ABSTRACT
PURPOSE: To describe the clinical outcome of amniotic membrane transplantation(AMT) for various ocular surface diseases. METHODS: We reviewed the medical records of 52 eyes from 46 patients which had underwent AMT for various ocular surface diseases. We scored each eyes from 0 to 4 for subjective symptoms (symptom score) and epithelial healing (epithelial grade) at three months after AMT. The clinical score was calculated as the symptom score time the epithelial grade. RESULTS: The mean clinical score among all ocular surface disease was 10.41+/-4.26. The mean clinical scores for each disease are as follows: 7.71+/-3.56 for corneal ulcers, 14.43+/-3.1 for persistent epithelial defects, 12.83+/-2.71 for exposure keratitis, 12.86+/-3.18 for herpes keratitis, 5.85+/-2.5 for bullous keratopathy, 10.53+/-4.27 for chemical corneal burns and 16.0+/-0.0 for shield ulcers. Subjective symptoms subsides and epithelial healing progressed in all patients treated by AMT. No complications occurred. CONCLUSIONS: AMT is an effective method for treating various ocular surface diseases, because AMT improves the subjective symptoms of patients and promotes the healing of epithelial lesions.
Subject(s)
Humans , Amnion , Burns , Keratitis , Medical Records , UlcerABSTRACT
PURPOSE: To describe the clinical outcome of amniotic membrane transplantation(AMT) for various ocular surface diseases. METHODS: We reviewed the medical records of 52 eyes from 46 patients which had underwent AMT for various ocular surface diseases. We scored each eyes from 0 to 4 for subjective symptoms (symptom score) and epithelial healing (epithelial grade) at three months after AMT. The clinical score was calculated as the symptom score time the epithelial grade. RESULTS: The mean clinical score among all ocular surface disease was 10.41+/-4.26. The mean clinical scores for each disease are as follows: 7.71+/-3.56 for corneal ulcers, 14.43+/-3.1 for persistent epithelial defects, 12.83+/-2.71 for exposure keratitis, 12.86+/-3.18 for herpes keratitis, 5.85+/-2.5 for bullous keratopathy, 10.53+/-4.27 for chemical corneal burns and 16.0+/-0.0 for shield ulcers. Subjective symptoms subsides and epithelial healing progressed in all patients treated by AMT. No complications occurred. CONCLUSIONS: AMT is an effective method for treating various ocular surface diseases, because AMT improves the subjective symptoms of patients and promotes the healing of epithelial lesions.
Subject(s)
Humans , Amnion , Burns , Keratitis , Medical Records , UlcerABSTRACT
PURPOSE: To describe the clinical outcome of AMT (amniotic membrane transplantation) for corneal ulcers, persistent epithelial defects, corneal perforations, and neurotropic ulcers. METHODS: We performed AMT on 10 cases of corneal ulcer, 5 cases of persistent epithelial defect, 2 cases of corneal perforation, and 3 cases of neurotropic ulcer from Agust 1999 to May 2002. Amniotic membrane was obtained from the women undergoing elective Cesarean section or normal delivery. We had applied one or two layers of fresh amniotic membrane, that is used within 4hours after resection, over the ulcer bed and anchored by interrupted and running suture technique with 10-0 Nylon. After AMT, Topical eye drops was used three times a day. RESULTS: After AMT, Visual acuity was improved in 6 eyes of 10 corneal ulcer patients and maintained in 3 eyes. In all patients the persistent epithelial erosion was healed and pain was subsided between 6 and 12 days after surgery. There were no leakage in corneal perforation patients, and stable ocular surface were achieved after mean period 15.5 days. The ocular surface was restored by AMT in all neurotropic ulcer patients. CONCLUSIONS: The AMT is an effective method for managing corneal ulcer or ocular surface diseases, that are refractory to conventional treatment. The AMT shortened the usage of broad spectrum antibiotics , increased compliance, and decreased corneal opacity and neovascularization.