ABSTRACT
In recent years, with the gradual maturity of achievable remote collection of digital health technology, more and more clinical research have applied this technology to improve the quality of data collection and reduce the burden on subjects. However, its technological characteristics of detachment from the diagnostic and treatment environment and real-time transmission of sensitive information also pose corresponding risks to the protection of subjects’ rights and interests and data standardization management, among which personal information protection and data control permissions are more prominent issues. Based on risk analysis and regulatory review, this paper explored the responsibilities of multiple parties, including the sponsors, researchers, clinical trial institutions, and ethics committee, as well as proposed five elements of special concern for ethical review, with a view to providing a reference for promoting the standardized development of digital health technology in clinical research.
ABSTRACT
From the perspective of medical institutions, this paper sorted out the contents of Article 32 of the Measures for Ethical Review of Life Sciences and Medical Research Involving Human regarding "exemption from ethical review". At the same time, combined with domestic and foreign regulations, this paper deeply considered and analyzed the applicable premise and special circumstances of the provisions from the implementation level, and then put forward suggestions from the perspective of practical operation of medical institutions, with a view to providing some practical guidance and reference for ethical practitioners of medical institutions.
ABSTRACT
From the perspective of medical institutions, this paper sorted out the background of the promulgation and important changes of Measures for Ethical Review of Life Science and Medical Research Involving Humans, and summarized the changes that may significantly affect the ethical review of medical institutions. It involved terminology changes and expansion of the scope of ethic review, clarification of the responsibilities and independence of the ethics committee, the refinement of the ethical review process, the emphasis on the protection of personal information and the rights and interests of subjects, and first proposal to exempt from ethical review. In addition, based on the concept of strengthening the ethical governance of science and technology in the new version of regulations, this paper shared the consideration on the governance of ethical review within medical institutions, including safeguarding the dignity and rights of subject, clarifying the role and position of ethical review, exempting the implementation of ethical review, and managing entrusted ethical review. With a view to providing a certain reference for the ethics practitioners and researchers in various medical institutions.
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Purpose/Significance To explore the application of information technology to strengthen surgical management and im-prove medical service capacity.Method/Process Taking Shanghai Chest Hospital as the research object,a surgical intelligent manage-ment platform is built based on digital twinning,and the retrospective data of surgery is collected through the internet of things to realize the quality supervision of surgical process.Result/Conclusion The empirical results show that the waiting time of CT positioning and the average access time in the surgical room decreases significantly,and the accuracy rate of surgical estimated time is significantly improved,which ensures the orderly connection of surgical links,and provides references for the intelligent transformation of surgical room.
ABSTRACT
In recent years, in order to meet the needs of high-quality development, more and more hospitals have begun to carry out refined drug management. Based on the theory of value chain management, this study analyzed and practiced the refined drug management. First of all, the value chain model of drug management was constructed to clarify the drug management process and classification. Secondly, the current situation and demand of drug management were analyzed to clarify the management needs of procurement, logistics, inventory, distribution and use in the management process. Then, based on the value chain theory, the basic activities and auxiliary activities of drug management were reconstructed and optimized. The performance evaluation suggested that refined drug management based on the value chain theory could improve the efficiency of drug management, provide better services for patients, and help the hospital develop with high quality.
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OBJECTIVE: To study the effect of Zhenju Jiangya Tablet (ZJ) on the injured endothelial cells and endothelium-dependent relaxation function of hyperlipidemia rabbits. METHODS: Male New Zealand rabbits were randomized into four groups: control group, hyperlipidemia group, ZJ group and sivastatin group. The endothelium-dependent relaxation function was evaluated by APV using intravascular Doppler, and the morphology of endothelial cells was detected by light microscopy and electron microscopy, and nitric oxide synthase was evaluated. RESULTS: ZJ reduced the lesions of hyperlipidemia vessels, and the APV after Ach injection of each group was (1.14+/-0.26), (1.74+/-0.59), (1.22+/-0.37) and (1.17+/-0.41) respectively. The eNOS of each group was (4.21+/-0.37), (1.43+/-0.88), (3.95+/-0.67) and (4.08+/-0.46) nmol x min(-1) x g(-1) respectively. CONCLUSION: ZJ can improve the abnormality of endothelial cells and endothelium-dependent relaxation function of hyperlipidemia.