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1.
Article in Chinese | WPRIM | ID: wpr-330223

ABSTRACT

Alisma orientalis is a traditional herb medicine commonly used in clinical. With the increasing report of its toxicity in clinical, the renal toxicity of Alisma orientalis has got gradually attention. This paper systematically reviews the research on the chemical material basis of Alisma orientalis including its chemical composition and toxicity of ingredients; and also declares its toxic ingredients and targets according to Network toxicology. Based on the controversy on renal toxicity of Alisma orientalis, we analyzed the possible reasons that may be associated with renal toxicity. It might be associated with the differences of the material basis composition and regulatory toxicology network, differences in employed processing technology, the metabolic function leading to accumulation of compounds, dosage and duration of the experiment and compatibility. The review provides possible reference and ideas for the quality control and rational use of Alisma orientalis.


Subject(s)
Alisma , Chemistry , Toxicity , Animals , Drugs, Chinese Herbal , Chemistry , Toxicity , Humans , Molecular Structure
2.
Article in Chinese | WPRIM | ID: wpr-246166

ABSTRACT

Development of the disease is the result of several factors involved in biological network changes. The nature of drug intervention is to regulate these pathological changes to the normal range. Advantages of traditional Chinese medicine (TCM) are to integrally and systematically regulate this biological networks and systematic pathology through multi-targets, multi-levels, multi-channels. Structural components TCM provides the controlled and precise basis "substance" for this regulation and also to clarify the "truth" of the nature of the regulation by the network pharmacology. Network pharmacology provides new strategy for the research on mechanism of structural components TCM. This study not only reflects the overall characteristics of the development of the disease, but also fully embodies the essence of TCM for preventing and treating diseases through changing traditional model on "one drug, one gene, one disease". This paper explores systematically the integration essence, features and research strategies of structural components TCM and the network pharmacology, understand the interaction of structural components TCM and body from the perspective of the overall concept of improving or restoring the balance of.biological networks. It is effective measure to reveal the structure of a multi-component for regulating biological networks mechanisms, and also provide new ideas and methods for further scientific research and innovation of structural component TCM.


Subject(s)
Drug Interactions , Drug Therapy , Drugs, Chinese Herbal , Chemistry , Pharmacology , Gene Regulatory Networks , Humans , Medicine, Chinese Traditional
3.
Article in Chinese | WPRIM | ID: wpr-330331

ABSTRACT

Most Chinese medicine has good clinical efficacy and application. However, the material basis is vague for the lack of basic research, the value of Chinese medicine is hard to reflect for the low technology level and product quality is difficult to maintain for the quality control indicator selection is incorrect. Chinese medicine Jinfukang oral liquid is a typical product of Chinese medicines. Jinfukang oral liquid was selected as a model drug in this article. Based on the overall concept and systems theory of traditional Chinese medicine, the research idea and technology system for modern Chinese medicine secondary exploitation was formed. The system includes three parts, for the first, basic research to make clear the components structure and their action mechanism, for the second, technology upgraded to optimize process and improve the product quality, for the last, exploring the associated industry to form the industrial chain. The research ideas and technology system based on the material basis research and development of modern Chinese medicine, guided with component structure in Chinese medicine and aimed clinical needs. This research ideas and technology system provides strategies and methods for the development of modern Chinese medicine secondary exploitation.


Subject(s)
Administration, Oral , Chemistry, Pharmaceutical , Reference Standards , Drug Therapy , Reference Standards , Drugs, Chinese Herbal , Reference Standards , Humans , Quality Control
4.
Article in Chinese | WPRIM | ID: wpr-341870

ABSTRACT

Chinese medicine prescriptions are the wisdom outcomes of traditional Chinese medicine (TCM) clinical treatment determinations which based on differentiation of symptoms and signs. Chinese medicine prescriptions are also the basis of secondary exploitation of TCM. The study on prescription helps to understand the material basis of its efficacy, pharmacological mechanism, which is an important guarantee for the modernization of traditional Chinese medicine. Currently, there is not yet dissertation n the method and technology system of basic research on the prescription of Chinese medicine. This paper focuses on how to build an effective system of prescription research technology. Based on "component structure" theory, a technology system contained four-step method that "prescription analysis, the material basis screening, the material basis of analysis and optimization and verify" was proposed. The technology system analyzes the material basis of the three levels such as Chinese medicine pieces, constituents and the compounds which could respect the overall efficacy of Chinese medicine. Ideas of prescription optimization, remodeling are introduced into the system. The technology system is the combination of the existing research and associates with new techniques and methods, which used for explore the research thought suitable for material basis research and prescription remodeling. The system provides a reference for the secondary development of traditional Chinese medicine, and industrial upgrading.


Subject(s)
Drug Prescriptions , Medicine, Chinese Traditional
5.
Article in Chinese | WPRIM | ID: wpr-310940

ABSTRACT

The purpose of the secondary exploitation of Chinese medicine is to improve the quality of Chinese medicine products, enhance core competitiveness, for better use in clinical practice, and more effectively solve the patient suffering. Herbs, extraction, separation, refreshing, preparation and quality control are all involved in the industry promotion of Chinese medicine secondary exploitation of industrial production. The Chinese medicine quality improvement and industry promotion could be realized with the whole process of process optimization, quality control, overall processes improvement. Based on the "component structure theory", "multi-dimensional structure & process dynamic quality control system" and systematic and holistic character of Chinese medicine, impacts of whole process were discussed. Technology systems of Chinese medicine industry promotion was built to provide theoretical basis for improving the quality and efficacy of the secondary development of traditional Chinese medicine products.


Subject(s)
Chemistry, Pharmaceutical , Economics , Reference Standards , China , Drug and Narcotic Control , Economics , Drugs, Chinese Herbal , Chemistry , Economics , Reference Standards , Humans , Medicine, Chinese Traditional , Economics , Reference Standards , Quality Control
6.
Article in Chinese | WPRIM | ID: wpr-287616

ABSTRACT

The secondary development of major traditional Chinese medicine varieties is one of important links during the modernization, scientification and standardization of traditional Chinese medicines. How to accurately and effectively identify the pharmacodynamic material basis of original formulae becomes the primary problem in the secondary development, as well as the bottleneck in the modernization development of traditional Chinese medicines. On the basis of the existing experimental methods, and according to the study thought that the multi-component and complex effects of traditional Chinese medicine components need to combine multi-disciplinary methods and technologies, we propose the study thought of the material basis of secondary development of major traditional Chinese medicine varieties based on the combination of in vivo and in vitro experiments. It is believed that studies on material basis needs three links, namely identification, screening and verification, and in vivo and in vitro study method corresponding to each link is mutually complemented and verified. Finally, the accurate and reliable material basis is selected. This thought provides reference for the secondary development of major traditional Chinese medicine varieties and studies on compound material basis.


Subject(s)
Absorption , Animals , Drug Discovery , Methods , Humans , Medicine, Chinese Traditional , Methods
7.
Article in Chinese | WPRIM | ID: wpr-287581

ABSTRACT

The secondary development of traditional Chinese medicines (TCMs) is an important content of TCM modernization process, as well as an important path for developing new TCM drugs. Under the guidance of the system theory, in response to the lack of the overall guideline and practical methods for the secondary development of TCMs at present, we introduced the overall thought of the secondary development of major TCM varieties, as well as the roles and contents of clinical research, pharmacology and pharmaceutics in the process of the secondary development of major TCM varieties, so as to provide systematic strategies and methods for the development of major TCM varieties.


Subject(s)
Biomedical Research , Drug Discovery , Methods , Humans , Medicine, Chinese Traditional , Methods , Pharmacology
8.
Article in Chinese | WPRIM | ID: wpr-307519

ABSTRACT

<p><b>OBJECTIVE</b>To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata.</p><p><b>METHOD</b>An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets.</p><p><b>RESULT</b>The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets.</p><p><b>CONCLUSION</b>It can enhance the bioavailability of PF by made it to pellets.</p>


Subject(s)
Administration, Oral , Animals , Antioxidants , Pharmacokinetics , Area Under Curve , Biological Availability , Flavonoids , Pharmacokinetics , Isoflavones , Pharmacokinetics , Male , Microspheres , Plant Roots , Chemistry , Pueraria , Chemistry , Random Allocation , Rats , Rats, Wistar , Tablets
9.
Article in Chinese | WPRIM | ID: wpr-246061

ABSTRACT

<p><b>OBJECTIVE</b>To prepare traditional Chinese medicine formula Qiqi pellets by extrusion-spheronization and study the optimal formulation and process.</p><p><b>METHOD</b>Qiqi pellets were prepared by a new style extrusion-spheronization equipment, the optimal formulation and process was obtained by the studies of influenitial factors and L9 (3(4)) orthogonal design, the micromeritic properties and product yield of pellets were determined.</p><p><b>RESULT</b>The formula Qiqi pellets prepared by extrusion-spheronization were all spheral with smooth surface; the product yield was high.</p><p><b>CONCLUSION</b>Extrusion-spheronization was suitable to produce Chinese Herbal Medicine pellets. The preparation process was simple and feasible; The quality of the prepared pellets was excellent. It was worth further study.</p>


Subject(s)
Astragalus propinquus , Chemistry , Cellulose , Chemistry , Drug Combinations , Drug Compounding , Methods , Drugs, Chinese Herbal , Chemistry , Ethanol , Chemistry , Lycium , Chemistry , Plants, Medicinal , Chemistry , Technology, Pharmaceutical , Methods , Water , Chemistry
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