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J. biomed. eng ; Sheng wu yi xue gong cheng xue za zhi;(6): 87-90, 2007.
Article in Chinese | WPRIM | ID: wpr-331389

ABSTRACT

The objective of this study was to prepare a biodegradable poly (DL-lactide) injectable gel of tinidazole. The formulation parameters evaluated in this study included polymer molecular weight, polymer concentration, solvent and drug loading, and orthogonal design was used to optimize the formulation. The preferable formulation was that 30% (w/w) poly(DL-lactide) (MW is 5 700) dissolved in 70% (w/w) N-methyl-2-pyrrolidone with 4%-6% (w/w) tinidazole.


Subject(s)
Delayed-Action Preparations , Drug Carriers , Chemistry , Gels , Lactic Acid , Chemistry , Polyesters , Polymers , Chemistry , Technology, Pharmaceutical , Methods , Tinidazole
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