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The clinical scenario of a young male is presented in this report who presented with severe pain and swelling of both lower limbs of 3-day duration. On evaluation, he proved to have myositis and further evaluation unraveled Brucellosis. The index case improved with conventional Brucella melitensis treatment confirming the cause and effect relationship. The Brucella infection is a male predominant disease and frequently presents with typical symptoms of fever, fatigue, etc., and the diagnosis often is straightforward. Nevertheless, neurobrucellosis is uncommon, developing in <5% of patients with Brucella infection and producing diverse neurological syndrome. There are very few reports of Myositis caused by Brucella described in the literature. The heaviest disease burden of B. melitensis lies in countries of the Mediterranean basin and Arabian Peninsula. However, the disease is not uncommon in India, Mexico, and Central America. Hence, clinicians need to be aware of this clinical entity all over the globe. Myositis as the first presentation of acute brucellosis is presented in this report.
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Objective To analyze the epidemiologic features and laboratory findings of acute and chronic brucellosis.Methods Two hundred and ninety-two patients with brucellosis admitted in Heilongjiang Agricultural Reclamation Bureau General Hospital during June 2015 to February 2017 were retrospectively reviewed,including 170 acute cases and 122 chronic cases;95 healthy subjects undergoing health check-up at the same period were randomly selected as control group.Epidemiological characteristics,clinical symptoms and findings of laboratory tests of acute and chronic brucellosis were analyzed with SPSS 18.0 software.Results The male to female ratio were 3.15 to 1 and 3.21 to 1 for acute and chronic brucellosis,respectively.The patients were mainly rural residents (74.12％ and 77.05％) and the majority of them were farmers (62.94％ and 66.39％).The onset time was mainly from March to June of the year (47.06％ and 46.72％).The proportion of acute brucellosis patients ≤ 14 years was higher than that of chronic brucellosis group (x2 =5.022,P ＜ 0.05);the proportion of acute brucellosis patients ＞ 64 years old was lower than that of chronic brucellosis group (x2 =3.900,P ＜ 0.05).The symptom of sweating and myosalgia in acute brucellosis was more frequent than that in chronic brucellosis (x2 =10.764 and 10.479,both P ＜ 0.01);while the symptom of weakness in chronic brucellosis was higher than that in acute brucellosis (x2 =5.347,P ＜ 0.05).The AST,ALT,γ-GT,ALP,LDH and HBDH levels in patients with acute and chronic brucellosis were significantly higher than those in the control group (t =3.602 and 5.205;2.529 and 2.682;2.669 and 1.941;5.169 and 7.068;3.601 and 2.240;3.469 and 3.954;P ＜ 0.05 or 0.01);while TP and ALB levels were reduced (t =-5.880 and-8.923;-8.106 and-8.774;all P ＜ 0.01).The CRP in the acute brucellosis group was significantly higher than that in the chronic brucellosis group (t =6.717,P ＜0.01).The therapeutic regimes for acute brucellosis and chronic brucellosis were same,the symptoms dissolved after successful treatment.Conclusion There are different clinical manifestations between acute and chronic brucellosis.Medication for brucellosis should be cautious and the changes of myocardial enzymes should be monitored.
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OBJECTIVE@#To investigate the association between the cluster of differentiation 14 (CD14)-159C/T (rs2569190) gene polymorphism and susceptibility to acute brucellosis in an Iranian population.@*METHODS@#The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the control group. Genotyping of the CD14 variant was performed using an amplification refractory mutation system-polymerase chain reaction method.@*RESULTS@#The prevalence of CD14-159 TT and CT genotypes were associated with increased risk of brucellosis [odds ratio (OR) = 1.993, 95% confidence interval (95% CI) = 1.07-3.71, P = 0.03 for CT; OR = 3.869, 95% CI = 1.91-7.84, P = 0.01 for TT genotype. Additionally, the minor allele (T) was significantly more frequently present in brucellosis patients than in controls (61% vs. 45%, respectively), and was a risk factor for brucellosis (OR = 3.058, 95% CI = 1.507-6.315, P = 0.01).@*CONCLUSIONS@#The findings provided suggestive evidence of association of the CD14-159C/T gene polymorphism with susceptibility to acute brucellosis in the Iranian population.
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Objective: To investigate the association between the cluster of differentiation 14 (CD14)-159C/T (rs2569190) gene polymorphism and susceptibility to acute brucellosis in an Iranian population. Methods: The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the control group. Genotyping of the CD14 variant was performed using an amplification refractory mutation system-polymerase chain reaction method. Results: The prevalence of CD14-159 TT and CT genotypes were associated with increased risk of brucellosis [odds ratio (OR) = 1.993, 95% confidence interval (95% CI) = 1.07-3.71, P = 0.03 for CT; OR = 3.869, 95% CI = 1.91-7.84, P = 0.01 for TT genotype. Additionally, the minor allele (T) was significantly more frequently present in brucellosis patients than in controls (61% vs. 45%, respectively), and was a risk factor for brucellosis (OR = 3.058, 95% CI = 1.507-6.315, P = 0.01). Conclusions: The findings provided suggestive evidence of association of the CD14-159C/T gene polymorphism with susceptibility to acute brucellosis in the Iranian population.
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No abstract available.