ABSTRACT
Objective@#To analyze the clinical and pathological features of Cronkhite-Canada syndrome (CCS), and to investigate the significance of IgG4 positive plasma cell infiltration.@*Methods@#Clinical presentations, endoscopic appearances and morphological features of 18 patients diagnosed with CCS at Peking Union Medical College Hospital during 2000-2016 were included in the study.There were 11 male and 7 female patients. IgG4 and IgG immunohistochemical stains were performed in total of 55 biopsies from the patients (36 polyps, 10 adenoma and 9 surrounding mucosa) and a control group of 58 cases (19 colonic mucosa, 7 colonic hyperplastic polyps, 9 inflammatory bowel disease and 23 adenoma).@*Results@#Average age of CCS was 59 years (range 47-69 years) and the male to female ratio was 11∶7. All patients had at least one ectoderm lesion. Fourteen cases had testicular abnormalities. Digestive tract symptoms were encountered in most cases. Four patients had a history of connective tissue disease. Endoscopically, multiple polyps were found to involve entire gastrointestinal tract except the esophagus. Morphologically, CCS polyps were characterized by prominent mucosal edema, mild to moderate inflammation, glands hyperplasia and cystic dilatation. Ten cases had colonic adenoma and one case had rectal adenocarcinoma. While none of the cases reached the diagnostic criteria of IgG4 disease, the positive rate of IgG4 positive plasma cells in adenoma of CCS was significantly higher than that in polyps and surrounding mucosa of CCS (60.0%∶13.9%∶0, P<0.01). The positive rate of IgG4 positive plasma cells of adenoma and polyp of CCS had an increased tendency compared to that of adenoma and polyp of control group (60.0%∶34.8%; 13.9%∶0).@*Conclusion@#The findings in the study do not support that CCS is a variant of IgG4 disease, although IgG4 positive plasma cells may be involved in the pathogenesis of CCS, which may be explored in future investigations.
ABSTRACT
Through analyzing the current situation of curriculum education,practice continuing education and hospital continuing education in the college of nursing ethics in China,this paper found that there were many prob-lems in the education system,teaching content,faculty and teaching methods of nursing ethics education in China,and proposed to build a lifelong education system,a practice teaching content,a " double type" teacher team and a diversity teaching methods system,thus forming a nursing ethics teaching system suitable for China's national con-ditions and meeting the needs of medical and health development in China.
ABSTRACT
Objective To investigate the clinical effect MEBO in treatment of burns. Methods A total of 60 patients were selected as the objects from Jan 2012 to Jan 2014, and were divided into observation group and control group ac-cording to random number table, each of 30 cases, the observation group treated with MEBO, while the control group treated with a topical silver sulfadiazine, the analgesic effect, pain conditions and treatment of patients during wound healing time situation were compared. Results The total effective rate of observation group was 90.0%, the analgesic effect was significantly better than the control group (90.0% vs 60.0%, P <0.05). The degree of pain during the treat-ment of patients in the observation group was significantly lighter than the control group (P <0.05). Shallow observation group Ⅱ patients, deep Ⅱ degree, degree Ⅲ wound healing time was significantly shorter than the control group (P <0.05). Conclusion MEBO in treating patients with burns conducive pain, can reduce pain, shorten healing time, worthy of promotion and application.