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Chinese Journal of Rehabilitation Medicine ; (12): 501-508, 2017.
Article in Chinese | WPRIM | ID: wpr-609691

ABSTRACT

Objective:To observe the changes of 5-HT1B and D1DR expression in nucleus of SNr/GPi-VL-SMA pathway in pre and post-exhaustive exercise,and investigate the central mechanism of SNr/GPi-VL-SMA pathway modulating the occurrence and development of exercise-induced fatigue.Method:Twenty-four male Wistar rats were randomly divided into control group (CG),immediately after exhaustion group (EG),and 90min after recovery group (RG),each consists of 8 rats.The expression level of 5-HT1B and D1DR receptors in each group were observed with the immunohistochemistry technique.Result:Compared with CG,the positive cell area/scanning area value (R value) and the average optical density value (AOD value) of 5-HT1B receptor in SNr and GPi of the EG and RG rats both decreased significantly (P < 0.05),while the R value and AOD value of D1DR both increased significantly(P< 0.05).The R value and AOD value of 5-HT1B receptor in VL of EG and RG rats increased significantly(P<0.05,P<0.01).In SMA,the R value and AOD value of 5-HT1B receptor of EG and RG rats increased significantly (P< 0.05),while,the R value and AOD value of D1DR receptor decreased significantly (P < 0.05).Conclusion:Changes of 5-HT1B receptor and D1DR receptor expression in the nuclei of ‘SNr/GPi-VL-SMA'pathway caused the changes of the neurotransmitters release,thus affecting the excitability of the electrical activity of neurons,this might be one of the important ways for ‘SNr/GPi-VL-SMA'pathway modulating the exercise-induced fatigue and exercise performance.

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