ABSTRACT
INTRODUÇÃO: A Psicopedagogia, enquanto área de conhecimento que estuda os processos de aprendizagem humana, encontra campo fértil de atuação e pesquisa, com as políticas de inclusão escolar, em especial no que tange às intervenções realizadas no Atendimento Educacional Especializado (AEE OBJETIVOS: Analisar como se estabelece, no âmbito organizacional educacional, a atuação do profissional da Psicopedagogia no AEE no que se refere aos alunos com necessidades educacionais especiais ou aos alunos da educação especial MÉTODO: Trata-se de um estudo bibliográfico, descritivo com análise qualitativa sobre os eixos psicopedagogia e o AEE. Foram encontrados fortes pontos de semelhança entre as áreas de atuação, tais como: objeto de estudo, formação profissional e alguns procedimentos de intervenção CONCLUSÃO: Pontos consistentes de interlocução entre as práticas das áreas, uma vez identificados, tendem a potencializar a ação dos profissionais e o desempenho na aprendizagem
INTRODUCTION: Psychopedagogy as an area of knowledge that studies human learning processes, finds a fertile field of activity and research with school inclusion policies, especially with regard to interventions carried out in Specialized Educational Assistance (SEA OBJECTIVES: To analyze how, in the educational organizational scope, the performance of the psychopedagogy professional in the SEA is established with regard to students with special educational needs or students of special education METHODS: This is a bibliographic, descriptive study with qualitative analysis on the psycho-pedagogical axes and the SEA. Strong points of similarity were found between the areas of activity, with relevant points being identified, such as: object of study, professional training CONCLUSION: The study showed consistent points of interlocution between the practices of the areas, which, identified, tend to enhance the action of professionals and performance in learning
ABSTRACT
PURPOSE: We evaluated the therapeutic effect of AEE788, a dual inhibitor of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinases on human salivary adenoid cystic carcinoma (ACC) cells growing in nude mice. Experimental Design: We examined the effects of AEE788 on salivary ACC cell growth and apoptosis. To determine the in vivo effects of AEE788, nude mice with orthotopic parotid tumors were randomized to receive oral AEE788 (50 mg/kg) three times per week, injected paclitaxel (200 microgram) once per week, AEE788 plus paclitaxel, or placebo. Mechanisms of in vivo AEE788 activity were determined by immunohistochemical analysis. RESULTS: Treatment of salivary ACC cells with AEE788 led to growth inhibition and induction of apoptosis. AEE788 inhibited tumor growth and prevented lung metastasis in nude mice. Furthermore, AEE788 potentiated growth inhibition and apoptosis of ACC tumor cells mediated by paclitaxel. Tumors of mice treated with AEE788 and AEE788 plus paclitaxel exhibited down-regulation of activated EGFR and its downstream mediators (Akt and MAPK), increased tumor and endothelial cell apoptosis, and decreased microvessel density, which correlated with a decrease in the level of MMP-9, MMP-2 and bFGF expression and a decrease in the incidence of vascular metastasis. CONCLUSIONS: These data show that tumor-associated endothelial cells are important in the process of tumor-metastasis. And VEGFR can be a molecular target for therapy of metastatic lung lesion of salivary ACC.