ABSTRACT
Asymmetric ventriculomegaly, interhemispheric cyst and dysgenesis of the corpus callosum (AVID) constitutes a rare imaging triad. Additional findings include subcortical and subependymal heterotopia, polymicrogyria, fused thalami, deficient falx, and hydrocephalus. The knowledge of this triad helps us to diagnose prenatally by sonography and fetal MRI. In this case report authors present MRI Imaging findings in a case of AVID syndrome in a 6year old male child presenting with history of seizures and delayed milestones.
ABSTRACT
Cell death plays important roles in living organisms and is a hallmark of numerous disorders such as cardiovascular diseases, sepsis and acute pancreatitis. Moreover, cell death also plays a pivotal role in the treatment of certain diseases, for example, cancer. Noninvasive visualization of cell death contributes to gained insight into diseases, development of individualized treatment plans, evaluation of treatment responses, and prediction of patient prognosis. On the other hand, cell death can also be targeted for the treatment of diseases. Although there are many ways for a cell to die, only apoptosis and necrosis have been extensively studied in terms of cell death related theranostics. This review mainly focuses on molecular imaging and therapeutic strategies directed against necrosis. Necrosis shares common morphological characteristics including the rupture of cell membrane integrity and release of cellular contents, which provide potential biomarkers for visualization of necrosis and necrosis targeted therapy. In the present review, we summarize the updated joint efforts to develop molecular imaging probes and therapeutic strategies targeting the biomarkers exposed by necrotic cells. Moreover, we also discuss the challenges in developing necrosis imaging probes and propose several biomarkers of necrosis that deserve to be explored in future imaging and therapy research.
ABSTRACT
Objective To discuss the applied value of multislice CT scan in combination with 99 MTC -MI-BI -SPECT for the diagnosis of isolated pulmonary nodule lesions.Methods 60 patients with solitary pulmonary nodules shadow in the X -ray film from July 2014 to August 2015 in our hospital were selected and detected by spiral CT scanning and 99mTC -MIBI -SPECT imaging.Scan results and pathological examination or surgery were com-pared,specificity,sensitivity and accuracy of pulmonary nodules were concluded about the method in the differential diagnosis isolation.Results The specificity,sensitivity and accuracy of multislice spiral CT scanning alone were 73.6%,78.2%,79.3% respectively;The specificity,sensitivity and accuracy of 99mTC -MIBI -SPECT imaging alone,were 82.6%,78.2%,79.3% respectively;The specificity,sensitivity and accuracy of multislice CT scan com-bined with 99mTC -MIBI -SPECT imaging were 93.3%,93.2%,93.8% respectively.The accuracy of combined detection was significantly higher than that of 99mTC -MIBI -SPECT examination(χ2 =6.783,P =0.010)or CT scan (χ2 =8.012,P =0.008).Conclusion Multislice CT scanning combined with 99mTC -MIBI -SPECT imaging has better effect in diagnosing pulmonary nodule lesions,which is superior to the method alone.The combination meth-od can obviously improve the detection rate of lung nodule lesions,which is,worthy of further promotion.