ABSTRACT

@#To investigate the prediction of serum amyloid beta protein level on hemorrhage transformation in acute cerebral infarction and its related factors. Methods A total of 114 patients with acute cerebral infarction were selected from March 2021 to October 2021，and divided into HT group （41 cases） and control group （73 cases） according to whether the hemorrhage was transformed. The general basic information and serum amyloid beta protein level after admission were recorded，and the risk factors of hemorrhage transformation after cerebral infarction were analyzed. Results There were no significant differences in age，gender，history of atrial fibrillation，Hyc and LDL between the two groups （P> 0.05）.There were statistically significant differences in serum Aβ level，history of hypertension，history of diabetes，uric acid level and NHISS score（≥10 points） between the two groups （P< 0.05）. Binary Logistic regression analysis showed that history of hypertension，serum uric acid level，NHISS score （≥10 points） and serum Aβ level were nonrisk factors for hemorrhage transformation of thrombolysis acute cerebral infarction. The difference of Aβ level between asymptomatic group and symptomatic group in HT group was statistically significant（P<0.05）. ROC curve analysis showed that the area under the curve of serum Aβ for predicting the risk of hemorrhage transformation after acute cerebral infarction was 0.909，the optimal cutoff value was 166.84ng/ml，the sensitivity was 87.8%，and the specificity was 79.5%. The results of appeal analysis suggest that serum Aβ level can also predict the severity of hemorrhage after transformation. Conclusion History of hypertension，high NHISS score after admission，elevated uric acid level and serum Aβ level in patients with acute cerebral infarction are the influencing factors of hemorrhage transformation.