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1.
Chinese journal of integrative medicine ; (12): 291-298, 2023.
Article in English | WPRIM | ID: wpr-971342

ABSTRACT

OBJECTIVE@#To explore the effects of Zishen Yutai Pills (ZYPs) on the quality of oocytes and embryos, as well as pregnancy outcomes in patients with diminished ovarian reserve (DOR) receiving in vitro fertilization-embryo transfer (IVF-ET). The possible mechanisms, involving the regulation of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), were also investigated.@*METHODS@#A total of 120 patients with DOR who underwent their IVF-ET cycle were randomly allocated to 2 groups in a 1:1 ratio. The patients in the treatment group (60 cases) received ZYPs from the mid-luteal phase of the former menstrual cycle by using gonadotropin-releasing hormone (GnRH) antagonist protocol. The patients in the control group (60 cases) received the same protocol but without ZYPs. The primary outcomes were the number of oocytes retrieved and high-quality embryos. Secondary outcomes included other oocyte or embryo indices as well as pregnancy outcomes. Adverse events were assessed by comparison of the incidence of ectopic pregnancy, pregnancy complications, pregnancy loss, and preterm birth. Contents of BMP15 and GDF9 in the follicle fluids (FF) were also quantified with enzyme-linked immunosorbent assay.@*RESULTS@#Compared with the control group, the numbers of oocytes retrieved and high-quality embryos were significantly increased in the ZYPs group (both P<0.05). After treatment with ZYPs, a significant regulation of serum sex hormones was observed, including progesterone and estradiol. Both hormones were up-regulated compared with the control group (P=0.014 and 0.008), respectively. No significant differences were observed with regard to pregnancy outcomes including implantation rates, biochemical pregnancy rates, clinical pregnancy rates, live birth rates, and pregnancy loss rates (all P>0.05). The administration of ZYPs did not increase the incidence of adverse events. The expressions of BMP15 and GDF9 in the ZYPs group were significantly up-regulated compared with the control group (both P<0.05).@*CONCLUSIONS@#ZYPs exhibited beneficial effects in DOR patients undergoing IVF-ET, resulting in increments of oocytes and embryos, and up-regulation of BMP15 and GDF9 expressions in the FF. However, the effects of ZYPs on pregnancy outcomes should be assessed in clinical trials with larger sample sizes (Trial reqistration No. ChiCTR2100048441).


Subject(s)
Infant, Newborn , Pregnancy , Female , Humans , Fertilization in Vitro/methods , Ovarian Reserve , Prospective Studies , Premature Birth , Embryo Transfer/methods , Ovulation Induction/methods , Gonadotropin-Releasing Hormone/therapeutic use
2.
Acta Academiae Medicinae Sinicae ; (6): 16-23, 2020.
Article in Chinese | WPRIM | ID: wpr-793069

ABSTRACT

To explore the mechanism of obstructive sleep apnea(OSA) by assessing the association between human TWIK-related acid-sensitive K channel-1(TASK-1) gene and OSA. A total of 164 patients with severe OSA and 171 patients without OSA were recruited from the Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region,China,from April to December 2016.Two single nucleotide polymorphisms(rs1275988 and rs2586886) in the TASK-1 gene were selected and genotyped using a Kompetitive Allele Specific PCR genotyping system. In patients with blood potassium 3.95 mmol/L in patients with TASK-1 GG genotype may be conducive to reducing the incidence of severe OSA.

3.
Chinese Medical Journal ; (24): 2059-2065, 2019.
Article in English | WPRIM | ID: wpr-802850

ABSTRACT

Background@#The pathogenesis of obstructive sleep apnea (OSA) remains not fully understood. This study aimed to explore the mechanism of OSA by assessing the association between the human tandem of P domains in a weak inwardly rectifying K+ channel (TWIK)-related acid-sensitive K+ channel-1 (TASK-1) gene and OSA.@*Methods@#A total of 164 patients with severe OSA and 171 patients without OSA were recruited from the Center for Hypertension of People’s Hospital of Xinjiang Uygur Autonomous Region (China) from April to December in 2016. Two single nucleotide polymorphisms (rs1275988 and rs2586886) in the TASK-1 gene were selected and genotyped using a kompetitive allele specific polymerase chain reaction genotyping system. Clinical-pathological characteristics and genotype data were compared between the severe and non-OSA groups to explore the association between TASK-1 gene polymorphism and severe OSA.@*Results@#There were no significant differences in genotype distribution, allele frequency, and the recessive and dominant model of the two selected single nucleotide polymorphisms (rs1275988 and rs2586886) between the severe and non-OSA groups in the total population (P < 0.05). However, for patients with a body mass index (BMI) ≥28 kg/m2, the distribution of genotypes and alleles, and the recessive model (GG + GA vs. AA) exhibited significant differences between the severe and non-OSA group (for genotypes: P = 0.014 and P = 0.026; for alleles: P = 0.006 and P = 0.011; for the recessive model: P = 0.005 and P = 0.009, respectively). The simple logistic regression analysis revealed that the GG genotype was a risk factor for OSA. The odds ratio (OR) and 95% confidence intervals (CI) were 4.902 (1.582–15.186, P = 0.006) for rs1275988 and 4.420 (1.422–13.734, P = 0.010) for rs2586886, respectively. In multivariate logistic regression analysis, the combination of GG genotypes of rs1275988 with BMI ≥28 kg/m2 increased the risk of severe OSA (OR = 8.916, 95% CI 4.506–17.645, P < 0.001).@*Conclusion@#Both the GG genotype of rs1275988 and GG genotype of rs2586886 in the TASK-1 gene may play as potential risk factors in obese patients with OSA.

4.
Chinese Medical Journal ; (24): 2059-2065, 2019.
Article in English | WPRIM | ID: wpr-774656

ABSTRACT

BACKGROUND@#The pathogenesis of obstructive sleep apnea (OSA) remains not fully understood. This study aimed to explore the mechanism of OSA by assessing the association between the human tandem of P domains in a weak inwardly rectifying K channel (TWIK)-related acid-sensitive K channel-1 (TASK-1) gene and OSA.@*METHODS@#A total of 164 patients with severe OSA and 171 patients without OSA were recruited from the Center for Hypertension of People's Hospital of Xinjiang Uygur Autonomous Region (China) from April to December in 2016. Two single nucleotide polymorphisms (rs1275988 and rs2586886) in the TASK-1 gene were selected and genotyped using a kompetitive allele specific polymerase chain reaction genotyping system. Clinical-pathological characteristics and genotype data were compared between the severe and non-OSA groups to explore the association between TASK-1 gene polymorphism and severe OSA.@*RESULTS@#There were no significant differences in genotype distribution, allele frequency, and the recessive and dominant model of the two selected single nucleotide polymorphisms (rs1275988 and rs2586886) between the severe and non-OSA groups in the total population (P > 0.05). However, for patients with a body mass index (BMI) ≥28 kg/m, the distribution of genotypes and alleles, and the recessive model (GG + GA vs. AA) exhibited significant differences between the severe and non-OSA group (for genotypes: P = 0.014 and P = 0.026; for alleles: P = 0.006 and P = 0.011; for the recessive model: P = 0.005 and P = 0.009, respectively). The simple logistic regression analysis revealed that the GG genotype was a risk factor for OSA. The odds ratio (OR) and 95% confidence intervals (CI) were 4.902 (1.582-15.186, P = 0.006) for rs1275988 and 4.420 (1.422-13.734, P = 0.010) for rs2586886, respectively. In multivariate logistic regression analysis, the combination of GG genotypes of rs1275988 with BMI ≥28 kg/m increased the risk of severe OSA (OR = 8.916, 95% CI 4.506-17.645, P < 0.001).@*CONCLUSION@#Both the GG genotype of rs1275988 and GG genotype of rs2586886 in the TASK-1 gene may play as potential risk factors in obese patients with OSA.

5.
Chinese Journal of Clinical and Experimental Pathology ; (12): 42-45, 2018.
Article in Chinese | WPRIM | ID: wpr-695061

ABSTRACT

Purpose To investigate the consistency and clinicopathologic correlation of BRAFV600E protein expression and gene mutation in papillary thyroid carcinoma. Methods BRAFV600E protein expression and genn mutation was detected respectively by immunohistochemistry of SP and real time-PCR, then the consistency between the both methods was analyzed by Kappa-test, the correlation between BRAFV600E and clinicopatho-logic parameters was analyzed by Chi-square test in papillary thyroid carcinoma. Results The gene mutation and protein expression rates of BRAFV600E were 89.3% and 88.3%, respec-tively, the differences were not significant, the concordance rate of the both methods was 97.0%, Kappa value was 0.847, the consistence was higher, meanwhile the mutation rates between age <45 and ≥45 were respectively 96.8% and 85.9%, there were significant differences, the positive rates of the both detec-tion methods were higher in thyroid capsule invaded group than non-invaded group, the differences were significant. Conclusion The both methods have higher consistency, the immunohisto-chemistry can be used as an initial screening tool for detecting gene mutation, the gene mutation of BRAFV600E is significantly associated with age and capsule invasion, the relationship is not found between BRAFV600E mutation and the other clinicopatholog-ic parameters.

6.
Journal of Kunming Medical University ; (12): 69-73, 2018.
Article in Chinese | WPRIM | ID: wpr-751934

ABSTRACT

Objective To explore the significance of modified pediatric early warning score (MPEWS) in emergency early warning triage and classification. Method Selecting ill children who came to emergency department from February of 2017 to January of 2018 as objects of study, and triage nurses of emergency department gave MPEWS to the sick children under the demand of the filed data collection. Furthermore, according to the five levels of disease severity classification, doctors gave the disease assessment and classification to the sick children, finding the relevance between the MPEWS and the severity of the disease.Result Consequently, there is a relevance between the MPEWS scores and the severity of the disease indeed (rs=-0.630, P < 0.001). The data show that the higher of the scores, the lower disease level, and the higher severity of the disease. ROC areas under the curve of the subjects is 0.996, and the confidence interval is 0.993-0.999 (P <0.05). That indicates that MPEWS exists statistical significance of emergency children judgement. The optimal number is 4.5, the sensitivity is 96%, and the specificity is 99.9%.Conclusions MPEWS is valuable in emergency early warning triage, children emergency severity assessment and identifying critical ill children in time.

7.
Acta Pharmaceutica Sinica ; (12): 1255-1261, 2017.
Article in Chinese | WPRIM | ID: wpr-779720

ABSTRACT

This study was designed to investigate the effect of minocycline on microglia activation of M1/M2 phenotypes. The model was induced by lipopolysaccharide (LPS) in BV-2 microglia cells, and was used to evaluate the effect and mechanism of minocycline. We measured nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1 beta (IL-1β) in M1 type microglia, and interleukin-10 (IL-10) and transforming growth factor beta (TGF-β) in M2 type microglia through enzyme linked immunosorbent assay (ELISA). We used flow cytometry to detect the expression of M1 marker CD16/32 and M2 marker CD206 in order to evaluate the influence of minocycline on microglia activation of M1/M2 polarization. Finally, we explored the mechanism of minocycline through detection of the protein expression in response to activation of toll like receptor 4 (TLR4)-mediated myeloid differentiation factor 88 (MyD88) dependent pathway, mitogen activated protein kinase (MAPK) signaling and nuclear factor-κB (NF-κB). The results suggest that minocycline obviously inhibited the production of NO, PGE2, TNF-α and IL-6, and increased the production of IL-10, TGF-β in LPS-stimulated BV-2 cells. Minocycline significantly down-regulated the expression of M1 marker CD16/32 and up-regulated the expression of M2 marker CD206. These results suggest that minocycline can inhibit the activation of microglia to M1 phenotype and promote the transformation of M2 phenotype through down-regulation of p38 and NF-κB signaling pathways.

8.
National Journal of Andrology ; (12): 234-238, 2015.
Article in Chinese | WPRIM | ID: wpr-319513

ABSTRACT

<p><b>OBJECTIVE</b>To explore various factors affecting the clinical pregnancy outcomes of artificial insemination with donor sperm (AID).</p><p><b>METHODS</b>We retrospectively analyzed 15,744 cycles of AID in 6302 women and investigated the association of the clinical pregnancy outcomes of AID with the treatment protocols, the times of insemination per cycle, the age of the infertile women, the status of the oviduct, and the number of AID cycles.</p><p><b>RESULTS</b>The pregnancy rate of AID was higher in the chlomiphene-treated women than in those of the natural cycle group (P = 0.003) but showed no significant differences either between the chloramiphene and human menopause gonadotropin (HMG) or between the HMG and natural cycle groups (P > 0.05), and so was it in the women that had received AID twice per cycle before and after ovulation (26.3%) than in those that had undergone only once before (7.0%) or after ovulation (23.7%) (P < 0.05). However, the pregnancy rate was remarkably lower in the women aged 35-40 years (16.5%), especially in those over 40 years (1.2%), than in those under 35 years (26.0%) (P < 0.05). There was no significant difference in the success rate of AID between the women with oviductal adhesion and those without (27.4% vs. 28.1%, P > 0.05). The pregnancy rate of the first cycle of AID (27.6%) was markedly higher than those of the second (24.7%), third (23.9%), and fourth (23.1%) (P < 0.01), but with no significant differences among the latter three cycles (P > 0.05), while that of the fifth cycle (19.0%) was remarkably lower than those of the first four (P < 0.01).</p><p><b>CONCLUSION</b>The age of the infertile women is an important factor affecting the success rate of AID. AID twice per cycle is better than once only. For those without oviductal factors, at least 4 cycles of AID are required before in vitro fertilization.</p>


Subject(s)
Adult , Female , Humans , Pregnancy , Age Factors , Fertilization in Vitro , Infertility, Female , Insemination, Artificial , Insemination, Artificial, Heterologous , Ovulation , Ovulation Induction , Pregnancy Outcome , Pregnancy Rate , Retrospective Studies
9.
Chinese Journal of Epidemiology ; (12): 983-986, 2011.
Article in Chinese | WPRIM | ID: wpr-241197

ABSTRACT

Objective Characteristics on AIDS high-risk behaviors in gay or bisexual men with suicide ideas were explored and analyzed.Methods A cross-sectional survey was conducted with the snowball sampling method adopted.Subjects with suicide ideas were collected from responses to the valid questionnaires and subjects with no suicide ideas were collected from the age comparable men.Results The overall rate of gays or bisexuals with suicide ideas was 20.2% in this survey.The attitude for homogeneity and marital status among the unmarried was more than that among the comparable group (P<0.05).The rate of AIDS high-risk behaviors as same-sex sexual harassment,bleeding during sexual intercourse in the last year,coitus with unfamiliar same-sex partners in cities,suffering from adult same-sex sexual abuse before the age of 16,having had sexual abuse and abusive behavior,having had active or passive anal kiss,having had active or passive coitus with fingers,alcohol consumption weekly at least once or more,hurt by gays because of attitude and/or same-sex sexual activity and hurt by heterosexual men because of attitude and/or same-sex sexual activity were significantly higher in gays and bisexual men with suicide ideas than those without (P<0.05).Data from multivariate logistic regression models suggested that harm from gays (Waldx2=6.637,P=0.010) and heterosexual men (Waldx2=5.835,P=0.016) due to attitude on homosexual activity appear to be the risk factors causing the suicide ideas.Conclusion Reducing the social discrimination and harm towards gays and bisexual men could reduce the occurrence of the suicide ideas and have a positive effect on curbing the prevalence of AIDS.

10.
Chinese Journal of Epidemiology ; (12): 642-646, 2010.
Article in Chinese | WPRIM | ID: wpr-277720

ABSTRACT

Objective To explore the situation of AIDS-related high risk behaviors among men who have sex with men (MSM) ever experienced partner-seeking in different sites. Methods Target sampling for cross-sectional study ( "snowball" ) and valid anonymous questionnaires were adopted to compare the differences of high risk behaviors related to AIDS. 1834 MSM were studied in nine cities who sought sex partners through internet, bars or bath ponds. Results Compared to the other corresponding groups, those MSM from the bath pond group had a significant larger number of total sexual partners, chances of having anal and oral sex with same sex, and ones of anal sex in the previous six months with the median number as 40, 16, 20 and 4 respectively. Interact group had a higher rate of bleeding (36.4%) when having sexual intercourse in the previous year and a lower proportion of 8.7% exchanged sex for money, and 14.9% and 13.3% in both bar and bath pond groups respectively. Bar group had significant lower rates of condom use with 79.6% while having sex with men and 45.3% with women, but higher rates(28.9% ) ever participated in group sex in the last year and 4.2% with H1V infection. Conclusion MSM had high risk behaviors related to AIDS appeared in different sites when seeking partners. Intervention strategy should be taken, according to the characteristics of different subpopulations, especially on the bath pond group.

11.
Chinese Journal of Epidemiology ; (12): 1223-1226, 2010.
Article in Chinese | WPRIM | ID: wpr-277699

ABSTRACT

Objective To investigate the AIDS-related high risk behaviors of men who havesex with men (MSM) who ever exchanged money for the same sex. Methods Target sampling forcross-sectional study and valid anonymous questionnaires were adopted to compare the differences ofAIDS-related high risk behaviors between MSM with the experience of exchanging money for thesame sex and those without that experience. 1959 rstadied samples were recruited in nine cities. SPSS13.0 was used and t, x 2 and Mann-Whitney tests were taken for statistical analysis. ResultsCompared to corresponding ones without "buying" the same sex experience, MSM who ever engagedin "buying" sex had the characteristics of being prone to in marriage and living in larger cities witholder age and higher income (P<0.01). They also had a significant larger number in the followingevents: total sexual panners, anal sex and oral sex episodes with same sex, number of sexualpartners, anal sex and oral sex in the previous six months, with the figure of median 50.0, 20.0,20.0, 5.0,4.0,5.0 respectively. 31.5% had ever participated in 'group sex', 48.0% had sex with malepartners away from his own region in the previous year, 70.5% had sexual intercourse withstrangers at MSM avenues in the last six months. The OR (95% CI) values were 2.288( 1.702-3.077), 3.231 (2.462-4.241 ), 2.840 (2.140-3.770). All the above mentioned figures werehigher than those without the experience, with significant differences. They had a significant lower rate of 45.7% of condom use while having sex with female partners (P<0.05). Conclusion MSM with the experience of exchanging money for the same sex would have more AIDS-related high risk behaviors, AIDS preventative measures should be taken to target different subgroups.

12.
Chinese Journal of Epidemiology ; (12): 142-145, 2010.
Article in Chinese | WPRIM | ID: wpr-277672

ABSTRACT

Objective To investigate the behavioral characteristics of men who have sex with men(MSM)with sadomasochism associated bleeding and to analyze the relationship with HIV/AIDS high risk behavior.Methods Using modified snowball sampling methods(target sampling methods)to carry out a cross-sectional study on persons with behavior of sadomasochism that associated with bleeding in MSM,using a valid questionnaire.Another control group without the related behavior was set up.SPSS 13.0 was used.Results People practicing sadomasochism associated with bleeding had higher percentage in the following indicators:number of accumulated same gender sexual partners (median=20),anal intercourse(median=10),oral intercourse(median=10),hand intercourse (median=15)with same gender sexual partners,number of same gender sexual partners in the previous six months(median=4),numbers of anal intercourse(median=3),hand intercourse(median=3),were more than in the control group.People with sadomasochism associated bleeding had higher rates in the following behaviors:condom was ever broken or slipped in the previous six months (22.6%),suffering from disease of sexual transmitted infections(28.0%),involving in group-sex intercourse(34.8%),having sex with same sex strangers at the place for MSM in the previous six months(62.2%),ever having initiative or passive behavior of oral-anal sex(64.0%),fist-sex(18.9%),finger-sex(66.7%),bleeding during sexual intercourse(58.3%),first coition object was pupil (33.8%),having strong suicide attempts(33.3%)and suicide attempt(23.6%)etc.were more than in the control group.Conclusion MSM who had the behavior of sadomasochism which associated with bleeding had the higher percentage of HIV/AIDS high risk behaviors than the persons without those behaviors.The latter group called for special concern on interventions.

13.
Chinese Journal of Epidemiology ; (12): 10-13, 2009.
Article in Chinese | WPRIM | ID: wpr-329547

ABSTRACT

Objective To explore the risk of sexual behaviors related to AIDS among unmarried men who often have sex with women.Methods Study objectives were recruited through target sampling and anonymous questionnaires were adopted.Men' s sexual behaviors were compared with each other between the group of men who always had sex with women (group A) and who never had sex with women (group B) in the past 6 months.Results The average numbers of same-gender partners among group A who acted as the male role in the past 6 months and who had anal intercourse in the last month were 5.64 and 3.09 respectively,which were both higher than those of group B's (P< 0.05).The rate of condom use among men in group A when having sex with men was 81.94% .The percentages of condom use among men in group A who having had oral or anal sex with male sex buyers last time were 15.38% and 70.27% respectively.They were all higher than those of group B' s (P<0.05 or 0.01 ).The rates of men in group A who were male sex workers and who having had sex with unknown men in gay places during the past 6 months were 27.59% and 61.70% respectively.Among group A,the percentages of men who had had sex with unknown men during the last time and who had had sex with nonlocal male partners during the past year were 43.06% and 40.28% respectively.They were all higher than those of group B's (P<0.01).The percentage of condom use among men in group A when having had sex with women during the past 6 months was 68.94%,but only 25.96% of the men used condom regularly.The rate of condom use in men from group A when having sex with women during the last sexual intercourse was 65.45%.Conclusion HIV high-risk sex behaviors were more ubiquitous among unmarried MSM who always had sex with women,suggesting that different interventions be developed to prevent them from transmitting HIV from MSM to women or other men.

14.
Chinese Journal of Epidemiology ; (12): 14-17, 2009.
Article in Chinese | WPRIM | ID: wpr-329546

ABSTRACT

Objective To study the AIDS related high risk behaviors and psychological appearances among men who have sex with men (MSM) who ever experienced childhood sexual abuse (CSA).Methods Target sampling for a cross-sectional study was developed and valid anonymous questionnaires were adopted to compare the differences of high risk behaviors related to AIDS and psychological appearances betwen those with or without CSA experiences among 2147 MSM from nine cities.Results Compared to corresponding ones without CSA experience,CSA group had a significant larger numbers in the following events: total sexual partners,anal sex episodes with same sex,female sexual partners and anal sex in the previous six months,with the figures of median as 20.0,10.0,3.0,3.0 respectively.In the previous year,30.8% of them had ever participated in 'group sex',19.2% ever exchanged money for sex,36.7% bled while having sexual intercourse,37.3% had sex with male partners away from his own region.All the above said figures were higher than non-CSA group,with significant differences.It also appeared that CSA experience had an impact on significant lower rate of condom use (67.3%) in the last anal sex.Those with CSA experience had more psychological problems which appeared as: 75.6% considered they would suffer from serious discrimination if their sexual orientation ever disclosed,34.7% had a strong intention of suicide and 24.3% ever having had suicidal attempts.The differences of the two groups showed statistical significance.Condusion CSA experience not only increased the number of AIDS related high risk behaviors in adulthood,but also had negative impact on their psychological appearances.It is of urgent need to carry out psychological intervention approaches to target on MSM with CSA experiences while childhood sexual education and rights assurance towards juvenile population should also not be neglected.

15.
Chinese Journal of Epidemiology ; (12): 668-671, 2009.
Article in Chinese | WPRIM | ID: wpr-266465

ABSTRACT

Objective To explore the risks on sexual behaviors related to AIDS among men who having sex with men (MSM) in floating population and to develop relevant interventions. Methods Study objectives were recruited through target sampling and anonymous questionnaires were adopted. Male sexual behaviors were compared between floating population and permanent registered residents.Results Among those MSM, the average numbers of same-gender partners, oral sex, anal sex and sex with females during the past 6 months among floating population were 9.61, 8.61, 7.52 and 1.17 respectively. Numbers of partners on oral sex and anal sex during the past month were 2.89 and 3.69 respectively. Both figures were higher than those of the permanent registered residents (P<0.05 or P< 0.01). The rates of condom use among floating population when having anal sex with men or with non-marital female partners were 37.15% and 23.28% respectively. The figures were all higher than those of permanent registered residents' (P<0.05 or P<0.01). Among floating population, the percentages of men who had sex with male sex workers or who had sex with men acquainted through inter-net or with stable female sex partners were 17.89%, 12.56%, and 31.86% respectively. The rates of men who had group sex among gay men, who bled when having sex with men or who had sex with men from other areas during the past year were 22.13%, 31.38% and 32.36% respectively. The figures were all higher than those of permanent registered residents' (P<0.05 or P<0.01). Conclusion Sex-related high risk behaviors were more ubiquitous among floating population than those of permanent registered residents because they were more likely to transmit HIV to people from/to other areas. More attention should be paid to the floating population with MSM in particular, when health interventions are carried out.

16.
Chinese Journal of Epidemiology ; (12): 426-429, 2008.
Article in Chinese | WPRIM | ID: wpr-313152

ABSTRACT

Objective To evaluate the effects of socioeconomic status on the distribution of cardiovascular risk factors and clinicaltreatments of patients with acute myocardial infarction in Beijing.Methods In Beijing, a prospective, muhi-center, registration study was carried out which including 800 patients who were consecutively hospitalized for ST-segment elevation acute myocardial infarction within 24 hours after event attack in 19 different hospitals in Beijing between November, 2005 and December, 2006.Indicators of socioeconomic status included self-reported personal income (<500, 500-2000,>2000 RMB/month), educational attainment (≤ 12 and > 12 years) and status of medical insurance (yes/no).According to categories of education, patients were categorized into two groups of lower socioeconomic status and higher socioeconomic status. Differences of cardiovascular risk factors and clinical treatments were compared across the two groups respectively. Results Proportion of diabetes and hyperlipidemia in patients with higher socioeconomic status was much higher than that of patients with lower socioeconomic status (P<0.05, P<0.01 respectively). Patients with lower socioeconomic status were more likely to be smokers (P <0.05). The rates of receiving coronary angiography and PTCA were much lower in patients with lower socioeconomic status. Medical insurance and income were the most important two socioeconomic factors determining the use of PTCA. Conclusion Compared to patients with lowersocioeconomic status,patients with higher socioeconomic status had higher rates of hyperlipidemia and diabetes but lower smoking rate among cardiovascular risk factors. The rates of receiving interventional therapies were much lower in patients with lower socioeconomic status.

17.
Chinese Journal of Epidemiology ; (12): 685-688, 2008.
Article in Chinese | WPRIM | ID: wpr-313114

ABSTRACT

Objective To explore the associations between partner-seeking activities through internet and HIV/AIDS related risk behaviours among men who have sex with men(MSM).Methods Target sampling.anonymous questionnaires were adopted and analyzed with SPSS 11.0.Results Data from 45.6% of the 2178 valid questionnaires showed that most partner-seeking activities was through internet.73.1% of them landed on gay website.in which 83.0% looked for sexual partners and 91.7% of them had intercourse with other men met through internet when compared with MSM who did not seek sex activities through internet.The internet group obviously had fewer numbers of partners(5.73 vs.10.3),oral sex partners(5.13 vs.8.71),passive anus sex partners(4.67 vs.8.26)and active anus sex partners (3.51 vs.6.06)in the past 6 months(P<0.01 respectively)and obviously had fewer group sex(16.7% vs.20.5%)activities in the past one year but had more activities on oral sex(94.7% vs.89.6%),anus sex(95.1% vs.86.5%),regular sexual partner(52.6% vs.46.7%)in the past 6 months(83.4% vs.75.5%)(P<0.01 respectively)and more likely to have finger intercourse(52.2% vs.38.5%),hemorrhage sexual intercourse(36.4% vs.21.9%,OR=2.04),non-local sexual intercourse(28.1% vs.22.7%)(P<0.01 respectively).Conclusion Seeking sexual partners through internet had positive and double effects on MSM's risk behaviours.suggesting that it is of urgent need to take the advange of internet and gay website to disseminate HIV/AIDS prevention message.

18.
Chinese Journal of Pathology ; (12): 305-308, 2008.
Article in Chinese | WPRIM | ID: wpr-306025

ABSTRACT

<p><b>OBJECTIVE</b>To study the loss of heterozygosity (LOH) on chromosome 3p in thyroid tumors.</p><p><b>METHODS</b>LOH at 11 microsatellite loci was analyzed in 74 cases of thyroid tumors (including 20 follicular adenomas, 24 follicular thyroid carcinomas and 30 papillary thyroid carcinomas) by polymerase chain reaction and silver stain.</p><p><b>RESULTS</b>LOH on chromosome 3p was detected in 71% of follicular thyroid carcinoma (17/24), 30% of the papillary thyroid carcinoma (9/30) and 10% of the follicular adenoma (2/20) case. Two minimal common deleted regions (CDR) (3p26-pter and 3p14.2-3p22) involving significant sites of LOH has identified in follicular thyroid carcinoma. There was also one CDR (3p25. 2-26.1) in papillary thyroid carcinoma.</p><p><b>CONCLUSIONS</b>LOH is more frequently identified in follicular thyroid carcinoma than in papillary thyroid carcinoma and follicular adenoma. The 3 CDR on chromosome 3p may harbor tumor suppressor genes involved in the pathogenesis of follicular thyroid carcinoma and papillary thyroid carcinoma.</p>


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Adenocarcinoma, Follicular , Genetics , Adenoma , Genetics , Carcinoma, Papillary , Genetics , Chromosome Mapping , Chromosomes , Chromosomes, Human, Pair 3 , Genetics , Genes, Tumor Suppressor , Physiology , Heterozygote , Loss of Heterozygosity , Microsatellite Repeats , Thyroid Neoplasms , Genetics
19.
Chinese Journal of Epidemiology ; (12): 844-847, 2007.
Article in Chinese | WPRIM | ID: wpr-294226

ABSTRACT

<p><b>OBJECTIVE</b>To study the risk sexual behaviors related to AIDS between heterosexual and homosexual men who have had sex with men.</p><p><b>METHODS</b>Target sampling, anonymous questionnaires were adopted to compare sexual behaviors between the two groups.</p><p><b>RESULTS</b>The total amount of sex partners with same-sex was 13.8 on average among heterosexual men including 3.8 with male partners in the past 6 months. Numbers of male partners who had oral sex with was 10.5 and anal sex was 12.4 which were both less than with same sex. Among heterosexual men, the total number of female partners was 4.9 on average but number of female partners in the past 6 months was 1.7 which were both more than that among the homosexuals who were all in marriage status. The rate of condom use was 68.8% (lower than that among homosexual men), among heterosexual men when having sex with men. The rate of condom use among heterosexual men during last anal intercourse was 91.3% with male partners or 63.7% with females. Both figures were higher than that among the homosexuals. The rates of condom use among the two groups were 91.3% and 71.0% respectively during the last anal intercourse with men which were higher than the corresponding rate of condom use during the last oral sex. The rate of heterosexual men who ever had engaged in group sex was 9.9% in the previous year and the incidence of bleeding was 16.7% during sexual intercourse. 11.4% of them reported ever having had sex with partners from other areas in the last year and 4.2% had experienced same-sex harassment before 16 years of age. 4.6% had paid for male-male sex. All these figures were lower than that of the homosexuals.</p><p><b>CONCLUSION</b>The characteristics of high risk sexual behaviors related to AIDS showed much difference in the two groups which called for attention among these groups of MSM.</p>


Subject(s)
Adult , Humans , Male , Young Adult , Acquired Immunodeficiency Syndrome , Epidemiology , Condoms , Heterosexuality , Homosexuality, Male , Risk Factors , Risk-Taking , Sexual Partners
20.
Chinese Journal of Epidemiology ; (12): 32-36, 2007.
Article in Chinese | WPRIM | ID: wpr-261656

ABSTRACT

<p><b>OBJECTIVE</b>To study the HIV related high-risk behaviors and associated factors on the spread of HIV among men having sex with men(MSM) who lived in mainland China and to provide evidence for developing related policies and intervention measures.</p><p><b>METHODS</b>Questionnaires were distributed at gay bars and volunteer activity venues in six big cities of China. Data on 1389 valid cases was collected and urine HIV screening test was provided. Data was analyzed with SPSS 11.0.</p><p><b>RESULTS</b>The respondents were 27.62 year olds on average with an average age for first intercourse at 19.18. The most commonly available way of finding a sex partner was through internet(43.07%), followed by gay bar and public bathrooms(35.29 % ). 6 months prior to the study, the average number of their male sex partners was 5.69 including 4.37 unfamiliar sex partners and the average number of anal-intercourse was 4.33 with 11.61 per cent of them had experienced group sex. 13 cases of them showed positive results for preliminary urine HIV screening test. In the prior 6 months, 32.46 per cent of those who had experienced intercourse using condom every time while 76.37 per cent of them during the last sex episode. In the previous 6 months, 47.18 per cent of those who had experienced intercourse with women never used condoms.</p><p><b>CONCLUSION</b>HIV high-risk behaviors are ubiquitous among MSM and AIDS intervention measures should be significantly strengthened in reaching MSM via a wide variety of conduits, especially internet. Meanwhile, a gay-friendly environment for prevention and control of AIDS is vital.</p>


Subject(s)
Adolescent , Adult , Aged , Humans , Male , Middle Aged , Young Adult , China , HIV Infections , Epidemiology , Psychology , Homosexuality, Male , Risk Factors , Sexual Partners , Psychology , Surveys and Questionnaires , Unsafe Sex , Psychology
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