ABSTRACT
INTRODUCCIÓN: El cáncer de esófago posee para el 2007 una tasa de incidencia estimada en Chile de 5,7x100.000 habitantes. Los tipos histológicos más frecuentes son carcinoma de células escamosas y adenocarcinoma, esta última ha experimentado un aumento de su incidencia. OBJETIVOS: Caracterizar población de pacientes diagnosticados con cáncer de esófago, entre los años 2002 y 2011, del Hospital Base de Valdivia (HBV). METODOLOGÍA: Estudio descriptivo retrospectivo, cuyos datos se obtuvieron por revisión de libros de biopsias del Servicio de Anatomía Patológica de Hospital Base Valdivia entre los años 2002-2011 registrando datos sobre sexo, edad y tipo histológico. Los datos fueron tabulados y graficados en programa Excel 2010. RESULTADOS: Se analizaron 151 biopsias, con promedio de edad 70 años. La incidencia promedio fue de 4,14/100.000 habitantes con una relación 5:3 para sexo masculino y femenino respectivamente. La incidencia anual para hombres fue de 1,7 en 2002 y 7,2 en 2011. La incidencia anual promedio para carcinoma escamoso fue de 3,4/100.000 habitantes, para adenocarcinoma 0,58/100.000 habitantes, y otros tipos histológicos 0,2/100.000 habitantes. DISCUSIÓN: La incidencia por género fue más baja para varones que las cifras nacionales, pero con tendencia al alza. El tipo histológico más frecuente fue carcinoma escamoso. A diferencia de lo esperado el adenocarcinoma no tiene tendencia al alza.
INTRODUCTION: The year 2007 the esophageal neoplasms has an estimated incidence in Chile of 5,7/100.000. The most frequently histologic kinds are the Squamous Cell Carcinoma and the Adenocarcinona, the last one has shown an incidence rise. OBJECTIVES: Epidemiologic characterization of esophagus neoplasm cases for the 2002-2011 period. METODOLOGY: Retrospective descriptive study, where the data was obtained by biopsy books revision from the anatomy department at Valdivia hospital. Tabulation and analysis performed whit excel 2010. RESULTS: 151 cases were analyzed, average age were 70 years. The average incidence for men cases: 1,7/100.000 in 2002 and 7,2/100.000 in 2011. The Squamous Cell Carcinoma average incidence: 3,4/100.000 and for the adenocarcinoma: 0,58/100.000. DISCUSSION: The average incidence was lower for men than the national rates, but it's increasing. The mostcommon histologic kind is the quamous Cell Carcinoma. The adenocarcinoma isn't increasing as was expected.
Subject(s)
Humans , Male , Adult , Esophageal Neoplasms/epidemiology , Carcinoma, Squamous Cell/epidemiology , Adenocarcinoma/epidemiology , Chile , Epidemiology, Descriptive , Incidence , Retrospective Studies , Age and Sex DistributionABSTRACT
Aims: The objective of this study was to determine the level of secretion of gammainterferon by interferon-primed and unprimed Caco-2 intestinal epithelial cells and their survival or growth following infection with Salmonella enterica subsp. enterica serovar Typhimurium (ATCC 14028), Salmonella enterica subsp. enterica serovar Typhimurium DT104 (ATCC 700408), and Candida albicans (Robin) Berkhout, anamorph (ATCC 10231) as well as the survival of the test microorganisms following infection. Study Design: Controlled laboratory experiments were performed using two different species of Salmonella and adenocarcinoma Caco-2 cells. Untreated/ unprimed Caco-2 cells served as control; Caco-2 cells’ growth and interferon production were then determined using, Enzyme Linked Immunosorbent Assay (ELISA) and flow cytometry. Place and Duration of Study: Department of Biological & Environmental Sciences Alabama A& M University and Center for Excellence in Post-Harvest Technologies, North Carolina A&T University USA April 2008 and February 2010. Methodology: Cell culture supernatants of Caco-2 intestinal epithelial cells, primed and unprimed with IFN-γ were infected with either wild-type Salmonella Typhimurium 14028, Candida albicans10231 or multi-drug resistant Salmonella Typhimurium DT104 were collected and analyzed. ELISA and flow cytometry were used to determine apoptosis, cell growth and interferon production. The Bioscreen-C Automated Growth Curve Analysis System was used under controlled environment to determine the growth of the microorganisms in the presence of different concentrations of IFN-γ. Results: Secretion of IFN-γ from Caco-2 cells that were previously treated with 50μg/ml, 20μg/ml, 10μg/ml, 5μg/ml, and 2.5 μg/ml of IFN-γ were not concentration dependent. However, the amount of IFN-γ released from Caco-2 cells was dependent on microbial stimulus type. Cells that were pretreated with 5 μg/ml and 2.5 μg/ml of IFN-γ and then infected with Salmonella Typhimurium DT104 showed an increase in the amount of IFN-γ in the culture medium after 5 minutes. IFN-y induced CaCo-2 cell death was dose-dependent for S.Typhimurium DT104 and Candida albicans. Results are reported as mean ± SEM fortriplicate values from three independent experiments at each time point and IFN-γ dose. Conclusion: These findings indicate that IFN-γ may serve as alternative antimicrobial compounds to reduce the persistence of multi-drug resistant microorganisms such as S. Typhimurium DT104. Induction of interferon-gamma production may be related to microbial virulence/pathogenicity. The potential of IFN-γ as a natural therapeutic for persistent infections in the immune-compromised populations still needs to be further investigated.
Subject(s)
Caco-2 Cells , Candida albicans/radiation effects , Humans , Interferon-gamma/therapeutic use , Intestinal Mucosa/microbiology , Intestinal Mucosa/pathology , Intestinal Mucosa/radiation effects , Salmonella typhimurium/classification , Salmonella typhimurium/radiation effectsABSTRACT
Primary seminal vesicle adenocarcinoma (PSVA) is an extremely rare disease without any unified diagnostic criterion. Differential diagnosis of PSVA from prostate cancer, colon cancer, and bladder cancer is necessary but difficult because of the lack of standard management. Radical resection is considered the mainstay of primary treatment that offers satisfactory prognosis. Most cases with PSVA are diagnosed at advanced stages because its early manifestation is nonspecific and it is rarely diagnosed in clinic. In this study, we described the case of a 52 year-old PSVA patient who was treated at the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, in July 2012. The patient underwent local excision, with tumor residuals visible under the naked eye. The patient benefits from a six-cycle paclitaxel (175 mg/m2) therapeutic regimen combined with cisplatin (60 mg/m2), as well as pelvic modulated radiotherapy with a radiation dose of 60 Gy/30 F. At present, the patient is disease-free and undergoes regu-lar follow-up.
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Gastric cancer is the leading cause of death of patients with malignancy and the most common malignancy in China.Stomach is also a secretory organ,thus the carcinogenesis of human stomach always accompanied neuroendocrine differentiation.There is not a explicit definition of neuroendocrine differentiation so far,and the influence of which in gastric patients prognosis is in dispute.With the deep intensive research of gastric adenocarcinoma,diagnosis and treatment in gastric adenocarcinoma with neuroendocrine differentiation becomes increasingly concerned.
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There are a few reports about coexistence of Henoch-Schonlein purpura (HSP) and a variety of malignancy in adults. The accompanying malignancies, in order of frequency, were hematologic malignancy, lung cancer and prostate cancer. Gastrointestinal tract (GIT) cancer associated with HSP was rarely reported which includes 2 cases of stomach cancer, 1 case of small bowel cancer and 1 case of esophageal cancer. Malignancy is proposed to be a triggering factor in the development of HSP, however pathogenesis of HSP associated with malignancy remains obscure. Here, we report 2 cases of HSP associated with malignancy in GIT. One is an adenocarcinoma of the colon and the other is a stomach adenocarcinoma with signet ring cell component.