Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 242
Filter
1.
Article in Chinese | WPRIM | ID: wpr-931250

ABSTRACT

Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addi-tion,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSA-LDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.

2.
Article in Chinese | WPRIM | ID: wpr-927419

ABSTRACT

OBJECTIVE@#To observe the effect of wheat-grain moxibustion at "Dazhui" (GV 14) on the expressions of Beclin-1 and GRP78 in spinal dorsal horn in rats with cervical spondylotic radiculopathy (CSR), and to explore the possible analgesic mechanism of wheat-grain moxibustion for CSR.@*METHODS@#A total of 48 SD rats were randomly divided into a sham operation group, a model group, a wheat-grain moxibustion group and a wheat-grain moxibustion+3-MA group, 12 rats in each group. The CSR model was prepared by spinal cord insertion method. Three days after modeling, the rats in the model group were intraperitoneally injected with 1 mL of 0.9% sodium chloride solution; the rats in the wheat-grain moxibustion group were treated with wheat-grain moxibustion at "Dazhui" (GV 14, 6 cones per time) on the basis of the model group; the rats in the wheat-grain moxibustion+3-MA group were intraperitoneally injected with 3-MA solution and wheat-grain moxibustion at "Dazhui" (GV 14, 6 cones per time). The three groups were intervened for 7 days, once a day. The gait score and mechanical pain threshold were observed before treatment and 7 days into treatment; after the treatment, the expressions of mRNA and protein of Beclin-1 in spinal dorsal horn were detected by real-time fluorescence quantitative PCR and immunohistochemistry; the expression of GRP78 protein in spinal dorsal horn was detected by Western blot method; the autophagosomes and ultrastructure in spinal dorsal horn neurons were observed by electron microscope.@*RESULTS@#After the treatment, compared with the sham operation group, in the model group, the gait score was increased and the mechanical pain threshold was decreased (P<0.01), and the expression of GRP78 protein in spinal dorsal horn was increased (P<0.01). Compared with the model group and the wheat-grain moxibustion+3-MA group, in the wheat-grain moxibustion group, the gait score was decreased and mechanical pain threshold was increased (P<0.01), and the expression of GRP78 protein in spinal dorsal horn was decreased, and the expressions of mRNA and protein of Beclin-1 were increased (P<0.01). Under electron microscope, the ultrastructure of spinal dorsal horn neurons in the wheat-grain moxibustion group was not significantly damaged, and its structure was basically close to normal, and the number of autophagosomes was more than the other three groups.@*CONCLUSION@#Wheat-grain moxibustion at "Dazhui" (GV 14) has analgesic effect on CSR rats. The mechanism may be related to moderately up-regulate the expression of Beclin-1, enhance autophagy and reduce endoplasmic reticulum stress.


Subject(s)
Animals , Beclin-1/genetics , Endoplasmic Reticulum Chaperone BiP , Moxibustion , RNA, Messenger , Radiculopathy/therapy , Rats , Rats, Sprague-Dawley , Spinal Cord , Spinal Cord Dorsal Horn , Spondylosis , Triticum/genetics
3.
Article in Chinese | WPRIM | ID: wpr-877666

ABSTRACT

OBJECTIVE@#To observe the protective effect of electroacupuncture (EA) at Neiguan (PC 6) on pulmonary function during one-lung ventilation (OLV) in patients with lobectomy, and explore its action mechanism.@*METHODS@#Sixty patients with lobectomy were randomly divided into an observation group and a control group, 30 cases in each one. The patients in the control group were treated with general anesthesia, and OLV was given when surgery began; when the surgery finished, air was removed from the thoracic cavity and two-lung ventilation was performed. On the basis of the treatment in the control group, the patients in the observation group were treated with EA (disperse-dense wave, 2 Hz/100 Hz of frequency) at Neiguan (PC 6) 30 min before anesthesia induction until the end of the surgery. The pulmonary function indexes [arterial partial pressure of oxygen (PaO@*RESULTS@#Compared with T@*CONCLUSION@#EA at Neiguan (PC 6) has protective effects on lung injury induced by OLV after lobectomy, and its mechanism may be related to the improvement of oxidative stress and inflammatory response.


Subject(s)
Anesthesia, General , Electroacupuncture , Humans , Lung , Lung Injury , One-Lung Ventilation
4.
Article in Chinese | WPRIM | ID: wpr-877624

ABSTRACT

OBJECTIVE@#To compare the therapeutic effect of acupuncture combined with wheat-grain moxibustion and oral fluoxetine hydrochloride capsule on perimenopausal depression with kidney deficiency and liver depression.@*METHODS@#A total of 60 patients of perimenopausal depression with kidney deficiency and liver depression were randomized into an observation group and a control group, 30 cases in each one. Acupuncture combined with wheat-grain moxibustion were adopted in the observation group. Acupuncture was applied at Baihui (GV 20), Yintang (GV 29), Fengchi (GB 20), etc. for 30 min. Wheat-grain moxibustion was applied at Ganshu (BL 18), Shenshu (BL 23), Mingmen (GV 4) and Yongquan (KI 1), 3 moxa-cones for each acupoint. The treatment in the observation group was given once every 2 days, 3 times a week. Fluoxetine hydrochloride capsule was given orally in the control group, 20 mg each time, once a day. Treatment for 8 weeks was required in the both groups. The scores of Hamilton depression scale (HAMD) and modified Kupperman scale were observed in the both groups before and after treatment, and at 1, 3, 6-month follow-up. The therapeutic efficacy was evaluated after treatment.@*RESULTS@#Compared before treatment, the scores of HAMD and modified Kupperman scale after treatment and at each time point of follow-up were decreased in the both groups (@*CONCLUSION@#Acupuncture combined with wheat-grain moxibustion can effectively treat perimenopausal depression with kidney deficiency and liver depression, and have more stable and sustained therapeutic effect compared with oral fluoxetine hydrochloride capsule.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Depression/therapy , Humans , Kidney , Liver , Moxibustion , Perimenopause , Treatment Outcome , Triticum
5.
Acta Pharmaceutica Sinica ; (12): 496-502, 2021.
Article in Chinese | WPRIM | ID: wpr-873765

ABSTRACT

Antibody-drug conjugates (ADCs) are one of the most important classes of anticancer therapeutics. Human epidermal growth factor receptor-2 (HER2), which is highly expressed in many types of aggressive cancers including breast and ovarian cancer, has been approved as an ideal target for ADCs. Lidamycin (LDM), developed by Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, is an enediyne-containing antibiotic with potent anti-tumor activity. LDM is a promising payload for ADCs. In the present research, using a special site-directed conjugating technology, we made a novel ADC (607-LDM) with a drug-to-antibody ratio (DAR) of 2 and composed of the anti-HER2 antibody 607 and LDM. The new ADC exhibited potent antitumor activity against human ovarian cancer SKOV3 and breast cancer BT-474 cells. It also induced apoptosis and G2/M arrest. In nude mice with SKOV3 xenografts and a tumor volume of 150-200 mm3, a single intravenous injection 607-LDM at 1 mg·kg-1 induced tumor growth inhibition of 72.4%, which was significant compared to either LDM (50.6%) or antibody (30.2%) treatment alone, or both in combination (50.1%, P < 0.05). All animal experiments were performed in accord with National Regulations and approved by the Animal Experiments Ethical Committee of College of Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences. The novel ADC designed in this study, 607-LDM, is a promising candidate for the treatment of HER2-positive cancers.

6.
Article in English | WPRIM | ID: wpr-902945

ABSTRACT

Objective@#Combined oral contraceptives (COCs) are used for various reasons. However, venous thromboembolism (VTE), a significant side effect, can be fatal. This study reports the first case series in Korea involving patients with COC-associated VTE registered at a university hospital. @*Methods@#This study recruited 13 patients diagnosed with COC-associated VTE between June 2006 and May 2018. Risk factors, including age, body mass index, smoking habits, estrogen dosage, type of progestin, and duration of COC use, were evaluated. @*Results@#Among patients with VTE, 9 showed pulmonary embolism (PE) concomitant with deep vein thrombosis (DVT). However, the remaining patients showed DVT (1 patient), PE (1 patient), and cerebral venous thrombosis (2 patients). The median duration between the onset of symptoms and a hospital visit was 3 days, and it sometimes took as long as 32 days. Among the 10 patients with PE, 1 high-risk group and 2 intermediate-high risk groups were treated with tissue plasminogen activators before anticoagulants. There were no cases of recurrence among patients who continued to take anticoagulants for 3 months. @*Conclusion@#These findings emphasize that healthcare professionals who prescribe or dispense COCs to women must inform them of the risk of VTE, including the risk factors, differences in risk depending on the type of progestin present in the product, and pertinent signs and symptoms. Efforts should also be made to inform patients of VTE, even through information campaigns such as brochures. Most importantly, women should remain alert for signs and symptoms of VTE when using COCs.

7.
Article in Korean | WPRIM | ID: wpr-901211

ABSTRACT

Objective@#Previous studies lacked an accurate analysis of age-specific mortality because they included either a single hospital’s data or survey-based method, rather than the patient’s information from the emergency room (ER). Therefore, this study analyzed the mortality risk by age group among patients who visited the ER with suicidal attempts using large-scale data. @*Methods@#Data were collected from the in-depth surveillance data of injury among patients who visited the ERs of 23 hospitals from January 2011 to December 2018. Their ages were divided into 10-year ranges for patients aged 15 years or older (15-24, 25-34, 35-44, 45-54, 55-64, 65-74, and ≥75 years). The patients’ sex, alcohol consumption before the injury, time of injury, place of injury, ambulance used for transport to the ER, disposition at the ER, and total deaths were investigated. @*Results@#The number of patients was 41,257, of which 38,229 (92.7%) survived and 3,082 (7.3%) died. The proportions of patients in each group who died from suicidal attempts in the 15-24, 25-34, 35-44, 45-54, 55-64, 65-74, and ≥75 years groups were 2.7%, 3.1%, 5.4%, 7.8%, 12.0%, 18.5%, and 21.8%, respectively (P<0.001). A statistically positive-response relationship was noted (P trend<0.001). As a result of adjusting for sex, age, place of injury, time of injury, and alcohol consumption in multivariate logistic regression analysis, and the odds ratios of deaths were 1.70, 2.37, 2.86, 5.18, 5.48, and 6.41, respectively (reference, 15-24 years). Moreover, compared to women, the men’s odds ratio of death was 1.58. @*Conclusion@#Among patients who visited the ER due to suicidal attempts, those of advanced age and males have high mortality.

8.
Article in English | WPRIM | ID: wpr-899540

ABSTRACT

Objectives@#The aim of this study was to determine the dental caries experience of children in Laos. @*Methods@#Oral examinations were performed on a total of 1,540 students in 513 primary school students, 537 middle school students, and 490 high school students and the results analyzed. @*Results@#The dft index (decayed-filled primary teeth index) of 6-year-old primary school children was 6.04. The DMFT index (decayed-filled-missing permanent teeth index) was 1.59 in 12-yearold middle school children and 2.04 in 15-year-old middle school children. @*Conclusions@#Caries experience in most of the age groups was on the high side. It is considered that in Laos, a treatment project to stop the progression of caries is necessary in parallel with a prevention project to lower the caries fatality rate.

9.
Article in Korean | WPRIM | ID: wpr-893507

ABSTRACT

Objective@#Previous studies lacked an accurate analysis of age-specific mortality because they included either a single hospital’s data or survey-based method, rather than the patient’s information from the emergency room (ER). Therefore, this study analyzed the mortality risk by age group among patients who visited the ER with suicidal attempts using large-scale data. @*Methods@#Data were collected from the in-depth surveillance data of injury among patients who visited the ERs of 23 hospitals from January 2011 to December 2018. Their ages were divided into 10-year ranges for patients aged 15 years or older (15-24, 25-34, 35-44, 45-54, 55-64, 65-74, and ≥75 years). The patients’ sex, alcohol consumption before the injury, time of injury, place of injury, ambulance used for transport to the ER, disposition at the ER, and total deaths were investigated. @*Results@#The number of patients was 41,257, of which 38,229 (92.7%) survived and 3,082 (7.3%) died. The proportions of patients in each group who died from suicidal attempts in the 15-24, 25-34, 35-44, 45-54, 55-64, 65-74, and ≥75 years groups were 2.7%, 3.1%, 5.4%, 7.8%, 12.0%, 18.5%, and 21.8%, respectively (P<0.001). A statistically positive-response relationship was noted (P trend<0.001). As a result of adjusting for sex, age, place of injury, time of injury, and alcohol consumption in multivariate logistic regression analysis, and the odds ratios of deaths were 1.70, 2.37, 2.86, 5.18, 5.48, and 6.41, respectively (reference, 15-24 years). Moreover, compared to women, the men’s odds ratio of death was 1.58. @*Conclusion@#Among patients who visited the ER due to suicidal attempts, those of advanced age and males have high mortality.

10.
Article in English | WPRIM | ID: wpr-891836

ABSTRACT

Objectives@#The aim of this study was to determine the dental caries experience of children in Laos. @*Methods@#Oral examinations were performed on a total of 1,540 students in 513 primary school students, 537 middle school students, and 490 high school students and the results analyzed. @*Results@#The dft index (decayed-filled primary teeth index) of 6-year-old primary school children was 6.04. The DMFT index (decayed-filled-missing permanent teeth index) was 1.59 in 12-yearold middle school children and 2.04 in 15-year-old middle school children. @*Conclusions@#Caries experience in most of the age groups was on the high side. It is considered that in Laos, a treatment project to stop the progression of caries is necessary in parallel with a prevention project to lower the caries fatality rate.

11.
Chinese Acupuncture & Moxibustion ; (12): 1333-1337, 2021.
Article in Chinese | WPRIM | ID: wpr-921055

ABSTRACT

OBJECTIVE@#To compare the clinical effect of acupuncture combined with wheat-grain moxibustion and oral sertraline hydrochloride dispersible tablets in the treatment of mild to moderate postpartum depression.@*METHODS@#Sixty patients with mild to moderate postpartum depression were randomly divided into an observation group and a control group, 30 cases in each group. Both groups were treated with psychotherapy. The control group was treated with oral sertraline hydrochloride dispersible tablets, 50 mg each time, once a day; the observation group was treated with acupuncture at Qihai (CV 6), Zusanli (ST 36), Xuehai (SP 10), Hegu (LI 4), Sanyinjiao (SP 6), Taixi (KI 3), etc. combined with wheat-grain moxibustion at Xinshu (BL 15), Pishu (BL 20), Ganshu (BL 18) and Shenshu (BL 23), once every other day, 3 times a week. Both groups were treated for 4 weeks as a course, with 2 consecutive courses of treatment. Before and after treatment and follow-up of 3 months after the end of treatment, the Hamilton depression scale (HAMD), Edinburgh postnatal depression scale (EPDS) and World Health Organization quality of life-BREF (WHOQOL-BREF) score of the two groups were compared, and the clinical effect was assessed.@*RESULTS@#After treatment and during follow-up, the HAMD and EPDS scores of the two groups were lower than before treatment (@*CONCLUSION@#Acupuncture combined with wheat-grain moxibustion can improve the depressive symptoms of patients with mild to moderate postpartum depression and improve their quality of life, and the clinical effect is more lasting and stable than oral sertraline hydrochloride dispersible tablets.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Depression, Postpartum/therapy , Female , Humans , Moxibustion , Quality of Life , Treatment Outcome , Triticum
12.
Chinese Acupuncture & Moxibustion ; (12): 1005-1009, 2021.
Article in Chinese | WPRIM | ID: wpr-921000

ABSTRACT

OBJECTIVE@#To observe the effect of auricular acupuncture on reduction rate of sertraline hydrochloride, and to explore the long-term efficacy of auricular acupuncture in patients with depression.@*METHODS@#Seventy-two patients with depression were randomly divided into an observation group (36 cases, 1 case dropped off) and a control group (36 cases, 2 cases dropped off). The patients in the control group were treated with conventional dosage reduction method, that is, the dosage of sertraline hydrochloride was reduced by 25% every week until the dosage was stopped completely on the premise of no aggravation of depressive symptoms. Based on the conventional dosage reduction method used in the control group, the patients in the observation group were treated with auricular acupuncture at Xin (CO@*RESULTS@#The dosage of sertraline hydrochloride in the observation group was less than that in the control group after 2, 3, 4 weeks of dosage reduction and during follow-up (@*CONCLUSION@#Auricular acupuncture could effectively reduce the dosage of sertraline hydrochloride, improve the dosage reduction rate, reduce the incidence of withdrawal syndrome and reduce the risk of long-term recurrence in patients with depression.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Acupuncture, Ear , Depression/drug therapy , Humans , Sertraline , Treatment Outcome
13.
Article in English | WPRIM | ID: wpr-914227

ABSTRACT

Combination treatment with hypomethylating agents (HMAs) and venetoclax is being used increasingly in elderly patients with acute myeloid leukemia (AML).Venetoclax with HMAs has been reported to be associated with tumor lysis syndrome (TLS) in AML patients with high leukemic burden. We present a case of an elderly AML patient with low leukemic burden who developed TLS while receiving venetoclax and azacitidine (AZA). A 74-year-old man with newly diagnosed AML with NPM1 mutation received combination therapy with venetoclax and AZA in an outpatient clinic. Within 12 hours after starting venetoclax and AZA, the patient was admitted to the emergency room with fever, general weakness, and laboratory findings consistent with TLS. Based on our results, we recommend monitoring at the start of the treatment with venetoclax and HMAs to prevent and control TLS regardless of the leukemic burden and favorable genetic ris

14.
Article in English | WPRIM | ID: wpr-895241

ABSTRACT

Objective@#Combined oral contraceptives (COCs) are used for various reasons. However, venous thromboembolism (VTE), a significant side effect, can be fatal. This study reports the first case series in Korea involving patients with COC-associated VTE registered at a university hospital. @*Methods@#This study recruited 13 patients diagnosed with COC-associated VTE between June 2006 and May 2018. Risk factors, including age, body mass index, smoking habits, estrogen dosage, type of progestin, and duration of COC use, were evaluated. @*Results@#Among patients with VTE, 9 showed pulmonary embolism (PE) concomitant with deep vein thrombosis (DVT). However, the remaining patients showed DVT (1 patient), PE (1 patient), and cerebral venous thrombosis (2 patients). The median duration between the onset of symptoms and a hospital visit was 3 days, and it sometimes took as long as 32 days. Among the 10 patients with PE, 1 high-risk group and 2 intermediate-high risk groups were treated with tissue plasminogen activators before anticoagulants. There were no cases of recurrence among patients who continued to take anticoagulants for 3 months. @*Conclusion@#These findings emphasize that healthcare professionals who prescribe or dispense COCs to women must inform them of the risk of VTE, including the risk factors, differences in risk depending on the type of progestin present in the product, and pertinent signs and symptoms. Efforts should also be made to inform patients of VTE, even through information campaigns such as brochures. Most importantly, women should remain alert for signs and symptoms of VTE when using COCs.

15.
Article in Chinese | WPRIM | ID: wpr-868701

ABSTRACT

Objective:To investigate the clinical efficacy of concurrent chemotherapy in intensity-modulated radiotherapy (IMRT) for patients with stage Ⅲ nasopharyngeal carcinoma (NPC).Methods:Clinical data of 251 patients with stage Ⅲ NPC treated with IMRT alone or concurrent chemoradiotherapy (CCRT) at Sun Yat-sen University Cancer Center from February 2001 to December 2008 were retrospectively analyzed. The prognostic factors of NPC were analyzed and the efficacy of CCRT was assessed. The survival rate was calculated by Kaplan-Meier method. The differences between two groups were analyzed by log-rank test. The prognostic factors were analyzed by Cox model.Results:The 10-year locoregional-free survival (LRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) for NPC patients were 88.6%, 81.1%, 68.8% and 75.1%, respectively. Univariate and multivariate analyses demonstrated that N staging and nasopharyngeal tumor volume were the most important prognostic factors, and concurrent chemotherapy significantly improved PFS and OS (both P<0.05). In T 3N 0-1 patients, there was no significant difference in survival indexes between IMRT alone and CCRT (10y-LRFS: 93.8% vs. 93.2%, P=0.933; 10y-DMFS: 80.9% vs. 86.8%, P=0.385; 10y-PFS: 70.6% vs. 77.7%, P=0.513; 10y-OS: 71.8% vs. 83.6%, P=0.207). For T 1-3N 2 patients, CCRT was significantly better than radiotherapy alone in LRFS, PFS, and OS (10y-LRFS: 87.3% vs. 66.7%, P=0.016; 10y-PFS: 70.2% vs. 41.0%, P=0.003; 10y-OS: 78.5% vs. 51.7%, P=0.008), whereas there was an increasing trend in DMFS (10y-DMFS: 80.3% vs. 66.4%, P=0.103). Conclusions:Concurrent chemotherapy can improve clinical prognosis of stage Ⅲ NPC patients, and the most survival benefits are obtained in the N 2 group. Individualized treatment options should be delivered based on the risk of treatment failure.

16.
Article | WPRIM | ID: wpr-834900

ABSTRACT

Objective@#When bike riding under the influence of alcohol, incidence of injury increases, although reports of highly severe injuries is rare. Therefore, this study aimed to determine how drinking alcohol affects bicycle injuries. @*Methods@#This study included patients who visited the emergency departments at 23 hospitals. Participants were enrolled in the emergency department-based injury in-depth surveillance program of the Korea Centers for Disease Control and Prevention, were over 15-years-old, and were injured while riding a bike either with or without alcohol intake.Patients with important data missing or insufficient data such as Excess Mortality Ratio-adjusted Injury Severity Score (EMR-ISS) were excluded from the analysis. @*Results@#A total of 28,094 patients were analyzed. The alcohol-intake group numbered 1,946 (6.9%) while the non-alcohol-intake group numbered 26,148 (93.1%). The incidence of severe injury (EMR-ISS≥25) in the alcohol-intake group was 451 (23.2%), whereas that in the non-alcohol-intake group was 2,881 (11.0%), which was statistically different between the two groups (P<0.001). According to multivariate logistic regression, the odds ratio of severe injuries in the alcohol-intake group was 2.04 (95% confidence interval, 1.80-2.30) compared to the non-alcohol-intake group after adjusting for age, alcohol use, type of road, sex, injury time, and transportation. @*Conclusion@#Alcohol is associated with an increase in the incidence of severe injuries. Therefore, as part of preventive measures, it will be necessary to tighten regulations on post-drinking bike riding and improve awareness through public relations.

17.
Article | WPRIM | ID: wpr-834889

ABSTRACT

Objective@#Personal mobility vehicles (PMV) have been used widely as a means of replacing bicycles in recent yearsbecause of their convenience and high economic efficiency. On the other hand, accidents related to PMV are alsoincreasing, but there have been few studies in this area. This study examined the factors that increase the severity ofdamage and determine the characteristics of the PMV compared to the accidents on a bicycle. @*Methods@#Retrospective observational studies were performed. The variables related to the accident were collected andanalyzed for patients who visited the emergency room due to a PMV and bicycle accident. Multivariate logistic regressionanalysis was used to determine the factors affecting the severity of the patients. The odds ratios were calculated andcompared between injuries related to PMV and bicycles. @*Results@#A total of 1,124 patients (bicycles 1,017, PMV 107) were enrolled in this study. In multivariate regression analysis,the severity of PMV was higher (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.06-2.83) than that of a bicycle.The factors affecting the severity of the patients were age (OR, 1.02, 95% CI, 1.01-1.03), alcohol use (OR, 1,70; 95% CI,1.04-2.70), ambulance transport (OR, 2.46; 95% CI, 1.78-3.40), and wearing a helmet (OR, 2.06; 95% CI, 1.36-3.13). @*Conclusion@#PMV showed higher severity of damage than a bicycle. The PMV, which is a new transportation means, isinsufficient for the prevention of safety compared to bicycles where driving regulations and wearing protective equipmentare common. Additional studies on the precise mechanisms of injury and damage are expected to prevent accidents andreduce their severity.

18.
Article in Korean | WPRIM | ID: wpr-901173

ABSTRACT

Objective@#Doctors or public health doctors at the nearest institution to a disaster scene often have to treat the casualties at the scene. Therefore, disaster medical education is necessary for medical students and doctors, but such education is not properly implemented. This study investigated the status of disaster medical education in Korean medical schools and the professors' thoughts on the appropriateness and necessity of disaster medical education. @*Methods@#A survey was conducted on working-level professors in charge of student education in emergency medicine in 40 medical schools. The survey asked the professors the current status of disaster medical education at each school and the professors' thoughts on the appropriateness and necessity of disaster medical education. @*Results@#Thirty-seven professors (92.5%) responded to the survey. Twenty-seven schools (73.0%) had a regular curriculum of disaster medicine. Disaster drills were conducted at 34 training hospitals (91.9%), while students of 10 schools (29.4%) were officially participating in the drill. Of the responders, 31 (83.8%) responded that disaster medicine is necessary for clinicians. Thirty-seven professors (100%) thought disaster medical education was necessary for medical students, and 20 (54.1%) of them responded that their schools did not provide adequate disaster medical education. @*Conclusion@#Many schools did not have a proper course on disaster medical education. Disaster medical education is necessary for medical students, but such education is not properly implemented.

19.
Article in English | WPRIM | ID: wpr-899530

ABSTRACT

Objectives@#In this study, we aimed to investigate the preventive and protective effects of new dentifrice containing dental type silica, tocopheryl acetate, fluorides, and sodium pyrophosphate on the mineral density of teeth and demineralization of tooth surfaces. @*Methods@#A total of 119 bovine teeth pre-treated with the new dentifrice at three different concentrations for the experiment were randomly allocated into two control (DW and PW) and one experimental (EC) groups. The enamel surface of all bovine teeth were demineralized using an artificial demineralization solution. The dentifrice was diluted with distilled water (DW) at 1:1, 1:2, and 1:3 ratios. The samples were treated with the demineralization solution for 4 h after treatment with the supernatants of each diluted dentifrice for 30 min, and this procedure was repeated 3 times over a period of 24 h. The samples were examined using micro-CT to determine the amount of reduced bone mineral density (BMD) comparing the control and experimental dentifrices. The surface changes of the samples were also examined using the scanning electron microscope (SEM). @*Results@#The average BMD of the bovine enamel surface between the treated and non-treated area with the dimineralization solution was significantly different in the control, DW, PW 1:1, PW 1:2, and PW 1:3 groups. However, there was no significant difference observed in the experimental groups, including EC 1:1, EC 1:2, and EC 1:3. The average BMD of the dimineralized surfaces based on the results of the 7 groups was significantly higher in every EC group when compared to the DW and three PW groups. @*Conclusions@#The new dentifrice containing dental type silica, tocopheryl acetate, fluorides, and sodium pyrophosphate is effective in inhibiting the decrease in BMD and demineralization of enamel surface, which was observed when the new dentifrice and demineralization solution was repeatedly applied to the samples for 24 h.

20.
Article in Korean | WPRIM | ID: wpr-893469

ABSTRACT

Objective@#Doctors or public health doctors at the nearest institution to a disaster scene often have to treat the casualties at the scene. Therefore, disaster medical education is necessary for medical students and doctors, but such education is not properly implemented. This study investigated the status of disaster medical education in Korean medical schools and the professors' thoughts on the appropriateness and necessity of disaster medical education. @*Methods@#A survey was conducted on working-level professors in charge of student education in emergency medicine in 40 medical schools. The survey asked the professors the current status of disaster medical education at each school and the professors' thoughts on the appropriateness and necessity of disaster medical education. @*Results@#Thirty-seven professors (92.5%) responded to the survey. Twenty-seven schools (73.0%) had a regular curriculum of disaster medicine. Disaster drills were conducted at 34 training hospitals (91.9%), while students of 10 schools (29.4%) were officially participating in the drill. Of the responders, 31 (83.8%) responded that disaster medicine is necessary for clinicians. Thirty-seven professors (100%) thought disaster medical education was necessary for medical students, and 20 (54.1%) of them responded that their schools did not provide adequate disaster medical education. @*Conclusion@#Many schools did not have a proper course on disaster medical education. Disaster medical education is necessary for medical students, but such education is not properly implemented.

SELECTION OF CITATIONS
SEARCH DETAIL