Desmitificación del uso medicinal de la marihuana: argumentos médicos, científicos y sociales en contra de su legalización / Demythologization of marijuana's medicinal use: medical, scientific and social arguments against its legislation

El consumo de marihuana es un tema controversial, aún más con la intensa campaña global para legalizarlo, argumentando sus beneficios medicinales; ocultándose sus efectos adictivos. El presente trabajo explica cómo esta droga afecta la estructura y funcionamiento del sistema nervioso. Los neurotransmisores involucrados en el proceso adictivo como la dopamina, involucrada con la sensación de placer, los receptores cannabinoides CB1 y CB2 con mayor distribución en el sistema nervioso central y periférico, respectivamente, los cuales además están asociados a alteraciones de la motivación y habilidades cognitivas. Hay variada información que refuerza la asociación entre el uso de marihuana y el debut o recaída de los trastornos psiquiátricos. La APA (American Psychiatry Association) considera que la marihuana no es beneficiosa para el tratamiento de trastornos psiquiátricos, además advierte que su uso afecta el neurodesarrollo

The use of marijuana is a controversial issue even more with the intense global campaing to legalize it, arguing its medicinal benefits; hiding their effects. The present work explains how this drug affects the structure and functioning of the nervous system. Neurotransmitters involved in the addictive process as dopamine, involving pleasure receptors, cannabinoid receptors CB1 and CB2 more widely distributed in the central nervous system and peripheral respectively, which are also associated with changes in motivation and cognitive abilities. There is a variety of information that reinforces the association between marijuana use and the onset or relapse of psychiatric disorders. The American Psychiatry Association (APA) considers that marijuana is not beneficial for the treatment of psychiatric disorders, and warns that its use affects neurodevelopment

Recent research progress on anti-addiction drugs / 中国药理学通报

Recent discoveries about the effects of drugs of abuse on the brain and the mechanisms of their addictions, and new actions of available medications are offering many opportunities for the discovery and development of novel medications to treat addictive disorders.This article reviews the current medications that have shown promising results for treating opioid, cocaine, methamphetamine, cannabis, alcohol and nicotine addictions.