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1.
Article in Chinese | WPRIM | ID: wpr-826342

ABSTRACT

To explore the risk factors of acute kidney injury(AKI)in adult primary nephrotic syndrome(PNS). Totally 185 patients with PNS were divided into AKI group(=51)and non-AKI group(=134).The demographic data and clinical and histological features at admission were compared between the two groups.The independent risk factors for AKI were evaluated by Logistics regression analysis. In 51 PNS patients with AKI,the common pathological types of AKI included minor glomerular abnormalities(29.4%),IgA nephropathy(25.5%),and membranous nephropathy(17.6%).The incidences of renal tubular casts and epithelial vacuoles in the AKI group were significantly higher than those in the non-AKI group(=0.004,=0.030).Males were more likely to suffer from AKI than females(=0.000).Patients in AKI group had significantly lower albumin level(=0.015)and higher levels of random urine protein,serum creatinine,uric acid,urea nitrogen,and triglyceride than non-AKI group(=0.030,=0.000,=0.000,=0.000,and =0.006),and polyserous and oliguria occurred more often in the AKI group(=0.000,=0.002).The AKI group had significantly higher incidences of high blood pressure and infections(=0.035,=0.000).Multivariate logistics regression analysis showed albumin(96 μmol/L),urea nitrogen(≥6.8 mmol/L),uric acid(≥400 μmol/L),diabetes,infection,and renal tubular casts were the independent risk factors for AKI. AKI complicating PNS is associated with a variety of factors.Its independent risk factors include the levles of albumin,serum creatinine,urea nitrogen,and uric acid,diabetes,infections,and renal tubular casts.


Subject(s)
Acute Kidney Injury , Adult , Creatinine , Female , Humans , Kidney , Male , Nephrotic Syndrome , Risk Factors
2.
Acta Pharmaceutica Sinica ; (12): 425-429, 2017.
Article in Chinese | WPRIM | ID: wpr-779609

ABSTRACT

This study was designed to investigate triterpenoids from the roots of Rosa laevigata Michx. The silica gel column chromatography was used to separate the chemical constituents from the roots of Rosa laevigata Michx. HPLC was used to analyze its purity and chemical constitution. Spectroscopy methods were used to determine their structures. Five constituents were isolated and identified as19α-OH-3β-E-feruloyl corosolic acid (1), 23-hydroxy-tormentic acid (2), 2α, 3β, 19α, 23-tetrahydroxy-12-en-28-oleanolic acid (3), 2α, 3α, 20β-trihydroxyurs-13 (18)-en-28-oic-acid (4), 2α, 3β, 20β-trihydroxyurs-13 (18)-en-28-oic-acid (5). Compound 1 was assigned as a new compound, compounds 4, 5 were obtained from the genus Rosa for the first time.

3.
Article in Chinese | WPRIM | ID: wpr-250411

ABSTRACT

To study the triterpenoids from the roots of Rosa laevigata. The silica gel column chromatography was used to separate the chemical constituents from the roots of Rosa laevigata Michx. HPLC was used to analyze its purity, chemical and spectroscopy methods were used to determine their structures. 12 constituents were isolated and identified as(2R, 19R)methyl 2-acetyloxy-19- hydroxyl-3-oxo-urs-12-en-28-carboxylate(1), pomonic acid (2), 18, 19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11, 13(18)-dien-28-oic acid(3), swinhoeic acid (4), myrianthic acid(5), 2α, 3β, 19α-trihydroxy-24-oxo-urs-12-en-oic acid (6), tormentic acid(7), arjunic acid (8), 1β-hydroxyeuscaphic acid(9), quadranoside Ⅷ (10), alpinoside(11), rubuside B (12). Compounds 1-4, 6, 9, 11-12 were obtained from this plant for the first time. Compounds 2-4, 6, 11-12 were obtained from the genus Rosa for the first time.

4.
Article in Chinese | WPRIM | ID: wpr-854132

ABSTRACT

Objective: To evaluate the antioxidant capacity of the main components from Dracaena cochinchinensis by HPLC-DPPH and provide a foundation for "spectrum-effect" quality control standard. Methods: The determination was developed on Phenomenex lura C18 column (250 mm × 4.6 mm, 5 μm) with gradient elution of methanol-acetonitril-0.2% H3PO4 and the detective wavelength was set at 306 nm. The column temperature was 35℃. Results: The DPPH free radical scavenging abilities of these five antioxidants were as follows: pterstilbene > resveratrol > luoreirin B > luoreirin A > 7,4'-dihydroxyflavone. The analysis on the structures of the five compounds showed that the hydroxymethylation didn't decrease the antioxidant activities of stilbenes. The symmetry of B ring of dihydrochalcone has the significant effect on the antioxidant activities. However, 7,4'-dihydroxyflavone didn't show the related activity in D. cochinchinensis. Conclusion: HPLC-DPPH can not only be used for screening the components with antioxidant potency but also for the purpose of quality evaluation of D. cochinchinensis, and the method proves to be selective, simple, and reproducible.

5.
Article in Chinese | WPRIM | ID: wpr-305369

ABSTRACT

The constituents in 95% ethanol extract of the root of Rosa cymosa Tratt were purified by column chromatography techniques, leading to isolation of eleven triterpenes. Their structures were elucidated by spectroscopic data as pomolic acid (1), fupenzic acid (2), ursolic acid (3), euscaphic acid (4), arjunic acid (5), tomentic acid (6), 3β-E-feruloyl corosolic acid (7), 1β-hydroxyeuscaphic acid (8), myrianthic acid (9), cecropiacic acid (10), and ilexoside B (11). Among them, compounds 3, 6-8, 10 and 11 were obtained from this plant for the first time, and compounds 7 and 10 were obtained from this genus for the first time.


Subject(s)
Drugs, Chinese Herbal , Chemistry , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Roots , Chemistry , Rosa , Chemistry , Triterpenes , Chemistry
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