ABSTRACT
Objective To explore the effect of dexmedetomidine on the neurological function and mast cells activation in the mouse with intracerebral hemorrhage(ICH).Methods The mouse was intraperitoneal-ly injected with dexmedetomidine at 30 min before intracerebral hemorrhage.After the preparation of intrace-rebral hemorrhage model,the neurological function,brain water content,number of mast cells around hemato-ma and expression levels of tryptase,IL-1β,TNF-α were detected.Results Compared with the control group,the neurological function score in the intracerebral hemorrhage group was significantly elevated(P<0.05),the brain water content was significantly increased(P<0.05),the mast cells number was significantly in-creased(P<0.05),and the tryptase,IL-1β and TNF-α expression levels were sinificantly increased(P<0.05);while the neurological function score in the dexmedetomidine group was significantly decreased(P<0.05),the brain water content was significantly decreased(P<0.05),the number of mast cells was signifi-cantly reduced and the tryptase,IL-1β and TNF-α expression levels were significantly decreased(P<0.05).Conclusion Dexmedetomidine could inhibit the activation of mast cells around hematoma and reduce the dam-age of neurological function after mouse intracerebral hemorrhage.
ABSTRACT
Objective To evaluate the effects of early mobilization combined with occupational therapy on delirium of mechanical ventilated patients. Methods Sixty- eight patients who were undergoing mechanical ventilation and met the inclusion as well as exclusion criteria were randomized into an intervention group (35 patients) and a control group (33 patients). Patients in both group were provided with ICU routine care to prevent delirium, while early mobilization combined with occupational therapy was given in intervention group. Incidence rate of delirium, length of delirium, dosage of sedation, length of mechanical ventilation, length of ICU stay and physical restraint rate were compared. Occurrence of adverse events during intervention was also observed. Results In intervention group ,the incidence rate of delirium was 25.71% (9/35), length of delirium was (1.69 ± 2.98)days, dosage of propofol was(2 189.71±1 222.23)mg, length of ventilation was (4.86±1.31)days, and physical restraint rate was 43.64% (146/275), all of which were significantly better than those in control group, which were 53.28%(17/33), (2 736.36±1 298.99) mg, (5.88±1.52)days, 53.28%(160/254) (χ2=4.788, 7.251, t=3.910, 2.980, P<0.05 or 0.01). There was no unpredicted issue occurred during intervention. Conclusions Early mobilization combined with occupational therapy is feasible which could alleviate ICU delirium, reduce the dosage of sedation, the length of mechanical ventilation, and the physical restraint rate.
ABSTRACT
Objective@#To evaluate the effects of early mobilization combined with occupational therapy on delirium of mechanical ventilated patients.@*Methods@#Sixty-eight patients who were undergoing mechanical ventilation and met the inclusion as well as exclusion criteria were randomized into an intervention group (35 patients) and a control group (33 patients). Patients in both group were provided with ICU routine care to prevent delirium, while early mobilization combined with occupational therapy was given in intervention group. Incidence rate of delirium, length of delirium, dosage of sedation, length of mechanical ventilation, length of ICU stay and physical restraint rate were compared. Occurrence of adverse events during intervention was also observed.@*Results@#In intervention group,the incidence rate of delirium was 25.71%(9/35), length of delirium was (1.69±2.98) days, dosage of propofol was (2 189.71±1 222.23) mg, length of ventilation was (4.86±1.31)days, and physical restraint rate was 43.64%(146/275), all of which were significantly better than those in control group, which were 53.28%(17/33), (2 736.36±1 298.99) mg, (5.88±1.52)days, 53.28%(160/254) (χ2=4.788, 7.251, t=3.910, 2.980, P<0.05 or 0.01). There was no unpredicted issue occurred during intervention.@*Conclusions@#Early mobilization combined with occupational therapy is feasible which could alleviate ICU delirium, reduce the dosage of sedation, the length of mechanical ventilation, and the physical restraint rate.
ABSTRACT
With the development of minimally invasive surgical technology, laparoscopic cholecysteeto-my, endoscopic retrograde cholangiopanereatography, endoscopic sphincterotomy and choledochoscopy were applied increasingly in the clinical practice. Based on the domestic and foreign literatures, this article re-viewes these minimally invasive surgical technologies.
ABSTRACT
Objective To study the very early diagnosis of acute myocardial infarction (AMI) by harmonic imaging integrated backscatter(IBS).Methods Thirty normal persons,12 cases at the very early stage of AMI (in 2 hours),36 cases with AMI (in 2-12 hours) were examined by IBS and the cyclic variation of integrated backscatter (CVIB) with HP Sonos 5500 ultrasonic system in different areas (the areas of myocardial infarction and no myocardial infarction).Results In the areas of AMI of the very early stage (in 2 hours),IBS was much higher than that of the areas of normal (14.7 vs 8.3,P
ABSTRACT
Objective To analyze the risk factors and treatment of early renal failure associated with orthotopic liver transplantation(RFALT).Methods Clinical data of 110 adult patients,who underwent orthotopic liver transplantation from January 2005 to December 2007,were retrospectively analyzed.These patients were divided into two groups based on whether RFALT occurred or not.Clinical and laboratory data in pre-and intra-operative periods were discussed with a univariate analysis,and then a logistic regression analysis was performed with variables that achieved a significant level of