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China Journal of Chinese Materia Medica ; (24): 2131-2138, 2019.
Article in Chinese | WPRIM | ID: wpr-773117


The dose-toxicity-effect relationship between licorice combined with rhubarb in purgation was studied. A total of 108 ICR mice were divided into control group,model group,positive group,low,medium and high-dose rhubarb groups,and low,medium and high-dose rhubarb-liquorice decoction group. After 6 days of continuous administration of loperamide hydrochloride,the constipation model of mice was replicated,and each group was given lactulose,different doses of rhubarb and rhubarb-liquorice decoction for 14 days. After administration,the defecation characteristics,blood biochemistry,liver,kidney and colon pathological changes in each group were compared. Based on the objective weight given by factor analysis,the dose-toxicity-effect relationship was comprehensively analyzed by multi-index scoring method. Two common factors were extracted by factor analysis,representing effect and toxicity respectively. The results showed that rhubarb could exert a diarrhea effect at the dosage of 1/2,2 and 8 times of the high limit set forth in the Chinese Pharmacopoeia,increase the defecation volume and the intestinal tract propulsion rate,reduce the time of anal and the oral transmission,and increase the water content of feces. The combination with licorice could alleviate its diarrhea effect,especially at the dosage of 1/2 times of the high limit set forth in the Chinese Pharmacopoeia. However,rhubarb showed obvious hepatic and colon toxicities at the dosage of 2 and 8 times of the high limit set forth in the Chinese Pharmacopoeia,and the combination with licorice could significantly reduce its toxicity. It shows that licorice has a " mediating" effect on rhubarb by alleviating the purgation property and reducing the toxicity.

Animals , Mice , Cathartics , Pharmacology , Colon , Dose-Response Relationship, Drug , Glycyrrhiza , Chemistry , Kidney , Liver , Mice, Inbred ICR , Plant Extracts , Pharmacology , Rheum , Chemistry , Toxicity Tests
Chinese Traditional and Herbal Drugs ; (24): 4552-4559, 2017.
Article in Chinese | WPRIM | ID: wpr-852436


To study the compatibility and application rules of Glycyrrhizae Radix et Rhizoma (GRR) in prescription by data mining. Using computer programming method to transform the information of 26 185 formulas containing GRR in traditional Chinese medicine recipe database to facilitate data analysis. Firstly, the herbs frequently compatible with GRR are found. Then the proportion of GRR and another medicine, family and genus of the diseases treated are counted, the efficacy of formulas as well as their relationship. Through data mining, it is found that GRR often used with Panax ginseng, Angelica sinensis, Poria cocos, Paeonia lactiflora, Zingiber officinale, Atractylodes macrocephala, and other drugs. The most commonly used ratio is 1:1. These herb-pairs are usually used for internal medical diseases and exerting clearing heat, relieving pain, resolving phlegm and relieving cough and asthma, interior-warming, reinforcing deficiency, and checking retching effect, etc. The properties and functions of GRR are the basis of its compatibility. The compatibility of GMM can increase efficiency and reduce toxicity. This paper will provide a basis for the research of the efficacy of GMM and provide reference for its clinical application.