ABSTRACT
Background: HIV/AIDS emerged as the most important public health issue of the late twentieth and early twenty-first centuries. Hope & Quality of life (QoL) of People living with HIV/AIDS are affected by multiple socio-demographic variables as a major predictor of Hope & QoL. Methods: This cross-sectional descriptive survey research design included a sample of 430 PLHIV attending the ART centre, District Government Hospital, Bagalkot. Data were collected using the self-report method and Hospital records by socio-demographic questionnaire, Herths Hope Scale and WHO QOLHIV-BREF scale. Pearson's Correlations, chi-square test and multiple linear regression analysis were used. Results: A significant positive association was found between Hope and QoL among PLHIV (r= 0.483, p<0.001). A significant regression equation (F429, 42= 1.842, R2=0.167, p<0.01). Married status i.e. married, Occupation i.e. doing Labor work has positively and 3rd and 4th clinical-stage have negatively predicted Hope of PLHIV. A Non significant regression equation (F429,42=1.37, R2=0.13, p<0.05). Being a private employee had positively and Heterosexual had negatively predicted and remained determinants have not predicted QoL among PLHIV and there was a significant association found between marital status and remained variables are not associated with Hope. There was a significant negative relationship found between Family monthly income and a positive relationship found between the duration of HIV and QoL. Marital status is significantly associated with QoL. Conclusions: The overall findings reveals that a significant positive correlation between Hope and QoL among PLHIV. There was a significant association found between marital status with Hope. There was a significant negative relationship found between Family monthly income and positive relationship found Duration of HIV and QoL.
ABSTRACT
Background: Despite being preventable and curable, TB is the leading cause of HIV associated mortality. It is the most common opportunistic infection among HIV positive individuals with CD4 cell count <500/ mm3. Worldwide the number of people infected with both HIV & TB is rising. The objective of the study was to describe the socio-demographic profile of HIV-TB co-infected patients and to assess the adherence of HIV TB Co-infected patients to anti tubercular treatment (ATT) attending ART Centre, RIMS, Ranchi.Methods: It was a hospital based prospective study done at Rajendra Institute of Medical Sciences (RIMS), Ranchi. Duration of study was 14 months. A total of 117 patients were registered during the study period and were followed up for adherence to ATT.Results: Out of 117 patients 4 were excluded. Among 113 patients, mostly were male (74.3%) and from rural background (69.9%). Majority (94.7%) of the patients came for regular follow up and took medicines as advised. Adherence was significantly associated with education (p=0.025).Conclusions: In this study it was concluded that education significantly affected adherence to ATT among HIV-TB Co-infected patients of ART Centre of RIMS, Ranchi.
ABSTRACT
Background & objectives: The treatment outcomes under national antiretroviral therapy (ART) programme are being evaluated in some ART centres in the country. We carried out this study to analyze the impact of first line antiretroviral therapy in HIV infected patients attending a free ART roll out national programme clinic in Pune, India. Methods: Antiretroviral naive HIV infected patients attending the clinic between December 2005 and April 2008 and followed up till March 31, 2011 were included in the analysis. The enrolment and follow up of these patients were done as per the national guidelines. Viral load estimations were done in a subset of patients. Results: One hundred and forty two patients with median CD4 count of 109 cells/μl (IQR: 60-160) were initiated on treatment. The median follow up was 44 months (IQR: 37-53.3 months). Survival analysis showed that the probability of being alive at the end of 5 years was 85 per cent. Overall increase in the median CD4 count was statistically significant (P<0.001). It was significant in patients with >95 per cent adherence (P<0.001). In 14 per cent patients, the absolute CD4 count did not increase by 100 or more cells/μl at the end of 12 months. Viral load estimation in a subset of 68 patients showed undetectable levels in 61 (89.7%) patients after a median duration of 46 months (IQR: 38.3-54.8). Interpretation & conclusions: The first line treatment was effective in patients attending the programme clinic. The adherence level influenced immunological and virological outcomes of patients.