ABSTRACT
In order to determine whether the central mediator participates in the mechanism of the EP biphasic fever, the following experiments were carried out: 1. Effect of EP in different doses on the fever pattern; 2. Changes of the cAMP content in CSF and in plasma during the EP biphasic fever. The results obtained demonstrated: 1. After EP were given intravenously in different doses, different fever patterns were produced. 2. The cAMP contents in CSF were increased markedly in every phase of the EP biphasic fever compared with the normal control. These changes of the cAMP content were paralleled and correlated apparently with the body temperature. However, there Were no obvious changes of the cAMP content in plasma during the EP biphasic fever. It demonstrated that cAMP increased in CSF was synthesized and released by CNS for oneself. The authors deduced from above: The wave of body temperature may be related to the changes of cAMP in center during the EP biphasic fever. The fluctuation of cAMP content in the center caused the set-point to move up and down, and further caused the fluctuation of the body temperature and formed the biphasic fever.