ABSTRACT
Objective:To systematically evaluate the effectiveness and feasibility of aerobic exercise intervention in schizophrenia patients.Methods:Randomized controlled trials on exercise interventions for patients with schizophrenia were searched in eight databases from built up to March 2023, including China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), WanFang Data, China Biomedical Literature Database, PubMed, Cochrane Library, EMBASE and Web of Science. The positive and negative symptom scale (PANSS) and its sub-scales were used as primary outcome indicators, and the negative symptom scale (SANS) and body mass index (BMI) were used as secondary indicators, and Meta-analysis was performed using R 4.1.0 and Stata 14.0.Results:Forty-seven studies including 3 139 patients with schizophrenia were included. Results of a network Meta-analysis based on 24 studies showed that aerobic exercise may be the most effective measure for reducing total PANSS scores in patients with schizophrenia. Compared to conventional treatment, combining aerobic exercise intervention improved patients' PANSS total score (MD= -5.09, 95% CI: -5.90~-4.28), SANS (MD= -12.17, 95% CI: -14.25~-10.10), and BMI (MD=-1.59, 95% CI: -1.93~-1.25). Meanwhile, subgroup analysis showed that 2 months of intervention was more appropriate (MD=-6.12, 95% CI: -7.22~-5.02) and the weekly total exercise time for 140-260 min was more appropriate (MD=-8.59, 95% CI: -12.93~-4.25) in terms of total PANSS score. The adherence rates between the trial and control groups showed no significant difference between the aerobic exercise intervention combined with conventional treatment and conventional treatment alone( P>0.05). Conclusion:Aerobic exercise intervention is an effective measure to relieve the symptoms of schizophrenia patients and has good compliance among inpatients.
ABSTRACT
Objective:To explore the effects of low-calorie diet intervention and aerobic exercise intervention on insulin levels and body composition in obese patients with type 2 diabetes.Methods:A total of 300 obese patients with early type 2 diabetes who were diagnosed and treated in the Department of Endocrinology, Xuanwu Hospital of Capital Medical University from July 2016 to July 2019 were selected as the research objects. According to the random sampling method, they were divided into a control group and an observation group with 150 cases each. Calorie diet intervention was given to control group, while the observation group was given low-calorie diet intervention and concentrated aerobic exercise intervention. Observation and evaluation of fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), body fat percentage, body weight, triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were conducted.Results:After 4 weeks of intervention, FBG, FINS, HOMA-IR, BMI, body fat percentage, body mass, TG, TC, HDL-C, LDL-C indicators of the observation group were (6.15±0.92) mmol/L and (14.12±1.11) mU/L, 2.67±0.32, (25.01±1.75) kg/m 2, (27.45±1.92)%, (70.01±3.56) kg, (3.01±0.30) mmol/L, (5.25±0.88) mmol/L, (2.25 ±0.42) mmol/L, (3.15±0.41) mmol/L. The control group were (8.18±1.28) mmol/L, (16.78±1.85) mU/L, 3.78±0.78, (27.36±2.45) kg/m 2, (29.78±2.39)%, (72.98±5.62) kg, (3.49±0.52) mmol/L, (6.23±1.08) mmol/L, (1.88±0.30) mmol/L, (3.98±0.89)mmol/L. The difference between the two groups was statistically significant ( t values were 5.47-16.13, all P<0.05). After 8 weeks of intervention, FBG, FINS, HOMA-IR, BMI, body fat percentage, body mass, TG, TC, HDL-C, LDL-C indicators of the observation were (5.06±0.45) mmol/L, (12.78±0.69) mU/L, 2.01±0.12, (23.25±1.18) kg/m 2, (25.05±1.19)%, (66.02±2.45) kg, (2.21±0.12) mmol/L, (4.03±0.41) mmol/L, (3.08 ±0.72) mmol/L, (2.65±0.15) mmol/L,while in the control group were (6.07±0.88) mmol/L, (14.09±1.05) mU/L, 2.95±0.45, (26.98±2.08) kg/m2, (27.18±2.06)%, (70.98±4.02) kg, (2.98±0.28) mmol/L, (5.16±0.71) mmol/L, (2.41±0.51) mmol/L, (3.29±0.39) mmol/L. The difference between the two groups was statistically significant ( t values were 5.47-30.96, all P<0.05). Conclusions:Low-calorie diet intervention combined with concentrated aerobic exercise intervention is more conducive to improving patients′ blood sugar and blood lipid levels, as well as reducing body weight.