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1.
Article in Chinese | WPRIM | ID: wpr-281676

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of the solid-state fermentation technology in extracting the ingredients of traditional Chinese medicine (TCM).</p><p><b>METHOD</b>Using Danggui Kushen pills as an example, four index ingredients of ferulic acid, matrine, matrine alkaloids and dry extract were compared comprehensively, and the difference between the two water extractions of fermented pills and unfermented pills was evalued.</p><p><b>RESULT</b>The comprehensive evaluated result was that extraction of fermented pills was better than that unfermented.</p><p><b>CONCLUSION</b>The solid-state fermentation is conducive to the extraction of prescription of Danggui Kushen pills.</p>


Subject(s)
Chemical Fractionation , Methods , Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Chemistry , Metabolism , Fermentation , Reproducibility of Results , Water , Chemistry
2.
Article in Chinese | WPRIM | ID: wpr-285362

ABSTRACT

<p><b>OBJECTIVE</b>To optimize the combination modes of medical materials in extract of Huanglian Jiedu decoction.</p><p><b>METHOD</b>Divided the medical materials of Huanglian Jiedu decotion into 15 groups and extracted by semi-bionic estraction (SBE), the contents of berberine, baicalin, geniposide, total alkaloid, total flavonoid, total integral calculus area of HPLC and extract of 1 000 were determined, standardized, weighted and evaluated, respectively.</p><p><b>RESULT</b>The maximum evaluated value Y for the extracting technique was AD + BC.</p><p><b>CONCLUSION</b>The optimal combination mode of the perscription is that Rhizoma Coptidis and Fructus Gardeniae, Radix Scutellariae and Cortex Phellodendri Amurensis are decocted together respectively then the two decoctions are merged.</p>


Subject(s)
Coptis , Chemistry , Dosage Forms , Drugs, Chinese Herbal , Gardenia , Chemistry , Phellodendron , Chemistry , Scutellaria baicalensis , Chemistry
3.
Article in Chinese | WPRIM | ID: wpr-262203

ABSTRACT

<p><b>OBJECTIVE</b>To optimize the extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction.</p><p><b>METHOD</b>The best extraction condition of the semi-bionic extraction for Guizhi Fuling pill decoction was optimized by uniform design was optimized with paeoniflorin, cinnamic acid, laetrile, pachymic acid, total polysaccharose and dry extract as the indexes.</p><p><b>RESULT</b>The optimized extraction condition is that extracting for 3 times with solvent pH values of 4.98, 7.35 and 8.00, respectively, and the total extracting time was 4.99 h.</p><p><b>CONCLUSION</b>In consideration of manufacturing fact, the pH value of thrice extractions is set at 5.0, 7.5, 8.0 respectively, and the extracting time is 2.0, 1.5, 1.5 h in turn.</p>


Subject(s)
Drugs, Chinese Herbal , Chemistry , Hydrogen-Ion Concentration
4.
Article in Chinese | WPRIM | ID: wpr-315344

ABSTRACT

<p><b>OBJECTIVE</b>To optimize the extraction condtions in the modification of Rhizoma Cyperi, which had been extracted by the technique of supercritical CO2 extraction.</p><p><b>METHOD</b>The semi-bionic extraction (SBE) conditions were optimized through homogeneous design while the extracts (< or = 1 000), the total area of HPLC and dry extracts were adopted as markers.</p><p><b>RESULT</b>The optimized SBE extraction conditions are the following: pH in first extraction was adjusted to 2.005 3. And then pH in second and third extraction adjusted to 6.508 2 and 8.945 6, time of the whole extracted process was 3.912 7 h.</p><p><b>CONCLUSION</b>Combine the faction of production,we make sure the conclusion is pH in first extraction was 2.00, pH in second and third extraction adjusted to 6.50 and 9.00, duration of run was 2.0 h, 1.0 h and 1.0 h, respectively.</p>


Subject(s)
Carbon Dioxide , Chemistry , Chromatography, Supercritical Fluid , Methods , Cyperus , Chemistry , Drugs, Chinese Herbal , Chemistry , Hydrogen-Ion Concentration , Rhizome , Chemistry
5.
Article in Chinese | WPRIM | ID: wpr-567512

ABSTRACT

Traditional Chinese medicine(TCM) injection,which plays a unique role in the clinical treatment,is Chinese original dosage form.But in recent years due to its quality problems or unscientifically clinical use,some adverse reactions have reported,even several injections had serious adverse reactions.So how to develop TCM injection becomes one of the topics the public and scholars most concerned about.Therefore,the three "bottleneck" problems of TCM injection on the current development,which are the material basis and TCM theory,clinical efficacy and safety,and also quality control,were analyzed and discussed in the article.Then the countermeasures were proposed and provided ideas for future research and development of TCM injection.

6.
Article in Chinese | WPRIM | ID: wpr-681699

ABSTRACT

WAE. Conclusion SBE method is better than the other three methods in the extraction of SFD components.

7.
Article in Chinese | WPRIM | ID: wpr-581263

ABSTRACT

Objective Comparing the serum fingerprint of four kinds of extract solution from Banxia Baizhu Tianma Decoction.Methods Taking rabbits as experiment animals,collecting blood,and separating serum after drenching semi-bionic enzyme extracting(SBEE) solution.HPLC was used to detect the fingerprints of medicated serum at different blood-collecting time in order to optimize the best blood collecting time,then the serum fingerprints of four kinds of solution collected were compared.Results HPLC showed that when blood collecting time was 2 h,the number and total area of chromatographic peak had the maximum value;SBEE Solution had the the maximum number and total area of chromatographic peak in the four kinds of solution at the best blood collecting time.Conclusion The component content in SBEE medicated serum is higher than that by other method.

8.
Article in Chinese | WPRIM | ID: wpr-681871

ABSTRACT

Objective:Optimising the technological parameters for the extraction of Maxingshigan Decoction (Herba Ephedrae, Semen Pruni Armeniacae, Gypsum Fibrosum, Radix Glycyrrhizae). Methods:Using the even design and TCL, ephedrine, glycyrrhetinic acid, hydrocyanic acid, calciumion and extract weight were taken as the indexes. Results:Optimal parameters: the pH values of the water for the 1st, 2nd and 3rd decoctions are 2.0 ,6.5 and 9.0,respectively; and the time of 3 decoctions are 2.0,1.0and 0.5h, respectively. Conclusion:Optimal parameters for Maximpshipan Decoction are feasible in extraction.

9.
Article in Chinese | WPRIM | ID: wpr-681728

ABSTRACT

Objective:To optimize the extraction condtions in the modification of the formula of Jiaotai Pill. Methods: The semi bionic extraction (SBE) conditions were optimized through homogeneous design while berberine, cinnamic acid, total alkaloids, volatile oil and dry extract were adopted as markers. Results: PH in first extraction was adjusted to 2.20 by the use of HCL solution. And then PH in second and third extraction adjusted to 6.50 and 7.80 , duration of run was 170 min, 80 min and 40 min, respectively. Conclusion: Semi bionic extraction in Jiaotai Pill is approximated to theoretical extraction value.

10.
Article in Chinese | WPRIM | ID: wpr-681352

ABSTRACT

Objective: The extract technologies for the components of Fuzhuang Capsules were optimized. Methods: Four methods: the semi bionic extraction (SBE), the water extraction (WE), the semi bionic extraction by precipitation with alcohol (SBAE) and the water extraction by precipitation with alcohol (WAE) were used to extract Fuzhuang Capsules, with panaxadiol, panaxatriol, ? sitosterol, icariine, betaine, total sugar and dried extractive taken as the marker, under the same conditions of drug granularity, solvent amount, decocting temperature, filtration, concentration, etc., and then four methods were compared and studied. Results: Through the comprehensive evaluation of seven markers, their comprehensive values Y decreased in the order of SBE, WE, SBAE and WAE. Conclusion: SBE is better than the other three methods in the extraction of the components of Fuzhuang Capsules, which is showed by the fact that the pH values of the water for the 1st, 2nd and 3rd decoctions are 3.4, 7.5 and 8.4, and the extraction times are 2.0h, 1.5h, and 1.5h respectively.

11.
Article in Chinese | WPRIM | ID: wpr-575791

ABSTRACT

AIM: To investigate the method for using semi-bionic extraction (SBE) on Simiao Yongan Decoction as an example. METHODS: Orthogonal design was used to optimize the extraction conditions of SBE with the evaluation markers such as chlorogenic acid, ferulic acid, glycyrrhizic acid, total polysaccharide, ethanol soluble extractives and dried extract. RESULTS: The optimized SBE conditions were as follows: The medical material was powdered through a sieve with 4 meshes) and extracted with 20% ethanol for three times, the pH of the three extractions were in proper order 3.50, 7.50, 8.50 ; the solvent volume was 10,8,8 times, respectively, and the extraction time was 1.5,1.0,1.0 h, respectively. CONCLUSION: The optimum extraction conditions are stable and practicable, and surpass the original SBE extraction conditions.

12.
Article in Chinese | WPRIM | ID: wpr-571300

ABSTRACT

AB; and there is not obvious difference in the TLC of 2 kinds of extraction liquid, but there is difference in the GC of volatile oil in them. Conclusion: It is the best combination to extract Rhizoma Coptidis and Cortex Cinnamomi seperately.

13.
Article in Chinese | WPRIM | ID: wpr-570427

ABSTRACT

Objective: To establish the quality standard for Huahaiyigan Effervescent Granules. Methods: Astragalus membranaceus(Fisch) Beg., Bupleurum chinenes DC., Polygonum cuspidatum Sieb. et Zucc. and Schisandra chinensis(Turcz.) Baill. were identified by TLC; and the content of schisandrin B was determined by HPLC. Results: Astragalus membranaceus(Fisch.) Beg., Bupleurum chinenes DC., Polygonum cuspidatum Sieb. et Zucc. and Schisandra chinensis(Turcz.) Baill. could be identified by TLC; schisandrin B showed a good linear relationship at a range of 0.848~4.240?g, r=0.9999; The average recovery was 98.16% and RSD was 1.12%. Conclusion: This method was available for quality control of Huahaiyigan Effervescent Granules

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