Polysomnographic Outcomes of 62 Patients in Dhaka City a Single-Center Study

Background: Obstructive sleep apnea (OSA) is a very common form of sleep disorder with associated health risks. OSA has been accompanied by more insidious conditions, like hypertension, heart disease, diabetes, stroke, and even daytime somnolence. For the diagnosis of sleep disorders, polysomnography is a comprehensive test. It records the patient`s brain waves, the oxygen level in the blood, ‘breathing and heart rate’, and ‘eye and leg movements during the study. Aim of the study: The aim of this study was to assess the effectiveness of polysomnography in the diagnosis of sleep apnea.Material & Methods:This comparative observational study was conducted in the Department of Otolaryngology &, Head Neck Surgery, Bashundara Ad-Din Medical College and Hospital, Bangladesh during the period from July 2020 to June 2021. In total 62 participants were included in the study population for this study. All the participants were divided into two groups. In group A, there were 5 healthy people without obstructive sleep apnea (No OSA group). On the other hand, in group B, there were 57 obstructive sleep apnea patients (OSA group). Ethical approval had been taken from the ethical committee of the mentioned hospital. Data were analyzed by using MS Office and SPSS version 23 programs as per need.Results:In analyzing the sleep scoring between both the groups, in both TRT minutes and total sleep time minutes we did not find any significant correlation (Table: 2). In analyzing the apnea, in comparing mean (±SD) obstructive, total, and AI calculations, we found significant correlations between the groups (Table: 3, Apnea; P values: 0.036, 0.035, and 0.024 respectively. In comparing different parameters of hypopneas (rule 1A), in most of the events, we found significant correlations except mean (±SD) central (Table 3 hypopneas: rule 1A) even, in comparing total mean (±SD) apneas and hypopneas combinedly we found the P-value as 0.002 (Table:3). In the OSA severity comparison between both the groups, in calculating AHI 1 to<15 events/hour, AHI 15 to<30 events/hour, and AHI ?30 events/hour we found significant correlations (P=.001, Table 3: OSA severity). In assessing the Mean (SD) AHI, OAI, RDI (AI+HI+RI), O2 Desats?3% and O2 Desats?3% Index (ODI) we found significant correlations (P values were 0.001, 0.041, 0.001, 0.003, 0.005 respectively). Besides these, in analyzing both the low SpO2 n (%) and snoring: n (%) there was a significant correlation between the group’s patients (P values were .007 and .001 respectively).Conclusion:Polysomnography may be considered an effective method for detecting measuring and treating obstructive sleep apnea (OSA). Sleep scoring and respiratory events analysis plays an important role in assessing the presence and severity of obstructive sleep apnea.

Craniofacial morphology in patients with obstructive sleep apnea: cephalometric evaluation / Morfologia craniofacial em pacientes com apneia obstrutiva do sono: avaliação cefalométrica

Abstract Introduction: Obstructive sleep apnea is characterized by a reduced airflow through the upper airways during sleep. Two forms of obstructive sleep apnea are described: the central form and the obstructive form. The obstructive form is related to many factors, such as the craniofacial morphology. Objective: To evaluate the correlation between the morphology of the cranial base, of the mandible and the maxilla, and obstructive sleep apnea severity. Methods: Eighty-four patients, mean age of 50.4 years old; 73 males and 11 females with obstructive sleep apnea were enrolled in the present study. Patients with high body mass index and comorbidities were excluded. Lateral cephalograms and polysomnography were collected for each patient to evaluate the correlation between craniofacial morphology and obstructive sleep apnea severity. A Spearman's rho correlation test between cephalometric measurements and obstructive sleep apnea indexes was computed. Statistical significance was set at p < 0.05. Results: Patients with a severe obstructive sleep apnea presented a reduction of sagittal growth of both effective mandibular length and cranio-basal length. The mandibular length was the only variable with a statistical correlation with apnea-hypopnea index. Vertical dimension showed a weak correlation with the severity of obstructive sleep apnea. No correlation with maxillary sagittal dimension was shown. Conclusion: Obstructive sleep apnea severity may be correlated to mandibular and cranial base growth. Facial vertical dimension had no correlation with obstructive sleep apnea severity.

Resumo Introdução: A apneia obstrutiva do sono é caracterizada por um fluxo de ar reduzido nas vias aéreas superiores durante o sono. Duas formas de apneia são descritas: a forma central e a forma obstrutiva. A forma obstrutiva tem sido relacionada a vários fatores, como a morfologia craniofacial. Objetivo: Avaliar a correlação entre a morfologia da base do crânio, da mandíbula e da maxila e a gravidade da apneia obstrutiva do sono. Método: Foram incluídos no presente estudo 84 pacientes com apneia obstrutiva do sono, com média de 50,4 anos; 73 homens e 11 mulheres. Pacientes com alto índice de massa corpórea e comorbidades foram excluídos. Foram coletados cefalogramas laterais e polissonografia para cada paciente para avaliar a correlação entre a morfologia craniofacial e a gravidade da apneia. Foi computado o coeficiente de correlação de postos de Spearman (rho) entre medidas cefalométricas e índices de apneia obstrutiva do sono. A significância estatística foi estabelecida em p < 0,05. Resultados: Pacientes com apneia obstrutiva do sono grave apresentaram redução do crescimento sagital do comprimento mandibular efetivo e do comprimento crânio-basal. O comprimento mandibular foi a única variável que apresentou correlação estatística com o índice de apneia-hipopneia. A dimensão vertical mostrou uma fraca correlação com a gravidade da apneia. Não foi demonstrada correlação com a dimensão maxilar sagital. Conclusão: A gravidade da apneia obstrutiva do sono pode estar correlacionada ao crescimento da base mandibular e craniana. A dimensão facial vertical não apresentou correlação com a gravidade da apneia.

A angústia existencial como disposição afetiva fundamental para a prática psicoterápica / Existential anguish as a fundamental affective disposition for psychotherapy practice / La angustia existencial como disposición afectiva fundamental para la práctica de la psicoterapia

A angústia é um conceito fundamental na clínica fenomenológica-existencial. Essa disposição afetiva tem na obra de Martin Heidegger um privilégio em relação às outras disposições, uma vez que ela, em seu caráter ontológico, é o motor da existência humana. O presente artigo se propôs a compreender a angústia como reveladora da verdade do Ser-aí no processo psicoterapêutico, com base nas contribuições do filósofo Heidegger e seus comentadores, sobretudo expoentes da psicologia fenomenológica-existencial. Perguntas como "Qual a verdade do Ser-aí?" e "O que a angústia revela dessa verdade?", nortearam a construção desta obra. O estudo se caracteriza enquanto pesquisa qualitativa, cuja metodologia é a pesquisa bibliográfica. Os resultados apontaram que a angústia revela a verdade do Ser-aí. O que chamamos de verdade é a essência deste ente: ter de ser. Ela aponta para seu caráter ontológico de abertura, para suas possibilidades, seu poder-ser mais próprio, liberdade e ao desvelamento do sentido do Ser. Por fim, a angústia ontológica, não restrita ao processo psicoterápico, movimenta o Ser-aí e revela possibilidades que por meio do cuidado torna possível a sua singularização. Dessa maneira, é essencial que o psicoterapeuta compreenda a angústia, facilitando ao paciente a apropriação e a responsabilização daquilo que ela revela.

Anguish is a fundamental concept in the phenomenological-existential clinic. This affective disposition has in Martin Heidegger's work a privilege over other dispositions, since it, in its ontological character, is the engine of human existence. This paper aims to understand anguish as revealing the truth of Being-there in the psychotherapeutic process, based on the contributions of philosopher Heidegger and his commentators, especially exponents of phenomenological-existential psychology. Questions such as "What is the truth of Being-there?" And "What does anguish reveal about this truth?" Guided the construction of this work. The study is characterized as a qualitative research, whose methodology is bibliographic research. The results indicated that anguish reveals the truth of Being-there. What we call the truth is the essence of this being: having to be. It points to its ontological character of openness, its possibilities, its own power-being, freedom and the unveiling of the meaning of Being. Finally, the ontological anguish, not restricted to the psychotherapeutic process, moves Being-there and reveals possibilities that, by their very nature. through care makes its uniqueness possible. Thus, it is essential for the psychotherapist to understand distress, facilitating the patient's appropriation and accountability of what it reveals.

La angustia es un concepto fundamental en la clínica fenomenológica-existencial. Esta disposición afectiva tiene en el trabajo de Martin Heidegger un privilegio sobre otras disposiciones, ya que, en su carácter ontológico, es el motor de la existencia humana. Este artículo tiene como objetivo entender la angustia como la revelación de la verdad del Ser-ahí en el proceso psicoterapéutico, basado en las contribuciones del filósofo Heidegger y sus comentaristas, especialmente los exponentes de la psicología fenomenológica-existencial. Preguntas como "¿Cuál es la verdad del Ser-ahí?" Y "¿Qué revela la angustia acerca de esta verdad?" Orientaron la construcción de este trabajo. El estudio se caracteriza por ser una investigación cualitativa, cuya metodología es la investigación bibliográfica. Los resultados señalaron que la angustia revela la verdad del Ser-ahí. Lo que llamamos la verdad es la esencia de este sujeito: tener que ser. Apunta a su carácter ontológico de apertura, a sus posibilidades, a su poderser más proprio, la libertad y el desvelamineto del significado del Ser. Finalmente, la angustia ontológica, no restringida al proceso psicoterapéutico, mueve el Ser-ahí y revela posibilidades que, por su propia naturaleza. a través del cuidado hace posible su singularidad. Por lo tanto, es esencial que el psicoterapeuta entienda la angustia, facilitando la apropiación y la responsabilidad del paciente de lo que se revela.

Correlation of Apnea Hypopnea Index Severity with Fasting Blood Sugars and HbA1C Values in Patients with Metabolic Syndrome

Introduction: The relationship between OSA and glycemichealth is a topic of increasing clinical and research interest.Community-based studies have suggested that the presenceand severity of OSA are independent predictors of insulinresistance and T2DM prevalence the aim of the present studywas to examine the potential correlation of OSA and HbA1Cvalues in patients with Metabolic SyndromeMaterial and Methods: A cross-sectional study was conductedamong a total of 63 patients with a history of metabolicsyndrome and were divided into two groups diabetic and nondiabetic. The risk of OSA was assessed by three structuredand validated questionnaires namely STOP-BANG, ESS,Modified Berlin. Fasting blood sugars and HbA1C was done.All patients were evaluated with Polysomnography level III.Results were analyzed using statistical methods (Descriptiveanalysis and correlation). Using SSPS version 22 used.Results: Out of the total of 63 subjects, there was a malepreponderance (Male - 61%) with a mean age of 50.9 ± 12.98years. Increased AHI was seen in 91% of the subjects (morethan 5) with the mean AHI of 29.63 ± 22.14. The mean FBS &HbA1C was 151.62 ± 49.5mg/dl & 7.22 ± 1.71 respectively.In both diabetic & non-diabetic groups, the correlation of FBS& HbA1C values with AHI was statistically not significant.Conclusion: AHI severity did not correlate with FBS andHbA1c values in patients with metabolic syndrome. However,in the non-diabetic subgroup with severe AHI the fastingblood sugar levels were above a higher limit of normal.

SLEEP-GOAL: A multicenter success criteria outcome study on 302 obstructive sleep apnoea (OSA) patients

@#Objective: To demonstrate SLEEP-GOAL as a more holistic and comprehensive success criterion for Obstructive Sleep Apnoea (OSA) treatment. Methods: A prospective 7-country clinical trial of 302 OSA patients, who met the selection criteria, and underwent nose, palate and/or tongue surgery. Pre- and post-operative data were recorded and analysed based on both the Sher criteria (apnoea hypopnea index, AHI reduction 50% and <20) and the SLEEP-GOAL. Results: There were 229 males and 73 females, mean age of 42.4±17.3 years, mean BMI 27.9±4.2. The mean VAS score improved from 7.7±1.4 to 2.5±1.7 (p<0.05), mean Epworth score (ESS) improved from 12.2±4.6 to 4.9±2.8 (p<0.05), mean body mass index (BMI) decreased from 27.9±4.2 to 26.1±3.7 (p>0.05), gross weight decreased from 81.9±14.3kg to 76.6±13.3kg. The mean AHI decreased 33.4±18.9 to 14.6±11.0 (p<0.05), mean lowest oxygen saturation (LSAT) improved 79.4±9.2% to 86.9±5.9% (p<0.05), and mean duration of oxygen <90% decreased from 32.6±8.9 minutes to 7.3±2.1 minutes (p<0.05). The overall success rate (302 patients) based on the Sher criteria was 66.2%. Crosstabulation of respective major/minor criteria fulfilment, based on fulfilment of two major and two minor or better, the success rate (based on SLEEP-GOAL) was 69.8%. Based solely on the Sher criteria, 63 patients who had significant blood pressure reduction, 29 patients who had BMI reduction and 66 patients who had clinically significant decrease in duration of oxygen <90% would have been misclassified as “failures”. Conclusion: AHI as a single parameter is unreliable. Assessing true success outcomes of OSA treatment, requires comprehensive and holistic parameters, reflecting true end-organ injury/function; the SLEEP-GOAL meets these requirements

The study of the effect of C-PAP therapy in type-II diabetic patients with obesity and obstructive sleep apnea

Type II diabetes mellitus (T2DM) is closely associated with Obstructive sleep apnea (OSA) and obesity. Type 2 diabetes and OSA may be pathophysiologically independent conditions although the joint association with obesity or visceral adiposity. There is a consistent relationship between obesity and OSA, which has been reported in 60-90% of OSA patients. The prevalence of obesity increases with a parallel increase in the prevalence of OSA. Continuous positive airway pressure (CPAP) therapy is an effective choice of treatment for OSA, an overnight test, or titration some patients may reduce apnea events by minimizes airway collapse by CPAP. Several studies showed that the effect of drug treatment with 3 months of C-PAP in patients with type 2 diabetes. In the present study, we include 300 patients in different groups, out of the 100 patients undergoing treatment of CPAP therapy minimum for three months. Blood sugar, HbA1c, and lipid profile were measured and an overnight sleep study was done. The obtained data shows the significant effect of therapy on physiological and biochemical parameters. AHI and BMI were highly significant in group II and Group III when compared to group I. FBS, HbA1C, and Lipid profile parameters also gave significance results (p-value <0.001) in group II and group III when compared with healthy subjects (group I).

Indicadores de los estudios de diagnóstico de los trastornos respiratorios vinculados al sueño y el riesgo de la simplificación / Indicators of diagnostic studies of sleep-related respiratory disorders and the risk of simplification

Datos recientes indican que los trastornos respiratorios del sueño afectan 15 a 20% de la población adulta y 5 a 10% de los niños. El Síndrome de apneas e hipopneas obstructivas del sueño (SAHOS) constituye una entidad de alto impacto epidemiológico con una creciente demanda en nuestro medio. Para comenzar a resolver el problema es necesario conocer los fundamentos básicos en la interpretación de los métodos diagnósticos. La confirmación es requerida ante la sospecha de SAHOS. Las guías de la Asociación Argentina de Medicina Respiratoria establecen que la polisomnografía (PSG) es el método diagnóstico estándar y acepta la poligrafía respiratoria (PR) como método equiparable considerando el contexto clínico del enfermo. Este artículo aborda el dilema del uso del índice de apnea e hipopnea (IAH) e índice de perturbación respiratoria (IPR) que definen la enfermedad y son usados para establecer su severidad. Resulta sorprendente que a pesar de la cantidad de datos que son analizados en un estudio del sueño, la atención se centre en este valor. Más de cuatro décadas han transcurrido desde la descripción original y nuestra capacidad de simplificación podría poner en riesgo las posibilidades de un entendimiento integral del SAHOS.

The latest data indicate that respiratory sleep disorders affect 15 to 20% of adults and 5 to 10% of children. Obstructive sleep apnea (OSA) means a high impact epidemiologic entity with a growing demand in our daily clinical practice. To begin to solve this problem it is necessary to know the basic fundaments in the interpretation of diagnostic methods. Confirmation is required in suspected OSA. Guidelines from Argentinian Respiratory Medicine Society recognize polysomnography (PSG) as the standard diagnostic method and respiratory polygraphy (RP) as comparable method considering the clinical context of the patient. This article summarizes the dilemma of using apnea and hypopnea index (AHI) that defines the disease and is used to assess the severity. It is surprising that despite the amount of data being analyzed in a sleep study, attention is focused on this value. More than four decades have passed since the original description and our ability to simplification could put on risk the chances of a comprehensive understanding of OSA.

The Characteristics of REM Sleep-Dependent Obstructive Sleep Apnea and NREM Sleep-Dependent Obstructive Sleep Apnea / 수면정신생리

OBJECTIVES: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that is characterized by repetitive collapse or partial collapse of the upper airway during sleep in spite of ongoing effort to breathe. It is believed that OSA is usually worsened in REM sleep, because muscle tone is suppressed during REM sleep. However, many cases showed a higher apnea-hypopnea index (AHI) during NREM sleep than during REM sleep. We aimed here to determine the characteristics of REM sleep-dependent OSA (REM-OSA) and NREM sleep-dependent OSA (NREM-OSA). METHODS: Five hundred sixty polysomnographically confirmed adult OSA subjects were studied retrospectively. All patients were classified into 3 groups based on the ratio between REM-AHI and NREM-AHI. REM-OSA was defined as REM-AHI/NREM-AHI > 2, NREM-OSA as NREM-AHI/REM-AHI > 2, and the rest as sleep stage-independent OSA (IND-OSA). In addition to polysomnography, questionnaires related to subjective sleep quality, daytime sleepiness, and emotion were completed. Chi-square test, ANOVA, and ANCOVA were performed. RESULTS: There was no age difference among subgroups. The REM-OSA group was comprised of large proportions of mild OSA and female OSA patients. These patients experienced poor sleep and more negative emotions than other two groups. The AHI and oxygen desaturation index (ODI) were lowest in REM-OSA. Sleep efficiency and N3 percentage of REM-OSA were higher than in NREM-OSA. The percentage of patients who slept in a supine position was higher in REM-OSA than other subgroups. IND-OSA showed higher BMI and larger neck circumference and abdominal circumference than REM-OSA. The patients with IND-OSA experienced more sleepiness than the other groups. AHI and ODI were highest in IND-OSA. NREM-OSA presented the shortest total sleep time and the lowest sleep efficiency. NREM-OSA showed shorter sleep latency and REM latency and higher percentage of N1 than those of REM-OSA and the highest proportion of those who slept in a lateral position than other subgroups. NREM-OSA revealed the highest composite score on the Horne and Östberg questionnaire. With increased AHI severity, the numbers of apnea and hypopnea events during REM sleep decreased, and the numbers of apnea and hypopnea events during NREM sleep increased. The results of ANCOVA after controlling age, sex, BMI, NC, AC, and AHI showed the lowest sleep efficiency, the highest AHI in the supine position, and the highest percentage of waking after sleep onset in NREM-OSA. CONCLUSION: REM-OSA was associated with the mild form of OSA, female sex, and negative emotions. IND-OSA was associated with the severe form of OSA. NREM-OSA was most closely related to position and showed the lowest sleep efficiency. Sleep stage-dependent characteristics could provide better understanding of OSA.

Whole Exome Sequencing in a Korean Child with Joubert Syndrome-related Disorders

Joubert syndrome and Joubert syndrome-related disorders (JSRDs) are rare autosomal recessive or X-linked disorders characterized by cerebellar vermis hypoplasia and a brain stem malformation, which presents as the “molar tooth sign” in magnetic resonance imaging (MRI). JSRDs are a group of clinically heterogeneous conditions that exhibit neurological manifestations and multiple organ involvement. JSRDs are also genetically heterogeneous, and approximately 20 causative genes that account for 45% of JSRDs have been identified. A 7-yr-old boy visited Wonkwang University Sanbon Hospital with the following presentations: no ocular fixation, ataxia, growth retardation, and hypotonia. Physical examination revealed facial dysmorphism, spindle shaped fingers, and height (99 cm) and weight (13 kg) below the third percentile. Ophthalmic examination revealed retinal dystrophy. A diagnosis of JSRDs was made based on clinical and brain MRI findings. We found two heterozygous variants c.2945 G>T; p.Arg982Met (G>T) and c.2216dupA; p.Phe740Valfs*2 (dupA) in AHI1, and a heterozygous c.3973C>T; p.Arg1325Trp (C>T) variant in KIF7 by whole exome sequencing (WES). Genetic analysis on the proband's father revealed that he had both AHI1 variants, but did not have the KIF7 variant, which was inconsistent with autosomal recessive inheritance. Therefore, the G>T variant and C>T variant were presumed to be of “uncertain significance.” Furthermore, one novel dupA variant was interpreted as “pathogenic,” while the second allele was not detected. Caution should be exercised while interpreting the significance of variants detected by WES. In addition, the involvement of genes other than the 20 known ones will require further investigation to elucidate the pathogenesis of JSRDs.

Evaluation of CMS50F as a screening test for patients with obstructive sleep apnea hypopnea syndrome / 天津医药

Objective To evaluate the diagnostic accuracy of CMS50F for screening in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Sixty-four volunteers with suspected OSAHS underwent simultaneous noc?turnal polysomnography (PSG), micromovement sensitive mattress sleep monitoring system(MSMSMS)and CMS50F. The ap?nea-hypopnea index (AHI) detected by PSG and MSMSMS was used as the diagnostic standard for OSAHS. The reliability of CMS50F for monitoring sleep was assessed. Results There was no statistic difference in CMS50F-ODI3 and PSG-AHI be?tween normal, mild and moderate OSAHS groups(P>0.05). The CMS50F-ODI3 was smaller than the PSG-AHI in severe OSAHS patients(P 0.05). The value of CMS50F-ODI3 was smaller than MSMSMS-AHI in severe OSAHS patients (P < 0.05). There was also a significant correlation between CMS50F- ODI3 and MSMSMS-AHI (r=0.867,P <0.05). MSMSMS-AHI≥5 events per hour was used as the threshold value to diagnose OSAHS, the sensitivity and specificity of CMS50F were 94.5%and 88.9%. Conclusion CMS50F can be used as a portable and reliable device for screening of pa?tients suspected OSAHS.

Efficacy and Safety of Newly Developed Korean Continuous Positive Airway Pressure Treatment in Patients with Obstructive Sleep Apnea Syndrome

BACKGROUND AND OBJECTIVES: Obstructive sleep apnea syndrome(OSAS) is characterized by repeated apnea, hypopnea, and micro-arousals during sleep. Among various treatment modalities of OSAS, continuous positive airway pressure(CPAP) treatment is the most effective and successful. The aim of this study was to compare efficacy and safety of newly developed Korean CPAP with standard CPAP in OSAS patients. MATERIALS AND METHOD: In total, 20 of 26 recruited OSAS patients completed the study. All subjects first used the standard CPAP for 4 weeks. After an at least 2 week wash-out period, the subjects used the newly developed CPAP for 4 weeks. Polysomnography, questionnaires associated with sleep, lipid profile, pulmonary function test, cardiac marker, and physical examinations were evaluated at baseline and were followed-up after each treatment. RESULTS: After treatment with the newly developed CPAP, the apnea-hypopnea index was decreased from 53.2/hr to 2.5/hr and was equivalent to that of the standard CPAP. Most of the changes in questionnaire scores, laboratory findings, and physical examinations after newly developed CPAP treatment were equivalent to those with standard CPAP. No serious adverse events were observed during the study. CONCLUSION: The efficacy and safety of a newly developed CPAP are equivalent to those of standard CPAP in OSAS patients.

The prevalence of hypertension in patients with obstructive sleep apnea hypopnea syndrome and their relationship / 天津医药

Objective To investigate the prevalence of hypertension in patients with obstructive sleep apnea hypopnea syndrome (OSA) and the relationship between blood pressure (BP) with respiratory ventilation function. Methods Patients with OSA (n=3 607) were included in this study and divided into 4 groups based on their apnea-hypopnea index (AHI) scores:control group (control, n=354) with AHI<5;mild OSAHS (mild, n=658) with 5≤AHI<15;moderate OSAHS (moder?ate, n=753) with 15≤AHI<30;and severe OSA (severe, n=1 842) with AHI≥30. BP were measured at 4 time points (daytime, evening, midnight, and morning). The midnight/ daytime average BP (RN/D) and morning/evening average BP (RM/E) ratios were calculated. Finally, the general profiles, prevalence of hypertension and average BP of 4 time points were compared among 4 groups. The correlations of MBP with AHI and LSaO2 were also analyzed. Results The prevalence of hypertension as well as MBP at daytime and in the morning in the mild group (34.65%), moderate group (39.04%) and severe group (55.37%) were all higher than that in control group (22.32%)(all P<0.05). The prevalence of hypertension as well as MBP at daytime and in the morning were both higher in severe group than those in mild and moderate groups. MPB in the evening and at midnight was higher in severe group than that in moderate group than that in mild group than in control group (P<0.05). Average MBP of all four time points rise with increasing AHI (all P<0.05). The ratios of nighttime to daytime MBP (RN/D) and of morning to evening MBP (RM/E) increased with the severity of the illness (F=9.821, 18.957;P<0.001). The day? time BP correlated well with AHI and lowest oxygen saturation (LSaO2;systolic BP, r=0.195,-0.206;diastolic BP, r=0.248,-0.251, P<0.01). Daytime MBP increased gradually with increasing AHI until MPB reached 61-65, at which point it either plateaued or dropped slightly. Conclusion OSA patients have a significant increase in midnight and morning BP and lose normal BP nycterohemeral rhythm. OSA is an independent risk factor for hypertension.

Abelson Helper Integration Site-1 Gene Variants on Major Depressive Disorder and Bipolar Disorder

OBJECTIVE: The present study aimed to explore whether 4 single nucleotide polymorphisms (SNPs) within the AHI1 gene could be associated with major depressive disorder (MD) and bipolar disorder (BD), and whether they could predict clinical outcomes in mood disorders. METHODS: One hundred and eighty-four (184) patients with MD, 170 patients with BD and 170 healthy controls were genotyped for 4 AHI1 SNPs (rs11154801, rs7750586, rs9647635 and rs9321501). Baseline and final clinical measures for MD patients were assessed through the Hamilton Rating Scale for Depression (HAM-D). Allelic and genotypic frequencies in MD and BD subjects were compared with those of each disorder and healthy group using the chi2 statistics. Repeated measures ANOVA was used to test possible influences of SNPs on treatment efficacy. RESULTS: The rs9647635 A/A was more represented in subjects with BD as compared with MD and healthy subjects together. The rs9647635 A/A was also more presented in patients with MD than in healthy subjects. With regard to the allelic analysis, rs9647635 A allele was more represented in subjects with BD compared with healthy subjects, while it was not observed between patients with MD and healthy subjects. CONCLUSION: Our findings provide potential evidence of an association between some variants of AHI1 and mood disorders susceptibility but not with clinical outcomes. However, we will need to do more adequately-powered and advanced association studies to draw any conclusion due to clear limitations.

Uma investigação do ser-aí do menino selvagem à luz do pensamento heideggeriano / An investigation of the Dasein of the wild boy through Heidegger's thought / Una investigación del ser-ahí del niño salvaje a luz del pensamiento heideggeriano

Este trabalho busca, na história de Victor de Aveyron, elementos para discutir o modo pelo qual a existência humana se constitui. Por não ter convivido em ambiente humano, Victor foi motivo de intensas discussões no meio científico, especialmente entre os empiristas e os racionalistas. Nesta pesquisa assumimos uma postura fenomenológica, trazendo a história do menino selvagem à discussão por meio da fenomenologia hermenêutica de Heidegger, apontando, assim, para o caráter de indeterminação, o "ter de ser", e de singularidade da existência, sempre em jogo na constituição do modo de ser do homem.

This work aims to find, in the story of Victor of Aveyron, elements to discuss the way in which human existence is constituted. For not having lived in the human environment, Victor was the subject of intense discussions within the scientific community, especially among empiricists and rationalists. In this research we take a phenomenological approach, bringing the story of the wild boy into the discussion through the Heidegger's phenomenology hermeneutic, pointing to the character of indeterminacy, mineness; and the singularity of the existence, always presented in the constitution of man's way of being.

Este trabajo busca en la historia de Víctor de Aveyron elementos para discutir el modo por el cual la existencia humana se constituye. Por no haber convivido en ambiente humano, Víctor ha sido motivo de intensas discusiones en el medio científico, especialmente entre los empiristas y los racionalistas. En esta investigación asumimos una postura fenomenológica, trayendo la historia do menino salvaje a discusión por medio de la fenomenología hermenéutica de Heidegger, apuntando, así, para el carácter de indeterminación, o "tener de ser", e de singularidad de la existencia, siempre en juego en la constitución del modo de ser del hombre.

Determinación y causalidad en salud colectiva: algunas consideraciones en torno a sus fundamentos epistemológicos / Determination and causality in Public Health: some considerations on its epistemological foundations

La discusión sobre los determinantes es muy prolífica en el campo de la salud, no obstante todavía hace falta reflexionar sobre la manera en que ésta es definida y entendida como una categoría que permite problematizar la realidad desde una mirada totalizadora y compleja y sobre los alcances que puede tener su aplicación en la salud colectiva. Este trabajo discute los conceptos de causalidad, que predomina en la visión positivista, y determinación utilizado por algunas visiones alternativas en el campo de la salud. Se exponen algunos argumentos en torno al tratamiento ontológico y epistemológico en el estudio del proceso salud-enfermedad a partir de algunos planteamientos de la fenomenología.

The discussion on the determinants is extremely prolific in the area of health. However, we still have to think about the way in which the determination is defined and understood as a category that allows to question reality, from an overall and complex view, and the extent that they can have their application in public health. This article discusses the concepts of causality, which is dominant in the positivist vision as well as determination and historicity, used by some alternative views on health. Some arguments are exposed on the ontological and epistemological approach to address the study of health-disease process, from considerations of phenomenology.

Diagnosis of sleep apnoea: some critical issues.

Rather than describing a method for determining which patients should be labelled as having a disease, sleep apnoea, this review describes assessment as a process for deciding whom to investigate, what degree of sleep apnoea they have, how important their symptoms are, whether symptoms are likely attributable to sleep apnoea, and what sort of treatment to offer, if any. Beginning with identifying patients at risk and use of clinical prediction rules, the review covers (i) measurement and implications of the apnoeahypopnoea index; (ii) distinguishing central from obstructive apnoeas; (iii) significance of associated periodic limb movements; (iv) the controversy about the use of portable monitors instead of laboratory polysomnography; (v) evaluation of symptoms associated with sleep apnoea; and (vi) the important role of trials of treatment.

Cephalometric predictors of obstructive sleep apnea

PURPOSE: This study was intended to perform cephalometric comparison between the patients with and without obstructive sleep apnea (OSA). The factors influencing the OSA in the lateral cephalogram was also investigated. PATIENT AND METHOD: Twenty four patients who visited Sleep Disorder Clinic in Dongsan Medical Center, Keimyung University and evaluated with polysomnograph(PSG) and cephalogram were included in the study. The patients had apnea-hypopnea episode(AHI) over 10 times per hour was diagnosed as OSA after overnight PSG. To evaluate hard and soft tissue profile, cephalometric radiogram were taken at maximal intercuspation(P1) and mandibular protruding position(P2). The diffefence between the OSA and normal group were evaluated statistically and the stepwise regression analysis was applied to analyse the cephalometric influencing factors to OSA. RESULT: The OSA Group(n=14) had significantly higher Body Mass Index(BMI) than control group(n=10). Lower facial height(ANSGn) was longer in OSA group. However statistically significant difference was not detected in other anteroposterior craniofacial measurements. The soft palate lenth (PNS-P), hyoid position (MP-Hyoid) had positive correlation between AHI (r=0.496, r=0.413, respectively, p<0.05). However, the measurements of oropharyngeal airway was not different between the two groups. The hypothesis, the antero-posteriorly narrow oropharyngeal airway might aggravate the airway resistance and can give rise to higher AHI, was not accepted in the study. This can be attributed by inclusion of the patients performed uvulopalatopharyngoplasty because of the tonsilar or soft palate hypertrophy in the present study. The results of regression analysis revealed that PNS-P, upper airway width(Nph1), upper facial heght(N-ANS), and lower facial height(ANS-Gn) could influence the degree of AHI (F value < 0.0001, R2 = 0.829). CONCLUSION: We suggest lateral cephalogram may utilized as a useful method to evaluate OSA. The patient with long soft palate, narrow upper airway width, long upper and lower facial height can be expected to have high risk of OSA. However, it should be emphasized the comphrehensive intraoral inspection including soft palate and tonsilar hypertrophy because lateral cepahlogram cannot visualize oropharyngeal status completely.

The comparison study of the Auto-CPAP application to treating and titrating severe OSAHS patients in daytime nap and nocturnal sleep / 中国实用内科杂志

Objective To find out the difference or the regularity by the comparison study on the Auto-CPAP application to treating severe OSAHS patients in daytime nap and nocturnal sleep.It also supplies an evidence for reducing the expense in treating and testing severe OSAHS patients.Methods The patients who complained of snoring or dyspnea during sleeping and excessive daytime somnolence were selected as the subjects.They were monitored by PSG or Auto-CPAP ventilator system.Meanwhile their somnolent level were estimated by Epwoth.After that the patients with more than 20 AHI were selected as the advanced subjects.They were treated respectively in daytime nap and in the nocturnal sleep.And the daytime treating time lasted more than one hour and less than two hours and thirty minutes.Monitoring items included AHI,AI,HI,the longest duration of apnea or hyponea(LAHT),the lowest SaO\-2,the highest CPAP pressure(HP),median pressure(MP),90% pressure(90%P) and 95% pressure(95%P).Results The therapeutical effect is distinguished and is the same with the severe OSAHS in both daytime nap and nocturnal sleep.And also they need the same CPAP pressure level basically.Conclusion The CPAP pressure level titrated in daytime nap treatment period can be used in the nocturnal sleep therapy for severe OSAHS patients.