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Objective A comprehensive evaluation of oral anticoagulants(OACs)was conducted using the A Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions(the Second Edition),to provide a reference for drug selection and clinical medication decisions in medical institutions.Methods Evaluation evidence was collected,and the drugs included in the evaluation were quantified on four dimensions of clinical properties(efficiency and safety),pharmaceutical properties,economy and others.Results All oral anticoagulants included in the evaluation had a score of 70 or higher in the comprehensive evaluation,while warfarin had the highest overall score.Clinical properties and pharmacologic properties were identified as the core attributes for drug selection evaluation.When considering only these factors,edoxaban received the highest score.Conclusion OACs are the preferred option for patients requiring long-term anticoagulation therapy.Various OACs offer distinct clinical advantages.Utilizing the Guidelines(Second Edition)for oral anticoagulant selection and evaluation can offer visual evidence for drug selection and promote the scientific,rational,and safe use of drugs in clinical management.
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OBJECTIVE To analyze the compatible stability of commonly used intravenous drugs in the intensive care units (ICU), and to provide a reference for improving medication safety in clinic. METHODS The commonly used intravenous drugs in the ICU of Hebei General Hospital were investigated and confirmed in April 1-30, 2022, and used as keywords to retrieve the relevant literature about compatible stability from PubMed, CNKI, Wanfang Data and other databases, and manually filtered with Micromedex database at the same time. Then, the compatible stability results of the included literature were analyzed descriptively. RESULTS Totally 32 commonly used intravenous drugs and 39 mixed infusion combinations were collected from ICU of this hospital. A total of 40 studies were included, only 2 studies followed all quality requirements; 18 studies validated their methods to guarantee correct reproducibility; 33 studies evaluated physical stability, including precipitate formation and pH changes; 32 studies evaluated chemical compatibility, mainly content/concentration changes. A total of 666 possible two-drug combinations were obtained from the included literature, of which 254 combinations of stability data were available, including 176 were stable, 68 were unstable, and 10 were contradictory. Totally 412 combinations had no stability results. Among two-drug combinations in ICU of this hospital, 42 combinations were stable, 14 combinations were unstable, and 2 combinations were contradictory. CONCLUSIONS The pH, solvent, excipients and preparation concentration are the factors that affect the stability. There are drug combinations with unstable compatibility of commonly used intravenous drugs in ICU of this hospital. The stability study methods are limited, and the stability data cannot meet the actual clinical needs.
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AIM: To explore the pharmacokinetic interactions between sorafenib and dapagliflozin in rats and to provide some theoretical basis for the rational clinical use of the two drugs. METHODS: An ultra -performance liquid chromatography-tandem mass spectrometry (UPLC / MS / MS) method was developed for the simultaneous determination of sorafenib and dapagliflozin. Male SD rats were randomly divided into 5 groups (6 rats in each group), including 100 mg / kg sorafenib group, 0.5 mg / kg dapagliflozin group, 1 mg / kg dapagliflozin group, and 100 mg/kg sorafenib combined with 0.5 mg/kg dapagliflozin group and 100 mg/kg sorafenib combined with 1 mg / kg dapagliflozin group, for sorafenib and dapagliflozin drug interaction study. All samples were analyzed using a validated UPLC/ MS/MS method, and the main pharmacokinetic parameters were calculated by compartment model. RESULTS: 1 mg/kg dapagliflozin increased the C
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Palbocicril, the first cyclin-dependent kinases 4 and 6 inhibitors, is a crucial milestone in the development history of antineoplastic drugs. It combined with aromatase inhibitor or fulvestrant as first-line, second-line or post-line therapy has good efficacy and safety for hormone receptor-positive, human epidermal growth factor receptor-2 negative locally advanced or metastatic breast cancer, which has a good application prospect. This article summarizes the clinical trials and safety studies related to palbociclib.
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Liver fibrosis is a key step in the progression of chronic liver diseases to liver cirrhosis and even liver cancer. In recent years, a large number of studies have shown the necessity of intervening in the process of liver fibrosis, and various anti-liver fibrosis drugs and active ingredients have been discovered. Non-coding RNAs also play an important role in the process of liver fibrosis, and searching for upstream non-coding RNAs that can regulate signaling pathways can provide new insights for anti-liver fibrosis treatment. This article introduces the process of liver fibrosis mediated by the TGF-β, Wnt/β-catenin, PI3K/Akt/mTOR, NF-κβ, Hippo, and MAPK signaling pathways, lists the latest anti-liver fibrosis drugs or active components in each signaling pathway, and summarizes the research advances in anti-liver fibrosis targets and drugs mediated by related non-coding RNAs, so as to provide new research ideas and treatment methods for anti-liver fibrosis treatment.
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Objective To comprehensively assess the strengths and weaknesses of the 24 antihypertensive drugs procured as Volume-based Procurement(VBP)and innovator drugs by using quantitative evaluation system,and to provide a reference for doctors and patients in medication guidance and pharmaceutical decision-making.Methods The Quantitative Evaluation Criteria in the"Quick Guide to Drug Evaluation and Selection in Chinese Medical Institutions"were refined and optimized.The 24 selected VBP and innovator antihypertensive drugs were quantitatively evaluated according to the optimized quantitative evaluation system with the help of Chinese and English databases such as China Knowledge Network,Wanfang data,Wipunet,Embased,PubMed,and Metstr,as well as guideline search tools such as Meikang MCDEX,Drugwise Data,Up To Date,Medical Pulse and other databases etc.Results Among the 24 antihypertensive drugs,only four innovator drug evaluation scores were higher than those of drugs selected as VBP,namely felodipine tablets,Fosinopril sodium tablets,indapamide extended-release capsules,Irbesartan hydrochlorothiazide tablets.there were five main differences in the evaluation scores,namely economy,consistency evaluation,drug expiry date,global use,and the status of manufacturing enterprises.It was found that 83%of the VBP drugs had higher evaluation scores than those of the innovator drugs.The economic score of the innovator drug was low,and the difference in the scores was between 1-11 points.Conclusion By using the quantitative evaluation system to evaluate the antihypertensive drugs,the advantages and disadvantages of the innovator and VBP antihypertensive drugs can be assessed comprehensively,and the digital characteristics of antihypertensive drugs can be given,and the evaluation score can provide the reference basis for the guidance and decision-making of medication for doctors and patients.
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Drug-drug interactions (DDI) of tyrosine kinase inhibitors (TKIs) mediated by metabolic enzymes and transporters have become an important issue in clinical practice recently. In addition to CYP450 enzymes, uridine diphosphate glucuronidases (UGTs) are another class of metabolic enzymes involved in the metabolism of TKIs, and most TKIs can inhibit the UGTs in vitro. Potential clinically meaningful DDIs may occur with the co-administration of TKIs and substrates or inhibitors of UGTs. This paper will mainly focus on the UGTs-mediated drug-drug and the effect of UGT1A genotype on the drug interactions of TKIs and explores strategies to address, aiming to provide clinicians and pharmacists with references for the safe and rational application of TKIs.
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Antidepressants are mainly used to treat mental illnesses. Traditional antidepressants mainly target monoamine neurotransmitters, but these drugs are slow to be effective and cannot meet clinical needs. Recently, therapeutics have been developed that depart from the traditional monoamine hypothesis and focus on the glutamatergic, GABAergic, opioidergic, and inflammatory systems. In recent years, great progress has been made in the development of new antidepressants, some of which have been applied in clinical practice. This article mainly summarizes the research mechanisms and treatment programs of new antidepressants, and briefly reviews common rapid-acting antidepressants.
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OBJECTIVE:To promote the safe use of severe ADR-inducing drugs in special population in our hospital. METHODS:According to detailed quantitative scoring rules of Quick Guide for Drug Evaluation and Selection in Chinese Medical Institutions,comprehensive evaluation database of drugs in our hospital was established. Drugs with ADR rating or ADE general terminology standard rating of 1,2,3 and 4 under the "safety" dimension were obtained from the database. According to the difference of the incidence of ADR ,4 kinds of severe ADR-inducing drugs ,such as very common (incidence≥10%),common (incidence 1%-<10%),occasional(incidence 0.1%-<1%)and rare (incidence <0.1%),were obtained. According to the quantitative scores of these 4 kinds of drugs in six special groups ,such as children ,pregnant women ,lactating women ,the elderly,patients with abnormal liver function ,and patients with abnormal kidney function ,the feasibility for special population to use drugs that cause severe ADR was analyzed. RESULTS :Among 1 172 chemical drugs in drug comprehensive evaluation database of our hospital ,18,73,61,and 357 kinds can cause very common ,common,occasional and rare severe ADR , respectively. Among them ,the incidence of severe ADR caused by tumor drugs was high ,so it was necessary to pay close attention to the use of tumor drugs in special populations. Totally 173 kinds of drugs were prohibited for children because the instructions clearly showed organ toxicity ,cytotoxicity and there were no guidelines recommending their use in children ,so the clinical medication should be used with extraordinary caution. There were 278 and 228 drugs prohibited for pregnant women and lactating women,which were prohibited for pregnant or lactating period due to embryonic toxicity and reproductive toxicity. There were 13 prohibited drugs for the elderly ,most of which were specialized drugs. Five kinds of drugs were prohibited in patients with abnormal liver function and seven were prohibited in patients with abnormal kidney function ,most of which were tumor drugs with strong hepatorenal toxicity. CONCLUSIONS :Established quantitative score system can provide effective guidance for the safe use of severe ADR-inducing drugs among 6 special populations as children ,pregant women ,lactating women ,the elderly ,the patients with abnormal liver function and the patients with renal
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OBJECTIVE:To provid e reference for hospital decision-maker to select and use repaglinide and naglinide reasonably. METHODS :Through reviewing literautre ,guideline and instruction ,full score system was estalished for comunni- cation between pharmacists and physicians ;from the aspects of clinical necessity ,effectiveness,safety,economy,medical insu- rance attribute ,essential medicine attribute ,original research attribute ,drug packaging attribute ,drug market and enterprise attributes,the Mini health technology assessment (Mini HTA )was carried out for repaglinide and nateglinide ,and scored on the basis of weight value. RESULTS :Repaglinide and naglinide ’s final score were 77 and 74,respectively. For type 2 diabetes,both of them could reduce postprandial blood glucose ,and had less side effect and good safety. They were both included in the medical insurance list. Both of them were original varieties ,easy to store and had a long period of validity. Although they were expensive in the treatment of type 2 diabetes,their manufacturers had a good reputation and were widely used in the world ,which was a good choice for patients with type 2 diabetes. But they were different to certain extent ;repaglinide could be used in patients with poor renal function [eGFR <30 mL/min] without dose adjustment ;nateglinide should be adjusted according to eGFR for renal excretion. Repaglinide was essential medicine but nateglinide wasn ’t;repaglinide didn ’t need shading storage but nateglinide did. In addition , a variety of liver drug enzyme inducers or inhibitors may interact with the two drugs ,and special groups should be used with. CONCLUSIONS :Mini HTA provide reference for the selection and rational use of repaglinide and nateglinide ;patients with type 2 diabetes can select suitable drug according to their own conditions and needs. When combined with other drugs ,blood glucose should be closely monitored to prevent the occurrence of hypoglycemia.
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OBJECTIVE: To establish a method for determination of fluconazole concentration in human plasma. METHODS: UPLC-MS/MS method was adopted to determine plasma after precipitated with acetonitrile. Using isotope fluconazole-d4 as internal standard, the determination was performed on ACQUITY UPLC BEH C18 column with mobile phase consisted of 0.1% formic acid-acetonitrile (gradient elution) at the flow rate of 0.3 mL/min. The column temperature was 40 ℃, and the sample size was 3 μL. ESI was used for positive ion scanning by multiple reaction monitoring mode. The ion pairs for quantitative analysis were m/z 307.1→220.0 (fluconazole) and m/z 311.1→223.0 (internal standard). RESULTS: The linear range of fluconazole was 10-5 000 ng/mL (r=0.998 1). The limits of quantitation was 10 ng/mL. RSDs of intra-day and inter-day were less than 8%; accuracy ranged 95.8%-106.7%. The extraction recovery ranged 97.3%-107.3% (RSD<5.0%, n=6), and matrix effect, dilution effect and residual effect didn’t influence quantitative analysis of the substance to be measured. CONCLUSIONS: The method is simple, rapid, specific and accurate, which can be used for therapeutic drug monitoring and pharmacokinetic study of fluconazole.
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OBJECTIVE: To standardize the management of temporary drug purchase, and to provide reference for drug selection in Hospital Pharmaceutical Administration and Drug Treatment Committee (Pharmaceutical Association). METHODS: Clinical pharmacists set up drug quantitative scoring table according to the 10 attributes of drugs as effectiveness, safety, economy, etc. 15 temporary purchased drugs submitted by departments in Oct. 2018 were graded according to the rules of the scoring table, and the evaluation results were fed back to Pharmaceutical Association. A retrospective evaluation of 20 temporary purchased drugs which were discussed at the Pharmaceutical Association from Jul. to Sept. 2018 was made according to previous approval model without using drug quantitative scoring table. The effect of pre-intervention was evaluated after using drug quantitative scoring table. RESULTS: Among 15 temporary purchased drugs, 2 of them scored below 60, and the unqualified rate was 13.3%. It suggested that 2 drugs could not be discussed at the meeting. Among 20 temporary purchased drugs that have been discussed at the meeting, 9 of them scored below 60, with the unqualified rate of 45.0%, suggesting that 9 drugs may have wasted the workload of the Pharmaceutical Association. CONCLUSIONS: Drug quantitative scoring table can play a pre-intervention role in the scoring of temporary purchased drugs to a certain extent. At the same time, the table can also be used as a relevant reference for hospital drug evaluation. It is helpful to optimize hospital drug use list and improve the level of rational drug use in clinic.
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OBJECTIVE: To establish a method for the concentration determination of apatinib mesylate in plasma of rats, and to investigate the effects of single and multiple administration of Wuzhi capsules on the pharmacokinetic behavior of apatinib mesylate in rats. METHODS: LC-MS/MS method was used to detect the plasma concentration of apatinib mesylate in rats. Using carbamazepine as internal standard, the determination was performed on Waters XBridge BEH C18 column with mobile phase consisted acetonitrile-0.1% formic acid solution (45 ∶ 55,V/V) at the flow rate of 0.3 mL/min. The column temperature was 40 ℃. The temperature of injector was 15 ℃, and the sample size was 2 μL. ESI was used for positive ion scanning in MRM mode. The ion pairs m/z used for quantitative analysis were 398.1→212.1 (apatinib mesylate) and 237.2→194.2 (internal standard). The rats were randomly divided into control group Ⅰ, observation group Ⅰ, control group Ⅱ, observation group Ⅱ, with 6 rats in each group. Control group Ⅰ were given single administration of apatinib mesylate intragastrically (50 mg/kg, similarly hereinafter). Observation group Ⅰ was given Wuzhi capsules intragastrically (450 mg/kg, similarly hereinafter), and then 10 min later given apatinib mesylate intragastrically. Control group Ⅱ was given normal saline intragastrically, once a day, for consecutive 7 d, and then were given single administration of apatinib mesylate. Observation group Ⅱ was given Wuzhi capsules intragastrically, once a day, for consecutive 7 d, and then 10 min later were given single administration of apatinib mesylate. The blood samples were collected from intraocular canthus vein plexus and determined 0.25, 0.5, 1.0, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 12.0, 24.0 h after intragastric administration, respectively. Pharmacokinetic parameters were apatinib mesylate were calculated and compared among those groups by using DAS 2.1 software and t-test. RESULTS: The linear range of apatinib mesylate were 2-2 000 ng/mL. The lower limit of quantitation was 2 ng/mL. RSDs of intra- day and inter-day were all lower than 10%, and the accuracy were 94.93%-104.68%. Matrix effect did not affect the quantitative analysis of the substance to be measured. Compared with control group Ⅰ, cmax, AUC0-24 h and AUC0-∞ of observation group Ⅰ were increased significantly, CLZ was decreased significantly (P<0.05). Compared with control group Ⅱ, AUC0-24 h and AUC0-∞ of observation group Ⅱ were increased significantly, and CLZ was decreased significantly (P<0.05). Compared with observation group Ⅰ, AUC0-24 h and AUC0-∞ of observation group Ⅱ were decreased significantly (P<0.05). CONCLUSIONS: Established LC-MS/MS method is sensitive and specific, and can be used for the concentration determination of apatinib mesylate in plasma of rats. Wuzhi capsules can influence in vivo pharmacokinetic behavior of apatinib mesylate in rats. The effect of multiple administration of Wuzhi capsules is weaker than that of single administration.
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OBJECTIVE: To systematically evaluate the effects of Shenqi fuzheng injection combined with conventional chemotherapy on the immune function of patients with advanced non-small cell lung cancer (NSCLC), and provide evidence-based reference for clinical medication. METHODS: Retrieved from Cochrane Library, PubMed, Medline, Embase, CNKI, Wanfang database, VIP and CBM, Shenqi fuzheng injection combined with conventional chemotherapy (trial group) versus conventional therapy (control group) for advanced NSCLC were collected. After literature screening, data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0 risk evaluation tool, Meta-analysis was performed by using Rev Man 5.3 statistical software. RESULTS: A total of 16 literatures were included, involving 1 324 cases. Results of Meta-analysis showed that there were no statistical significance in the difference of objective remission rate (ORR) [RR=1.14, 95%CI(0.91,1.43), P=0.25] and the level of CD8+ [MD=-1.26,95%CI(-4.10, 1.59),P=0.39] between 2 groups. The levels of CD3+ [MD=17.48, 95%CI(13.40, 21.56), P<0.000 01 ], CD4+[MD=12.26, 95%CI(8.39 16.13), P<0.000 01], CD4+/CD8+ [MD=0.33,95%CI(0.27, 0.39),P<0.000 01] and the percentage of NK cells [MD=9.33, 95%CI(5.72, 12.94), P<0.000 01] in trial group were significantly higher than control group. Results of subgroup analysis for medication duration of Shenqi fuzheng injection showed that after 1-14 d treatment of Shenqi fuzheng injection, the levels of CD3+ [MD=17.11, 95%CI(12.37 ,23.17),P<0.000 01], CD4+[MD=13.28,95%CI(8.33, 18.23),P<0.000 01], CD4+/CD8+[MD=0.36,95%CI(0.28,0.43),P<0.000 01] and the percentage of NK cells [MD=12.06,95%CI(7.52,16.61),P<0.000 1] in trial group were significantly higher than control group. After 21 d treatment of Shenqi fuzheng injection, the levels of CD3+[MD=14.88, 95%CI(7.51,22.26),P<0.000 01], CD4+[MD=10.56,95%CI(5.57,15.56),P<0.000 01], CD8+[MD=3.02, 95%CI(1.80, 4.23),P<0.000 01], CD4+/CD8+[MD=0.29,95%CI(0.23, 0.35),P<0.000 01] and the percentage of NK cells [MD=5.58,95%CI(2.49, 8.67),P=0.000 4] in trial group were significantly higher than control group. There was no statistical significance in the level of CD8+ between 2 groups after 7-14 d treatment of Shenqi fuzheng injection [MD=-4.26,95%CI(-12.60, 4.09),P=0.32]. The incidence of leukopenia, nausea and vomiting, and renal dysfunction in trial group were significantly lower than control group. There was no statistical significance in the incidence of hemoglobin decreased and thrombocytopenia between 2 groups. The results of publication bias showed that there was a greater possibility of publication bias in this study. CONCLUSIONS: Shenqi fuzheng injection combined with conventional chemotherapy may improve the immune function of patients with advanced NSCLC and improve the safety after chemotherapy. But more large-scale, milltiple-center and high-quality RCT are needed to validate this conclusion.
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OBJECTIVE:To establish the method for simultaneous determination of tenacissoside A,tenacissoside H and tenacissoside I in Marsdenia tenacissima. METHODS:UPLC-MS/MS method was adopted. The determination was performed on a Phenomenex Kinetex XB-C18column with mobile phase consisted of 0.1% formic acid solution-acetonitrile(gradient elution)at the flow rate of 0.2 mL/min. The column temperature was set at 40 ℃,and sample size was 5 μ L. Multiple reaction monitoring (MRM)mode was adopted with electrospray ion source as ion source,using positive ion scanning. Source jet voltage was 5 500 V,nebulizer pressure was 60 psi,heating pressure was 60 psi,curtain pressure was 20 psi and cone temp was set at 600 ℃. RESULTS:The linear ranges of tenacissoside A,tenacissoside H and tenacissoside I were 0.1-10 ng/mL(r=0.999 7),0.025-10 ng/mL(r=0.999 5),0.025-10 ng/mL(r=0.998 9),respectively;limited of quantation were 0.1,0.025,0.025 ng/mL,limited of detection were 0.05,0.012 5,0.012 5 ng/mL,respectively;RSDs of precision,stability and reproducibility tests were<4.0%. The recoveries were 97.67%-99.00%(RSD=0.47%,n=6),95.00%-101.67%(RSD=2.59%,n=6),96.67%-103.33%(RSD=2.83%, n=6). CONCLUSIONS:The method is simple,precise,stable and reproducible,and can be used for simultaneous determination of tenacissoside A,tenacissoside H and tenacissoside I in M.tenacissima.
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Objective:To determine and investigate the stability of ginkgo biloba extract injection from three different manufactur-ers respectively in 0.9% NaCl infusion and 5% glucose infusion under different conditions (room temperature, high temperature and light). Methods:Ginkgo biloba extract injection was mixed with the two kinds of infusions,and then divided into the normal tempera-ture group,the high temperature group and the light group. The appearance,insoluble particles,pH and content of flavonoids after the relevant treatment were investigated. The appearance and insoluble particles were tested according to the characteristics of the inspec-tion method described in Chinese Pharmacopoeia(2015 edition,volume IV,the general rule),and the content of flavonoids was detec-ted by HPLC-UV. Results:All the mixed solutions were yellow. No significant changes were found in the appearance,pH value,in-soluble particles and contents of quercetin and isorhamnetin in all the mixed solutions in 24 h. The pH value of the mixed solution with 5% glucose infusion was lower than that with 0.9% NaCl infusion,and all the pH values met the standard in Chinese Pharmacopeias. The kaemphenol content in the injection from Shenwei pharmaceutical company was higher than that from the other manufacturers, while the content of kaemphenol in all the injections was within the standard range. Conclusion:The quality of Ginkgo biloba extract injection from the three different manufacturers is stable under different conditions.
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Objective:To study the stability of compound Kushen mixed liquid to provide reliable evidence for safe clinical drug application.Methods:Compound Kushen injection was mixed respectively with 0.9% sodium chloride injection and 5% glucose injection,and then placed under the different conditions for 0,1,2,4,8,12,24 and 48 h.HPLC was conducted to determine the content changes of four components in compound Kushen mixed liquid,and the appearance,pH and insoluble particles were observed as well.Results:The mixed liquid of compound Kushen with 0.9% sodium chloride injection was stable in 48 h without the influence of light and temperature.However,the mixed liquid of compound Kushen with 5% glucose injection had poorer stability with storage time shorter than 12 h at room temperature and 2 h at high temperature.Conclusion:The stability of the mixed liquid of compound Kushen is closely related to the pH value of solvent.0.9% Sodium chloride injection is recommended as the solvent,and the mixed liquid should be used up in 48 h.
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OBJECTIVE:To develop a method for the simultaneous determination of 5 components in Shuganning injections. METHODS:HPLC method was adopted. The determination was performed on Symmetry? C18 column with mobile phase consisted of methanol-0.4% phosphoric acid(gradient elution)at the flow rate of 1.0 mL/min. The detection wavlengths were set at 238 nm (geniposide,baicalin) and 327 nm (chlorogenic acid,baicalein,scutellarin). The column temperature was 30 ℃ and the sample size was 10 μL. RESULTS:The linear ranges were 0.4062-26.0 μg/mL for chlorogenic acid(r=0.9999),2.5000-160.0 μg/mL for geniposide (r=0.9999),6.5620-420.0 μg/mL for baicalin (r=0.9999),0.3125-20.0 μg/mL for baicalein (r=0.9996), 0.5859-37.5 μg/mL for scutellarin (r=0.9998). The limits of quantify were no higher than 31.20 ng,limits of detection were no higher than 15.60 ng. RSDs of precision, stability and reproducibility tests were lower than 2.0% ;the recoveries were 97.72%-101.10%(RSD=1.21%,n=6),97.67%-102.40%(RSD=1.87%,n=6),97.64%-101.10%(RSD=1.31%,n=6), 96.45%-100.10%(RSD=1.47%,n=6),96.16%-101.10%(RSD=1.69%,n=6),respectively. CONCLUSIONS:The method is simple,precise,stable and reproducible,and can be used for simultaneous determination of 5 components in Shuganning injection.
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OBJECTIVE:To improve the hospital workflow and efficiency in temporary drug purchase approval process. METHODS:The approval function for temporary drug purchase was introduced into office automation(OA)system in our hospi-tal,and the effects were evaluated. RESULTS:According to ensuring the administrative approval process,system function permis-sion assignment and approval process design in temporary drug purchase in our hospital,functions for approving temporary drug purchase were established in OA system. It achieved convenient,efficient,timely,networking and paperless approval work,as well as standardized record,checking out at any time and automatic statistics for drug purchase. CONCLUSIONS:Introducing tem-porary drug purchase approval function into hospital OA system can simplify workflow,provide better service for clinic,and pro-mote development of hospital pharmacy management.
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Objective To evaluate the correlation and difference of reversed phase high performance liquid chromatography (RP-HPLC) and fluorescence polarization immunoassay (FPIA) on determining serum concentration of carbamazepine.Methods Fifty serum samples were collected,both RP-HPLC and FPIA methods were employed to determine the concentration of carbamazepine.The results were analyzed by paired t test,Bland-Altman and Deming regression methods,respectively.Results The results of measuring 50 samples by the two methods showed that FPIA datas were significantly higher than RP-HPLC datas,and there was statistically significant difference(P<0.05) and poorer consistency between two methods;There was good correlation between carbamazepine concentrations determined by the two methods.Deming regression equation was CFPIA=1.195 3 CRP-HPLC-0.144 0,and Pearson correlation coefficient was 0.968 5.Conclusion Clinicians should pay more attention to the difference of carbamazepine concentration determination by different methods when carbamazepine individualized dosage regimen was adjusted according to therapeutic drug monitoring.