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International Eye Science ; (12): 554-558, 2020.
Article in Chinese | WPRIM | ID: wpr-798300


@#AIM: To compare the medical effects and economic benefits between spherical headed silicone intubation(SHSI)and endoscopic dacryocystorhinostomy(En-DCR), to further verify the therapeutic effect of modified SHSI under endoscope on NLDO.<p>METHODS: The 43 patients with 50 eyes of NLDO were randomly divided into SHSI group(21 cases and 25 eyes)and En-DCR group(22 cases and 25 eyes). Then to compared the intraoperative bleeding volume, monocularoperation time, surgical discomforta, nd hospitalization time between the two groups of patients. Followed-up to 12mo after surgery, the clinical efficacy was evaluated according to the situation of tear overflow and lacrimal lavage at the last follow-up, and the cost-effectiveness ratio(C/E)was used to evaluate the economic benefits.<p>RESULTS: The intraoperative blood loss and surgical discomfort visual analogue scores of patients in the SHSI group were significantly lower than those in the En-DCR group(4.96±1.989mL <i>vs</i> 27.60±14.950mL, 2.84±0.64 <i>vs</i> 4.88±0.84). Monocular surgery time and hospital stay were significantly shorter than those in the En-DCR group(13.40±6.007min <i>vs</i> 59.64±12.786min, 0.50±0.010h <i>vs</i> 137.280±23.085h)(All <i>P</i><0.001). At the last follow-up, the clinical effectiveness rate of the two groups was no difference(88% <i>vs</i> 96%, <i>P</i>>0.05), but the C/E(13.57)of patients in SHSI group was far smaller than that of En-DCR(121.50).<p>CONCLUSION: Endoscopic SHSI and En-DCR are both effective surgical methods for nldo. But SHSI surgery is relatively lower difficult and has significant cost-effective advantages.

Chinese Pharmacological Bulletin ; (12): 164-167, 2019.
Article in Chinese | WPRIM | ID: wpr-857275


Drug addiction has not only seriously damaged the addicts' health, but also caused a huge social and economic burden, threatening public safety. Meanwhile, the number of drug addicts continues to rise and the relapse rate remains high. Actually drug addiction is a kind of chronic brain disease. It is of no avail to reduce the psychological requirement of addicts via alternative drug treatments such as methadone, non-pharmacological treatments, surgical treatment, mindfulness therapy, and repeated transcranial magnetic stimulation etc. In fact, the rate of relapse is still high, accompanied by a series of huge limitations. Therefore, it is of great importance to find new therapeutic drugs and methods for drug addiction. In recent years, numerous studies of intestinal flora and neuropsychiatric diseases have been reported, gradually revealing the link between the intestinal microbiota and the nervous system. With the discovery of the "microbiota-gut-brain axis", the effect of gut microbiota on related aspects of drug addiction has won increasing attention. As a result, this thesis will review the research progress of the relationship between gut microbiota, neuropsychiatric diseases and drug addiction by means of looking up domestic and foreign documents.

Chinese Pharmacological Bulletin ; (12): 1226-1230, 2018.
Article in Chinese | WPRIM | ID: wpr-705180


Aim To explore the effect of rhynchophyl-line on the expression of tyrosine hydroxylase ( TH) in hippocampus of methamphetamine-induced condition place preference ( CPP) mice. Methods Metham- phetamine was injected intraperitoneally to mice, and the expression of TH was observed by immunohisto-chemistry and Western blot. Results The CPP mouse model was established successfully by methamphet-amine ( 4 mg·kg-1) . Ketamine ( 15 mg·kg-1) , rhynchophylline low dosage group (40 mg·kg-1) and rhynchophylline high dosage group ( 80 mg·kg-1) could remove the effect of methamphetamine on CPP mice. The result of immunohistochemistry showed that methamphetamine ( 4 mg·kg-1) could increase the number of TH positive cells in hippocampus while ket-amine (4 mg·kg-1), rhynchophylline (40, 80 mg· kg-1) group could attenuate the change. Western blot-ting indicated the expression of TH of model group in-creased significantly, whereas ketamine ( 15 mg· kg-1) , rhynchophylline ( 40, 80 mg·kg-1) group presented less expression. Conclusions The CPP in-duced by methamphetamine in mice may be inhibited to some extent by rhynchophylline, and its mechanism may be associated with the expression of TH.