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Objective To explore the effect of mental nursing intervention on gastric cancer with liver metastasis patients treated with TACE sequential chemotherapy.Methods Sixty four gastric cancer patients with liver metastasis,no hopes of accepting operations,were included.All patients were divided into control group (32 cases) and observation group (32 cases).The former received routine nursing care and the later received extra mental nursing intervention.The anxiety,depression and quality of life in both groups were evaluated and compared.Results After extra mental nursing intervention,the SDS and SAS scores of the observation group [(41.6 ± 1.8) points and (41.6 ± 2.3) points] were significantly lower than those of the control group [(50.9 ± 1.9) points and (53.0 ± 3.5) points,P =0.040,P =0.036,respectively].The quality of life scores,including the physiological function,body pain,general self rating,vitality,social function,emotional function and mental health score were (45.26 ± 38.26)points vs (35.17 ± 33.65) points (P =0.044),(71.98 ± 17.36) points vs (63.01 ± 18.41) points (P =0.039),(55.59 ± 12.78) points vs (49.67 ± 12.43) points (P =0.048),(74.82 ± 14.23) points vs (55.61 ± 10.58) points (P =0.027),(75.47 ± 12.15) points vs (57.22 ± 14.78) points (P =0.031),(70.24 ± 22.00) points vs (45.92 ± 34.76) points (P =0.004),(78.31 ± 19.11) points vs (67.23 ± 11.96) points (P =0.037),respectively,the scores in the observation group were significantly higher than those in the control group (all P ＜ 0.05).Conclusion The extra mental nursing intervention on gastric cancer with liver metastasis patients,treated with TACE sequential chemotherapy,can not reduce the patients'negative mood,improve the patients'compliance with chemotherapy and the confidence to treatment,but improve the quality of patients'life effectively.
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Objective To investigate the effect on blood coagulation function and immune function in patients with gas-tric cancer by laparoscopic radical gastrectomy and open operation. Methods In our hospital from June 2011 to June 2014,selected hospitalized patients with gastric cancer 30 cases as the research object,15 cases were undergone tradi-tional open operation in patients with the establishment of the control group, the remaining 15 cases received laparo-scopic radical resection of gastric cancer,set up the observation group,the changes of the TT,APTT,INR,FIB,D-D of blood coagulation indexes of two groups were compared,and changes in two groups of patients with immune function indexes of CD3+,CD4+,CD8+,CD4+/CD8+,and the operation time,bleeding amount of two groups of operation,ambula-tion time, hospital stay, postoperative complications were compared between two groups. Results In the observation group and the control group after 24 h,the FIB,D-D was significantly higher than the preoperative,and the observa-tion group patients after operation significantly were higher than the control group (P<0.05). After operation 1 weeks,CD3+,CD4+, CD8+, CD4+/CD8+of observation group showed no significant changes (P>0.05). CD3+, CD4+, CD4+/CD8+of control group after 1 weeks significantly changed compared with the preoperative, and CD3+, CD4+, CD4+/CD8+ of observation group compared with the control group,the difference was statistically significant(P<0.05). But CD8+of the control group had no obvious change before and after surgery(P>0.05). The observation group patients' out of bed activity time, postoperative hospitalization time was significantly shorter than that in the control group,the amount of bleeding observation group was significantly less than that the control group(P<0.05). Conclusion Laparoscopic radical gastrectomy for gastric cancer curative has good effect, compared with open radical gastrectomy for gastric cancer with less bleed-ing, fewer complications, patients recovered quickly, the advantages of immune function in patients with small inter-ference, but the effects of laparoscopic operation on blood coagulation in patients with more significant, corresponding measures should be taken to prevent the formation of thrombus coagulation abnormalities caused by postoperative.
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Objective To explore the effect of psychological nursing intervention on the pain, sleep quality and life quality of patients with gastric cancer. Methods A total of 84 cases of gastric cancer patients from January 2013 to January 2014 were randomly divided into intervention group and control group, 42 cases in each group, the control group was received conventional care, while the intervention group focused on the implementation of psychologicalnurs-ing intervention, SAS, SDS scores, VAS scores and PSQI scores before and after the intervention, and the general health, physiological function, physiological function, body pain, vitality, social function, emotional function, mental health quality of life scores were compared before and after intervention between two groups. Results After intervention, the SAS scores, SDS scores, VAS scores decreased significantly than before intervention and intervention group were lower than control group(P<0.05),the PSQI scores were significantly lower than before the intervention and intervention group were lower than the control group (P<0.05), after the intervention,the physical function, physical function, bodily pain, vitality, social functioning, role emotional, mental health scores were significantly higher than before intervention and intervention group were higher than the control group(P<0.05). Conclusion Positive psychological nursing interven-tion for gastric cancer helps to alleviate patients anxiety, depression and other negative psychological, reduce pain and improve sleep quality in patients, to further improve the quality of life of patients.
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Objective To study the effect of comfortable nursing of cancer related fatigue and quality of life in patients with gastric cancer. Methods A total of 76 cases in our hospital for gastric cancer radical operation of gastric cancer patients from January 2013 to January 2014 as the observation objects, randomly were divided into observation group and control group, 38 cases in each group. The control group underwent conventional symptomatic care, the intervention group mainly implemented comfortable nursing, the quality of life of fatigue of RPFS scores and QOL scores were com-pared between the two groups before and after intervention. Results There were no significant differences in behavior, emotion, body tired, cognitive RPFS scores between intervention group and control groups before intervention (P>0.05). After the intervention, the behavior fatigue, emotional fatigue, body fatigue and cognitive RPFS scores in interven-tion group and control group were significantly reduced compared with before intervention, and there was statistically significant difference between two groups (P<0.05). The physical function, role function, cognitive function, emotional function, social function of QOL scores of intervention group and control groups had no significant difference before in-tervention (P>0.05). After the intervention, the physical function, role function, cognitive function, emotional function, social function and QOL scores in intervention group and control group increased significantly compared with before in-tervention, there was statistically significant difference between two groups (P<0.05). Conclusion After radical opera-tion of gastric cancer patients, comfortable nursing intervention can reduce patient cancer-related fatigue, improve the quality of life of patients, conducive to the resumption of the disease.
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Objective To discuss Effect of negative psychological and life quality of humanized nuring intervention in patients with laparoscopic radical gastrectomy in the operation room. Methods 60 patients in our hospital from December 2012 to December 2014 were Selected, who underwent laparoscopic radical gastrectomy for gastric cancer as the re-search objects, and they were randomly divided into control group and observation group, 30 cases in each group. Con-trol group received routine nursing intervention. The observation group received humanistic care on the basis of the control group. Results The SAS, SDS scores of two groups before the intervention were compared, the difference was not statistically significant(P>0.05); After intervention, the SAS, SDS scores of two groups were significantly lower than those before intervention, the difference was statistically significant (t=9.234, 8.638, 7.742, 6.752, P<0.05), and after the intervention, SDS, SAS scores of observation group were significantly lower than the control group, the difference was statistically significant(t=6.342, 5.238, P<0.05). Before the intervention, the quality of life of body function, role function, emotional function, cognitive function, social function scores of two groups were compared, with no significant difference(P>0.05); after the intervention, the quality of life of body function, role function, the emotional function, cognitive function, social function the scores of two groups were significantly higher, and quality of life of body func-tion, role function, the emotional function, cognitive function, social function scores of the observation group were (50.21±5.62), (53.28±9.06), (52.15±3.65), (51.26±5.72), (50.35±3.41) respectively, was significantly higher than that of the control group, the difference was statistically significant(t=3.632, 3.216, 4.742, 3.725, 6.386, P<0.05). Conclusion The nursing intervention can improve negative psychological of patients with gastric cancer, can improve the quality of life of body function, role function, emotional function, cognitive function, social function, so that patients can revieve oper-ation actively and is good for recover.
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Objective To investigate the expression of KAI1 protein in tissues of papillary thyroid cancer (PTC) and follicular thyroid cancer,and the effect of KAI1 protein in invasion and metastasis of PTC.Methods The clinical data of 58 patients with PTC (PTC group),17 patients with follicular thyroid cancer (follicular cancer group) and 30 patients with benign thyroid tumor (control group) were retrospectively analyzed from January 2006 to August 2009.The expression of KAI1 protein in PTC tissues,follicular thyroid cancer tissues and benign thyroid tumor tiasues were detected by immunohistochemistry method.Results The positive expression rate of KAI1 protein in PTC group was 48.3％(28/58),in follicular cancer group was 47.1％(8/17),in control group was 86.7 ％(26/30).There was significant difference between PTC group,follicular cancer group and control group (P＜ 0.01).There was no significant difference between PTC group and follicular cancer group (P ＞ 0.05).There was no significant difference in the positive expression rate of KAI1 protein of PTC tissues among the different sex,age and size of the primary lesion (P＞ 0.05).The positive expression rate of KAI1 protein in the TNM Ⅰ was 88.9％(8/9),the TNM Ⅱ was 60.9％(14/23)and the TNM Ⅲ-Ⅳ was 23.1％ (6/26),there was significant difference in the positive expression rate of KAI1 protein among the different TNM stage (P ＜ 0.01).The positive expression rate of KAI1 protein in the lymph node metastasis patients was 32.3％ (10/31),the non-lymph node metastasis patients was 66.7％ (18/27),there was significant difference (P ＜ 0.05).Conclusion The expression of KAI1 protein may reflect the PTC metastasis and the clinical evolution of tumors,the KAI1 protein may inhibit the invasion and metastasis of PTC.
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Objective To compare the accuracy of endoscopic ultrasound (EUS) with double contrast enhanced ultrasound ( DCUS) in the preoperative staging of gastric malignancies. Methods This study included 162 patients with biopsy proven gastric cancer who underwent surgical resection as primary management of their malignancies. All patients underwent DCUS and EUS prior to surgical intervention with the results of the ultrasound findings compared with the pathological stages of the resected specimen. Results Among the 162 gastric cancer patients, there were 42 cases of T1, 49 cases of T2, 56 cases of T3, and 15 cases of T4 tumors. The overall accuracy of DCUS and EUS for the determination of loco-regional tumor infiltration ( T Staging) was 77. 2% and 74. 7% , (χ2 = 0. 273, P = 0. 603). Comparison of ultrasound techniques revealed that DCUS was superior to EUS only for a tumor depth of T3 (χ2 =5. 009, P = 0.025). Lymph nodes were correctly staged with DCUS and EUS in 78.4% and 57. 4% of cases, respectively ( χ2 = 16. 370,P =0.001). Using DCUS, the sensitivity of the technique was 78. 4% with a specificity of 78. 5%. In comparison, EUS had a sensitivity of 49. 5% with a specificity of 69. 2%. DCUS also detected a higher incidence of positive lymph nodes than EUS for poorly differentiated (81. 5% vs. 42. 6% ,χ2 =17. 338, P < 0. 01) and overall tumor types (78.4% vs. 49. 5% , χ2 = 17.523, P < 0. 01). Conclusions Double contrast-enhanced ultrasonography offers another noninvasive approach for the preoperative evaluation of gastric cancer. DCUS was comparable to EUS in tumor depth evaluation. DCUS offers an advantage in the detection of lymph node metastases, especially in poorly differentiated tumors.
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Objective To compare the efficacy of Lichtenstein and transabdominal preperitoneal patch repair(TAPP) in the treatment of primary inguinal hernia in adults. Methods The clinical data of 223 patients who received Lichtenste and 121 patients who underwent TAPP in our hospital between January 2002 and January 2006,were analyzed retrospectively.The efficacy and complications of the two methods were compared.Results The rate of intraoperative injury of the inner organs in the TAPP group was significantly higher than that in the Lichtenstein group [5.8%(7/121) vs 0.4%(1/223),?2=7.626,P=0.006],while no significant difference was detected in the rate of abdominal organ injury between the two groups [0.8%(1/121) vs 3.1%(7/223),?2=0.969,P=0.325].The rate of postoperative complications in the TAPP group was significantly lower than that in the Lichtenstein group [14.0%(17/121) vs 36.3%(81/223),?2=18.881,P=0.000].In the TAPP group,during a follow-up of(14?7) months,one case of recurrence was found(0.8%).Whereas in the Lichtenstein group,the patients were followed up for(16?8) months,two of them had recurrence(0.9%).No significant difference existed in the recurrence rate between the two groups(?2=0.000,P=1.000).Conclusions Both the Lichtenstein and TAPP have benefits and drawbacks.Individulized therapy is recommended for the patients with inguinal hernia.It is important for surgeons to know the indications of the operations.
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Objective To explore the effect of combined application of improved microencapsulation and intravenous injection of donor liver cells and spleen cells on pancreatic islet xenografts. Methods New born male pigs and SD rats were selected as donors and recipients respectively, and pig pancreatic islet cells were microencapsulated by static electricity improvement microencapsulation. Islet transplantation was performed after injection of donor liver cells and spleen cells via tail vein. The changes in blood glucose and serum C-peptide, the function-possessed days of islet xenografts and diabetes rats living period were observed. Results In combined application group, the function-possessed days of islet xenografts and diabetes rats living period were significantly prolonged (P
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Objective To explore the prevention and treatment of lymphorrhagia due to lymph node dissection in gastric carcinoma. MethodsClinical data of 743 patients undergoing radical gastrectomy plus lymphadenectomy from January 1997 to March 2004 were analyzed retrospectively. ResultsThe patients in D3 or D4 lymphadenectomy suffered from a higher lymphorrhagia rate than those in D2 lymphadenectomy(P