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The Korean Journal of Parasitology ; : 375-384, 2017.
Article in English | WPRIM | ID: wpr-203201

ABSTRACT

Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis α-actinin 2, Tvα-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tvα-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tvα-actinin 2 antibodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tvα-actinin 2 protein. Both T. vaginalis and rTvα-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4+CD25− regulatory T cells (Treg cells) incubated with rTvα-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tvα-actinin 2 modulates immune responses via IL-10 production by Treg cells.


Subject(s)
Animals , Humans , Mice , Antibodies , Blotting, Western , Dendritic Cells , Enzyme-Linked Immunosorbent Assay , Epithelial Cells , Interleukin-10 , Prostate , T-Lymphocytes , T-Lymphocytes, Regulatory , Trichomonas vaginalis , Trichomonas
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