Glucose and lipid metabolism characteristics in the male primary aldosteronism patients / 国际检验医学杂志

Objective To investigate the characteristics of glucose and lipid metabolism in the male primary aldosteronism(PA) patients .Methods 125 male PA patients screened out by using plasma aldosterone/renin ratio(ARR) plasma aldosterone concen‐tration measurement were enrolled in the study(PA group) ,at the same time 127 male patients with essential hypertension(EH) were also recruited as EH group ,who had similar blood pressure levels and hypertension course .Clinical data and biochemical indi‐cators of each group were collected and the characteristics of glucose and lipid metabolism in the male PA patients were analyzed . Results Serum potassium level of PA group was lower than EH group(P<0 .05) .Compared with EH group ,there were significant increase of triglycerides concentration in PA group(P<0 .05) ,and significant decrease of HDL‐C concentration in PA group(P<0 .05) .Oral glucose tolerance test(OGTT) 2 h glucose level and waist in PA group were higher or larger than that in EH group (P<0 .05) .Conclusion Compared with EH patients ,glucose and lipid metabolism disorder are more severe in male PA patients , the symptoms are mainly abdominal obesity and impaired glucose tolerance .

Ratio of plasma aldosterone concentration to renin activity in screening for primary aldosteronism:the current situation and influencing factors / 中国实用内科杂志

The ratio of plasma aldosterone concentration to renin activity (ARR) is a sensitive parameter for screening of primary aldosteronism (PA) and for predicting prognosis after adrenalectomy in patients with PA.Study of the influencing factors for ARR,especially medications,sodium intake and posture,is of great significance for improving the screen efficacy of ARR.This paper introduces the current application of ARR in screening for PA and optimization of its determining conditions.

Plasma aldosterone/renin ratio——a sensitive screening test and parameter for primary aldosteronism / 中华内分泌代谢杂志

Plasma aldosterene/renin ratio (ARR) is a sensitive screening test and parameter for primary aldosteronism(PA).The use of ARR leads to a marked increase in the detection rate of PA in the hypertensive population.However,ARR remains a nonstandardized test,and the cutoff value of ARR used in the different studies is varied.Further and systematical studies are needed to improve the accuracy of the test.