ABSTRACT
Objective: To investigate the chemical constituents in leaves of Ilex ficoidea. Methods: The various chromatographic techniques were used to isolate and purify the compounds and their structures were identified by the spectral data and physicochemical properties. Results: Sixteen compounds were isolated from 95% ethanol extract and identified as friedelan-3-one (1), 4-epifriedelin (2), lupeol (3), oleanolic acid (4), 3-acetoxy-oleanoic acid (5), 3β-acetoxy-6α, 13β-dihydroxyolean-7-one (6), 2-(4-hydroxybenzyl) malic acid (7), quercetin-3-O-α-L-arabinopyranoside (8), hyperoside (9), cis-syringin (10), ethyl-O-β-L-arabinopyranoside (11), emodin (12), chrysophanol (13), physcion (14), α-spinasterol (15), and β-sitosterol (16). Conclusion: All the compounds are isolated from the species for the first time, among which compounds 1, 2, 6-8, 12, and 13 are isolated from the plants in genus Ilex L. for the first time.