ABSTRACT
Objective To investigate the mechanism and the related factors of fetal hypoxia in intrahepatic cholestasis of pregnancy (ICP). Methods Cord blood total bile acids(TBA), hypoxanthine (HX), and endothelin (ET) concentrations were measured in 30 newborns of mothers with ICP and 30 infants of normal pregnancy as control, and the cord nucleated red blood cells (NRBC) were counted as well. Results (1)The mean cord arterious plasma HX concentration in hypoxic fetuses of mothers with ICP was significantly higher than those in fetuses without hypoxia of mothers with ICP and fetuses of normal pregnancy(18.68?15.73)?mol/L, (6.87? 2.82)?mol/L, (6.81?2.83)?mol/L( P 0.05) and the mean cord arterious plasma ET concentration (72.44?12.23) ng/L,(70.16?26.61) ng/L,(67.27?43.56) ng/L, P =0.910) among the three groups. (2) In ICP group, the mean cord serum TBA concentration in hypoxic fetuses was significantly higher than that in fetuses without hypoxia, while the latter was higher than that in control group (23.77?11.82)?mol/L,(14.86?5.46)?mol/L,(9.28?4.39)?mol/L;( P