ABSTRACT
Acquired ichthyosis is a rare condition and ususually occurs in adult patients with various systemic diseases and drugs that affect cholesterol metabolism. As a rule when the underlying disease goes into remission, the ichtyosis regress. Clinically and histopathologically it is similar to ichthyosis vulgaris. We report a 43-year-old man with acquired ichthyosis, who associated with diabetes mellitus, chronic renal failure and hypertension.
Subject(s)
Adult , Humans , Cholesterol , Diabetes Mellitus , Hypertension , Ichthyosis Vulgaris , Ichthyosis , Kidney Failure, Chronic , MetabolismABSTRACT
Acquired ichthyosis is similar to ichthyosis vulgaris clinically and histologically, but it may develop in patients with several systemic disease and secondary to multiple drugs. Acquired ichthyosis was observed in four patients who had recieved bone marrow transplantation. Immunosuppression or abnormality of the immune system after bone marrow transplants may have a role in the pathogenesis of acquired ichthyosis.
Subject(s)
Humans , Bone Marrow Transplantation , Bone Marrow , Ichthyosis Vulgaris , Ichthyosis , Immune System , Immunosuppression TherapyABSTRACT
A 42-year-old woman presented with ichthyosiform eruptions on her trunk and buttock which developed 20 days prior to consulatation. She had taken the cholesterol-lowering drug(lovastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase inhibitor) for 4 months. After stopping the drug, the skin lesions gradually improved and after two months most of the lesions had disappeared. After 3 months of follow up the skin lesions could not be seen any more. Acquired ichthyosis in our patient could be an untoward effect of HMG CoA reductase inhibitor by disturbing the skin lipid metabolism.
Subject(s)
Adult , Female , Humans , Buttocks , Follow-Up Studies , Hydroxymethylglutaryl CoA Reductases , Ichthyosis , Lipid Metabolism , Lovastatin , Oxidoreductases , SkinABSTRACT
Although acquired ichthyosis has been associated with a number of systemic illnesses, an association with sarcoidosis has rarely been reported. We report a patient with aquired ichthyosis of the lower and upper extrimities whose diagnosis of cutaneous sarcoidosis was confirmed by histologic examination. Systemic involvement in the patient revealed occular, pulmonary and nerve disease. A diagnosis of sarcoidosis must be considered when a patient presents with acquired ichthyosis.