ABSTRACT
Background: Diabetes mellitus is a group of metabolic disorder characterized by chronic hyperglycemia with disturbances in carbohydrate, fat, and protein metabolism due to defects in insulin secretion, insulin action, or both. Diabetic dyslipidemia is characterized by increases low-density lipoprotein cholesterol (LDL-C), decreased high-density lipoprotein cholesterol (HDL-C) level, and elevated triglyceride (TG) levels. Objectives: The objectives of this study were to correlate the lipid profile with age, gender, and body mass index (BMI) of type 2 diabetes mellitus (T2DM) patients. Materials and Methods: A total of 76 T2DM patients were studied at Diabetes, Obesity, and Thyroid Center, Gwalior, Madhya Pradesh, between May 2016 and May 2017. After detailed demographic details including age, sex, weight, height, and BMI, total cholesterol (TC), TG, LDL-C, very LDL-C (VLDL-C), and HDL-C were estimated for all the patients. Results: The mean age of diabetes patients was 54.80 ± 11.07 years. The mean duration of diabetes was 5.38 ± 4.90 years. Lipid profile of T2DM patients was similar across the different age and BMI groups (P > 0.05). Except HDL-C (P < 0.001) which was significantly low among males other lipid parameters such as TC, TG, LDL-C, and VLDL-C were comparable between genders (P > 0.05). TC, TG, LDL‑C, and VLDL-C were showed positive correlation with fasting plasma glucose and postprandial glucose, whereas HDL-C showed negative correlation (P > 0.05). Conclusion: There was no significant difference in TC, TG, HDL-C, LDL-C, and VLDL-C level between different age and BMI groups. We found a significantly lower HDL-C level among the male population.
ABSTRACT
Background: Obesity is a major health problem which might contribute to many other problems such as heart disease and hypertension as well as diabetes due to abnormal lipid profile. The main objective of the current study was to compare the effectiveness of diet or treadmill exercise on normalizing the lipid profile of obese subjects. Methods: Forty women complaining from obesity was enrolled in this study and was randomly divided into 4 groups: control group: 10 obese women which don’t receive any thing, diet group: 10 obese women which received polysaturated fatty acid diet, exercise group: 10 obese women which received treadmill exercise for 30 minutes and lastly diet/exercise group: 10 obese women which received both diet and exercise. Measurement of weight, body mass index, and lipid profile for all groups was measured before and after 60 days of treatment intervention. Results: Diet and exercise should have a highly significant decrease of weight and body mass index and normalizing the lipid profile (p≤0.05) under the current situation used in this study. Conclusions: It was concluded that the combination of diet and exercise was highly effective in normalizing the lipid profile and overcoming obesity.