Role of phosphoglycerate mutase 1 in the occurence and development of tumor / 上海交通大学学报（医学版）

Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway, is highly expressed in multiple tumor tissues and negatively correlated with the prognosis of cancer patients. PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG) in glycolysis pathway, then promoting anabolic pathways, energy generation, and maintaining redox balance during cancer cell proliferation and metastasis. The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy. In this review, the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.

Role of phosphoglycerate mutase 1 in the occurence and development of tumor / 上海交通大学学报（医学版）

Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway,is highly expressed in multiple tumor tissues and negatively correlated with the prognosis of cancer patients.PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG) in glycolysis pathway,then promoting anabolic pathways,energy generation,and maintaining redox balance during cancer cell proliferation and metastasis.The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy.In this review,the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.