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1.
Chinese Pharmacological Bulletin ; (12): 1270-1272,1273, 2015.
Article in Chinese | WPRIM | ID: wpr-602804

ABSTRACT

Aim To explore the effect of Osthole (Ost)on the right ventricle remodeling in monocrot-alinetreated rats and the possible mechanism.Meth-ods ♂ SD rats were randomly divided into normal control group,model group,low dose of Ost treatment group (10 mg·kg -1 )and high dose of Ost treatment group (20 mg·kg -1 ).All rats were given a single dose of MCT 50 mg·kg -1 subcutaneously to establish the right ventricle remodeling except normal control group.Then the rats in Ost treatment group were ga-vaged once daily.After 28 days of administration,the right ventricle(RV)and left ventricle plus septum(LV+SEP)were weighed separately.RV hypertrophy in-dex (RVHI)were measured by the relative weight rati-o of RV to LV +SEP.The morphological changes of right ventricle were executed by HE staining.The pro-tein expression of PPARαand PPARγwere detected by Western blot.Results Compared with the control group,RVHI was increased obviously (P <0.05 ), myocardial hypertrophy and structure disorders were observed in model group.The protein expression of PPARαand PPARγwere down-regulated significantly in model group (P <0.05).Compared with the model group,the value of RVHI (P <0.05),myocardial hy-pertrophy,structure disorders were improved signifi-cantly in Ost treatment group.The protein expression of PPARαand PPARγwere up-regulated in Ost treat-ment group (P <0.05).Conclusion Ost can attenu-ate the right ventricle remodeling induced by MCT in rats,which may be related to up-regulating the expres-sion of PPARαand PPARγ.

2.
Article in Chinese | WPRIM | ID: wpr-600135

ABSTRACT

Objective To study the clinical efficacy of Danhong injection for the treatment of idiopathic pul-monary fibrosis.Methods 84 patients with idiopathic pulmonary fibrosis were randomized into the control group ( prednisone treatment) and the observation group ( based on the prednisone treatment, added the Danhong injec-tion),42 patients per group.The clinical efficacy,oxygen partial pressure and CO diffusing capacity,the TGF-β1 in the serum and pulmonary ventilation in the two groups were observed and compared after 6-week treatment. Results Compared with the control group, the total effective rate was significantly increased ( 92.9% vs 71.4%) in the observed group(P<0.05);compared with the control group,the oxygen partial pressure [(67.57 ±9.93) vs (51.74 ±9.21)]mmHg and CO diffusing capacity[(18.98 ±3.44) vs (15.83 ±3.06)]mL/(min· mmHg) were obviously increased in the observed group after treatment( P<0.05);compared with the control group,the content of TGF-β1 in the serum was significantly reduced [(1.15 ±0.13) vs (3.02 ±0.28)]μg/L and the pulmonary ventila-tion [(1.85 ±0.36) vs (1.69 ±0.30)]L was obviously increased in the observed group after treatment(P<0.05);compared with the control group,the incidence of adverse reactions was obviously reduced (4.8%vs 19.0%) in the observed group(P<0.05).Conclusion The treatment of Danhong injection for the idiopathic pulmonary fibrosis has the significant efficacy and high safety,can effectively correct th hypoxemia,significantly improve the lung function, which is worthy of clinical promotion.

3.
Article in Chinese | WPRIM | ID: wpr-447378

ABSTRACT

Objective To explore the method and effect of treating thoracolumbar fracture with posterior bone grafts on first stage and transpedicular internal fixation .Methods The clinical data of 22 cases with thoraco-lumbar fracture ,treated with posterior bone grafts on first stage and transpedicular internal fixation at the same time , were analyzed and assessed .Results In this group,the vertebral height and physiological curve were recovered satis-factorily,no loss of which was found in the long-term follow-up.There were no loosening of internal fixation ,infection and iatrogenic nerve injury .All patients had achieved bone fusion in one year after the operation of posterior bone grafts,and their nerve functions were recovered .Conclusion The operation of transpedicular internal fixation is safe and reliable ,and is proved to be an effective method of treatment for patients with thoracolumbar fracture .

4.
Chinese Pharmacological Bulletin ; (12): 519-522, 2014.
Article in Chinese | WPRIM | ID: wpr-446413

ABSTRACT

Aim To investigate the effect of icariin ( ICA) on renal interstitial fibrosis in SHR and explore its mechanism. Methods Fourteen male SHR of 13-week-old were randomly divided into model group( n=7 ) and ICA group ( n=7 ) , and WKY as control group (n=7). One week after adaptive breeding,the rats in the ICA group were given ICA 40 mg·kg-1,ig,bid to 26-week-old. The other rats in the model group and control group were given the same amount of normal sa-line. Then, the morphological changes of the kidney were observed by HE and Masson staining,respective-ly. The contents of plasma aldosterone andⅢcollagen were measured by double antibody sandwich method. The mRNA expressions of TGF-β1 , Smad2 , CTGF and FN were examined by real time RT-PCR. Results Compared with the normal control group, the kidney structures of model group were disordered,the mesang-ial matrix and the tubular interstitial fibrosis were in-creased. The contents of plasma aldosterone and Ⅲcollagen were increased in model group ( P <0. 01 ) . And the mRNA expressions of TGF-β1 , Smad2 , CTGF and FN in kidney tissues were up-regulated in model group( P <0. 01 or P <0. 05 ) . Compared with the model group,the kidney structures were improved and the contents of plasma aldosterone and Ⅲ collagen were reduced, as well as the mRNA expressions of TGF-β1,Smad2,CTGF and FN in kidney tissues were down-regulated(P<0. 01 or P<0. 05)in ICA group. Conclusion ICA may have anti-renal interstitial fi-brosis effect on SHR,and the mechanism might be re-lated to the reduced plasma aldosterone levels and the down-regulated expression of TGF-β1 and Smad2 .

5.
Article in Chinese | WPRIM | ID: wpr-431865

ABSTRACT

Objective To explore the method and effect of prosthetic replacement for the management of intertrochanteric fracture in the elderly.Methods 24 elderly patients with intertrochanteric fracture were treated with prosthetic replacement.According to the Evans classification,there were 4 cases of Evans Ⅱ,16 Evans Ⅲ and 4 Evans Ⅳ.Results The mean time to ambulation following the surgery was (6.0 ± 2.2) days.No prosthetic loosening or infection were observed in the follow-up of 6 to 27 months(average 12 months).According to the Harris hip score,the excellent and good rate was 83.3%.Conclusion Prosthetic replacement is safe and effective for intertrochanteric fractures in elderly patients,which allows early ambulation and have a relatively low rate of complications.

6.
Article in Chinese | WPRIM | ID: wpr-420568

ABSTRACT

Objective To explore the clinical effect of bone allograft plus interlock plate internal fixation in the treatment of tibial plateau fractures.Methods 43 patients with tibial plateau fractures were treated by open reduction,bone allograft,locking plate fixation and early knee joint function training.Results All patients were followed up for 8 ~ 14 months with an average of 10 months.All patients achieved bone union and the duration of union was averaged 6.9 months.Knee joint function was rated based on HSS score system as excellent in 30 cases,good in 9 cases,fair in 3 cases and poor in 1 case.The excellent and good rate was 90%.Conclusion Reliable effect can be achieved for fracture of tibial plateau treatment with bone allograft plus interlock plate internal fixation.It provides satisfactory function of the knee.It has many advantages,such as stable and durable fixation and avoidance of secondary compression of tibial plateau.

7.
Article in Chinese | WPRIM | ID: wpr-679697

ABSTRACT

Objective: To explore the mechanism of Qiangpi Bujing Huayu Yizhi Capsule(QBHYC) in treatment of multi-infarct dementia(MID).Methods: The complex MID model was made by administration of Small Chengqi Decoction and injection of emboli into the internal carotid artery.The dementia rats were randomly divided into 4 groups,the sham operation group,the operation group,the Chinese materia medica group and the western medicine group.The activity of SOD and the content of MDA in the rats' plasma and brain were detected by photochemical methods,and the mechanism of the possible intervention effects of QBHYC was analyzed.Results: The activity of SOD in the Chinese materia medica group was significant increased,while the content of MDA of this group was attenuated,compared with that of the operation group and the western medicine group,it had highly significant difference(P

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