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1.
National Journal of Andrology ; (12): 1093-1097, 2014.
Article in Chinese | WPRIM | ID: wpr-319560

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the effect of adjuvant hormonal therapy (AHT) immediately after radical surgery for high- risk organ-confined or locally advanced prostate cancer using the PSA-related biochemical relapse rate within 2 years after surgery.</p><p><b>METHODS</b>We retrospectively analyzed 62 cases of high-risk organ-confined or locally advanced prostate cancer. The patients were treated by laparoscopic radical prostatectomy or radical retropubic prostatectomy after MRI and ECT systemic bone imaging examination, which revealed no regional lymph node or bone metastasis. Thirty-two of the patients (group A) received AHT orally or subcutaneously from 2 weeks to 1 months after operation, and another 30 (group B) were left untreated. We followed up the patients for 2 years, measuring the serum PSA level every 3 months, performing ECT every 6 months, and recording the adverse reactions, medication dura- tion, and the patients'quality of life.</p><p><b>RESULTS</b>All the operations were successfully accomplished. The rate of 2-year biochemical relapse-free survival was 78.13% (25/32) in group A and 53.33% (16/30) in group B.</p><p><b>CONCLUSION</b>AHT immediately after radical surgery can improve the rate of biochemical relapse-free survival of the patients with high-risk organ-confined or locally advanced prostate cancer and check the progression and metastasis of the disease.</p>


Subject(s)
Aged , Antineoplastic Agents, Hormonal , Therapeutic Uses , Chemotherapy, Adjuvant , Disease Progression , Disease-Free Survival , Humans , Laparoscopy , Male , Middle Aged , Neoplasm Recurrence, Local , Blood , Neoplasm Staging , Prostate-Specific Antigen , Blood , Prostatectomy , Methods , Prostatic Neoplasms , Blood , Drug Therapy , Pathology , General Surgery , Quality of Life , Retrospective Studies
2.
National Journal of Andrology ; (12): 1091-1094, 2013.
Article in Chinese | WPRIM | ID: wpr-267982

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the clinical effect and application value of the modified method of prepuce-degloving repair (PDR) in the treatment of urethrocutaneous fistula (UCF) following hypospadias surgery.</p><p><b>METHODS</b>We retrospectively analyzed 87 cases of UCF caused by hypospadias repair from May 2001 to December 2011, of which 61 were treated by simple closure or Y-V plasty of the fistula (group A), and the other 26 by modified PDR (group B). We compared the success rate of surgery and long-term recurrence between the two groups.</p><p><b>RESULTS</b>The total success rates of repair were 78.7 and 96.2% in groups A and B, respectively. Thirteen cases in group A did not respond to surgery, of which 6 failed to be cured by the second operation but later were treated successfully by modified PDR. In comparison, there was only 1 case of failure in group B, which was cured by a second PDR.</p><p><b>CONCLUSION</b>Modified PDR can significantly improve the success rate and reduce the recurrence rate of UCF after hypospadias surgery, which deserves wide clinical application.</p>


Subject(s)
Child , Child, Preschool , Foreskin , General Surgery , Humans , Hypospadias , General Surgery , Male , Reconstructive Surgical Procedures , Methods , Retrospective Studies , Treatment Outcome , Urinary Fistula , General Surgery , Urologic Surgical Procedures, Male
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