1.
Chinese Pharmaceutical Journal
;
(24): 612-615, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-859135
ABSTRACT
OBJECTIVE: To evaluate the antimalarial activity of Isodon yuennanensis for the development of neo-style antimalarial drugs or lead compounds from plants. METHODS: The crude extract and compounds from I. yuennanensis were screened for antimalarial activities by β-hematin formation inhibition assay, and the results were expressed as IC50 values. RESULTS: The crude extract, as well as some compounds, showed β-hematin formation inhibition activities in different degrees. CONCLUSION: The ethyl acetate fraction derived from the 70% acetone extract of I. yuennanensis and the compounds 2, 12, and 13 obtained from the ethyl acetate fraction are worthy of deeper research due to their significant antimalarial activities.