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1.
Article in English | WPRIM | ID: wpr-928940

ABSTRACT

Computational medicine is an emerging discipline that uses computer models and complex software to simulate the development and treatment of diseases. Advances in computer hardware and software technology, especially the development of algorithms and graphics processing units (GPUs), have led to the broader application of computers in the medical field. Computer vision based on mathematical biological modelling will revolutionize clinical research and diagnosis, and promote the innovative development of Chinese medicine, some biological models have begun to play a practical role in various types of research. This paper introduces the concepts and characteristics of computational medicine and then reviews the developmental history of the field, including Digital Human in Chinese medicine. Additionally, this study introduces research progress in computational medicine around the world, lists some specific clinical applications of computational medicine, discusses the key problems and limitations of the research and the development and application of computational medicine, and ultimately looks forward to the developmental prospects, especially in the field of computational Chinese medicine.


Subject(s)
Algorithms , Computer Simulation , Humans
2.
Article in Chinese | WPRIM | ID: wpr-928000

ABSTRACT

Rich experience of clinical diagnosis and treatment has been accumulated in the developmental history of Chinese medicine, and the efficacy has been increasingly accepted by the public. However, the evaluation of clinical efficacy is currently based more on scientific evidence instead of merely the changes of patient symptoms. In Chinese medicine, the changes of major disease indicators, patient symptoms, and pathogenesis are the major criteria for the evaluation of clinical efficacy. The lack of well-accepted and uniform criteria and the uncertainty of subjective evaluation limit the development of clinical Chinese medicine. Evidence-based medicine combines clinical skills with the current best evidence. Narrative medicine, utilizing people's narratives in clinical practice, emphasizes patient feelings, willingness, and value orientation. The introduction of both evidence-based medicine and narrative medicine into the evaluation of clinical efficacy refers to the construction of the clinical efficacy evaluation system in a paradigm of participatory diagnosis and treatment. It can fully reflect the characteristics of Chinese medicine, respect the values of patients, and achieve universal clinical evidence. Therefore, it helps to improve the diagnosis and treatment, the relationship between doctors and patients, patients' life quality and decision-making awareness, and finally the new evaluation model of clinical efficacy of Chinese medicine.


Subject(s)
Evidence-Based Medicine , Humans , Medicine, Chinese Traditional , Narrative Medicine , Physicians , Treatment Outcome
3.
Article in English | WPRIM | ID: wpr-914190

ABSTRACT

Background@#The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity. Bone morphologic protein 7 (BMP-7) has been shown to reduce renal fibrosis induced by transforming growth factor-beta1. The aim of this study was to investigate the epigenetic effect of SFN on BMP-7 expression in diabetes-induced renal fibrosis. @*Methods@#Streptozotocin (STZ)-induced diabetic mice and age-matched controls were subcutaneously injected with SFN or vehicle for 4 months to measure the in vivo effects of SFN on the kidneys. The human renal proximal tubular (HK11) cell line was used to mimic diabetic conditions in vitro. HK11 cells were transfected to over-express HDAC2 and treated with high glucose/palmitate (HG/Pal) to explore the epigenetic modulation of BMP-7 in SFN-mediated protection against HG/Pal-induced renal fibrosis. @*Results@#SFN significantly attenuated diabetes-induced renal fibrosis in vivo. Among all of the HDACs we detected, HDAC2 activity was markedly elevated in the STZ-induced diabetic kidneys and HG/Pal-treated HK11 cells. SFN inhibited the diabetes-induced increase in HDAC2 activity which was associated with histone acetylation and transcriptional activation of the BMP-7 promoter. HDAC2 over-expression reduced BMP-7 expression and abolished the SFN-mediated protection against HG/Pal-induced fibrosis in vitro. @*Conclusion@#Our study demonstrates that the HDAC inhibitor SFN protects against diabetes-induced renal fibrosis through epigenetic up-regulation of BMP-7.

4.
Article in Chinese | WPRIM | ID: wpr-908903

ABSTRACT

Objective:To analyze the level and latent categories of the training needs of the nursing staff of the social volunteer teams in Jiangsu Province, and to provide basis for the targeted training.Methods:From March to July in 2018, 224 elderly care teachers from 13 social volunteer teams of 100 Red Cross societies in Jiangsu Province were surveyed for the knowledge of the care for the aged and the needs of training by the self-designed questionnaires. A total of 207 valid questionnaires were collected, with an effective recovery rate of 92.4%. SPSS 21.0 and Latent GOLD 5.1 software were used for description analysis, hierarchical clustering and latent category analysis.Results:The number of answer of "very need" to knowledge and skills among the aged care teachers for the elderly, such as psychological care, elderly volunteer services and recreational activities for the elderly, was 196, 196 and 193, with a proportion of 94.7%, 94.7% and 93.2%, respectively. Cluster analysis showed that training needs could be divided into four aspects: life care knowledge and skills, health care knowledge and skills, psychological care knowledge and skills, and spiritual comfort knowledge and skills. The results of latent category analysis showed that the aged care teachers could be divided into three groups based on their different training needs: high demand group for overall knowledge and skills, partial demand group for overall knowledge and skills, and high demand group for medical care and psychological care knowledge and skills. The corresponding latent probability of the three groups were 80.2%, 13.0%, 6.8%, respectively.Conclusion:The training for the aged care of social volunteer teams should pay attention to the teaching of spiritual comfort knowledge and skills for the elderly. The training program should be oriented to the multi-level and individualized needs of the teachers, so as to meet the needs of the aged care teachers for their own development.

5.
Article in Chinese | WPRIM | ID: wpr-906240

ABSTRACT

Objective:The hypoglycemic effects and mechanisms of total flavonoids from Potentillae Discoloris Herba(TFE) on insulin resistance through the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt) signaling pathway in db/db mice were investigated. Method:The 24 db/db mice were randomly divided into four groups, model group, metformin group and TFE 100,400 mg·kg<sup>-1</sup> group respectively. The 6 db/m mice as normal control group. After 4 weeks treatment, the mice were processed and the levels of fasting blood glucose(FBG), glycated serum protein(GSP),fasting blood insulin(FINS),triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) in serum were detected. Homeostatic model assessments of insulin resistance(HOMA-IR)were quantified. Hematoxylin-eosin(HE)staining of liver and pancreatic tissues were examined. The expression of IR<italic>β</italic>, IRS-1,PI3K,phosphorylation-PI3K (p-PI3K), Akt, phosphorylation-Akt(p-Akt) and glucose transporter 4(GLUT4) in livers were assessed by Western blot. Result:Compared with normal group, model group showed liver and pancreas injury. FBG, GSP, TC, TG, LDL-C, FINS and MDA levels in serum were significantly increased (<italic>P</italic><0.01), HDL-C and SOD levels in serum were significantly decreased (<italic>P</italic><0.05), liver glycogen content was significantly decreased (<italic>P</italic><0.01), as well as expression of IR, IRS-1, p-PI3K/PI3K, p-Akt/Akt and GLUT4 protein in liver tissues were significantly decreased (<italic>P</italic><0.01). Compared with model group, TFE was able to relieve liver and pancreas injury,while the levels of FBG, GSP, TC, TG, FINS and MDA in serum were significantly decreased (<italic>P</italic><0.05), HDL-C and SOD levels liver were significantly increased (<italic>P</italic><0.05), liver glycogen content was significantly increased (<italic>P</italic><0.01), and the expressions of IRS-1, p-PI3K/PI3K, p-Akt/Akt and GLUT4 protein in liver tissues were significantly up-regulated (<italic>P</italic><0.05). Conclusion:These findings indicate that TFE has the potential to reduce blood sugar and alleviates insulin resistance through the PI3K/Akt signaling pathway in the livers of db/db mice.

6.
Article in Chinese | WPRIM | ID: wpr-886503

ABSTRACT

@#Objective    To analyze the correlation between the gray value of epicardial fat and the prognosis of patients with atrial fibrillation (AF) treated by thoracoscopic radiofrequency ablation. Methods    The clinical data of 97 patients, including 75 males and 22 females with an average age of 57.8±9.4 years, who underwent thoracoscopic radiofrequency ablation in Fuwai Hospital from 2017 to 2018 were analyzed retrospectively. The left atrial fat volume and average gray scale were calculated by left atrial enhanced CT. According to the average gray scale of left atrial fat tissue, the patients were divided into three groups: a high gray scale group, a medium gray scale group and a low gray scale group. The patients were followed up at 3, 6 and 12 months after operation. The end point of follow-up was the recovery rate of sinus rhythm. Survival analysis was used to analyze the correlation between CT features of epicardial fat enhancement and prognosis. Results    After adjustment of body mass index, body surface area, gender and left atrial end diastolic diameter, regression analysis showed that the fat gray of left atrial enhanced CT was correlated with the type of AF (OR=0.30, 95%CI 0.12-0.79, P=0.014). Cox regression analysis showed that the fat gray value of left atrial CT predicted the recurrence of AF after thoracoscopic radiofrequency ablation (OR=0.92, 95%CI 0.85-0.99). The Kaplan-Meier curve showed significant difference in the long-term recurrence rate of AF among the three groups (P=0.011). The lower left atrial fat enhanced CT gray scale was, the higher long-term recurrence rate of AF was. Conclusion    The gray value of left atrial fat enhanced CT can effectively predict the recurrence of AF after radiofrequency ablation in thoracoscopic surgery.

7.
Article in Chinese | WPRIM | ID: wpr-882625

ABSTRACT

Objective:To observe the clinical efficacy of Dushen Decoction and Zhenwu Decoction in the treatment of chronic congestive heart failure (CCHF) of Yang deficiency and blood stasis type. Methods:From March 2017 to December 2019, 120 patients with CCHF of Yang-deficiency and blood stasis type admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine were selected, and they were divided into study group and control group according to the randomized number table method, with 60 in each group. The control group was given western medicine of conventional treatment, and the study group was combined with Dushen Decoction and Zhenwu Decoction on the basis of the control group. Both groups were treated for 1 month. Before and after treatment, TCM syndrome scores were performed, serum TNF-α, IL-17 and CRP were detected by ELISA, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) were detected by color doppler echocardiography the adverse reactions during the treatment were recorded and the clinical efficacy was evaluated. Results:The total effective rate was 91.7% (55/60) in the study group and 71.7% (43/60) in the control group, with significant difference between the two groups ( χ2=8.015, P=0.005). After treatment, the scores of palpitation, dyspnea, chilly limbs, dull tongue and edema in the study group were significantly lower than those in the control group ( t=13.953, 13.915, 30.945, 32.339, 20.403, P<0.001). After treatment, LVEF [(56.28 ± 4.34)% vs. (42.47 ± 4.56)%, t=16.993] in the study group was significantly higher than that of the control group ( P<0.01); LVEDD [(44.32 ± 6.23) mm vs. (53.81 ± 5.19) mm, t=9.066] and LVESD [(31.28 ± 4.62) mm vs. (37.51 ± 4.73) mm, t=7.299] in the study group were significantly lower than those in the control group ( P<0.01). After treatment, the serum levels of TNF-α, IL-17 and CRP in the study group were significantly lower than those in the control group ( t=12.644, 15.975 and 14.379, P<0.001). The incidence of adverse reactions was 6.7% (4/60) in the control group and 8.3% (5/60) in the study group, and there was no significant difference between the two groups ( χ2=0.120, P=0.729). Conclusion:Dushen Decoction and Zhenwu Decoction in the treatment of CCHF can improve the clinical symptoms, improve the cardiac function, reduce inflammatory factors, improve the treatment efficiency with good safety.

8.
Article in Chinese | WPRIM | ID: wpr-921957

ABSTRACT

OBJECTIVE@#To analyze the clinical characteristics and genetic variants in a two-month-and-one-day male infant with aldosterone synthase deficiency.@*METHODS@#Clinical data of the child was collected. Whole exome sequencing was carried out by next generation sequencing(NGS). Candidate variants were verified by Sanger sequencing.@*RESULTS@#The infant had measured 54 cm (-2.1 SD) in length and 3.9 kg (-2.8 SD) in weight, and featured recurrent vomiting, poor feeding, apathetic appearance and failure to thrive. Blood electrolyte testing showed low sodium and increased potassium. Serum cortisol, adrenocorticotrophic hormone, 17-alpha-hydroxyl progesterone, androstenedione, and testosterone were all within the normal ranges. The plasma renin activity activity was increased, and plasma aldosterone level was low. NGS revealed that the infant has harbored compound heterozygous variants of the CYP11B2 gene, namely c.1334T>G(p.Phe445Cys) inherited from his father and c.1121G>A(p.Arg374Gln) inherited from his mother. Neither variant was reported previously, and both were predicted to be deleterious for the function of the protein product.@*CONCLUSION@#The compound heterozygous variants of c.1334T>G (p.Phe445Cys) and c.1121G>A (p.Arg374Gln) of the CYP11B2 gene probably underlay the disease in this patient.


Subject(s)
Child , Cytochrome P-450 CYP11B2/genetics , Genetic Testing , High-Throughput Nucleotide Sequencing , Humans , Infant , Male , Mutation , Whole Exome Sequencing
9.
Article in Chinese | WPRIM | ID: wpr-879608

ABSTRACT

OBJECTIVE@#To explore the genetic basis for a girl featuring bone and tooth mineralization disorder, premature deciduous teeth, rickets and short stature.@*METHODS@#Genomic DNA was extracted and subjected to high-throughput whole exome sequencing. Suspected variants were confirmed by Sanger sequencing. Impact of potential variants was analyzed with bioinformatic software.@*RESULTS@#The child was found to carry compound heterozygous missense variants of the ALPL gene, including c.1130C>T (p.A377V), a known pathogenic mutation inherited from her father, and c.1300G>A (p.V434M) inherited from her mother, which was unreported previously and predicted to be likely pathogenic based on standards and guidelines from the American College of Medical Genetics and Genomics (PM2+PM5+PP3+PP4).@*CONCLUSION@#The compound heterozygous variants of c.1130C>T (p.Ala377Val) and c.1300G>A (p.Val434Met) of the ALPL gene probably underlay the disease in this child. Above finding has enriched the spectrum of ALPL gene variants.


Subject(s)
Alkaline Phosphatase , Child , Female , Genomics , High-Throughput Nucleotide Sequencing , Humans , Hypophosphatasia/genetics , Mutation , Whole Exome Sequencing
10.
Chinese Journal of Urology ; (12): 472-473, 2020.
Article in Chinese | WPRIM | ID: wpr-869688

ABSTRACT

Extrarenal Wilms′ tumor is extremely rare and has no characteristic clinical manifestations. Diagnosis is difficult before surgery, and is often confirmed by histopathology. Comprehensive treatment by surgery, chemotherapy and radiotherapy is currently adopted for such patients, and the overall survival rate can reach about 90%. Here we report a 2-year-old child with Wilms′ tumor in the left scrotum.

11.
Chinese Journal of Biotechnology ; (12): 908-919, 2020.
Article in Chinese | WPRIM | ID: wpr-826885

ABSTRACT

A multiplex PCR method was developed to detect the main pathogens of Qinghai Tibetan sheep endometritis. First, the genomes of five standard bacterial strains were extracted and specific primers were selected; the multiplex PCR method was established by using the genome of the standard strain as a template. The samples were collected by sterile cotton swab from Tibetan sheep uterus, and then placed in LB medium and numbered. After 48 h, the genomes of cultured bacteria were extracted and detected by single PCR method, then the positive samples were recorded. The positive samples detected by single PCR were selected for multiplex PCR detection and recorded again. The coincidence rate between these two methods was calculated to measure the accuracy of multiplex PCR. In order to identify the species of the pathogen, 30 positive samples verified by single and multiplex PCR were randomly selected for bacterial isolation and identification. In the 600 samples, the infected ratio of Streptococcus agalactiae (GBS) was 47.33%, Escherichia coli 34.83%, Staphylococcus aureus 6.5%, Salmonella and Trueperella pyogenes were negatively detected. Among the positive samples detected by multiplex PCR, the positive ratio of GBS was 45.50%, E. coli 33.50%, S. aureus 6.5%. Comparison of two detection results, Multiplex PCR detection coincidence rate is more than 95%. The isolated pathogens were identified as E. coli, GBS and S. aureus, which was consistent with the results of two methods. The multiplex PCR method was successfully established and the main pathogens of endometritis in Qinghai Tibetan sheep were GBS, E. coli and S. aureus.


Subject(s)
Animals , Bacteria , Genetics , Bacteriological Techniques , Methods , Endometritis , Microbiology , Female , Multiplex Polymerase Chain Reaction , Reference Standards , Polymerase Chain Reaction , Sensitivity and Specificity , Sheep , Sheep Diseases , Microbiology , Tibet
12.
Article | WPRIM | ID: wpr-836522

ABSTRACT

Methods@#An online survey was conducted on 452 Chinese international students from February 6 to 12, 2020. The respondents were classified into “the Low-frequency group” (< one time/week; n=144), “the Mid-frequency group” (one-two times/week; n=133), and “the High-frequency group” (≥three times/week; n=175) according to their frequency of using university foodservice. The dietary life was compared among the three groups.Binominal logistic regression models were constructed to determine the associations between the frequency of university foodservice use and the changes in dietary life. @*Results@#More than 2/3 (68.1%) of the respondents used the university foodservice at least once per week. Chinese international students who were males and Han Chinese people, lived on campus, had stayed longer in Korea, and had no cooking facilities tended to use the university foodservice more often. The level of satisfaction with the university foodservice was not high (3.52 out of 5-points). Only 20% ate meals three times per day, and only 22% ate breakfast almost every day. The frequencies of overeating and skipping meals increased after studying in Korea. The frequency of university foodservice use, along with the length of residence in Korea, was associated with these negative changes in dietary life. Overeating (OR=2.11) and skipping meals (OR=1.79) were more likely to increase after studying in Korea in the Mid-frequency group than in the High-frequency group. @*Conclusions@#The frequency of university foodservice use was associated with the dietary life of Chinese international students in Korea. A high frequency (i.e. ≥three times/week) of using university foodservice may positively affect the dietary life of Chinese international students in Korea.

13.
Int. braz. j. urol ; 45(1): 183-186, Jan.-Feb. 2019. graf
Article in English | LILACS | ID: biblio-989970

ABSTRACT

ABSTRACT We present the case of a 28 year old patient with an incomplete tear of the tunica albuginea occurred after having sexual intercourse in the female superior position. The diagnostic assessment was performed first clinically, then with CT, owing to its high resolution, allowed to exactly detect the tear location leading to precise preoperative planning. After adequate diagnosis through imaging and proper planning, the patient was performed a selective minimally invasive surgical approach to repair the lesion. The patient had good erection with no angular deformity or plaque formation after a 3-month follow-up.


Subject(s)
Humans , Male , Adult , Penile Diseases/surgery , Penis/injuries , Rupture/surgery , Penile Diseases/diagnostic imaging , Penis/surgery , Penis/diagnostic imaging , Rupture/diagnostic imaging , Tomography, X-Ray Computed , Minimally Invasive Surgical Procedures
14.
Article in Chinese | WPRIM | ID: wpr-733453

ABSTRACT

Objective To construct a"Field and Disaster Nursing"course which is suitable for the military and local higher nursing education, on-the-job and post training education to organic integrate the modern disaster nursing teaching and military field nursing teaching. Methods Based on the methods of qualitative and quantitative research, such as literature research, interviews and observational method, a preliminary plan of curriculum design was established, and an expert consultation table was designed.The Delphi expert consultation method was used to conduct two rounds of consultation with 30 related experts on disaster relief.Quantitative data were obtained and statistical data were analyzed. Results The final screening results of the curriculum content applicability index are 4 first grade, and 23 for the two level.A set of"Field and Disaster Nursing"curriculum had been set up that is suitable for education and training needs of the military and local fusion. Conclusion The construction of this course provides a training thought for exploring disaster nursing education suitable for China's national conditions, and has reference and guiding significance for further implementation of military and civilian integration and multi participatory disaster nursing teaching practice.

15.
Article in Chinese | WPRIM | ID: wpr-746046

ABSTRACT

Objective To obtain the full-length sequence of the vacuolar protein sorting 34 coding gene (vps34) of Sporothrix globosa (S. globosa) and to investigate the role of vps34 gene during the phase transition from mycelium to yeast in S. globosa. -ethods The 3′ end and 5′ end of the vps34 gene of S. globosa were amplified by rapid amplification of cDNA ends ( RACE ) . The obtained sequences were spliced and analyzed by bioinformatics software. Quantitative reverse transcription PCR ( qRT-PCR ) was used to analyze the expression of vps34 gene in mycelial and yeast phases. Results The vps34 gene of S. globosa was 3228 bp in length. The coding sequence was 3000 bp and encoded 999 amino acids with a mo-lecular mass of 111. 49×103 and an isoelectric point of 6. 38. It contained three domains including C2 PI3K class Ⅲ, PI3Ka Ⅲ and PI3Kc Ⅲ. The results of qRT-PCR showed that the expression of vps34 gene in yeast-phase S. globosa was higher than that in mycelial phase at 24 h (P<0. 05), and the greatest difference between them was observed at 48 h (P<0. 01). Conclusions Vps34p participates in the process of dimor-phic transformation of S. globosa. The obtainment of the full-length vps34 gene of S. globosa lays the founda-tions for further study on the function of Vps34p.

16.
Journal of Experimental Hematology ; (6): 1455-1462, 2019.
Article in Chinese | WPRIM | ID: wpr-775699

ABSTRACT

OBJECTIVE@#To investigate the regulatory mechanism of miR-152 on proliferation, metastasis and tumorigenesis of human acute monocytic leukemia SHI-1 cells.@*METHODS@#The purchased SHI-1 cell line was treated with miR-152 over-expression (miR-152 agomir group) or miR-152 inhibition (miR-152 antagomir group), and the negative control (NC) group was set up. The cell proliferation of each group was detected by CCK-8 assay. Scratch healing assay was employed to determine the migration of cells. Transwell assay was used to measure the invasion of cells. The expressions of Cyclin D1, Caspase-3, MMP-2, TIMP-2, E-cadherin and N-cadherin were detected by Western blot. The flow cyronetry with annexin V-FITC/PI double staining was applied to detect the cell apoptosis. The tumorigenesis of cells was examined by tumor formation experiment in nude mice.@*RESULTS@#Compared with the NC group, the cell proliferation, migration and invasion ability in miR-152 agomir group were significantly decreased (P<0.05), while that in miR-152 antagomir were significantly up-regulated (P<0.05) . Compared with the NC group, the protein expression of Cyclin D1, MMP-2, N-cadherin were down-regulated in miR-152 agomir group, but the protein expression of Caspase-3, TIMP-2 and E-cadherin were all up-regulated siginificantly. At the same time, the apoptosis were enhanced, but the timorigenicity in nude mice were significantly decreased (all P<0.05). The protein expression of Cyclin D1, MMP-2, N-cadherin in miR-152 antagomir group, showed high levels but Caspase-3, TIMP-2 and E-cadherin protein showed low levels in comparison with NC group. At the same time, the apoptosis was decreased but the timorigenicity in nude mice was significantly enhanced (all P<0.05) .@*CONCLUSION@#miR-152 can inhibit the proliferation, metastasis and tumorigenesis of SHI-1 cell line, at the same time induce cell apoptosis, thus providing a theoretical basis for the treatment of acute lymphoblastic leukemia.


Subject(s)
Animals , Apoptosis , Cell Line, Tumor , Cell Proliferation , Humans , Mice , Mice, Nude , MicroRNAs , Genetics
17.
Article in Chinese | WPRIM | ID: wpr-752519

ABSTRACT

Objective To evaluate the European Heart Surgery Risk Assessment System (EuroSCORE II), the US National Cardiovascular Registry Database Risk Score System (NCDRCathPCI Risk Score System), and the age, creatinine, and left ventricular ejection fraction (ACEF) score for major adverse cardiovascular and cerebrovascular events(MACCE) in patients after percutaneous coronary intervention (PCI). Methods A retrospective analysis of 404 consecutive patients with postoperative PCI patients scored and early prognosis. Calibration was assessed by the Hosmer-Lemeshow (H-L) test, and discrimination was assessed by the receiver operating characteristic (ROC) curve. ResuLts There were 17 cases (4.21%) of MACCE. EuroSCORE II, NCDRCathPCI, and ACEF predicted the area under the ROC curve of elderly patients with PCI after surgery were 0.871, 0.785, and 0.744, respectively (P < 0.01); the difference between EuroSCORE II and ACEF was statistically significant (P < 0.05). The EuroSCORE II and NCDRCathPCI scoring systems predict good MACCE calibration (EuroSCORE II: 5.14, 95% CI 4.63-5.70; NCDRCathPCI: 4.71, 95% CI 4.47-4.97); and the ACEF scoring system underestimates MACCE. The number of cases ( ACEF: 49.41 cases, 95% CI 19.57-124.97). ConcLusions For the elderly patients with postoperative PCI, all three scores can better predict the occurrence of postoperative in-hospital MACCE, and the predictive value of EuroSCORE II is better.

18.
Article in Chinese | WPRIM | ID: wpr-743519

ABSTRACT

Objective To analyze the clinical and molecular genetic characterizations of X-linked adrenal dysplasia congenita(AHC) onset in infant.Methods Seven children (from 7 families) with X-linked AHC who were admitted to the Department of Endocrinology,Genetics and Metabolism,Children's Hospital Affiliated to Zhengzhou University,from July 2012 to June 2017 were selected.All patients were screened for dosage-sensitive-sex reversal-adrenal hypoplasia congenital critical region on the X chromosome gene1 (DAX1/NR0B1) mutations.The clinical manifestation and laboratory examination were analyzed,their clinical characterizations were summarized.Results Seven patients were all male,the onset age of the patients were from after birth to 7 months old,and 4 patients (4 families) had a family history of X-linked recessive inheritance.The clinical manifestations were skin pigmentation [100.0% (7/7 cases)],vomiting [71.4% (5/7 cases)],no weight gain [57.1% (4/7 cases)] and poor spirit [28.6% (2/7 cases)].Laboratory tests showed that hyperkalemia and hyponatremia,increased coricotrophin,normal or decreased cortisol,17α-hydroxyprogesterone,progesterone,aldosterone and dehydroepiandrosterone.Testosterone levels increased in 5 patients.The abnormalities of adrenal glands imaging could be seen in 2 patients.Two patients were misdiagnosed as congenital adrenal cortical hyperplasia.Then the definitive diagnosis were made by genetic test.DAX1/ NR0B1 gene mutations were found in all patients.Five patients were novel mutations (c.114_126del,c.872G > A,c.56delG,c.884T > G,c.1217delG).Conclusions The clinical manifestations of X-linked AHC with infant onset include pigmentation,poor spirit and growth retardation,which should be differentiated from congenital adrenal cortical hyperplasia.Hormone levels such as elevated blood 17α-hydroxyprogesterone and family history are the main identification points,and AHC cannot be excluded when testosterone level increases.Five novel mutations are found in this study,which enrich the gene database.

19.
Chinese Journal of Epidemiology ; (12): 1563-1568, 2019.
Article in Chinese | WPRIM | ID: wpr-800272

ABSTRACT

Objective@#To study the correlation between meteorological factors and the incidence of hand, foot and mouth disease (HFMD) in Xinjiang Uygur Autonomous Region (Xinjiang) so as to provide scientific evidence for the early warning, prediction, prevention and control of HFMD.@*Methods@#Data on HFMD surveillance and related population was collected from the China Information System for Disease Control and Prevention from 2011 to 2018. Meteorological data was obtained from http://www.tianqihoubao.com. Correlation analysis on meteorological factors and the incidence of HFMD in Xinjiang was conducted, using the Excel 2007, SPSS 17.0, and Spatial Distribution Map by ArcGIS 10.2 software.@*Results@#HFMD usually occurred between April and July. Numbers of patients reached the top in May and June. Temperature was positively correlated with the incidence of HFMD (r=0.370, P<0.01) while precipitation was positively correlated with the incidence of HFMD (r=0.747, P<0.01). The temperature threshold appeared as 5 ℃-35 ℃ for the incidence of HFMD. Interval period was one month between the peak of both the incidence of HFMD and the precipitation. A power function relationship (y=0.009 4x2.332 9, R2=0.898 9) was noticed between the precipitation and the incidence of HFMD.@*Conclusions@#The incidence of HFMD was closely related to the meteorological factors including temperature and precipitation in Xinjiang during 2011-2018. Our findings have provided evidence for the development of early warning system on HFMD in Xinjiang.

20.
Article in Chinese | WPRIM | ID: wpr-797141

ABSTRACT

Objective@#To evaluate the European Heart Surgery Risk Assessment System (EuroSCORE II), the US National Cardiovascular Registry Database Risk Score System (NCDRCathPCI Risk Score System), and the age, creatinine, and left ventricular ejection fraction (ACEF) score for major adverse cardiovascular and cerebrovascular events(MACCE) in patients after percutaneous coronary intervention (PCI).@*Methods@#A retrospective analysis of 404 consecutive patients with postoperative PCI patients scored and early prognosis. Calibration was assessed by the Hosmer-Lemeshow (H-L) test, and discrimination was assessed by the receiver operating characteristic (ROC) curve.@*Results@#There were 17 cases (4.21%) of MACCE. EuroSCORE II, NCDRCathPCI, and ACEF predicted the area under the ROC curve of elderly patients with PCI after surgery were 0.871, 0.785, and 0.744, respectively (P < 0.01); the difference between EuroSCORE II and ACEF was statistically significant (P < 0.05). The EuroSCORE II and NCDRCathPCI scoring systems predict good MACCE calibration (EuroSCORE II: 5.14, 95% CI 4.63-5.70; NCDRCathPCI: 4.71, 95% CI 4.47-4.97); and the ACEF scoring system underestimates MACCE. The number of cases (ACEF: 49.41 cases, 95% CI 19.57-124.97).@*Conclusions@#For the elderly patients with postoperative PCI, all three scores can better predict the occurrence of postoperative in-hospital MACCE, and the predictive value of EuroSCORE II is better.

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