Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 5 de 5
Add filters

Year range
China Pharmacy ; (12): 988-992, 2023.
Article in Chinese | WPRIM | ID: wpr-972273


OBJECTIVE To compare the efficacy, safety and economy of tacrolimus (TAC), cyclosporin A (CsA), cyclophosphamide (CTX) and rituximab (RTX) in the treatment of membranous nephropathy (MN). METHODS Retrieved from Pubmed, the Cochrane Library, Wanfang data, CNKI and health technology assessment (HTA) official website, HTA reports, systematic reviews/meta-analysis and pharmacoeconomic studies about TAC, CsA, CTX and RTX combined with glucocorticoid in the treatment of MN were collected during the inception and Mar. 2022. After data extraction and quality evaluation, descriptive analysis was performed on the results of the included studies. RESULTS A total of 15 articles were included, involving 13 systematic reviews/meta-analysis and 2 pharmacoeconomic studies. In terms of efficacy, TAC and CsA showed significant advantages in increasing the response rate, and could improve the levels of urine protein, serum albumin, serum creatinine and serum total cholesterol. In terms of safety, the incidence of adverse reaction induced by TAC, CsA and RTX was low and the symptoms were mild. In terms of economics, CTX cost lower but caused severe adverse reaction; TAC cost higher but showed higher remission rate and good safety. CONCLUSIONS TAC combined with glucocorticoid may be the recommended scheme for MN.

China Pharmacy ; (12): 1409-1414, 2022.
Article in Chinese | WPRIM | ID: wpr-927185


OBJECTIVE To provide reference for scientifi c and standardized development of clinical comprehensive evaluation of drugs in China. METHODS Guided by the theory of total quality management (TQM),drawing lessons from the successful experience of the British and German conducting evaluation ,combining with plan-do-check-act cycle and other quality management methods and tools ,drug clinical comprehensive evaluation of total quality management system was constructed in accordance with the requirements for our country related policy and local practice. RESULTS & CONCLUSIONS To construct total quality management system of clinical comprehensive evaluation of drugs in China from 5 aspects of organization system ,management process,assessment system ,evaluation and supervision platform ,support and guarantee mechanism. The organization system included national ,provincial and medical institutions ;management process should focus on the key links in the 3 stages of theme selection,evaluation and implementation ,and result transformation and application ;assessment system ,evaluation and supervision platform,support and guarantee mechanism should be established together so as to further improve the scientificity ,rationality, practicality and standardization of total quality management of clinical comprehensive evaluation of drugs. The development of total quality management is an effective starting point to promote the continual improvement of the drug clinical comprehensive evaluation;relevant government departments and the implementation of evaluation of medical institutions should further set up quality management consciousness ,establish report quality feedback mechanism and the results co-constructing and sharing mechanism and strengthen professional personnel training and innovation synergy regulation mode to ensure that the authenticity and reliability of evaluation results.

China Pharmacy ; (12): 1515-1519, 2021.
Article in Chinese | WPRIM | ID: wpr-881291


OBJECTIVE:To esta blish a special management system of carbapenems ,and to standardize the clinical and rational application of carbapenem antibacterial drugs. METHODS :According to the requirements of the relevant documents of National Health Commission of the People ’s Republic of China ,the special management system of carbapenems in the First Affiliated Hospital of University of Science and Technology of China (called“our hospital ”in short )was constructed. The use intensity,reasonable rate of prescription and the detection rate of carbapenem resistant Enterobacteriaceae were analyzed before and after management. RESULTS :The special management system of carbapenems in our hospital included organization construction,information construction of special management ,prescription review of special management drugs ,prescription comment intervention and so on. After the implementation of the special management system ,the intensity of carbapenems use decreased from 2.78 to 2.03,the reasonable rate of prescription increased from 62.8% to 98.3%(P<0.05). The detection rates of Acinetobacter baumannii ,Escherichia coli and Pseudomonas aeruginosa resistance to carbapenems decreased from 91.4%,2.4%, 49.5% to 79.7%,1.6%,39.7%,respectively. However ,the detection rate of Klebsiella pneumoniae resistance to imipenem increased from 34.4% to 50.0%. CONCLUSIONS :The special management system of carbapenems in our hospital has achieved some results in practice ,which helps to reduce the abuse of these drugs and improve the reasonable level of drug use and reduce the detection rate of drug-resistant bacteria. At the same time ,hospital infection control of K. pneumoniae resistance to imipenem should be strengthened.

China Pharmacy ; (12): 1646-1649, 2020.
Article in Chinese | WPRIM | ID: wpr-822634


OBJECTIVE:To provide referenc e for the construction of prescription review model in medical institution and key monitored drugs management. METHODS :A multidisciplinary collaborative prescription review mode was established in the First Affiliated Hospital of University of Science and Technology of China (called“our hospital ”for short ). The prescription management group (composed of the president in charge ,the director of pharmacy department ,the director of medical department and the person in charge of pharmacy ,medicine,nursing and administrative management )was set up under the Pharmaceutical Affairs Management and Drug Treatment Committee ;and then prescription review expert group (be responsible for providing professional technical consultation and final evaluation of prescriptions )and prescription review working group (be responsible for the initial evaluation of prescriptions )were set up. According to the Drug Administration Law ,the Law of Licensed Doctors and the Law of Anti-unfair Competition Act and so on ,the Measures for the Supervision and Administration of Drug Purchase ,Sale and Use in our hospital was formulated. The multi-disciplinary collaborative prescription review procedure was established to intervene key monitored drugs prescriptions. The utilization rate of key monitored varieties and prescription reasonability in our hospital were investigated before (Jun. 2019)and after the intervention (Sept. 2019)by the mode. RESULTS :The multidisciplinary collaborative prescription review mode was established sucessfully. The proportion of key monitored drugs in total drug sales amount decreased from 1.322% before intervention to 0.735% after intervention (P=0.010). The irrational rate of prescriptions decreased from 46.76% before intervention to 15.70% after intervention (P=0.023). The main types of irrational prescriptions were inappropriate usage and dosage (18.52%),inappropriate indications(12.50%),inappropriateroute of administration (9.26%)before intervention changed into inappropriate usage and dosage (15.70%)after intervention ; other irrational prescription types had been significantly improved. CONCLUSIONS : The multidisciplinary collaborative prescription review model shows significant effect on key monitored drugs and reduce irrational use of this variety in the clinic significantly.

China Pharmacist ; (12): 949-951, 2016.
Article in Chinese | WPRIM | ID: wpr-493980


Objective:To study the effect of quality control circle(QCC)on the reasonable ratio of clinical prescriptions. Methods:The dispensed prescriptions in orthopedic emergency department were reviewed in our hospital,and the reasons of unreasonable prescriptions were analyzed. According to the QCC technique,the activities were implemented,the standardized work process was made out and the results were studied. Results:After the six-month QCC activities,the unreasonable ratio of emergency orthopedics prescriptions was reduced from 70% to 21% ,and the target yield rate was 140% and the improvement rate was 70% . Conclusion:The QCC has obvious effect on the improvement of reasonable ratio of emergency orthopedics prescriptions.