ABSTRACT
Adrenocortical oncocytoma is a rare epithelial tumor only described in adults and in most cases, benign and non-functioning. Histologically characterized by cells with eosinophilic granular cytoplasm and ultra-structurally by the presence of numerous closely packed mitochondria. We report a case of adrenal oncocytoma developed in a 10-year-old girl who presented a left adrenal mass with low voice tone, excessive hair growth, and elevation of the plasma testosterone and dehydroepiandrosterone sulfate levels as a result of overproduction of adrenal steroid hormones. After the left adrenalectomy, her hormone levels were normalized.
Subject(s)
Adult , Child , Humans , Adenoma, Oxyphilic , Adrenalectomy , Cytoplasm , Dehydroepiandrosterone Sulfate , Eosinophils , Hair , Mitochondria , Plasma , Testosterone , Virilism , VoiceABSTRACT
Adrenocortical oncocytoma is a rare epithelial tumor only described in adults and in most cases, benign and non-functioning. Histologically characterized by cells with eosinophilic granular cytoplasm and ultra-structurally by the presence of numerous closely packed mitochondria. We report a case of adrenal oncocytoma developed in a 10-year-old girl who presented a left adrenal mass with low voice tone, excessive hair growth, and elevation of the plasma testosterone and dehydroepiandrosterone sulfate levels as a result of overproduction of adrenal steroid hormones. After the left adrenalectomy, her hormone levels were normalized.
Subject(s)
Adult , Child , Humans , Adenoma, Oxyphilic , Adrenalectomy , Cytoplasm , Dehydroepiandrosterone Sulfate , Eosinophils , Hair , Mitochondria , Plasma , Testosterone , Virilism , VoiceABSTRACT
Objective To explore the clinical features of adrenocortical oncocytoma for better understanding. Methods A total of 586 patients with adrenal cortical adenoma were retrospectively analyzed in our hospital from January 1993 to November 2009, in which 18 were diagnosed as adrenal cortical oncocytoma pathologically, with 7 male and 11 female, aged ( 45.5 ± 15.9 ) years, and the disease course of( 13.3 ± 13.1 )months. Results 6 patients suffered from Cushing's syndrome, 2 primary hyperaldosteronism, 1 had clinical features of both Cushing's syndrome and primary hyperaldosteronism, and 9 were nonfunctional. 4 cases were misdiagnosed as pheochromocytoma preoperatively. All 18 patients were diagnosed by B-mode ultrasound and operation ( 13 by laparoscopy, 5 by laparotomy). 11 tumors were located in the left adrenal while 7 in the right, with the average tumor size of 5.6 cm in diameter. Histopathologically, 1 was oncocytic adrenocortical carcinoma, while 17 were adrenocortical oncocytoma, in which 5 were potentially malignant and 12 were benign. 11 patients were followed up for 20.5±20.1 months. 2 patients were dead, and 9 were alive with tumor recurrence in 1 case.ConclusionsAdrenocortical oncocytoma is a pathological diagnosis and the clinical manifestations are various. The tumors are usually large in size, and can easily be found by ultrasound, but may be wrongly diagnosed as pheochromocytoma.Being different from previous reports, the majority of these patients present with endocrine dysfunction. Most of these cases are benign, but malignant potential is obvious. Therefore,follow-up is very important.
ABSTRACT
Adrenocortical oncocytoma is a very rare disease which has been reported in 40 cases. A 27-years-old female patient was admitted for a suspicious hepatocellular mass on ultrasonogram. On CT scan, sono-guided needle biopsy and 18F-FDG PET scan, all results were unsatisfactory. During laparotomy, the mass was originated from Rt. adrenal gland and liver was pushed sideward by the mass. On pathology report, an adrenocortical oncocytoma was diagnosed. Adrenocortical oncocytoma has pathological characteristics comprised of oncocytes with granular, eosinophilic cytoplasm, and sufficient mitochondria in their cytoplasm. There were no established criteria for differential diagnose between benign and malignant adrenocortical oncocytoma. There are no sufficient data for the long-term outcome of adrenocortical oncocytoma in the medical literature. Thus we report a case of adrenocortical oncocytoma with review of the related literature.