ABSTRACT
@#Fibroepithelial stromal polyp, more commonly known as acrochordon, skin tag, or soft fibroma is a type of mesenchymal tumor occurring among women of reproductive age. Fibroepithelial polyp, although the most common cutaneous tumor, is rare in the vulvovaginal region and there is currently no established protocol in approaching these kinds of lesions. Presented here is a series of cases of gradually enlarging labial masses among reproductive age women. These giant vulvar masses presented as solitary, flesh-colored, polypoid masses, initially non-tender but later becoming associated with local pain. Diagnosis is mainly through history, clinical examination aided by ultrasonography, and histopathologic examination, which would show a central fibrovascular core covered with squamous epithelium. Surgical excision serves as both diagnostic and therapeutic modality for these lesions. Vulvar fibroepithelial polyp do not seem to be as rare as literature says, they are relatively easy to diagnose and presents with benign clinical course.
Subject(s)
Vulvar Neoplasms , Vulvar DiseasesABSTRACT
Contexto: los acrocordones son protrusiones benignas de piel presentes en zonas de roce; usualmente acompañan a enfermedades metabólicas. Objetivo: caracterizar la asociación entre la severidad de presentación de acrocordones y el riesgo cardiometabólico medido en función del índice de masa corporal y obesidad central en pacientes mayores de 18 años que acuden a la Consulta de Dermatología Hospital San Francisco de Quito (HSFQ). Sujetos y métodos: pacientes de ambos sexos, mayores a 18 años que acuden espontáneamente a Consulta Externa del Servicio de Dermatología del Hospital San Francisco de Quito, perteneciente al Instituto Ecuatoriano de Seguridad Social, durante los meses septiembre a octubre de 2015. Antecedentes familiares y personales de la enfermedad, medición de peso, talla, perímetro de cintura y presencia de acrocordones (coloración, número y localización) asociados a acantosis nigricans. Resultados: se estudiaron 111 sujetos, con una edad media de 47 años; predominaron pacientes del sexo femenino (60,7%). Se determinó en el 55,9% de casos un índice de masa corporal (IMC) superior a 30 Kg/m2, siendo el fototipo IV más común (59,4%) asociado a obesidad abdominal (69,3%). La zona más afectada es cuello (96,4%); se catalogaron como severos el 75,6% de casos. La prevalencia de acrocordones de coloración mixta y forma severa de la enfermedad estuvo presente en 39 pacientes (29%). Un IMC ≥30 Kg/m2 y la forma severa de acrocordones es considerado un factor riesgo, sin demostrarse asociación estadística (OR 1,83; IC 95% 0,76-4.41). Sujetos con IMC ≥ 30 Kg/m2 tiene mayor riesgo de presentar acrocordones de forma severa asociados a acantosis nigricans (OR 2,62; IC 95% 1,07-6,36). Conclusión: se demostró relación estadística en el grupo de pacientes con obesidad y acrocordones de presentación severa, que presentan acantosis nigricans asociada. (AU)
Context: acrochordons are benign skin protrusions present in areas of friction; they usually accompany metabolic diseases. Ojective: to characterize the association between the severity of the presentation of acrochordons and the cardiometabolic risk measured according to the body mass index and central obesity in patients over 18 years of age who attend the San Francisco de Quito Hospital Dermatology Consultancy (HSFQ). Subjects and methods: patients of both sexes, over 18 years of age, who spontaneously go to the External Consultation of the Dermatology Service of the San Francisco de Quito Hospital, belonging to the Ecuadorian Social Security Institute, from September to October 2015. Main measurements: Family and personal history of the disease, measurement of weight, height, waist circumference and presence of acrochordons (coloration, number and location) associated with acanthosis nigricans. Results: 111 subjects were studied, with an average age of 47 years; female patients predominated (60.7%). A body mass index (BMI) greater than 30 kg / m2 was determined in 55.9% of cases, with phototype IV being the most common (59.4%) associated with abdominal obesity (69.3%). The most affected area is neck (96.4%); 75.6% of cases were classified as severe. The prevalence of acrochordons of mixed coloration and severe form of the disease was present in 39 patients (29%). A BMI =30 Kg / m2 and the severe form of acrochordons is considered a risk factor, without showing a statistical association (OR 1.83, 95% CI 0.76-4.41). Subjects with BMI = 30 Kg / m2 have a higher risk of presenting acrochordons of severe form associated with acanthosis nigricans (OR 2.62, 95% CI 1.07-6.36). Conclusion: Statistical relationship was demonstrated in the group of patients with obesity and acrochordons of severe presentation, who presented associated acanthosis nigricans. (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Severity of Illness Index , Cardiovascular System , Birt-Hogg-Dube Syndrome , Body Mass Index , Risk , ObesityABSTRACT
Objective: An acrochordon, is a small, soft, common, benign, usually pedunculated neoplasm that is found particularly in persons who are obese. Acrochordons have been reported to have an incidence of 46% in the general population. Most acrochordons vary in size from 2 to 5 mm in diameter, although larger acrochordons upto 5 cm in diameter are sometimes evident. They may occur singly or in multiples and they are most often found in intertriginous areas (e.g., axillae, neck, eyelids). We report an unusual presentation of acrochordon in a 38-year-old multipara who presented with complains of some mass in the private parts since three months. She was diagnosed to have acrochordon of the clitoris.
ABSTRACT
O acrocórdon é geralmente tumor benigno, peduncular, que acomete tanto o sexo feminino como o masculino e surge na idade adulta, sendo mais comum na meia idade. Alguns indivíduos podem ter mais probabilidade de serem acometidos, principalmente obesos e diabéticos. A maioria tem tamanho pequeno. Surgem mais facilmente em áreas de fricção, mas podem ocorrer em qualquer parte do corpo. Ocasionalmente pode exigir remoção devido a crescimento atípico, torção, irritação e dor, a depender do local acometido. Algumas condições comuns da pele podem imitar o acrocórdon ? a verruga de região genital é uma delas. Apesar de essa lesão ser acometida pelo papilomavírus humano, o acrocórdon algumas vezes pode estar associado a ela. Assim, é importante o exame histológico do material biopsiado.
Vulvar acrochordon: a report of two cases The acrochordon is usually a benign, stalk tumor, which affects both men and women. It is an adult-onset disease, being more common in middle-aged individuals. Some individuals may be more prone to the disease, especially those obese and diabetic. Most are small and develop more easily in areas of friction, but they may occur anywhere in the body. Occasionally removal may be required due to atypical growth, torsion, irritation or pain depending on the affected sites. Some common skin conditions may mimic acrochordon. Genital wart is one of these conditions, although it is affected by the human papiloma virus. The acrochordon may sometimes be associated with this infection. Therefore, histological examination of biopsy material is important.
ABSTRACT
Background: Skin tags (ST) are common tumors. They mainly consist of loose fibrous tissue and occur on the neck and major flexures as small, soft, pedunculated protrusions. Decrease in endocrine, hormone level and other factors are thought to play a role in the evolution of ST. Leptin is an adipocyte-derived hormone that acts as a major regulatory hormone for food intake and energy homeostasis. Leptin deficiency or resistance can result in profound obesity and diabetes in humans. A role of mast cell in the pathogenesis of ST is well recognized. Aims: To investigate the role of leptin in the pathogenesis of ST and to clarify whether there is a correlation between mast cell count and leptin level in ST. Methods: Forty-five skin biopsies were taken from 15 patients with ST. From each patient, a biopsy of a large ST (length >4 mm), a small ST (length <2 mm) and a normal skin biopsy (as a control) were taken. The samples were processed for leptin level. Skin biopsies were stained with hematoxylin and eosin and toluidine blue-uranyl nitrate metachromatic method for mast cell count was used. Results: There was a significant increased level of leptin in the ST compared to the normal skin. It was highly significant in small ST than in big ST (P = 0.0001) and it was highly significant in small and big ST compared to controls, P = 0.0001 and P = 0.001, respectively. There was a significant increase in mast cell count in the ST, which did not correlate with the increased levels of leptin. Conclusion: This is the first report to demonstrate that tissue leptin may play a role in the pathogenesis of ST. The significant increase in the levels of leptin and mast cell count in ST may indicate a possible role of adipoimmune in the benign skin growths.
ABSTRACT
Acrochordons are commonly found in middle aged rnan. They are mostly a few millimeters in size. The authors report an exceptionally large(10x5cm) one with a 3cm pedicle, which is thought to be the largest one in the Korean literature.