conclusion In the head CTA scanning, combined the use of NI 6 guided automatic adjustment tube current and low tube voltage(100 kV)technique not only can get better image quality but also significantly decreased the radiation dose.

14.
Chinese Journal of Radiology ; (12): 794-799, 2017.
Article in Chinese | WPRIM | ID: wpr-659575

ABSTRACT

Objective To study the impacts of different tube voltage and different noise index(NI) guided automatic tube current modulation on the image quality and radiation dose in cerebrovascular imaging and determine the optimal scanning condition. Methods PH3 angiographic CT head phantom was used for head CTA examination. Scanning protocols: all the scanning objectives were divided into three groups according to the different tube voltages of 80, 100 and 120 kV. Each group applied certain tube current(300,400 mA)and automatic tube current modulation technique with NI from 3 to 10 to perform head CTA. There were 30 scanning proposals with different parameter combinations of tube voltage and tube current. The radiation dose [ CT dose index volume (CTDIvol), dose length product (DLP) and effective dose (ED)], objective indicators of images(CT value of the blood vessels and its noise, CT value of brain tissue and its noise, signal-to-noise ratio , contrast-to-noise ratio) and the subjective scores of the five cerebrovascular segments were recorded. Differences of CT value of the blood vessels and its noise, CT value of brain tissue and its noise, signal-to-noise ratio and contrast-to-noise ratio between different tube voltages and tube currents were analyzed by One-Way ANOVA. Results When the tube voltage was certain, the CTDIvol, DLP and ED were all dropped while NI was increased from 3 to 10. Compared with group(120 kV, 300 mA), CTDIvol of group with 100 kV, 300 mA decreased 35.32%(12.22/34.59), CTDIvol of group(100 kV, NI=6) decreased 46.72%(16.16/34.59). Compared with group(100 kV, 300 mA), CTDIvol of group (100 kV, NI=6) decreased 17.61%(3.94/22.37). When the tube voltage was certain and the tube current and NI were not certain, there is no statistical difference (P>0.05) between CT values of blood vessel and brain, while blood vessel noise, noise of brain, SNR and CNR showed statistical difference (P<0.05). When tube current and NI were certain while tube voltage was varied, all objective indicators discussed above all exhibited statistical difference (P<0.05). SNR and CNR of group(100 kV, NI=6) were higher than group(120 kV, 300 mA) with 6.31%(2.69/42.66)and 7.18%(2.64/36.78), respectively. The tube voltage, NI and tube current had no effect on the subjective scores of first and second grade vessel but greater impact on the fourth and fifth grade vessel. Conclusion In the head CTA scanning, combined the use of NI 6 guided automatic adjustment tube current and low tube voltage(100 kV)technique not only can get better image quality but also significantly decreased the radiation dose.

15.
Article in Chinese | WPRIM | ID: wpr-807949

ABSTRACT

Objective@#To investigate Oct4 and Sox2 protein expression in tongue squamous cell carcinoma (TSCC) and the relationships between the expressions of Oct4 and Sox2 and clinical pathological characteristics and survival of patients.@*Methods@#The paraffin imbedded tissue specimens of 51 patients with histologically confirmed TSCC were included. Immunohistochemistry was employed to detect the protein expression of Oct4 and Sox2 in 51 TSCC tissue samples. The protein expression levels of Oct4 and Sox2 and their relationships with both clinicopathological features and survival of patients with TSCC were evaluated.@*Results@#In 51 TSCC cases,positive expressions of Oct4 and Sox2 were mainly located in the nucleus of tumor cells. The expression of Oct4 was strongly positive in 27 cases (53%), weakly positive in 16 (31%) and negative in 8 (16%), whereas that of Sox2 was strongly positive in 25 cases (49%), weakly positive in 22 (43%) and negative in 4 (8%). Oct4 and Sox2 expression levels were significantly correlated with the histological grade of TSCC (P=0.004, P=0.006, respectively), not correlated with age, gender, T stage, tobacco smoking and alcohol consumption status (P>0.05), but Oct4 expression level was significantly associated with lymph node metastasis (P=0.001). Sox2 expression level was not associated with lymph node metastasis (P>0.05). The expression of Sox2 was significantly correlated with Oct4 (P<0.001). Oct4 and Sox2 expression was associated with poor overall survival of patients with TSCC (P=0.001, P=0.002, respectively), cases with higher Oct4 and Sox2 expression had the poorest overall survival (P<0.001). Sox2 expression and lymph node metastasis were independent prognostic factors of overall survival in patients with TSCC (P=0.02, P=0.001, respectively).@*Conclusions@#Sox2 had independent prognostic effects on overall survival, suggesting that Sox2 expression may be an usefull indicator for predicting the prognosis of patients with TSCC.

16.
Journal of Practical Radiology ; (12): 1887-1889,1911, 2016.
Article in Chinese | WPRIM | ID: wpr-605880

ABSTRACT

Objective To investigate the gastrointestinal imaging (GI)performance of herniation of pure abdominal omental fat (PAOF)into the esophagus hiatus(EH).Methods 7 cases of PAOF herniated into EH found by GI and MSCT were collected.The performance of GI was analyzed and compared with MSCT.Results 4 cases with large soft tissue shadow around lower segment esophagus,its density are lower,esophageal mucosa was showed coarse disorderly in the range of 2-4 cm of lower segment esophageal in the mucous membrane phase,of which 1 case with the mucosal line of esophagus at the j unction of esophagus and the superior border of the soft tissue slung up.Mild stenosis lumen of flexible wall was displayed in the filling phase,the upper bound of the lesions was often visible.3 cases with obtuse His angle,of which 1 case its change was shown with position.A more larger cystic fat density shadow was showed in MSCT right side of lower segment esophagus.3 cases were almost normal GI performance,among them 1 case of esophageal diaphragmatic ampulla lasting and a smaller cystic fat density shadow was showed in MSCT right side lower segment esophagus.The connection of the lower part of cystic fat density shadow to abdominal fat was showed all in 7 cases by MSCT MPR,and left gastric artery was shown to point to or protruded into EH by arcuate form.Conclusion A slight change of mucous membrane and lumen of lower segment esophagus which bounded above with larger and fade soft tissue density shadow and His angle obtuse variable were the special GI performance of the herniation of PAOF into EH,and the diagnose depended on MSCT.

17.
Article in Chinese | WPRIM | ID: wpr-309139

ABSTRACT

<p><b>OBJECTIVE</b>This study described the clinical, surgical, and radiographic findings of simple bone cysts.</p><p><b>METHODS</b>A retrospective study was conducted for patients diagnosed with simple bone cysts in the Department of Oral and Maxillofacial Surgery of the Affiliated Stomatological Hospital of Nanchang University from March 2005 to March 2015. Clinical, radio-graphic, surgical, and follow-up data were gathered. Results were statistically analyzed by central tendency and dispersionusing SPSS 20.0 software.</p><p><b>RESULTS</b>Eleven cases of simple bone cysts were collected, including three male and eight female patients. Ten cases (90.9%) were asymptomatic and one case developed symptoms of swelling. All of the cases had no history of trauma in the affected area, and all were solitary; ten cases (90.9%) were unilocular, and one (9.1%) was multilocular.The shape of each lesion could be assigned to four categories: cone (3 cases), round (2 cases), oval (4 cases), and irregular (2 cases). The treatment in 10 cases consisted of surgery to explore the cavity and curettage of the bone walls. During surgery,the bone cavity in seven cases (70%) was vacant, whereas serous fluid was found in two cases (20%) and serous-bloody fluid in one case (10%). Of the ten cases, three cases exhibited complete bone healing and seven cases showed new bone formation.</p><p><b>CONCLUSION</b>Simple bone cysts of the jaws are usually asymptomatic and appear incidentally on routine radiographies. The prevalence is higher in the mandible and young people. The patient usually has no history of trauma, and the bone cavity of lesion is mostly vacant. Curettage of the bone walls of the lesion is suggested for simple bone cysts. Systemic clinical and radiologic follow-up are necessary to ensure successful treatment.</p>


Subject(s)
Bone Cysts , Dental Caries , Female , Hospitals , Humans , Jaw Cysts , Diagnosis , Pathology , Male , Mandible , Mandibular Diseases , Radiology , Retrospective Studies , Software
18.
Article in Chinese | WPRIM | ID: wpr-790622

ABSTRACT

Objective To evaluate the physical dependence of total Ervatamia yunnansis alkaloid .Methods The physi-cal dependence of total Ervatamia yunnansis alkaloid was observed by jump test in mice and spontaneous withdrawal test in rats .Results In the jump test ,after injecting total Ervatamia yunnansis alkaloid (total dosage of 140 and 430 mg/kg) for 7 days continuously ,the mice didn't show any withdrawal symptom and the loss of body weight .In the spontaneous withdrawal test ,two dosages of total Ervatamia yunnansis alkaloid (total dosage of 210 and 775 mg/kg) were continuously given for 30 days .The withdrawal response and the loss of body weight were not found in rats after drug withdrawal .Conclusion Total Ervatamia yunnansis alkaloid showed no obvious withdrawal symptoms in mice and rats ,which suggests that it has no physical dependence .

19.
China Pharmacy ; (12): 4532-4533,4534, 2015.
Article in Chinese | WPRIM | ID: wpr-605233

ABSTRACT

OBJECTIVE:To observe the changes of heart type fatty binding protein (H-FABP) and brain natriuretic peptide (BNP)when carvedilol and bisoprolol in the treatment of elderly patients with chronic heart failure(CHF). METHODS:110 CHF patients were randomly assigned into carvedilol group and bisoprolol group (n=55). Carvedilol group was given carvedilol 3.125 mg,bid,doubling dose every 2 weeks to reach target dose 25mg or maximum tolerant dose;bisoprolol group was given bisoprolol 1.25 mg,qd,doubling dose every 2 weeks to reach target dose 10 mg or maximum tolerant dose. Treatment course lasted for 6 months. Clinical effective rate of 2 groups were observed after treatment. Echocardiography was used to measure the changes of LVEDD,LVEF,SBP and DBP before and after treatment. The plasma concentration of BNP and H-FABP were measured by radio-immunoassay. RESULTS:After treatment,total effective rate of carvedilol group(96.4%)was higher than that of bisoprolol group (89.2%),with statistical significance(P<0.05). Compared with before treatment,the levels of LVEDD,LVEF,BNP,H-FABP, SBP and DBP in 2 groups were all decreased significantly after treatment,with statistical significance (P<0.01 or P<0.05). CON-CLUSIONS:Both carvedilol and bisoprolol can significantly improve cardiac function,but carvedilol efficacy is more significant. At the same time,significant decrease of H-FABP before and after treatment indicate that H-FABP can be used as a reliable index of heart failure treatment effect.

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Chinese Journal of Geriatrics ; (12): 1265-1268, 2013.
Article in Chinese | WPRIM | ID: wpr-439277

ABSTRACT

Objective To evaluate the correlation between plasma high sensitivity C reactive protein (hs-CRP) level and global registry of acute coronary events (GRACE) scores,and its predictive value for long-term (5 years) cardiovascular events in middle-aged and elderly patients with acute coronary syndrome (ACS).Methods 138 middle aged and elderly patients with ACS were divided into three groups according to GRACE scores:low risk group,middle risk group,high risk group.And based on quartiles of hs-CRP levels,subjects were segregated into 4 groups (Q1 to Q4).All subjects were followed up for about 5 years and adverse cardiovascular disease events were recorded.Results The hs-CRP level was gradually increased along with increasing risk according to GRACE risk stratification (hs-CRP low risk group,0.09 ± 0.22 ; middle risk group,0.21 ± 0.04 ;high risk group,0.43±0.23,P<0.001).Meantime,GRACE risk scores were gradually increased along with increasing hs-CRP levels from Q1 to Q4 (Q1:133.0 ± 43.6; Q2:161.9 ± 60.2; Q3:169.3±52.6; Q4:188.4±47.5; all P<0.001).Regression analysis showed that hs-CRP level was positively correlated with GRACE risk scores (r=0.576,P<0.001).During a follow-up period of about 5 years,96 cardiovascular events were recorded.Receiver operating characteristic(ROC) curve analysis showed that area under the ROC curve (AUC) of hs-CRP was 0.821 (95 %CI:0.749-0.892,P<0.001) and AUC of GRACE risk score was 0.869 (95%CI:0.801 0.938,P<0.001) in the evaluation of the long-term risk of incident cardiovascular events.The differences in prediction of long-term cardiovascular events in middle-aged and elderly patients with ACS were not significant (P =0.237) between GRACE risk score and hs CRP level.Conclusions Plasma hs-CRP level is positively associated with GRACE score.Both of them can predict long-term adverse cardiovascular events in middle-aged and elderly patients with acute coronary syndrome.

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