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1.
Journal of the Korean Neurological Association ; : 95-98, 2017.
Article in Korean | WPRIM | ID: wpr-47046

ABSTRACT

A cavernous angioma (CA) and a developmental venous anomaly may consist a mixed vascular malformation (MVM). Two bleeding foci were observed in a MVM of a man with epilepsy. The hemodynamic association between the two foci was not clear. An advance of neuroimaging may enhance the susceptibility of detection of MVMs. We should consider a MVM when a daughter bleeding focus occurs near the main bleeding focus associated with a CA.


Subject(s)
Brain , Cerebral Hemorrhage , Epilepsy , Hemangioma, Cavernous , Hemodynamics , Hemorrhage , Neuroimaging , Nuclear Family , Vascular Malformations
2.
Annals of Surgical Treatment and Research ; : 49-52, 2016.
Article in English | WPRIM | ID: wpr-59523

ABSTRACT

The Currarino triad is a unique complex of congenital caudal anomalies, including anorectal malformation, sacral bony defect and presacral mass. This triad may be associated with Mullerian duct anomalies, such as duplication of the vagina and uterus. Each of these diseases has a familial tendency and sometimes coexist within families. But, when coexisting in familial cases, nearly all reported cases revealed mutations of the motor neuron and pancreas homeobox 1 (MNX1) gene. Familial cases of Currarino triad combined with Mullerian duct anomaly without MNX1 gene mutation are very rare. Here we report cases of mother and daughter, who had Currarino triad and Mullerian duct anomaly without MNX1 gene mutation, along with a brief literature review.


Subject(s)
Humans , Genes, Homeobox , Mothers , Motor Neurons , Mullerian Ducts , Nuclear Family , Pancreas , Uterus , Vagina
3.
Korean Journal of Legal Medicine ; : 92-97, 2011.
Article in Korean | WPRIM | ID: wpr-205763

ABSTRACT

The usefulness of DNA databases is well known. In Korea, many cases have been solved since the establishment of DNA databases in 2010. DNA profiles obtained from criminal evidence are analyzed and are kept in databases, and matching profile is searched. On the matching occasion, DNA databases can provide some investigative information. Close family members, for example father, son or brother, share more alleles than unrelated people. This genetic closeness can be searched using the so called familial searching, and many successful cases have been reported. Management of DNA databases including familial searching needs continuous monitoring and control, especially from ethical view points. Many different views for familial searching have been presented, and each country running DNA databases has their own different policies. We present the utility, approaches and different policies of familial searching as well as arguments for and against familial searching. We also suggest that our appropriate guidelines be mandatory and a proper administrative process be prepared for the start of familial searching.


Subject(s)
Humans , Alleles , Criminals , Databases, Nucleic Acid , DNA , Fathers , Korea , Running , Siblings
4.
Korean Diabetes Journal ; : 16-20, 2010.
Article in English | WPRIM | ID: wpr-138695

ABSTRACT

A conference was convened by the Korean Diabetes Association and the Korean Endocrine Society on September 7, 2009 to discuss and organize the results of research on intensive glucose control for the prevention of cardiovascular disease in patients with type 2 diabetes. Professor Kyung Soo Park led the conference, and Professors Kwang Won Kim and Ho Young Son acted as chairmen. Professors Doo Man Kim, Tae Sun Park, and Bong Soo Cha reported on intensive glucose control and diabetic complications, including the UK Prospective Diabetes Study (UKPDS), Diabetes Control and Complication Trial (DCCT) research results, the recently published Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), and Veterans Affairs Diabetes Trial (VADT) research, as well as meta-analyses. Professor Jeong-Taek Woo reported on the manuscript written by the committee for the Korean Diabetes Association which dealt with the treatment of diabetes mellitus. Professors Kyung Soo Ko, Joong Yeol Park, Hyun Shik Son, Moon-Kyu Lee, Dong-Won Byun, and Yoon-Sok Chung participated in the discussion and collected information for the manuscript from all of the participants. The aim of the debate was to determine how to establish target goals for intensive glucose control and how to individualize those goals. The participants concluded that there was no need to modify the recommendation of maintaining an HbA1c under 6.5%, the current blood glucose treatment goal that is recommended by the Korean Diabetes Association. In addition, individual target goals for glucose control were recommended depending on the situation of each patient. We report on the consensus statement from the meeting.


Subject(s)
Humans , Blood Glucose , Cardiovascular Diseases , Consensus , Diabetes Complications , Diabetes Mellitus , Drug Combinations , Gliclazide , Glucose , Indapamide , Perindopril , Solar System , Veterans
5.
Korean Diabetes Journal ; : 16-20, 2010.
Article in English | WPRIM | ID: wpr-138694

ABSTRACT

A conference was convened by the Korean Diabetes Association and the Korean Endocrine Society on September 7, 2009 to discuss and organize the results of research on intensive glucose control for the prevention of cardiovascular disease in patients with type 2 diabetes. Professor Kyung Soo Park led the conference, and Professors Kwang Won Kim and Ho Young Son acted as chairmen. Professors Doo Man Kim, Tae Sun Park, and Bong Soo Cha reported on intensive glucose control and diabetic complications, including the UK Prospective Diabetes Study (UKPDS), Diabetes Control and Complication Trial (DCCT) research results, the recently published Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), and Veterans Affairs Diabetes Trial (VADT) research, as well as meta-analyses. Professor Jeong-Taek Woo reported on the manuscript written by the committee for the Korean Diabetes Association which dealt with the treatment of diabetes mellitus. Professors Kyung Soo Ko, Joong Yeol Park, Hyun Shik Son, Moon-Kyu Lee, Dong-Won Byun, and Yoon-Sok Chung participated in the discussion and collected information for the manuscript from all of the participants. The aim of the debate was to determine how to establish target goals for intensive glucose control and how to individualize those goals. The participants concluded that there was no need to modify the recommendation of maintaining an HbA1c under 6.5%, the current blood glucose treatment goal that is recommended by the Korean Diabetes Association. In addition, individual target goals for glucose control were recommended depending on the situation of each patient. We report on the consensus statement from the meeting.


Subject(s)
Humans , Blood Glucose , Cardiovascular Diseases , Consensus , Diabetes Complications , Diabetes Mellitus , Drug Combinations , Gliclazide , Glucose , Indapamide , Perindopril , Solar System , Veterans
6.
Yonsei Medical Journal ; : 39-44, 2009.
Article in English | WPRIM | ID: wpr-83534

ABSTRACT

PURPOSE: To evaluate the merit of umbilical artery Doppler study as a predictive marker of perinatal outcome in preterm small for gestational age (SGA) infants. MATERIALS AND METHODS: A total of 218 patients at 27 - 36 weeks of gestational age (GA) who received antenatal umbilical artery Doppler velocimetry and delivered singleton infants with SGA. The ratio of peak-systolic to end-diastolic blood flow velocities (S/D) in the umbilical artery was measured in each patient. The patients were divided into 3 groups: the normal group with S/D ratios of less than 95th percentile (n = 134), elevated S/D ratio group of 95th or more percentile (n = 41), and those with absent/reversed end diastolic flow (n = 43). Maternal characteristics and neonatal outcomes of these groups were comparatively analyzed. RESULTS: The gestational age (GA) at the time of diagnosis of SGA, the mean GA at delivery, and the mean birth weight showed statistically significant difference among three groups (p < 0.001). Also, poor perinatal outcome was significantly increased in infants with abnormal S/D ratio (13.4% vs. 31.7% vs. 67.4%, p < 0.001). Multivariate logistic regression analysis revealed umbilical artery Doppler study as a significant independent factor for prediction of poor perinatal outcome (odds ratio: 3.7, 95% confidence interval 1.4 - 9.5, p = 0.007). CONCLUSION: Antenatal umbilical artery Doppler velocimetry is shown as a significantly efficient marker in predicting perinatal outcome in preterm SGA infants.


Subject(s)
Female , Humans , Infant, Newborn , Pregnancy , Blood Flow Velocity , Infant, Small for Gestational Age , Multivariate Analysis , Predictive Value of Tests , Pregnancy Outcome , Retrospective Studies , Ultrasonography, Doppler/methods , Ultrasonography, Prenatal/methods , Umbilical Arteries/diagnostic imaging
7.
Journal of the Korean Academy of Family Medicine ; : 475-483, 2008.
Article in Korean | WPRIM | ID: wpr-89621

ABSTRACT

BACKGROUND: Recently, there has been an increase of emerging concerns between dietary fiber and diabetics. Increasing intake of dietary fiber leads to delaying absorption of glucose, and lowering of serum insulin levels. In the past studies, there were inconsistent glycemic control effect of beta-glucan. Our purpose was to assess the glycemic control effect of beta-glucan in adults. METHODS: Electronic searches (Cochrane, PubMed, EMBase), hand-searching and review of reference were done. The search term for beta-glucans [mh], "Avena sativa" [mh], "Hordeum" [mh], beta glucan* [tw], oat [tw], barley [tw], with no language restriction were used. All RCT that included available data of beta-glucan or that could impute dose of beta-glucan, at least one relevant outcome of glycemic control, run-in period more than 2 weeks, and intervention period of more than 2 weeks or greater were selected. A fixed-effect model was used to assess the summary effect of studies. RESULTS: A total of 43 articles were identified, 4 studies met our inclusion criteria and then analyzed. In pooled analysis, the effect size of fasting glucose level was 0.13 (95%CI: -1.25 to 1.51), and serum insulin level was -0.95 (95%CI, -2.37 to 0.47). It was impossible to adjust for sex and age owing to the lack of raw data. CONCLUSION: In this review, the results suggested that there were negative impacts of beta-glucan on fasting glucose and serum insulin level in adults, but we concluded that there was insufficient evidence to confirm about glycemic control effect. More powerful and well-designed RCT were required to confirm about glycemic control effect of beta-glucan.


Subject(s)
Adult , Humans , Absorption , Avena , beta-Glucans , Diabetes Mellitus , Dietary Fiber , Electronics , Electrons , Fasting , Glucose , Hordeum , Insulin
8.
Journal of the Korean Balance Society ; : 155-160, 2007.
Article in Korean | WPRIM | ID: wpr-54580

ABSTRACT

BACKGROUND AND OBJECTIVES: Congenital nystagmus (CN) is an ocular oscillation that usually manifests during early infancy. To report a novel mutation in FERM domain containing 7 (FRMD7) gene in a Korean family with CN. MATERIALS AND METHODS:Genomic DNA was prepared from peripheral blood leukocytes and direct sequencing of the entire coding and adjacent intronic regions was performed to detect sequence variation of FRMD7 gene, where mutations were found recently in patients with familial CN. The family showed an X-linked pattern of inheritance without father-to-son transmission. RESULTS: Three family members with CN exhibited two sequence variations which were a novel mutation (c. 875T>C; Leu292Pro) and a polymorphism (c. 1403G>A; Arg468His, dbSNP rs#6637934). The proband was hemizygous for both variations and his mother and maternal grandmother were heterozygous carriers. CONCLUSION: This study provides an additional evidence for mutations in FRMD7 as a common cause of X-linked CN and expands its mutation spectrum.


Subject(s)
Humans , Clinical Coding , DNA , Introns , Leukocytes , Mothers , Nystagmus, Congenital , Wills
9.
Journal of Korean Society of Spine Surgery ; : 225-233, 2006.
Article in Korean | WPRIM | ID: wpr-70358

ABSTRACT

STUDY DESIGN: Establishment of a multipotent neural stem cell line from the adult mouse cerebrum. OBJECTIVES: To establish a daughter cell line, B2A1, from B2 cells through the limiting dilution method, and to determine if the cells have the characteristics of neural stem cell (NSCs) using immunocytochemistry and RT-PCR methods. SUMMARY AND LITERATURE REVIEW: In the development of NSCs, differentiated organ or tissue-derived multipotent stem cells have attracted considerable interest because of the lack of ethical issues. Previously, a glial precursor cell line (B2 cells) was generated from the primary cultures of oligodendrocytes/ astrocytes in an adult BALB/c mouse brain. These cells exhibited the cell-type specific markers for immature neuroectodermal cells, astrocytes, and oligodendrocytes in serum-contained media. MATERIALS AND METHODS: The primary cultures of oligodendrocytes/astrocytes were established from the whole brains of 12 to 16-week-old BALB/c mice from either gender. After 6 months with 25 serial passages, the culture consisted of a morphologically homogeneous cell population, which was designated as B2 cells. A subclone, B2A1, was isolated from B2 cells through two consecutive limiting dilutions. RESULTS: More than 90% of B2A1 cells showed immunopositivity for nestin, a specific marker for NSC. The cells also showed immunopositivity for the neuronal, astrocytic and oligodendroglial markers. These cells expressed the genotypic mRNA messages for both neural progenitor cells and differentiated neuronoglial cells. These positive immunocytochemical reactions and mRNA messages for neuronoglial cells varied according to the extrinsic growth factors used. However, the treatment of extrinsic growth factors did not produce any significant differences in the nestin-immunopositive cells. CONCLUSIONS: B2A1 cells have the immunocytochemical and cytogenetic properties of NSCs, and the capacity to differentiate into neuronoglial cells.


Subject(s)
Adult , Animals , Humans , Mice , Astrocytes , Brain , Cell Line , Cerebrum , Cytogenetics , Ethics , Immunohistochemistry , Intercellular Signaling Peptides and Proteins , Multipotent Stem Cells , Nestin , Neural Plate , Neural Stem Cells , Neurons , Nuclear Family , Oligodendroglia , RNA, Messenger , Serial Passage , Stem Cells
10.
Journal of Korean Medical Science ; : 781-789, 2006.
Article in English | WPRIM | ID: wpr-14649

ABSTRACT

beta-Glucan is a polysaccharide in the form of fiber and the main element of fiber in grains such as barley, oats, yeast and mushrooms. Many studies have examined the efficacy of beta-Glucan in terms of the lipid lowering effects, blood sugar reduction, weight reduction, immune modulator, and anticarcinogenic effect. However, there is no comprehensive review article on the biomedical issues regarding beta-Glucan. The authors searched for systematic reviews and clinical experiments for each relevant topic and reviewed the biomedical effects of beta-Glucan, for the purpose of developing research strategies for the future.


Subject(s)
Humans , Animals , beta-Glucans/administration & dosage , Neoplasms/drug therapy , Infections/drug therapy , Dose-Response Relationship, Drug , Dietary Supplements , Dietary Fiber/administration & dosage , Cholesterol/blood , Body Weight/drug effects , Blood Glucose/analysis , Anticholesteremic Agents/pharmacology
11.
Journal of Korean Society of Endocrinology ; : 398-405, 2004.
Article in Korean | WPRIM | ID: wpr-131914

ABSTRACT

The familial occurrence of a pituitary adenoma associated with multiple endocrine neoplasia (MEN) type 1 or Carney complex is a well-recognized entity. However, an isolated familial somatotropinoma is a rare inherited disease, which is characterized by clustering of a somatotrophic adenoma and acromegaly or gigantism in a family, but without other manifestations of MEN type 1, with only 68 cases, in 28 families, described in the literature. The mode of inheritance is autosomal dominant, with incomplete penetration, but the genetic background of these pituitary adenomas remains unknown. A family exists where both the father and son were affected. Endocrinological investigations confirmed hypersecretion of GH and IGF-1, and the pituitary adenomas were identified by magnetic resonance image in both cases. There was no symptom of MEN type 1 or other form of endocrine dysfunction. Herein is reported a case of an isolated familial somatotropinoma in Korea, with a review of the literature


Subject(s)
Humans , Male , Acromegaly , Adenoma , Carney Complex , Fathers , Gigantism , Growth Hormone-Secreting Pituitary Adenoma , Insulin-Like Growth Factor I , Korea , Multiple Endocrine Neoplasia , Pituitary Neoplasms , Somatotrophs , Wills
12.
Journal of Korean Society of Endocrinology ; : 398-405, 2004.
Article in Korean | WPRIM | ID: wpr-131911

ABSTRACT

The familial occurrence of a pituitary adenoma associated with multiple endocrine neoplasia (MEN) type 1 or Carney complex is a well-recognized entity. However, an isolated familial somatotropinoma is a rare inherited disease, which is characterized by clustering of a somatotrophic adenoma and acromegaly or gigantism in a family, but without other manifestations of MEN type 1, with only 68 cases, in 28 families, described in the literature. The mode of inheritance is autosomal dominant, with incomplete penetration, but the genetic background of these pituitary adenomas remains unknown. A family exists where both the father and son were affected. Endocrinological investigations confirmed hypersecretion of GH and IGF-1, and the pituitary adenomas were identified by magnetic resonance image in both cases. There was no symptom of MEN type 1 or other form of endocrine dysfunction. Herein is reported a case of an isolated familial somatotropinoma in Korea, with a review of the literature


Subject(s)
Humans , Male , Acromegaly , Adenoma , Carney Complex , Fathers , Gigantism , Growth Hormone-Secreting Pituitary Adenoma , Insulin-Like Growth Factor I , Korea , Multiple Endocrine Neoplasia , Pituitary Neoplasms , Somatotrophs , Wills
13.
The Korean Journal of Thoracic and Cardiovascular Surgery ; : 711-720, 2003.
Article in Korean | WPRIM | ID: wpr-203128

ABSTRACT

BACKGROUND: Complete resection by the surgery has been selected as the treatment of choice in lung cancer patients, but in cases of recurrence after excision or inoperable cases, the importance of anticancer chemotherapy has been emphasized. If one can select a set of the sensitive chemotherapeutic agents before anticancer chemotherapy, it will give more favourable results. Subrenal capsular assay has been recognized as a useful in-vivo chemosensitivity test of thoracic and abdominal tumors and it can be done in a short time for a rapid interpretation of tumor responsiveness to anticancer chemotherapeutic drugs. It has been reported that various kinds of cancer cells can be implantable to the kidney, but so far there is no comparative study of xenogeneic cell implantation on liver, spleen and kidney. The author implanted the human lung cancer cells under the capsule of S.D rat's liver, spleen and kidney respectively and compared the pattern of growth and histology. MATERIAL AND METHOD: After incubation of human lung cancer cell line (SW-900 G IV) in RPMI 1640 (Leibovitz L-15 medium) culture media, 3x3x3 mm size fibrin clots which contain 108 cancer cells were made. Thereafter the fibrin clots were implanted at subcapsule area of liver, spleen and kidney of S.D. female rat. For immune suppression, cyclosporin-A (80 mg/Kg) was injected subcutaneously daily from post-implantation first day to sixth day. The body weight was measured at pre and post implantation periods. The growth pattern and the size of tumor mass were observed and the pathologic examination and serum tumor marker tests were performed. RESULT: Body weight increased in both of control and experimental groups. Serum Cyfra 21-1 was not detected. Serum levels of CEA and NSE revealed no significant change. The SCC-Ag increased significantly in implanted group. The growth rate of human lung cancer cells which was implanted on spleen was higher than on liver or kidney. The surface area, thickness, and volume of tumor mass were predominant at spleen. The success rates of implantation were 80% on kidney, 76.7% on spleen and 43.3% on liver. Pathologic examination of implanted tumors showed characteristic findings according to different organs. Tumors that were implanted on kidney grew in a round shape, small and regular pattern. In the spleen, tumors grew well and microscopic neovascularization and tumor thrombi were also found, but the growth pattern was irregular representing frequent daughter mass. Human lung cancer cells that were implanted in the liver, invaded to the liver parenchyme, and had low success rate of implantation. Microscopically, coagulation necrosis and myxoid fibrous lesion were observed. CONCLUSION: The success rate of implantation was highest in the kidney. And the mass revealed regular growth that could be measured easily. The SCC-Ag was presented earlier than CEA or Cyfra21-1. The Cyfra21-1 was not detected at early time after implantation. The best model for tumor implantation experiment for chemosensitivity test was subrenal capsular analysis than liver and spleen and the useful serum tumor marker in early period of implantation was the SCC-Ag.


Subject(s)
Animals , Female , Humans , Rats , Body Weight , Cell Line , Cell Transplantation , Culture Media , Drug Therapy , Fibrin , Heterografts , Kidney , Liver , Lung Neoplasms , Lung , Models, Animal , Necrosis , Nuclear Family , Recurrence , Spleen
14.
Journal of the Korean Neurological Association ; : 191-194, 2003.
Article in Korean | WPRIM | ID: wpr-109683

ABSTRACT

Familial idiopathic striopallidodentate calcification is a disorder radiologically characterized by bilateral calcifications of the brain without abnormalities in the serum calcium level and related endocrinological parameters. We report a 70-year-old woman presented with slowly progressive gait disturbance, dementia and Parkinsonism. She had bilateral and symmetric calcifications of the basal ganglia, thalamus, dentate nucleus, and subcortical white matter on the brain CT. One son and two granddaughters also showed calcifications of the basal ganglia, suggesting an autosomal dominant inheritance.


Subject(s)
Aged , Female , Humans , Basal Ganglia , Brain , Calcium , Cerebellar Nuclei , Dementia , Gait , Parkinsonian Disorders , Thalamus , Wills
15.
Journal of Korean Neurosurgical Society ; : 60-64, 2002.
Article in Korean | WPRIM | ID: wpr-146648

ABSTRACT

Several cases of familial occurrence of gliomas have been reported, but little has been known on the importance of genetic factors, which indeed remains controversial. In establishing the genetic basis for cancer susceptibility, the evaluation of a single family is perhaps the most satisfactory and meaningful approach. We report a family in which the 47-year-old father had glioblastoma in cerebellar vermis and his 14-year-old daughter developed pilocytic astrocytoma in cerebellar hemisphere. Karyotypic analysis of this family showed no abnormal findings in chromosomes.


Subject(s)
Adolescent , Humans , Middle Aged , Astrocytoma , Fathers , Glioblastoma , Glioma , Karyotype , Nuclear Family
16.
Journal of the Korean Pediatric Society ; : 728-732, 1999.
Article in Korean | WPRIM | ID: wpr-7734

ABSTRACT

Freeman-Sheldon syndrome is a rare syndrome first described by Freeman and Sheldon in 1938. Features of the syndrome include a characteristic facial appearance with multiple skeletal anomalies due to abnormal muscle tone. Since its first description, the syndrome has been called the Freeman-Sheldon syndrome, Windmill-Vane-Hand syndrome and Whistling-Face syndrome. The diagnosis may be made clinically during the first year of life. The majority of reported cases of Freeman-Sheldon syndrome are autosomal dominantly inherited but a clinically indistinguishable autosomal recessive type has been reported. We experienced a case of Freeman-Sheldon syndrome in a newborn who presented with prominent supraorbital ridge, sunken eyes, telecanthus, short nose, long philtrum, and marked microstomia. The neck was short. The hands showed symmetrically clenched fingers with camptodactyly and feet demonstrated bilateral talipes equinovarus. His father has a slight microstomia and contractures of both fingers.


Subject(s)
Humans , Infant, Newborn , Clubfoot , Contracture , Diagnosis , Fathers , Fingers , Foot , Hand , Lip , Microstomia , Neck , Nose
17.
Tuberculosis and Respiratory Diseases ; : 394-399, 1999.
Article in Korean | WPRIM | ID: wpr-172801

ABSTRACT

We report a case of congenital and familial antithrombin III deficiency developing massive pulmonary thromboembolism. A 44-year-old man was admitted to our hospital because of sudden chest pain and severe dyspnea. Five years ago, he was operated due to a mesenteric vein thrombosis of unknown cause. On admission, radioisotopic venogram showed deep vein thrombosis and lung scintigram showed multiple segmental perfusion defects. His plasma antithrombin III level was 10.5 mg/dL which was less than 50% of normal and those of a son and two daughters were also decreased. After treatment with tissue plasminogen activator, heparin and coumadin, his symptom and lung scintigram were significantly improved. As far as we reviewed, there were very rare reports with congenital antithrombin III deficiency presenting as pulmonary thromboembolism in Korea.


Subject(s)
Adult , Humans , Antithrombin III , Antithrombin III Deficiency , Chest Pain , Dyspnea , Heparin , Korea , Lung , Mesenteric Veins , Nuclear Family , Perfusion , Plasma , Pulmonary Embolism , Thrombosis , Tissue Plasminogen Activator , Venous Thrombosis , Warfarin
18.
Journal of the Korean Radiological Society ; : 441-447, 1998.
Article in Korean | WPRIM | ID: wpr-99889

ABSTRACT

PURPOSE: To determine how clinical and angiographic factors relate to the amount of subarachnoid blooddetected by computerized tomography in patients with a ruptured aneurysm. MATERIALS AND METHODS: Between January1996 and December 1997, 22 patients with a posterior communicating artery aneurysm were retrospectively evaluated. RESULTS: Oval(three of four cases), funnel(both cases), and daughter-sac (four of five cases) types of aneurysmalsac were found among the 13 patients with a large amount of subarachnoid blood ; eight of these had a past historyof hypertension or diabetes. Seven of eleven cases of cylindrical-type aneurysmal sac were found among the 9patients with a small amount of sularachnoid blood ; eight of these had no past history of hypertension ordiabetes. The average S/N ratio (ratio of maximum sac length to neck diameter) of patients with a small amount ofblood was higher than that of patients with a large amount of blood(2.72 vs 2.07). CONCLUSION: Although manyfactors influence the amount of subarachnoid blood in an aneurysmal rupture, we found that a large amount of bloodwas frequently present in the oval, funnel and daughter sac types of aneurysm, when S/N ratio was low, and when anunderlying disease such as hypertension or diabetes was present. Conversely, a small amount of blood was presentin the cylindrical type, when S/N ratio was high, and where there was no of underlying disease.


Subject(s)
Humans , Aneurysm , Aneurysm, Ruptured , Hypertension , Intracranial Aneurysm , Neck , Nuclear Family , Retrospective Studies , Rupture
19.
Journal of Korean Neurosurgical Society ; : 1598-1604, 1998.
Article in Korean | WPRIM | ID: wpr-107831

ABSTRACT

Familial intracranial aneurysm is rare. We have clipped two posterior circulation intracranial aneurysms in mother and son. Mother was 48 years old and presented with severe headache and drowsy mentality. A basilar artery bifurcation aneurysm was found on DSA(digital subtraction angiography) and successfully clipped with transsylvian pterional approach. Her son was 24-year-old and presented with seizure and drowsy mentality. An aneurysmal sac was found on the bifurcation of vertebral artery and posterior inferior cerebellar artery. We have clipped it successfully with far lateral suboccipital approach. The authors recommended the use of screening test, such as MRIand high resolution CT, on the group of patients with the characteristic features of familial intracranial aneurysm.


Subject(s)
Humans , Middle Aged , Young Adult , Aneurysm , Arteries , Basilar Artery , Headache , Intracranial Aneurysm , Mass Screening , Mothers , Seizures , Vertebral Artery
20.
Journal of the Korean Neurological Association ; : 121-126, 1993.
Article in Korean | WPRIM | ID: wpr-154220

ABSTRACT

Facioscapulohumeral muscular dystrophy (FSHD) is a genetically trarlsmitted benign muscular dystrophy which has autosomal dominant inheritance pattern. It starts anytime within the first 30 years of life, and usually involves the face and shoulder girdle, and finally the pelvic muscles with very slow progression. Authors-report a fanily consisting of a father, two sons and one daughter, who had suffered from exertional dyspnea, weakness of facial muscle and winged scapulae, all wlth a slow progressive course. Two of these patients were biopsied arld confirmed light microscopically and electron microsopically.


Subject(s)
Humans , Dyspnea , Facial Muscles , Fathers , Inheritance Patterns , Muscles , Muscular Dystrophies , Muscular Dystrophy, Facioscapulohumeral , Nuclear Family , Scapula , Shoulder
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