Effect of Coix-seed Reactive Derivatives (CRD) on Skin Pigmentation: A Randomized Controlled Trial / 日本補完代替医療学会誌

We evaluated the effects of the extract of Coix-seed Reactive Derivatives (CRD) on female skin pigmentation. Ninety females with facial pigmentation were assigned randomly to 3 groups and CRD (2g/day, 4g/day or placebo) was administrated for 8weeks. We confirmed the safety of CRD, and both the rate of change of facial pigmentation and erythema in 4g/day group decreased significantly (p<0.01). Further studies are needed to define the optimal dose of CRD.