Research in effect of modified drug preparation method on reduction of air bubble formation in infusion bags / 中国实用护理杂志

Objective To investigate a new method to reduce air bubbles formation during drug preparation. Methods 200 portions of drugs from hospital pharmacy were randomly divided into the control group and the experimental group with 100 portions in each group. In the experimental group, the infusion bags were put flat on the desktop, the needles pierced into the bags parallel, and immersed in the liquid inside. In the control group, the infusion bags were put perpendicular to the desktop, the needle pierced into the bags vertically, the needles do not immersed in the liquid. Air bubble formation in the infusion bags was compared between the two groups. Results Air bubble formation in the experimental group was significantly less than that of the control group. Conclusions The modified new method for drug preparation can reduce the formation of air bubbles.

Effect of valsartan on the expressions of Toll-like receptor 4 and myeloid differentiation factor 88 in the arteries of diabetic rats / 中华内分泌代谢杂志

ay be useful for preventing or treating early inflammation in the arteria of diabetic rats.

Regulative effect of complement factor H and adrenomedullin on HBZY-1 rat mesangial cells cultured under high glucose concentration / 中华内分泌代谢杂志

The renal protective effect of complement factor H(CFH)and adrenomedullin (AM) on rat mesengial ceils (HBZY-1) cultured under high glucose levels was investigated. Results indicated that AM and CFH inhibited the expressions of transforming growth factor-β1 and extracellular matrix in HBZY-1 cells, suggesting that CFH and AM in combination seem to show some renal protective effects on diabetic nephropathy.

The role of adrenomedullin in diabetic nephropathy / 中国病理生理杂志

AIM: To investigate the role of adrenomedullin (AM) in diabetic nephropathy. METHODS: We observed the changes in the expression and secretion of AM, TGF-? 1 in the cultured human mesangial cells under high glucose condition and the contents of the laminin and type IV collagen in the supernatants. The effect of intervention with AM was also observed. RESULTS: High glucose condition resulted in increase in the expression and secretion of AM TGF-? 1 laminin and type IV collagen. AM reversed the influence of high glucose on the cultured human mesangial cells. CONCLUSION: These results showed that high glucose condition is one of stimulating factors of AM and the renal protective action of AM may be associated with suppression of TGF-? 1 and reducing excessive accumulation of laminin and type IV collagen.