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1.
Article in Chinese | WPRIM | ID: wpr-922052

ABSTRACT

There are five-year transitional period for manufacturers after the issue of regulation(EU) 2017/746 on


Subject(s)
European Union , Marketing , Reagent Kits, Diagnostic
2.
Chinese Journal of Endemiology ; (12): 426-430, 2021.
Article in Chinese | WPRIM | ID: wpr-883739

ABSTRACT

Iodine is an essential trace element for growth and development of fetus. More and more surveys currently show that the urinary iodine level of pregnant women is between 100 - 149 μg/L, which is lower than the level recommended by the World Health Organization (WHO). Under this level of iodine nutrition, different investigations have shown different effects on thyroid function of pregnant women, and the impact on growth and development of the fetus requires long-term objective evaluation. At present, there are three aspects: development, intelligence quotient (IQ), and psychological behavior. There are not many studies on comprehensive evaluation. This article combs the related published research to provide a reference for further clarifying the influence of iodine nutrition level during pregnancy on thyroid function of pregnant women and the growth and development of their offspring.

3.
Chinese Journal of Endemiology ; (12): 337-341, 2021.
Article in Chinese | WPRIM | ID: wpr-883721

ABSTRACT

Objective:The iodine excretion of adult individuals was calculated by two creatinine correction methods of urinary iodine, and the significance and value of the methods to measure individual iodine nutrition levels were assessed to provide a reference basis for further epidemiological investigation and study of iodine deficiency disorders.Methods:Healthy adults aged 18 - 59 years from Fujian Province were recruited and their 24 h urine, fasting urine, and morning spot urine (8:00 - 12:30) were collected and the corresponding urinary iodine and creatinine concentrations were measured. The estimated 24 h urinary iodine excretion was calculated using two different creatinine correction and creatinine estimation formulas were compared with the measured 24 h urinary iodine excretion.Results:There were no significant differences in measured 24 h urinary iodine excretion value, estimated 24 h urinary iodine excretion value 1 of fasting urine and morning spot urine, and estimated 24 h urinary iodine excretion 2 of fasting urine and morning spot urine between genders (μg/d: 195.5 vs 190.9, 190.0 vs 181.7, 160.2 vs 144.2, 174.8 vs 179.2, 148.3 vs 131.5); there were no significant differences in measured 24 h urinary iodine excretion and fasting urinary estimated 24 h urinary iodine excretion 1, estimated 24 h urinary iodine excretion 2 ( P > 0.05), and there were significant differences in measured 24 h urinary iodine excretion and morning spot urinary estimated 24 h urinary iodine excretion 1, estimated 24 h urinary iodine excretion 2 ( P < 0.01). And there were significant linear correlations between measured 24 h urinary iodine excretion and estimated 24 h urinary iodine excretion 1 of fasting urine and morning spot urine, estimated 24 h urinary iodine excretion 2 of fasting urine and morning spot urine ( r = 0.772, 0.266, 0.828, 0.391, P < 0.01). Conclusions:It is feasible to estimate 24 h urinary iodine excretion in adults with creatinine-corrected fasting urinary iodine concentration. Creatinine-corrected fasting urinary iodine concentration can be used as an individual iodine nutrition level evaluation index, but whether it is applicable to children and pregnant women remains to be further studied.

4.
Chinese Journal of Endemiology ; (12): 205-210, 2021.
Article in Chinese | WPRIM | ID: wpr-883694

ABSTRACT

Objective:To understand the epidemic situation of drinking-water-borne endemic fluorosis in Fujian Province, and to provide more information for control and evaluation of the disease.Methods:In 2019, all villages in the 36 drinking-water-borne endemic fluorosis areas in Fujian Province were selected, in which the situation of water improvement was investigated, fluorine content of drinking water was tested and dental fluorosis of all the children aged 8 to 12 was examined. The urinary fluoride content and skeletal fluorosis of people over 25-year old was investigated in some of those villages.Results:A total of 153 disease affected villages were investigated, in which the water improvement projects were all completed. The fluoride content in each tap water sample of the water improvement project ranged from 0.00 to 1.05 mg/L, and the qualified rate was 100.00% (153/153). The normal operation rate of the water improvement projects was 95.42% (146/153). The detection rate of dental fluorosis in children aged 8 to 12 was 2.72% (76/2 789) with a dental fluorosis index 0.07. The detection rate of children's dental fluorosis was statistically different in different age groups, so was it in areas with different coverage rate of water improvement projects ( P < 0.05). The geometric mean of urinary fluorine level in adults was 0.80 mg/L ( n = 3 765), and the detection rate of skeletal fluorosis was 2.00% (6/300). Conclusion:Although some achievements have been made in the prevention and control of drinking-water-borne endemic fluorosis in Fujian Province, it is still necessary to further consolidate and enhance the water improvement projects.

5.
Chinese Journal of Endemiology ; (12): 854-856, 2021.
Article in Chinese | WPRIM | ID: wpr-909111

ABSTRACT

Objective:To understand the assessment results of external quality control of iodine deficiency disorders laboratories of centers for disease control and prevention at the three levels of province, city and county, so as to promote the improvement of testing ability of laboratories at all the three levels in Fujian Province.Methods:In 2019, iodine deficiency disorders laboratories of one provincial and nine municipal centers for disease control and prevention in Fujian Province participated in the external quality control blind sample examination of urinary iodine, salt iodine and water iodine; iodine deficiency disorders laboratories of 84 county-level centers for disease control and prevention participated in the blind sample examination of external quality control of urinary iodine and salt iodine. The external quality control assessment results were collected and analyzed by descriptive statistics.Results:The qualified rates of urinary iodine, salt iodine and water iodine in provincial and municipal iodine deficiency disorders laboratories all reached 100.0% (10/10); the qualified rate of urinary iodine in county-level iodine deficiency disorders laboratories was 96.4% (81/84), and the qualified rate of salt iodine was 100.0% (84/84).Conclusion:The overall detection capacity of provincial, municipal and county-level iodine deficiency disorders laboratories in Fujian Province remains at a high level, and the urinary iodine detection capacity of some county-level iodine deficiency disorders laboratories still needs to be improved.

6.
Chinese Journal of Endemiology ; (12): 927-932, 2020.
Article in Chinese | WPRIM | ID: wpr-866235

ABSTRACT

As a member of the tumor suppressor gene inhibitor of growth (ING) family, ING4 participates in tumor growth, invasion and metastasis by affecting various cell processes such as cell cycle and apoptosis. As the most common malignant tumor of head and neck and endocrine, thyroid cancer has increased dramatically year by year, and the pathogenesis is still unclear. Its development involves the up-regulation of oncogene expression and down-regulation of tumor suppressor gene expression. In this paper, we describe the research status of ING4 and thyroid cancer by combining relevant reports and data at home and abroad.

7.
Chinese Journal of Endemiology ; (12): 537-541, 2020.
Article in Chinese | WPRIM | ID: wpr-866159

ABSTRACT

The implementation of mandatory iodized salt in Taiwan made a great achievements by eliminated the widespread goiter in 1970s, which is earlier than mainland China. The policy of mandatory iodized salt lasting until 2003, on which Taiwan changed its policy in accordence with the request of WTO. Iodized salt policy changed from mandatory to optional, in the aftermath of the change, the urine iodine level of citizens drop significantly that may be produce negative impact, and finally adjustments have to made. As what have happened in Taiwan, in 2017 a series of changes similar to Taiwan carried out in mailand China, but follow-up impact is lacking especially large-scale survey data. Therefore, this paper introduces Taiwan's experience in detail for reference.

8.
Chinese Journal of Endemiology ; (12): 146-149, 2020.
Article in Chinese | WPRIM | ID: wpr-866072

ABSTRACT

Objective:To analyze the disease burden of iodine deficiency disorders (IDD) and its changes in China in 1990 and 2016.Methods:Based on the data of Global Burden of Disease Study 2016 (GBD 2016), a descriptive statistical method was used to compare and analyze the changes of deaths number, mortality, disability adjusted life year [DALY, including years of life lost (YLL) and years lived with disability (YLD)], DALY rate and other disease burden indicators caused by IDD in China in 1990 and 2016.Results:The GBD 2016 data showed that the deaths number from IDD in China decreased from 259.31 in 1990 to 116.41 in 2016, the mortality decreased from 0.022 827/100 000 in 1990 to 0.008 515/100 000 in 2016; and the mortality in different age groups had decreased, the children mortality in the < 5 years old group had decreased from 0.088 639/100 000 to 0.009 875/100 000. The DALY and YLD due to IDD in China increased from 406.13 thousand person-years and 391.68 thousand person-years in 1990 to 455.05 thousand person-years and 451.95 thousand person-years in 2016, while YLL decreased from 14.45 thousand person-years to 3.10 thousand person-years; the DALY rate, YLL rate, and YLD rate decreased from 35.75 person-years per 100 000, 1.27 person-years per 100 000 and 34.48 person-years per 100 000 in 1990 to 33.29 person-years per 100 000, 0.23 person-years per 100 000 and 33.06 person-years per 100 000 in 2016. The main component of DALY for IDD was YLD, and the proportion increased from 96.44% in 1990 to 99.32% in 2016.Conclusions:The mortality of IDD in China has decreased, and IDD in the younger age group has been effectively controlled; however, the disease burden, especially the burden caused by disability has increased, and the disability of the population due to IDD should be given special attention.

9.
Article in Chinese | WPRIM | ID: wpr-866060

ABSTRACT

Objective:To investigate the iodine nutritional status among children aged from 8 - 10 and pregnant women in Xiamen City before and after adjustment of salt iodine concentration, and scientifically evaluate the suitability of the new standard iodized salt adjustment policy for Xiamen City.Methods:In the pre-adjustment period (2011) and the post-adjustment period (2018), cross-sectional research methods and stratified cluster sampling methods were adopted in six districts of Xiamen City. The salt samples of residents and pregnant women, urine samples of children aged from 8 - 10 and pregnant women were collected to determine the iodine level; thyroid of children aged from 8 - 10 was examined. Changes in salt iodine, urine iodine and goiter prevalence before and after adjusting iodine content of salt were compared.Results:The median of salt iodine in residents after the adjustment (23.5 mg/kg) was significantly lower than that of before (28.9 mg/kg, Z = - 10.512, P < 0.05), the median of salt iodine in pregnant women after the adjustment (23.7 mg/kg) was significantly lower than that of before (29.2 mg/kg, Z = - 12.622, P < 0.05); the consumption rate of qualified iodized salt in residents after the adjustment (95.7%, 1 196/1 250) was significantly lower than that of before (97.1%, 1 608/1 656; χ 2 = 4.250, P < 0.05); before and after adjustment of salt iodine concentration, the consumption rate of qualified iodized salt in pregnant women was 94.7% (124/131) and 95.9% (579/604), respectively. No significant difference was found when comparing the consumption rate of qualified iodized salt in pregnant women (χ 2 = 0.015, P > 0.05). There was significant difference in median urinary iodine (from 204.2 to 183.9 μg/L, detected in 652, 1 250 urine samples, respectively) of children aged 8 - 10 years ( Z = - 3.583, P < 0.05); the difference of iodine nutritional status in pregnant women before and after adjustment of salt iodine concentration(130.2, 130.8 μg/L, detected in 132, 604 urine samples, respectively) was not significant ( Z = - 1.715, P > 0.05). The thyroid goiter rate of children aged 8 - 10 years had reduced from 1.1% (14/1 239) to 0.2% (2/1 253), the difference was statistically significant (χ 2 = 9.195, P < 0.05). Conclusions:As a whole, the measure of control and prevention of iodine deficiency disorders through iodized salt is implemented well in Xiamen City. After adjustment of salt iodine concentration, the iodine status of children aged from 8 to 10 is adequate, but the pregnant women has showed iodine deficiency.

10.
Article in Chinese | WPRIM | ID: wpr-802873

ABSTRACT

The health-related quality of life (HRQoL) is the individual subjective evaluation of disease and treatment on their physical, mental and social health status, and is an important part of health and medical services.Chronic kidney disease (CKD) is a kind of diseases that has lasted for more than 3 months of abnormal renal structure or function.It is one of the diseases that seriously affect children′s HRQoL.This article reviews the emergence, development, evaluation tools of children′s HRQoL and its application in the field of nephrology.

11.
Chinese Journal of Endemiology ; (12): 810-814, 2019.
Article in Chinese | WPRIM | ID: wpr-790934

ABSTRACT

Objective To understand the iodine nutritional status of children aged 8 to 10 years old and pregnant women in the new standard iodized salt pilot areas of Fujian Province,and to analyze the rationality of urine specific gravity correction for urinary iodine.Methods In the 3rd,6th,9th,12th,15th and 21th months after supplying of new standard iodized salt in March 2012,the first to sixth phases' assessment were conducted in Xindian Town of Xiang'an District,Xiamen City and Yongfu Town,Xinqiao Town of Zhangping City,Longyan City.Totally 200 children aged 8 to 10 years old and 50 pregnant women were selected from each town,home salt samples and urine samples were collected,salt iodine,urinary iodine and urine specific gravity were tested.Salt iodine was detected by "General Test Method in Salt Industry-Determination of Iodine" (GB/T 13025.7-2012);urinary iodine was detected by "Method for Determination of Iodine in Urine by As3+-Ce4+ Catalytic Spectrophotometry" (WS/T 107-2006);urine specific gravity was detected by digital refractometer.Results From the first to sixth phases' assessment,the iodized salt coverage rates of children aged 8 to 10 years old and pregnant women were > 95%,the edible rates of qualified iodized salt were > 90%.The measured medians of urinary iodine of children aged 8 to 10 years old were 216.7,219.5,188.1,206.7,209.2,and 201.0 μg/L,respectively;except the third phase's assessment,which was in the iodine appropriate level (100-199 μg/L),the other five phases/ assessment were all higher than the iodine appropriate level (200-299 μg/L);the medians of urinary iodine of children aged 8 to 10 yearsold after urine specific gravity correction were 215.0,213.6,197.3,202.9,204.3,and 197.7 μg/L,respectively;there were no significant differences in urinary iodine between the measured and urine specific gravity correction (Z =-0.131,-0.183,-1.052,-1.180,-0.311,-0.368,P > 0.05).The measured medians of urinary iodine of pregnant women were 134.0,132.2,120.9,115.6,113.3,and 123.3 μg/L,respectively,which were in the iodine deficiency level (< 150 μg/L);the medians of urinary iodine of pregnant women after urine specific gravity correction were 207.3,197.1,168.8,158.3,171.8,and 181.7 μg/L,respectively;there were significant differences in urinary iodine between the measured and urine specific gravity correction (Z =-6.419,-6.406,-5.990,-6.648,-7.008,-8.034,P < 0.01).Conclusions The iodine nutrition of children aged 8 to 10 years old is appropriate in the new standard iodized salt pilot areas of Fujian Province,while that of pregnant women is mild iodine deficiency.Further research is needed to use urine specific gravity to calibrate the concentration of urinary iodine to assess the iodine nutritional level of the focused populations in the regions.

12.
Chinese Journal of Endemiology ; (12): 743-746, 2019.
Article in Chinese | WPRIM | ID: wpr-790919

ABSTRACT

Objective To validate a developing method for determination of iodine in serum by inductively coupled plasma mass spectrometry (ICP-MS).Methods Ammonium chloride,ethanolamine,ascorbic acid and water were mixed at a certain ratio,adding ethanol as sensitization,to dilute samples in the ratio of 1 ∶ 20,and then the diluted samples were analyzed by ICP-MS.Re was used as the internal standard.Serum samples were from 8 different individuals.After combining,they were divided into 4 groups,control group and low,medium and high iodine groups.Iodine groups were added with potassium iodide (100 mg/L),iodine standard solution 1.5,9.0,15.0 μl.The methodological evaluation of this method was done through standard curve linearity,sample detection limit,precision,recovery and accuracy in determining biological sample.And the results were compared with the current serum iodine arsenic cerium catalytic spectrophotometry standard method (WS/T 572-2017).Results The linear range of the calibration curve was 0-300 μg/L and the linear correlative coefficients of the standard curve were 0.999 8-1.000 0.The detection limit was 0.38 μg/L (the sample amount was 0.2 ml).The coefficients of variation (CV) were all below 2% for 4 serum samples in precision.The recovery rate was in a range of 95.8%-108.5%.No significant difference was found between the results of the 15 serum samples determined by the standard method andthis new method (t =1.139,P > 0.05).Conclusions The newly developed method in determination of iodine in serum by ICP-MS,has wide linear range,high sensitivity,good precision,and wide applicability.It is suitable for application in determining serum iodine.

13.
Chinese Journal of Endemiology ; (12): 731-734, 2019.
Article in Chinese | WPRIM | ID: wpr-790916

ABSTRACT

Objective To understand the effects of salt iodine content adjustment on iodine nutritional status of residents in Fujian Province.Methods In 2009 (before the adjustment) and 2014 (after the adjustment),cross-sectional research methods and stratified cluster sampling methods were adopted,17 and 19 survey sites (residential committees and villages) were selected,respectively.At each survey site,20 adults,30 pregnant women,30 lactating women and 50 children (8-10 years old) were selected in 2009;50 adults,50 pregnant women,50 lactating women and 100 children (8-10 years old) were selected in 2014.Random urine samples in one day were collected,and the urinary iodine content was measured by "the Arsenic and Cerium Catalyzed Spectrophotometric Method" (WS/T 107-2006).The results of before and after the adjustment were compared and iodine nutrition was evaluated.Results Before and after adjustment of salt iodine content,the urinary iodine median of children and adults was 208.7,202.8,163.0 and 157.6 μg/L,respectively,and after the adjustment,the iodine nutrition was at the appropriate level (100-199 μg/L).The urinary iodine median of lactating women was 128.9 and 107.4 μg/L before and after the adjustment,iodine nutrition was at an appropriate level (≥ 100 μg/L).The urinary iodine median of pregnant women was 149.2 and 124.0 μg/L before and after the adjustment,which were deficient (< 150 μg/L).Conclusion After down-regulating the iodized salt content,the iodine nutrition of the general residents in Fujian Province is basically at an appropriate level,and pregnant women have different levels of iodine deficiency.

14.
Chinese Journal of Endemiology ; (12): 218-221, 2019.
Article in Chinese | WPRIM | ID: wpr-744285

ABSTRACT

Objective To analyze the iodine nutritional status among pregnant women,breasffeeding women,0-2 years old infants,8-10 years old children,18-45 years old women and men in both urban and rural areas of Xiamen 3 years after promotion of new standard iodized salt.Methods The Huli and Xiang'an were selected as the urban and rural study sites in Xiamen City,from March 2015 to March 2016.Each study site was further divided into five geographic locations (east,south,west,north and center).In each location,one township was randomly selected.In each town,2 tap water samples,60 salt samples of residents,and urine samples of 40 children aged from 8-10 years old,20 pregnant women,12 breastfeeding women,0-2 years old infants,18-45 years old women and men were collected to determine the iodine level.The water iodine and urinary iodine were detected by arsenic cerium catalytic spectrophotometry;salt iodine was detected by direct titration.Results The medians of salt iodine in urban and rural were 23.0 and 25.3 μg/L,respectively.The coverage rates of iodized salt in urban and rural area were 99.3% (298/300) and 94.0% (282/300),respectively.The consumption rates of qualified iodized salt were 93.7% (281/300) and 90.7% (272/300),respectively.The medians of tap water iodine in urban and rural were 4.1 and 4.4 μg/L,respectively.In urban and rural areas,the medians of urinary iodine of pregnant women were 167.6 and 119.6 μg/L,respectively.The medians of urinary iodine of breastfeeding women were 121.6 and 101.2 μg/L,respectively.The medians of urinary iodine of infants were 165.9 and 110.5 μg/L,respectively.The medians of urinary iodine of children were 208.9 and 167.2 μg/L,respectively.The medians of urinary iodine of women aged 18-45 were 132.5 and 154.5 μg/L,respectively.The medians of urinary iodine of men aged 18-45 were 131.7 and 154.5 μg/L,respectively.Conclusions After 3 year promotion of new standard iodized salt,the iodine status of pregnant women in urban,breastfeeding women,0-2 years old infants,children aged 8 to 10 and adults aged 18 to 45 is adequate,but the pregnant women in rural has showed iodine deficiency.So surveillance and health education should be continuously strengthened in the future.Scientific salt iodization should continue to ensure the amount of iodine intake.

15.
Clinical Medicine of China ; (12): 549-552, 2018.
Article in Chinese | WPRIM | ID: wpr-706728

ABSTRACT

Objective To investigate the preventive effects of lamivudine combined with chemotherapy drugs on hepatitis B virus reactivation in patients with HBV infection and tumor. Methods From July 2014 to February 2017,a total of one hundred and twenty patients with HBV infection and tumor in Nanchong Central Hospital were selected and were divided into the observation group and control group with 60 cases in each group. The control group received conventional chemotherapy and liver protection treatment,the observation group was given lamivudine prophylaxis treatment(100 mg/d,1 time/d) based on the treatment in the control group, two groups were treated for 8 weeks. Results The rates of hepatitis B virus reactivation in the observation group and the control group were 5. 0%(3/60) and 33. 3%(20/60),respectively,and the difference between the two groups was statistically significant (χ2=15. 692,P<0. 05) . There was no significant difference in serum glutamic acid transferase and aspartic transferase in the patients before and after treatment ( P>0. 05 ) , and the control group showed an upward trend ( P<0. 05) . After treatment,the serum ALT and AST in the observation group ((31. 98±6. 33)U/L,(26. 38±4. 98)U/L) were lower than those in the control group((43. 89±6. 73)U/L, (51. 78±5. 99)U/L)(t=8. 294,11. 842,P<0. 05). After treatment,the HBV DNA in the observation group and the control group((0. 16±0. 04) ×103copies/ml,(5. 02±1. 72) ×103copies/ml) were lower than those before treatment ((14. 55±2. 14)×103copies/ml,(14. 09±1. 98 copies/ml )(t=25. 498,8. 142,P<0. 05),and the HBV DNA in the observation group after treatment was also lower than that of the control group. The difference between the two groups was statistically significant ( t=24. 292,P<0. 05) . Conclusion Lamivudine combined with chemotherapy drugs used in patients with HBV infection and tumor can prevent hepatitis B virus reactivation,it does not affect the patient′s liver function,it can inhibit the replication of hepatitis B virus,so it has good application values.

16.
Chinese Journal of Endemiology ; (12): 562-564, 2018.
Article in Chinese | WPRIM | ID: wpr-701376

ABSTRACT

Objective To establish reference values for thyroid hormone in school-age children in iodineadequate nutrition areas.Methods Totally 128 8-10-year-old healthy children (male:62,female:66) were screened rigorously in iodine-adequate nutrition areas (median of urinary iodine:100-200 μg/L).The values of total triiodothyronine (TT3) total thyroxine (TT4) free triiodothyronine (FT3),free thyroxine (FT4),thyrotropin (TSH),thyroglobulin (Tg),thyroid peroxidase antibody (TPOAb),and thyroglobulin antibody (TgA) in serum were determined through the Access 2 Immunoassay System (Beckman-Coulter,USA) using a chemiluminescence detection system.Results Normal reference ranges for thyroid function indicators in children (95% confidence limit) of TT3,TT4,FT3,FT4,TSH,and Tg were 1.63-3.36 nmol/L,110.65-186.67 nmol/L,4.65-7.25 pmol/L,9.75-15.59 pmol/L,1.10-5.54 mU/L,and 3.75-36.27 μg/L,respectively.There was no significant difference in hormone levels between boys and girls (P > 0.05).The thyroid function indices were substantially different between children and adults.Conclusions Normal reference range of thyroid function index of children is different from that of adults.It is necessary to establish the reference range of thyroid function indices for children in order to diagnose thyroid diseases and monitor iodine nutrition.

17.
Article in Chinese | WPRIM | ID: wpr-699254

ABSTRACT

Objective To investigate the clinical efficacy of porcine small intestine submucosa-derived (SIS) mesh and polypropylene (PP) mesh applied in anterior abdominal wall incisional hernia repair.Methods The retrospective cohort study was conducted.The clinical data of 59 patients who underwent anterior abdominal wall incisional hernia repair in the First Affiliated Hospital of Sun Yat-Sen University between January 2012 and December 2017 were collected.Of 59 patients,22 undergoing anterior abdominal wall incisional hernia repair with SIS mesh and 37 undergoing anterior abdominal wall incisional hernia repair with PP mesh were respectively allocated into the SIS group and PP group.Surgeons selected surgical procedures according to hernia ring situations of patients.Observation indicators:(l) intra-and post-operative recovery situations;(2) follow-up.Follow-up using outpatient examination and telephone interview was performed to detect long-term complications of patients including foreign body sensation or pain in abdominal wall and hernia recurrence up to May 2018.Measurement data with normal distribution were represented as (x)±s,and comparison between groups was done using t test.Measurement data with skewed distribution were described as M (range),and comparison between groups was done using Mann-Whitney U test.Comparison of count data was analyzed using the chi-square test or Fisher exact probability.Results (1) Intra-and post-operative recovery situations:patients of the SIS group and PP group underwent successfully anterior abdominal wall incisional hernia repair.There were 2,3,3,14 and 5,26,1,5 patients undergoing open Onlay repair,open Sublay repair,laparoscopic intraperitoneal onlay mesh repair,laparoscopic combined with open mesh repair in the SIS group and PP group respectively.The volume of intraoperative blood loss,cases of postoperative incisional seroma and surgical site infection were (23± 11)mL,7,5 in the SIS group and (30± 13)mL,3,1 in the PP group respectively,with statistically significant differences between groups (t=-2.238,P<0.05).(2) Follow-up:patients of the SIS group and PP group were respectively followed up for 29.3 months (6.0-66.0 months) and 31.0 months (7.0-76.0 months),with no statistically significant difference between groups (Z =-1.388,P>0.05).During the follow-up,foreign body sensation or pain in abdominal wall and hernia recurrence were detected in 6,6 patients in the SIS group and 4,2 patients in the PP group respectively,with a statistically significant difference in hernia recurrence between groups (P<0.05) and with no statistically significant difference in foreign body sensation or pain in abdominal wall between groups (P>0.05).Conclusion Compared with polypropylene mesh,anterior abdominal wall incisional hernia repair using SIS mesh has higher incidence rate of postoperative incisional seroma,surgical site infection and hernia recurrence,but fewer volume of intraoperative blood loss.

18.
Journal of Clinical Pediatrics ; (12): 424-427, 2018.
Article in Chinese | WPRIM | ID: wpr-694697

ABSTRACT

Objective To explore the clinical features, treatment and follow-up of Cockayne syndrome with renal involvement. Method The clinical data of one child with Cockayne syndrome confirmed by gene detection with renal injury were reviewed, and the clinical features of renal involvement in Cockayne syndrome were summarized. Results A male child aged 3 years and 8 months had clinical manifestations of mental retardation, growth retardation, special face and photosensitive dermatitis, and renal involvement was manifested by nephrotic syndrome. Cranial CT showed symmetrically calcification in bilateral basal ganglia. The targeted next generation sequencing results showed homozygous mutations of c.394_398del and p.Leu132Asnfs in ERCC8 gene (NM_000082) of the child, and the same heterozygous mutation was found in both his parents (non-consanguineous marriage). After the diagnosis of nephrotic syndrome, full dose prednisone was given for experimental treatment. The urine protein decreased but did not disappear, which was considered hormone resistance. After 4 months of combined treatment with cyclosporin, the urine protein turned negative. During 20 months of follow-up, urine protein remained negative and renal function remained stable. The renal involvement in Cockayne syndrome was seldomly reported, and its clinical manifestations are heterogeneous. Condusion Renal involvement in Cockayne syndrome may be manifested with nephrotic syndrome which should be noticed.

19.
China Pharmacy ; (12): 1133-1135, 2017.
Article in Chinese | WPRIM | ID: wpr-510076

ABSTRACT

OBJECTIVE:To explore the effect of clinical pharmacist intervention on the rational use of Alanyl-glutamine injection.METHODS:Referring to package inserts of Alanyl-glutamine injection,Clinical Pharmacy Consensus of Parenteral Nutrition,ASPEN Nutrition Therapy Guidelines for Critically Ill Patients,related domestic and foreign literatures,evaluation criteria for Alanyl-glutamine injection rational use was formulated.After collecting Alanyl-glutamine injection cases (497 cases) in the second quarter of 2015 and those cases (385 cases) in the second quarter of 2016,rational use of Alanyl-glutamine injection were analyzed comparatively before and after intervention.RESULTS:The utilization rate and irrational rate of Alanyl-glutamine injection were 4.6% and 52.9% before intervention as well as 2.9% and 10.9% after intervention,with statistical significance (P<0.05).There was statistical significance in hyper-indication,excessive concentration of drug liquid,excessive supply of amino acid,irrational compatibility and solvent selection,long treatment course before and after intervention (P<0.05).CONCLUSIONS:Clinical pharmacists reduce irrational rate of drug use and guarantee safe and effective drug use through formulating evaluation criteria for Alanyl-glutamine injection rational use and providing pharmaceutical intervention on rational use of Alanyl-glutamine injection.

20.
Chinese Journal of Endemiology ; (12): 353-356, 2017.
Article in Chinese | WPRIM | ID: wpr-614426

ABSTRACT

Objective To investigate the coverage of iodized salt and the iodine status among children aged from 8-10 years in both urban and rural areas of Xiamen after promotion of new standard iodized salt,and to provide scientific evidence for adjustment of control strategy.Methods After 3 year promotion of new standard iodized salt,Huli and Xiang'an were selected as the urban and rural investigation sites,respectively in 2015.Each investigation site was further divided into five sampling areas,namely east,west,south,north and central.In each sampling area,one town was randomly selected and 2 tapping water samples were collected to determine the iodine level;in each town,4 villages were randomly selected and 15 residents were selected and edible salt samples were collected to determine the iodine level.Moreover,one primary school was selected in each town,and 40 children aged from 8-10 years old were randomly selected to perform thyroid examination and urinary iodine level determination.The water iodine was detected by arsenic cerium catalytic spectrophotometry;salt iodine was detected by direct titration;urinary iodine was detected by arsenic cerium catalytic spectrophotometry;thyroid was examined by B ultrasound.Results The iodine concentration was lower than 10 μg/L in drinking water in both urban and rural areas.The coverage rate of iodized salt in urban and rural areas was 99.3% (298/300) and 94.0% (282/300),respectively.The consumption rate of qualified iodized salt was 93.7% (281/300) and 90.7% (272/300),respectively.The prevalence of goiter was 3.8% (8/210) both in urban and rural areas.The prevalence of thyroid nodule was 17.6% (37/210) and 19.5% (41/210),respectively.No significance was found when comparing the prevalence of goiter and the prevalence of thyroid nodule (x2 =0.000,0.252,all P > 0.05).The median of urinary iodine was 208.9 and 167.2 μg/L,respectively.The statistical analysis found that the urban children had higher iodine level when comparing with rural counterparts (Z =4.030,P < 0.01).The prevalence of goiter in male and female was 2.4% (5/208) and 5.2% (11/212),respectively,and no significant difference was detected (x2=2.222,P> 0.05).The prevalence of thyroid nodule in male and female children was 13.5% (28/208) and 23.6% (50/212),respectively,the analysis showed that the female children had higher prevalence of thyroid nodule (x2 =7.115,P < 0.01).The median of urinary iodine in male and female children was 197.8 and 169.6 μg/L,respectively,and the urinary iodine level was significantly higher in male when comparing with female children (Z =2.218,P < 0.05).Conclusions After promotion of new standard iodized salt,the iodine nutrition of children aged from 8-10 years in both urban and rural areas of Xiamen were good.The goal of eliminating iodine deficiency disorders was achieved.The iodine supplement measure should be further promoted to ensure the adequate level of iodine in residents,adhere to the iodine supplement measure,promote a healthy lifestyle,ensure the amount of iodine intake.

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